Navigation Links
Genes Might Be Key to Parkinson's Spread
Date:5/15/2012

TUESDAY, May 15 (HealthDay News) -- Researchers have identified gene variants that speed the progression of Parkinson's disease, and they say their findings could help identify patients who would benefit most from early treatment.

The researchers, from the University of California-Los Angeles, say their findings also may help efforts to develop new therapies.

Parkinson's disease is a progressive movement disorder marked by tremor, slowness and rigidity.

The researchers followed 233 patients for an average of about five years after they were diagnosed with the disorder. They focused on two variants of the SNCA gene, which is known to play a role in a person's risk for Parkinson's disease.

The study found that patients with the "Rep1 263bp" variant of the SNCA gene had a fourfold faster decline in their ability to move. The decline was even more rapid in patients with both the "Rep1 263bp" and "rs356165" variants of the gene.

"This is a relatively small study ... but the effects we're seeing are actually quite large," primary investigator Dr. Beate Ritz, vice chairwoman of the department of epidemiology at UCLA's School of Public Health, said in a university news release.

The study was published today in the journal PLoS One.

Doctors currently can't predict how rapidly Parkinson's disease patients will reach the point where they require a wheelchair or other mobility aids.

"But if our results are confirmed, these gene variants can now identify patients who are likely to have faster progression," study co-author Dr. Jeff Bronstein, professor of neurology at UCLA's School of Medicine, said in the news release.

The accelerated rate of disease progression in patients with these two gene variants means they may be able to provide researchers with faster results on tests of new drugs for Parkinson's, the researchers said.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about Parkinson's disease.

-- Robert Preidt

SOURCE: University of California-Los Angeles, news release, May 11, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
2. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
3. Genes, environment, or chance?
4. UCLA study reveals how genes interact with their environment to cause disease
5. Long-Distance Runners May Have Endurance in Their Genes
6. Genes Behind Tooth Development Discovered
7. Smoking significantly increases risk of aneurysm in people with certain genes
8. Increasing neurogenesis might prevent drug addiction and relapse
9. Genetic Disease Foundation Encourages Americans to Know Their Genes at KnowYourGenes.org in Observance of World Rare Disease Day
10. Cluster of Genes Tied to Alcoholism
11. Cardiogenesis Reports Fourth Quarter and Full-Year 2009 Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Might Be Key to Parkinson's Spread
(Date:2/10/2016)... ... 10, 2016 , ... Early this week, Team Iconic at J. Walter Thompson ... as the first global confectionery brand sourced from 100% sustainable cocoa. , The Nestlé ... their product, through activities that focus on better farming, better lives and better cocoa. ...
(Date:2/10/2016)... ... ... As part of its ongoing series of aquatic therapy related webinars, HydroWorx ... dynamic expert and thoughtful presentation to give attendees a better sense of how to ... free to attend, but registration is required. , Rehabilitation of Offensive Lineman ...
(Date:2/10/2016)... ... February 10, 2016 , ... Emergency rooms provide emergency ... find. Unfortunately, this can leave patients with dental emergencies at risk of losing a ... offering emergency dental care. , Common dental emergencies include:, , ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... will bring together more than 200 of the country’s top healthcare executives to ... , “The true benefit of the Forum is the provider-centric perspective, experience, expertise ...
(Date:2/10/2016)... ... February 10, 2016 , ... AHRA: ... winner and inspirational speaker Jan Fox will serve as keynote speaker at the ... provide participants with tools to more effectively communicate with their own organizational staff ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... VIEW, Calif. , Feb. 10, 2016 ... of a synergistic confluence of various technologies ... value propositions, previously unavailable. These opportunities create ... and convergence, in turn, drives the development ... entrepreneurial scenario is characterized by technology convergences, ...
(Date:2/10/2016)... SAN DIEGO , Feb. 10, 2016 ... biopharmaceutical company developing novel, clinical-stage therapies for sickle cell ... an underwritten public offering of 29,090,910 units at a ... unit consists of one share of the Company,s common ... the Company,s common stock at an exercise price of ...
(Date:2/10/2016)... , Feb. 10, 2016 /PRNewswire/ - The President ... has announced the release of an anti-radiation product ... a revolutionary breakthrough in the treatment of cancer ... exposure. It will assist in the healing of ... It will also protect only the healthy cells ...
Breaking Medicine Technology: