Navigation Links
Genes May Predict Lymphoma Treatment Outcome
Date:11/26/2008

Screens might be used to determine which patients will benefit, researchers say

WEDNESDAY, Nov. 26 (HealthDay News) -- Gene activity patterns can tell doctors whether people with a certain type of non-Hodgkin lymphoma have a better chance of survival with treatment, according to a new study.

Three different signatures of gene activity, or expression -- a measure of the biological activity of a gene -- have been identified in people with diffuse large B-cell lymphoma (DLBCL). One signature, stromal-2, was linked to poor prognosis.

In studying thousands of genes in DLBCL tumors, the researchers determined that nonmalignant immune and structural cells lying near the tumor cells also have a great effect on how well patients respond to therapy.

"These biological variations are significant in patients treated with the current standard of care," study leader Dr. Louis M. Staudt of the U.S. National Cancer Institute, said in a news release issued by the organization. "Our results provide many fresh ideas about how existing drugs might be utilized to overcome the remaining resistance of some DLBCL tumors to our current therapy."

The findings were published in the Nov. 27 issue of the New England Journal of Medicine.

Diffuse large B-cell lymphoma, an aggressive type of non-Hodgkin lymphoma with several subtypes, makes up 30 percent of all newly diagnosed cases. The standard treatment for DLBCL is a combination five drugs -- cyclophosphamide, hydroxydoxorubicin (doxorubicin, Adriamycin), Oncovin (vincristine), prednisone and rituximab. Known as R-CHOP, this treatment cures up to 60 percent of patients.

Combining the new gene signature model with the International Prognostic Index (IPI), an index to predict survival of DLBCL patients based on factors such as age, stage of the tumor and spread of the cancer, improved how well both models predicted prognosis. According to the resea
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Database to Help Speed Search for Bipolar Disorder Genes
4. Is Perfect Pitch All in the Genes?
5. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
6. Genes Boost Risk for Rheumatoid Arthritis, Lupus
7. The genes involved in rheumatoid arthritis identified
8. If you think cancer genes are simple, you dont know JAK
9. Test for lung cancer looks for discomforting quiet among protective genes
10. Hushed Genes Might Mean Higher Lung Cancer Risk
11. EURYI project to understand how the brain wires during embryogenesis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes May Predict Lymphoma Treatment Outcome
(Date:9/2/2015)... ... ... A recent survey by Consumer Reports ( http://bit.ly/1h67tL8 ) sheds light on ... consumers. It was reported that 33% are paying an average of $39 more out-of-pocket ... $100 compared to last year. Among the drugs that saw the highest increases were ...
(Date:9/2/2015)... ... September 02, 2015 , ... World ... Free Pocket Cop, a safety invention that protects people from crime and other ... billion," says Scott Cooper, CEO and Creative Director of World Patent Marketing. "The ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... SERVICE GROUP is internationally known as an industry leader specializing in surplus used ... world, selling more than 100,000 pieces of medical equipment every year. Erik Tivin, ...
(Date:9/2/2015)... ... September 02, 2015 , ... Ovarian cancer continues to ... woman’s risk of getting ovarian cancer in her lifetime is approximately 1 in 75. ... of ovarian cancer, and 14,000 will die. , There is no test to ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... to bring awareness to International Overdose Awareness Day. The goal is to provide ... the warning signs so that they may get help. , Lakeview ...
Breaking Medicine News(10 mins):Health News:Watertree Health President Responds to Consumer Reports Survey on Rising Prescription Drug Prices 2Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 2Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 3Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 4Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 5Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 6Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 7Health News:Over 1800 Lots of Surplus Used Medical Equipment 2Health News:Over 1800 Lots of Surplus Used Medical Equipment 3Health News:National Ovarian Cancer Coalition's DFW Chapter Features First Annual Teal Lights Display This Friday, September 4th, "National Wear Teal Day" 2Health News:National Ovarian Cancer Coalition's DFW Chapter Features First Annual Teal Lights Display This Friday, September 4th, "National Wear Teal Day" 3Health News:August 31 is International Overdose Awareness Day – Lakeview Health to Help Bring Awareness 2
... Alcohol Provides Parents Resources to Help Manage Teen ... Access to Alcohol in the ... Alcohol today challenged New York area parents to take a tough,topic ... a roundtable discussion featuring a panel of experts from the fields,of ...
... to a study using a dynamic in vitro gastrointestinal ... SHQ) ulcerative colitis drug LIALDA (mesalamine) demonstrated a delivery ... 5-aminosalicyclic acid (5-ASA), is released over a prolonged period ... site of inflammation in ulcerative colitis. In this in ...
... any more sensitive in detecting biological motion compared with ... of Vision, an online, free-access publication of the Association ... Eric Hiris of St. Mary,s College of Maryland, (St ... on the subject begin with statements to the effect ...
... employee assistance,division of Recovery Resources Inc., is offering ... of October in,recognition of national Drug-Free Work Week ... an effective drug free workplace program. The ... 2007" in an,effort to educate businesses about the ...
... - With Photo - Business Executives Encouraged to ... Stroke and Funds for the Stroke Association Tom ... Olympic gold medallist, today launched ,Siemens Stroke for Stroke,Week, ... to,highlight the positive benefits of regular exercise and to ...
... New benefit offered to 10,000 Medicare Choice PPO members at no additional ... ... YORK, Oct. 17 Effective January 1, 2008, Group,Health Incorporated (GHI) has ... call a toll-free number to speak with,their own independent Personal Health Advocate ...
Cached Medicine News:Health News:Parents Encouraged to Set an Example for Their Teens and Help Stop Underage Drinking 2Health News:Parents Encouraged to Set an Example for Their Teens and Help Stop Underage Drinking 3Health News:Parents Encouraged to Set an Example for Their Teens and Help Stop Underage Drinking 4Health News:Parents Encouraged to Set an Example for Their Teens and Help Stop Underage Drinking 5Health News:LIALDA demonstrates prolonged release of mesalamine in an in vitro study using a simulated colon 2Health News:LIALDA demonstrates prolonged release of mesalamine in an in vitro study using a simulated colon 3Health News:AssistNow Offers Area Employers Complimentary Needs Assessment in Recognition of National Drug-Free Work Week 2Health News:James Cracknell Launches Siemens Stroke for Stroke Week 2Health News:James Cracknell Launches Siemens Stroke for Stroke Week 3Health News:James Cracknell Launches Siemens Stroke for Stroke Week 4Health News:GHI to Provide Independent Personal Health Advocate for Medicare Members 2
(Date:9/2/2015)... Demers Ambulances is proud to announce it has ... for the states of Mississippi , ... "This will enable Demers to effectively meet ... Executive Vice-President for Demers Ambulances. "Emergency Equipment Professionals has three ... Alabama , giving them a strategic advantage. ...
(Date:9/2/2015)... 2015 Elekta, a global cancer management ... September 10, 6:30-8:30 p.m., at Elekta,s North American headquarters in ... Survivorship " will feature Professional BMX athlete, Josh Perry ... tumor with Leksell Gamma Knife®, Elekta,s radiosurgery system for treating ... will be diagnosed in Georgia in ...
(Date:9/2/2015)... -- Boston Scientific Corporation (NYSE: BSX ) is scheduled ... on September 17, in New York City ... and Dan Brennan , executive vice president and chief ... session regarding the company with the host analyst beginning at ... the question and answer session will be available on the ...
Breaking Medicine Technology:Demers Ambulances has named Emergency Equipment Professionals (EEP) Inc. as their dealer for the states of MS, AL and TN 2Elekta to Host Cancer Survivorship Event at Company's Learning and Innovation Center (LINC) in Atlanta 2Elekta to Host Cancer Survivorship Event at Company's Learning and Innovation Center (LINC) in Atlanta 3Boston Scientific To Participate In 2015 Morgan Stanley Global Healthcare Conference 2
... PARSIPPANY, N.J., June 20, 2011 Watson Pharmaceuticals, Inc. ... company, announced today that Siggi Olafsson, Executive Vice President, ... the Company,s business at the 2011 Wells Fargo Securities ... Eastern Time at the InterContinental Boston in Boston, Massachusetts. ...
... directors of Eli Lilly and Company (NYSE: LLY ... 2011 of $0.49 a share on outstanding common stock.   ... shareholders of record at the close of business on August ... developing a growing portfolio of pharmaceutical products by applying the ...
Cached Medicine Technology:
The ImagingPlanet 80 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 80 mm focal length adapter an excellent decision for use with your Zeiss surgical micro...
The ImagingPlanet 55 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 55mm focal length adapter an excellent decision for use with your Zeiss surgical micro...
The ImagingPlanet 70 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 70 mm focal length adapter an excellent decision for use with your Leica surgical micr...
... Archive Manage and ... ,Introducing Optronics DVMR- office, the ... designed for the physician's office ... a variety of high-resolution cameras ...
Medicine Products: