Navigation Links
Genes Seem to Affect Tissues Differently
Date:12/23/2008

Finding may help unravel how diseases form,,

TUESDAY, Dec. 23 (HealthDay News) -- The same gene acting very differently in different tissues may contribute to certain human traits, including how likely a person is to get a disease, a new report says.

Researchers at Duke University Medical Center found a wide variance in gene expression -- the amount of protein it tells cells to produce. Such variation can lead to alternative splicing, a process that can create different proteins from the same gene and might be important to disease formation.

"A genetic variant might influence the expression of a gene or the type of protein that is made because of splicing changes in brain cells but not in blood cells, or in blood cells but not brain cells," senior author David Goldstein, director of the Center for Human Genome Variation at Duke's Institute for Genome Sciences and Policy, said in a university news release.

As such, researchers should look at tissue directly affected by a disease, such as brain tissue, when studying epilepsy or Alzheimer's disease. Often, researchers look at gene expression in blood cells, because they are easy to obtain and work with, he said.

The findings were published in the Dec. 22 online version of PLoS Biology.

In the Duke study, researchers found dramatic variations in gene expression in blood and brain cells.

"It really shows that we need to build up a very comprehensive picture of how genetic variation influences gene expression in specific tissues," first author Erin Heinzen said in the same news release.

Goldstein said the findings will "reorient our attention toward what is happening in specific and relevant tissues. At the same time, we're looking at the way that genetic variation influences the types of proteins that are made, as opposed to just the abundance."

More information

The Genetics Home Reference has more about how genes affect protein production.



-- Kevin McKeever



SOURCE: Duke University Medical Center, news release, Dec. 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. SNPs of ABC transporter genes linked to lung cancer risk
2. ThermoGenesis Introduces New Cell Separation Technology for Veterinary Use at Major Equine Convention
3. 11 New Cholesterol Genes Identified
4. Few Ontario women with invasive ovarian cancer referred for genetic testing of breast cancer genes
5. ThermoGenesis Corp. Provides Updated Information for Conference Call/Webcast to Discuss Management Transition
6. ThermoGenesis Corp. Schedules Conference Call/Webcast to Discuss Management Transition
7. ThermoGenesis Announces Management Transition; Provides Update on Operational Milestones
8. Organogenesis Receives Two Prestigious Awards for Economic Impact and Manufacturing Excellence
9. China West II Files Suit Against Genesis Pharmaceuticals and Capital Research Group Inc, Announces Conference Call Details
10. Genes May Predict Lymphoma Treatment Outcome
11. Researchers ID Suite of Genes in Aging Process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a ... health care, have expanded their existing home health joint venture through an agreement, ... been operating a joint venture home health company with Asante, delivering clinically integrated ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the ... – Miles by Moonlight to raise money for the American Heart Association Heart Walk. ... , Teams will work together to keep their treadmills moving for 5 hours. Treadmills ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis , ... supply chains, has published the first annual edition of its Global CSR ... than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that analyzed ... ... & Performance Index ...
(Date:9/12/2017)... , Sept. 12, 2017  ValGenesis Inc., the ... (VLMS), is pleased to announce the appointment of ... of its Board of Directors and Chairman of ... enables life science companies to manage their entire ... of paper in this process. Furthermore, ValGenesis VLMS ...
Breaking Medicine Technology: