Navigation Links
Genes Might Help Some Smokers Kick the Habit
Date:5/31/2012

THURSDAY, May 31 (HealthDay News) -- Smokers' genes may help predict whether they'll respond to drug treatments for nicotine addiction, a new study indicates.

Researchers analyzed data from more than 6,000 smokers in community-based studies and a clinical treatment study and found that the same gene variations that make it difficult to stop smoking also increase the chances that heavy smokers will respond to nicotine-replacement therapy and drugs that reduce the craving for nicotine.

"People with the high-risk genetic markers smoked an average of two years longer than those without these high-risk genes, and they were less likely to quit smoking without medication," study first author Dr. Li-Shiun Chen, an assistant professor of psychiatry at Washington University of Medicine in St. Louis, said in a university news release.

"The same gene variants can predict a person's response to smoking-cessation medication, and those with the high-risk genes are more likely to respond to the medication," Chen said.

In the clinical treatment study, smokers with the high-risk variants were three times more likely than those without the variants to respond to treatments such as nicotine gum, nicotine patches, the antidepressant bupropion (Wellbutrin is one brand) and other drugs used to help people stop smoking.

The findings, published online May 30 in the American Journal of Psychiatry, suggest it may eventually be possible to analyze smokers' genes in order to predict if they'll benefit from drug treatments for nicotine addiction.

"Smokers whose genetic makeup puts them at the greatest risk for heavy smoking, nicotine addiction and problems kicking the habit also appear to be the same people who respond most robustly to pharmacologic therapy for smoking cessation," senior investigator Dr. Laura Jean Bierut, a professor of psychiatry, said in the news release.

The gene variants in this study aren't the only ones involved in whether a person smokes, becomes addicted or has difficulty quitting, but they are an important part of the overall nicotine-addiction puzzle, the researchers said.

"These variants make a very modest contribution to the development of nicotine addiction, but they have a much greater effect on the response to treatment," Bierut said. "That's a huge finding."

More information

The American Cancer Society offers a guide to quitting smoking.

-- Robert Preidt

SOURCE: Washington University of Medicine in St. Louis, news release, May 30, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Genes predict if medication can help you quit smoking
2. Obesity genes may influence food choices, eating patterns
3. Study Ties Genes to Lower Urinary Tract Symptoms, Prostate Cancer Risk
4. Strategy discovered to activate genes that suppress tumors and inhibit cancer
5. Genes Might Be Key to Parkinsons Spread
6. Living longer - variability in infection-fighting genes can be a boon for male survival
7. Mystery of the missing breast cancer genes
8. Blond Genes May Vary Around the World
9. Genes Might Cause Some to Shun Pork
10. Genes Associated With Autism Also Related to Schizophrenia
11. 2 repressor genes identified as essential for placental development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SOUTH SAN FRANCISCO, Calif. , June 24, ... GBT ), a biopharmaceutical company developing novel ... with significant unmet needs, today announced the closing ... 6,400,000 shares of common stock, at the public ... the shares in the offering were offered by ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
Breaking Medicine Technology: