Navigation Links
Genes Might Help Some Smokers Kick the Habit
Date:5/31/2012

THURSDAY, May 31 (HealthDay News) -- Smokers' genes may help predict whether they'll respond to drug treatments for nicotine addiction, a new study indicates.

Researchers analyzed data from more than 6,000 smokers in community-based studies and a clinical treatment study and found that the same gene variations that make it difficult to stop smoking also increase the chances that heavy smokers will respond to nicotine-replacement therapy and drugs that reduce the craving for nicotine.

"People with the high-risk genetic markers smoked an average of two years longer than those without these high-risk genes, and they were less likely to quit smoking without medication," study first author Dr. Li-Shiun Chen, an assistant professor of psychiatry at Washington University of Medicine in St. Louis, said in a university news release.

"The same gene variants can predict a person's response to smoking-cessation medication, and those with the high-risk genes are more likely to respond to the medication," Chen said.

In the clinical treatment study, smokers with the high-risk variants were three times more likely than those without the variants to respond to treatments such as nicotine gum, nicotine patches, the antidepressant bupropion (Wellbutrin is one brand) and other drugs used to help people stop smoking.

The findings, published online May 30 in the American Journal of Psychiatry, suggest it may eventually be possible to analyze smokers' genes in order to predict if they'll benefit from drug treatments for nicotine addiction.

"Smokers whose genetic makeup puts them at the greatest risk for heavy smoking, nicotine addiction and problems kicking the habit also appear to be the same people who respond most robustly to pharmacologic therapy for smoking cessation," senior investigator Dr. Laura Jean Bierut, a professor of psychiatry, said in the news release.

The gene variants in this study aren't the only ones involved in whether a person smokes, becomes addicted or has difficulty quitting, but they are an important part of the overall nicotine-addiction puzzle, the researchers said.

"These variants make a very modest contribution to the development of nicotine addiction, but they have a much greater effect on the response to treatment," Bierut said. "That's a huge finding."

More information

The American Cancer Society offers a guide to quitting smoking.

-- Robert Preidt

SOURCE: Washington University of Medicine in St. Louis, news release, May 30, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Genes predict if medication can help you quit smoking
2. Obesity genes may influence food choices, eating patterns
3. Study Ties Genes to Lower Urinary Tract Symptoms, Prostate Cancer Risk
4. Strategy discovered to activate genes that suppress tumors and inhibit cancer
5. Genes Might Be Key to Parkinsons Spread
6. Living longer - variability in infection-fighting genes can be a boon for male survival
7. Mystery of the missing breast cancer genes
8. Blond Genes May Vary Around the World
9. Genes Might Cause Some to Shun Pork
10. Genes Associated With Autism Also Related to Schizophrenia
11. 2 repressor genes identified as essential for placental development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... and Video Remote Interpreting (VRI) within Healthcare, recently partnered with Heart City ... interpreting (VRI). , For nearly 23 years, Heart City Health Center has provided ...
(Date:2/10/2016)... ... February 10, 2016 , ... Compliancy Group ... associations of medical professionals throughout the country. The Guard was specifically designed to ... and procedures, employee training, regulatory updates, and compliance coaching. , In addition to ...
(Date:2/10/2016)... ... 2016 , ... Emergency rooms provide emergency care to stabilize critical health issues, ... with dental emergencies at risk of losing a tooth or their smiles. Dr. Marine ... Common dental emergencies include:, , Avulsed or knocked-out teeth , ...
(Date:2/10/2016)... ... February 10, 2016 , ... Dr. Peyman ... is now offering a variety of comprehensive procedures for facial enhancement. The treatments ... volume restoration, lip enhancement and nasal reshaping. , As a result, patients ...
(Date:2/10/2016)... ... February 10, 2016 , ... Ongoing news of the ravages of traumatic ... to conduct a survey that takes a closer look at cases of TBI being ... and causes of TBI among the aging population, and identifies the challenges associated with ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... REDWOOD CITY, Calif., Feb. 10, 2016   Genomic Health, Inc. ... progress for the quarter and year ended December 31, 2015. ... in the fourth quarter of 2015, compared with $69.1 million in ... a constant currency basis, revenue increased 9 percent compared with the ... --> U.S. revenue was $63.9 million in the fourth ...
(Date:2/10/2016)... --> --> This press release is intended for U.S. and EU ... .  --> A separate press release has been prepared for use in ... continues to strengthen its presence in Japan ... strengthen its presence in Japan   ... strengthen its presence in Japan   ...
(Date:2/10/2016)... DIEGO , Feb. 10, 2016 ... gene therapy manufacturing, and Renova™ Therapeutics, a biopharmaceutical company ... other chronic diseases, have entered into a Manufacturing Services ... cGMP-grade RT-100 (Ad5.hAC6) Drug Product for use in Renova,s ... --> This relationship will leverage Lonza,s expertise ...
Breaking Medicine Technology: