Navigation Links
Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
Date:2/9/2010

Age, gender, genetics affect odds of remaining recurrence-free, research shows

TUESDAY, Feb. 9 (HealthDay News) -- U.S. scientists have discovered there are genetic profiles that play a part in prognosis with non-small cell lung cancers, and those profiles differ depending on the age and gender of the patient.

The researchers analyzed genetic and clinical data from 787 patients who were divided into subgroups based on sex and age (below or above age 70). The findings are published in the Feb. 10 issue of the Journal of the American Medical Association.

In those younger than 70, 25 percent of high-risk patients (those with the shortest recurrence-free survival) showed increased activation of a gene called Src, compared to 6 percent of low-risk patients. In addition, activation of tumor necrosis factor pathways (which are related to death of cells or tissue) was seen in 76 percent of high-risk patients and in 42 percent of low-risk patients.

Among patients aged 70 and older, high-risk patients showed increased activation of the wound healing pathways (40 percent vs. 24 percent) and invasiveness pathways (64 percent vs. 20 percent) compared to low-risk patients, the study authors reported.

The study also found gender differences in lung cancer biology. High-risk female patients had increased activation of the invasiveness and STAT3 gene pathways, while high-risk male patients had increased activation of the STAT3, tumor necrosis factor, wound healing and epidermal growth factor receptor (EGFR) pathways. EGFR is a protein that promotes cell growth and multiplication.

"We believe our findings represent a [new] approach to defining clinically relevant cohorts of non-small cell lung cancer stratified by age and sex that are enriched for specific pathway activity and that would be more apt for therapeutic intervention when planning clinical trials with drugs that target specific pathway-related abnormalities or tumor biology," wrote William Mostertz, of Duke University, and colleagues.

"With genomic [tests] now being increasingly practical and clinically applicable, with turnaround times of five to seven days, we believe our findings . . . represent a step forward in defining pathway-driven cohorts of non-small cell lung cancer that likely explain the age- and sex-specific difference seen in non-small cell lung cancer," the researchers concluded.

More information

The American Cancer Society has more about non-small cell lung cancer.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, Feb. 9, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists Spot Genes Tied to Aging
2. Scientists ID a protein that splices and dices genes
3. Genes May Influence Preterm Births
4. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
5. Genes of pregnant women and their fetuses can increase the risk of preterm labor
6. NIH scientists identify maternal and fetal genes that increase preterm birth risk
7. Very Obese People May Be Missing Genes
8. Scientists map out regulatory regions of genome, hot spots for diabetes genes
9. Mutating Genes May Lead to Premature Births
10. Genes, Diet Offer New Clues to Parkinsons Disease
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... 2016 , ... Give To Cure today announced that it is ... Give To Cure’s campaign that is crowdfunding clinical trials to help find cures faster ... through a smart device. In 2015 alone, Venmo processed $7.5 billion in transactions among ...
(Date:2/5/2016)... ... February 05, 2016 , ... Dr. Justin Scott and Dr. ... Annual No Cost Dental Day to individuals in need. The event is scheduled to ... No Cost Dental Day is to provide dental care to community members in need. ...
(Date:2/5/2016)... IL (PRWEB) , ... February 05, 2016 , ... In ... disguised form as a dream. A hallmark feature of patients with eating disorders is ... needs. The eating disorder behaviors and obsessions are regarded as maladaptive means for coping ...
(Date:2/5/2016)... ... February 05, 2016 , ... Calls Blacklist has just been updated by mobile ... and the developer has fixed known bugs within the app. Calls Blacklist allows its ... while not consuming any of their device’s battery power or memory. It provides a ...
(Date:2/5/2016)... ... , ... When one is tired of trying to cram belongings into spare space that just ... a storage unit, but before hastily spending money on a unit, take these tips into ... But what one is often not told when utilizing these services are some tips on ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016 Aethlon Medical, Inc. ... , Chairman and CEO, will be presenting at Source Capital ... New York, NY at 2:15 p.m. ET on ... an Immunotherapy Panel discussion taking place at 3:15 p.m. ET. ... replay approximately one hour after the conclusion of the live ...
(Date:2/5/2016)... 2016 --> ... "Fetal (Labor & Delivery) and Neonatal Care Equipment Market ... Oximeter, Phototherapy/Jaundice Management Devices, CPAP, Capnograph, & Resuscitator) - ... studies the global market over the forecast period of ... 6.28 Billion in 2015 and is poised to grow ...
(Date:2/4/2016)... DUBLIN, Ohio , Feb. 4, 2016 ... Pricing Program, or those already participating in the program, ... Guidance, often referred to as the , Mega-Guidance , ... the final guidance is published in September 2016. ... 340B Product and Service Marketing , summarizes the Mega-Guidance,s ...
Breaking Medicine Technology: