Navigation Links
Genes Might Help Some Smokers Kick the Habit
Date:5/31/2012

THURSDAY, May 31 (HealthDay News) -- Smokers' genes may help predict whether they'll respond to drug treatments for nicotine addiction, a new study indicates.

Researchers analyzed data from more than 6,000 smokers in community-based studies and a clinical treatment study and found that the same gene variations that make it difficult to stop smoking also increase the chances that heavy smokers will respond to nicotine-replacement therapy and drugs that reduce the craving for nicotine.

"People with the high-risk genetic markers smoked an average of two years longer than those without these high-risk genes, and they were less likely to quit smoking without medication," study first author Dr. Li-Shiun Chen, an assistant professor of psychiatry at Washington University of Medicine in St. Louis, said in a university news release.

"The same gene variants can predict a person's response to smoking-cessation medication, and those with the high-risk genes are more likely to respond to the medication," Chen said.

In the clinical treatment study, smokers with the high-risk variants were three times more likely than those without the variants to respond to treatments such as nicotine gum, nicotine patches, the antidepressant bupropion (Wellbutrin is one brand) and other drugs used to help people stop smoking.

The findings, published online May 30 in the American Journal of Psychiatry, suggest it may eventually be possible to analyze smokers' genes in order to predict if they'll benefit from drug treatments for nicotine addiction.

"Smokers whose genetic makeup puts them at the greatest risk for heavy smoking, nicotine addiction and problems kicking the habit also appear to be the same people who respond most robustly to pharmacologic therapy for smoking cessation," senior investigator Dr. Laura Jean Bierut, a professor of psychiatry, said in the news release.

The gene variants in this study aren't the only ones involved in whether a person smokes, becomes addicted or has difficulty quitting, but they are an important part of the overall nicotine-addiction puzzle, the researchers said.

"These variants make a very modest contribution to the development of nicotine addiction, but they have a much greater effect on the response to treatment," Bierut said. "That's a huge finding."

More information

The American Cancer Society offers a guide to quitting smoking.

-- Robert Preidt

SOURCE: Washington University of Medicine in St. Louis, news release, May 30, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Genes predict if medication can help you quit smoking
2. Obesity genes may influence food choices, eating patterns
3. Study Ties Genes to Lower Urinary Tract Symptoms, Prostate Cancer Risk
4. Strategy discovered to activate genes that suppress tumors and inhibit cancer
5. Genes Might Be Key to Parkinsons Spread
6. Living longer - variability in infection-fighting genes can be a boon for male survival
7. Mystery of the missing breast cancer genes
8. Blond Genes May Vary Around the World
9. Genes Might Cause Some to Shun Pork
10. Genes Associated With Autism Also Related to Schizophrenia
11. 2 repressor genes identified as essential for placental development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... Park, KS (PRWEB) , ... June 27, 2016 , ... ... in retailers of Eyeglasses . , Millions of individuals in the United States ... eyeglasses have become a way to both correct vision and make a fashion statement. ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a ... and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is ... to some of the world’s leading providers of cereal and other breakfast foods. Its ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: