Navigation Links
Genes Might Be Key to Parkinson's Spread
Date:5/15/2012

TUESDAY, May 15 (HealthDay News) -- Researchers have identified gene variants that speed the progression of Parkinson's disease, and they say their findings could help identify patients who would benefit most from early treatment.

The researchers, from the University of California-Los Angeles, say their findings also may help efforts to develop new therapies.

Parkinson's disease is a progressive movement disorder marked by tremor, slowness and rigidity.

The researchers followed 233 patients for an average of about five years after they were diagnosed with the disorder. They focused on two variants of the SNCA gene, which is known to play a role in a person's risk for Parkinson's disease.

The study found that patients with the "Rep1 263bp" variant of the SNCA gene had a fourfold faster decline in their ability to move. The decline was even more rapid in patients with both the "Rep1 263bp" and "rs356165" variants of the gene.

"This is a relatively small study ... but the effects we're seeing are actually quite large," primary investigator Dr. Beate Ritz, vice chairwoman of the department of epidemiology at UCLA's School of Public Health, said in a university news release.

The study was published today in the journal PLoS One.

Doctors currently can't predict how rapidly Parkinson's disease patients will reach the point where they require a wheelchair or other mobility aids.

"But if our results are confirmed, these gene variants can now identify patients who are likely to have faster progression," study co-author Dr. Jeff Bronstein, professor of neurology at UCLA's School of Medicine, said in the news release.

The accelerated rate of disease progression in patients with these two gene variants means they may be able to provide researchers with faster results on tests of new drugs for Parkinson's, the researchers said.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about Parkinson's disease.

-- Robert Preidt

SOURCE: University of California-Los Angeles, news release, May 11, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
2. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
3. Genes, environment, or chance?
4. UCLA study reveals how genes interact with their environment to cause disease
5. Long-Distance Runners May Have Endurance in Their Genes
6. Genes Behind Tooth Development Discovered
7. Smoking significantly increases risk of aneurysm in people with certain genes
8. Increasing neurogenesis might prevent drug addiction and relapse
9. Genetic Disease Foundation Encourages Americans to Know Their Genes at KnowYourGenes.org in Observance of World Rare Disease Day
10. Cluster of Genes Tied to Alcoholism
11. Cardiogenesis Reports Fourth Quarter and Full-Year 2009 Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Might Be Key to Parkinson's Spread
(Date:3/24/2017)... ... March 24, 2017 , ... The law firm of Enea, Scanlan ... to announce Westchester resident Lauren C. Enea has joined the firm as an associate ... concentrate her practice in elder law, Medicaid planning and applications, and Wills, Trusts and ...
(Date:3/24/2017)... ... , ... “Finding Christ Through Social Media: Year One #A365DayJourney ... writer’s path toward true communion with God. “Finding Christ Through Social Media: Year ... of published author Lea Michelle Johnson, a follower of Christ, wife and mother ...
(Date:3/23/2017)... ... March 23, 2017 , ... In 2016 the World Health Organization declared ... be four million Zika-related cases in the Americas within the next year. Lyme disease ... reported per year skyrocketing to an estimated 329,000. Yet, Zika, Lyme and other insect ...
(Date:3/23/2017)... ... 23, 2017 , ... PAINWeekEnd (PWE) Oklahoma City, on April ... will be an educational and exciting program providing busy clinicians and allied healthcare ... pain. , Oklahoma is in a healthcare crisis. The state ranks 46th in ...
(Date:3/23/2017)... ... 23, 2017 , ... March is National Kidney Month – the perfect time ... to maintaining good health. Every day, two kidneys filter about 120 to 150 quarts ... your blood, eliminating waste, regulating fluid levels and blood pressure, supporting bone health and ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... March 23, 2017 The key factors ... increasing diabetic population, accelerating economic growth and increasing healthcare expenditure. ... are higher life expectancy of ESRD patients, rising demand for ... However, the expansion of the market is hindered by high ... ...
(Date:3/23/2017)... BARBARA, Calif. and INDIANAPOLIS ... (NYSE: LLY ) and the William Sansum ... the lives of Latino people affected by diabetes through ... tremendous burden of diabetes and cardiovascular disease bears a ... United States ," said David Kerr , ...
(Date:3/23/2017)... 2017   BioSpace , the leading biotechnology and ... Indiana Biosciences Research Institute and over 20 ... institutions to bring the state,s life sciences industry to ... an artistic representation of the region,s booming biotechnology and ... President Mike Pence , a long-time advocate of ...
Breaking Medicine Technology: