Navigation Links
Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
Date:2/9/2010

Age, gender, genetics affect odds of remaining recurrence-free, research shows

TUESDAY, Feb. 9 (HealthDay News) -- U.S. scientists have discovered there are genetic profiles that play a part in prognosis with non-small cell lung cancers, and those profiles differ depending on the age and gender of the patient.

The researchers analyzed genetic and clinical data from 787 patients who were divided into subgroups based on sex and age (below or above age 70). The findings are published in the Feb. 10 issue of the Journal of the American Medical Association.

In those younger than 70, 25 percent of high-risk patients (those with the shortest recurrence-free survival) showed increased activation of a gene called Src, compared to 6 percent of low-risk patients. In addition, activation of tumor necrosis factor pathways (which are related to death of cells or tissue) was seen in 76 percent of high-risk patients and in 42 percent of low-risk patients.

Among patients aged 70 and older, high-risk patients showed increased activation of the wound healing pathways (40 percent vs. 24 percent) and invasiveness pathways (64 percent vs. 20 percent) compared to low-risk patients, the study authors reported.

The study also found gender differences in lung cancer biology. High-risk female patients had increased activation of the invasiveness and STAT3 gene pathways, while high-risk male patients had increased activation of the STAT3, tumor necrosis factor, wound healing and epidermal growth factor receptor (EGFR) pathways. EGFR is a protein that promotes cell growth and multiplication.

"We believe our findings represent a [new] approach to defining clinically relevant cohorts of non-small cell lung cancer stratified by age and sex that are enriched for specific pathway activity and that would be more apt for therapeutic intervention when planning clinical trials with drugs that target specific pathway-related abnormalities or tumor biology," wrote William Mostertz, of Duke University, and colleagues.

"With genomic [tests] now being increasingly practical and clinically applicable, with turnaround times of five to seven days, we believe our findings . . . represent a step forward in defining pathway-driven cohorts of non-small cell lung cancer that likely explain the age- and sex-specific difference seen in non-small cell lung cancer," the researchers concluded.

More information

The American Cancer Society has more about non-small cell lung cancer.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, Feb. 9, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists Spot Genes Tied to Aging
2. Scientists ID a protein that splices and dices genes
3. Genes May Influence Preterm Births
4. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
5. Genes of pregnant women and their fetuses can increase the risk of preterm labor
6. NIH scientists identify maternal and fetal genes that increase preterm birth risk
7. Very Obese People May Be Missing Genes
8. Scientists map out regulatory regions of genome, hot spots for diabetes genes
9. Mutating Genes May Lead to Premature Births
10. Genes, Diet Offer New Clues to Parkinsons Disease
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... TherapySites, the leading website and ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to extend ... exclusive benefits and promotional offers. , "TCA is extremely excited about this new ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, ... Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility ... home to some of the world’s leading providers of cereal and other breakfast foods. ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
Breaking Medicine Technology: