Navigation Links
Genes Seem to Affect Tissues Differently
Date:12/23/2008

Finding may help unravel how diseases form,,

TUESDAY, Dec. 23 (HealthDay News) -- The same gene acting very differently in different tissues may contribute to certain human traits, including how likely a person is to get a disease, a new report says.

Researchers at Duke University Medical Center found a wide variance in gene expression -- the amount of protein it tells cells to produce. Such variation can lead to alternative splicing, a process that can create different proteins from the same gene and might be important to disease formation.

"A genetic variant might influence the expression of a gene or the type of protein that is made because of splicing changes in brain cells but not in blood cells, or in blood cells but not brain cells," senior author David Goldstein, director of the Center for Human Genome Variation at Duke's Institute for Genome Sciences and Policy, said in a university news release.

As such, researchers should look at tissue directly affected by a disease, such as brain tissue, when studying epilepsy or Alzheimer's disease. Often, researchers look at gene expression in blood cells, because they are easy to obtain and work with, he said.

The findings were published in the Dec. 22 online version of PLoS Biology.

In the Duke study, researchers found dramatic variations in gene expression in blood and brain cells.

"It really shows that we need to build up a very comprehensive picture of how genetic variation influences gene expression in specific tissues," first author Erin Heinzen said in the same news release.

Goldstein said the findings will "reorient our attention toward what is happening in specific and relevant tissues. At the same time, we're looking at the way that genetic variation influences the types of proteins that are made, as opposed to just the abundance."

More information

The Genetics Home Reference has more about how genes affect protein production.



-- Kevin McKeever



SOURCE: Duke University Medical Center, news release, Dec. 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. SNPs of ABC transporter genes linked to lung cancer risk
2. ThermoGenesis Introduces New Cell Separation Technology for Veterinary Use at Major Equine Convention
3. 11 New Cholesterol Genes Identified
4. Few Ontario women with invasive ovarian cancer referred for genetic testing of breast cancer genes
5. ThermoGenesis Corp. Provides Updated Information for Conference Call/Webcast to Discuss Management Transition
6. ThermoGenesis Corp. Schedules Conference Call/Webcast to Discuss Management Transition
7. ThermoGenesis Announces Management Transition; Provides Update on Operational Milestones
8. Organogenesis Receives Two Prestigious Awards for Economic Impact and Manufacturing Excellence
9. China West II Files Suit Against Genesis Pharmaceuticals and Capital Research Group Inc, Announces Conference Call Details
10. Genes May Predict Lymphoma Treatment Outcome
11. Researchers ID Suite of Genes in Aging Process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... June 23, 2016 Bracket , a leading ... next generation clinical outcomes platform, Bracket eCOA (SM) 6.0, ... June 26 – 30, 2016 in Philadelphia ... Clinical Outcome Assessment product of its kind to fully integrate ... Bracket eCOA 6.0 is a flexible platform for electronic ...
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
Breaking Medicine Technology: