Navigation Links
Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
Date:2/9/2010

Age, gender, genetics affect odds of remaining recurrence-free, research shows

TUESDAY, Feb. 9 (HealthDay News) -- U.S. scientists have discovered there are genetic profiles that play a part in prognosis with non-small cell lung cancers, and those profiles differ depending on the age and gender of the patient.

The researchers analyzed genetic and clinical data from 787 patients who were divided into subgroups based on sex and age (below or above age 70). The findings are published in the Feb. 10 issue of the Journal of the American Medical Association.

In those younger than 70, 25 percent of high-risk patients (those with the shortest recurrence-free survival) showed increased activation of a gene called Src, compared to 6 percent of low-risk patients. In addition, activation of tumor necrosis factor pathways (which are related to death of cells or tissue) was seen in 76 percent of high-risk patients and in 42 percent of low-risk patients.

Among patients aged 70 and older, high-risk patients showed increased activation of the wound healing pathways (40 percent vs. 24 percent) and invasiveness pathways (64 percent vs. 20 percent) compared to low-risk patients, the study authors reported.

The study also found gender differences in lung cancer biology. High-risk female patients had increased activation of the invasiveness and STAT3 gene pathways, while high-risk male patients had increased activation of the STAT3, tumor necrosis factor, wound healing and epidermal growth factor receptor (EGFR) pathways. EGFR is a protein that promotes cell growth and multiplication.

"We believe our findings represent a [new] approach to defining clinically relevant cohorts of non-small cell lung cancer stratified by age and sex that are enriched for specific pathway activity and that would be more apt for therapeutic intervention when planning clinical trials with drugs that target specific pathway-related abnormalities or tumor biology," wrote William Mostertz, of Duke University, and colleagues.

"With genomic [tests] now being increasingly practical and clinically applicable, with turnaround times of five to seven days, we believe our findings . . . represent a step forward in defining pathway-driven cohorts of non-small cell lung cancer that likely explain the age- and sex-specific difference seen in non-small cell lung cancer," the researchers concluded.

More information

The American Cancer Society has more about non-small cell lung cancer.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, Feb. 9, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists Spot Genes Tied to Aging
2. Scientists ID a protein that splices and dices genes
3. Genes May Influence Preterm Births
4. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
5. Genes of pregnant women and their fetuses can increase the risk of preterm labor
6. NIH scientists identify maternal and fetal genes that increase preterm birth risk
7. Very Obese People May Be Missing Genes
8. Scientists map out regulatory regions of genome, hot spots for diabetes genes
9. Mutating Genes May Lead to Premature Births
10. Genes, Diet Offer New Clues to Parkinsons Disease
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... 24, 2017 , ... The California State University Institute for Palliative Care ... or interested in palliative care education and research. The Symposium, “Innovate. Investigate. Educate: ... San Diego on Sept. 28 and 29, 2017, on the campus of California State ...
(Date:2/24/2017)... ... February 24, 2017 , ... The International Association of Eating Disorders Professionals ... What You See” body image mannequin art competition. Selected from 15 submissions from around ... winner revealed at the 31st annual iaedp Symposium, March 22 – 26 in Las ...
(Date:2/24/2017)... ... 2017 , ... The Radiology Business Management Association will select the ... annual Building Better Radiology Marketing Programs conference, held this year from March ... Nine awards are given out in five categories. They are:, , ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... Senior International Elite division on February 12th. Ms. Esparza qualified into this ... elite qualifier competition held in Las Vegas, Nevada. Frida is one of approximately ...
(Date:2/23/2017)... ... February 23, 2017 , ... Thinksport, the ... The Jensie Gran Fondo of Marin. For the second year in a row, ... mineral-based sunscreen. , “We are thrilled to provide our safe, non-toxic sunscreen to ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... 2017 Nevro Corp. (NYSE: NVRO), a global medical ... treatment of chronic pain, today reported financial results for the ... 2016 Accomplishment & Highlights: Achieved ... increase of 228% as reported, over the prior year ... of 612% over the prior year International ...
(Date:2/23/2017)... Research and Markets has announced the addition of the "Oesophageal ... their offering. ... The latest research Oesophageal Cancer Drugs Price Analysis and Strategies - ... Cancer market. The research answers the following questions: ... Oesophageal Cancer and their clinical attributes? How are they positioned in ...
(Date:2/23/2017)... 23, 2017 Regulus Therapeutics Inc . ... development of innovative medicines targeting microRNAs, today announced it ... results on Thursday, March 2, 2017 after the market ... and webcast on March 2, 2017 at 5:00 p.m. ... 2016 financial results and provide a general business update.  ...
Breaking Medicine Technology: