Navigation Links
Genes May Link Hip Fractures and Heart Disease
Date:10/20/2009

Risks for breaks rise if a brother or sister has heart failure or stroke, study finds

TUESDAY, Oct. 20 (HealthDay News) -- People with cardiovascular conditions such as heart failure and stroke -- and probably their close relatives as well -- may have an increased risk for hip fractures, a new study has found.

Genetic factors might explain the relationship, including "specific genes involved in cellular mechanisms shared by the vasculature [blood vessels] and bone," said Dr. Karl Michaelsson, an associate professor of medicine at Uppsala University in Sweden and an author of a report on the finding in the Oct. 21 issue of the Journal of the American Medical Association.

The study, which involved 31,936 twins in the Swedish Twin Registry, found more than a fourfold increased risk for hip fractures for people who had heart failure, which is a progressive loss of the heart's ability to pump blood, and about a fivefold increased risk for those who'd had a stroke, compared with people with no diagnosis of cardiovascular disease. An increased risk was also found for people with other heart conditions, such as blocked coronary arteries.

The researchers also found that if one twin had a cardiovascular condition, the other twin also faced an increased risk for hip fracture -- even if that twin was healthy. They described those individuals as "pseudoexposed," meaning that because they are twins, they share the genetic factors that increase the risk for fractures.

For instance, hip fracture risk was 3.7-fold higher for a healthy twin whose twin had heart failure and 2.9-fold higher if the twin had had a stroke.

The finding means that anyone with a close relative, such as a brother or sister, with cardiovascular disease should be aware of a probable increased risk for hip fractures, Michaelsson said.

"I recommend to them to have their fracture risk evaluated by a bone scan to assess bone mineral density and a clinical examination by a physician with special interest in the problem of osteoporosis," he said.

Osteoporosis is the gradual weakening of bone generally seen in older people and usually of greater concern for women.

But osteoporosis is often overlooked in men, just as cardiovascular disease can be in women, said Dr. Lori Mosca, director of preventive cardiology at New York-Presbyterian Hospital/Columbia University Medical Center.

"The important message I took away from this as a clinician is that if you have a patient with cardiovascular disease, they may be at risk for fractures, and it is important to look at their risk factors for both," Mosca said.

The Swedish study is the latest entry in "a growing body of evidence that links osteoporosis and cardiovascular disease," she said. "There is a lot of interest in understanding a possible common pathway."

Lifestyle factors that contribute to both osteoporosis and cardiovascular risk include nutrition, smoking and lack of exercise, Mosca said. "What is unique about this particular study is that it evaluates the potential for both lifestyle factors and genetic factors to contribute to pathology," she said.

More research is needed, however, to identify the specific genetic factors linking the two risks, Mosca and Michaelsson said. "I do think this is possible, and we are on our way to performing such an investigation," Michaelsson said.

The Swedish study was possible because of a registry that includes twins born in the country between 1914 and 1944 and followed for decades. Another national registry identified Swedish twins diagnosed with cardiovascular disease and fractures between 1964 and 2005.

A limitation of the study, though, is that it covers just one ethnic group, Michaelsson acknowledged. "We cannot directly generalize our results to other ethnic groups," he said.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has tips on bone health.



SOURCES: Karl Michaelsson, M.D., associate professor, medicine, Uppsala University, Sweden; Lori Mosca, M.D., M.P.H., Ph.D., director, preventive cardiology, New York-Presbyterian Hospital/Columbia University Medical Center, New York City; Oct 21, 2009, Journal of the American Medical Association


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Database to Help Speed Search for Bipolar Disorder Genes
4. Is Perfect Pitch All in the Genes?
5. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
6. Genes Boost Risk for Rheumatoid Arthritis, Lupus
7. The genes involved in rheumatoid arthritis identified
8. If you think cancer genes are simple, you dont know JAK
9. Test for lung cancer looks for discomforting quiet among protective genes
10. Hushed Genes Might Mean Higher Lung Cancer Risk
11. EURYI project to understand how the brain wires during embryogenesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. ... articles published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm ... sciences executive with extensive sequencing and genomics experience, as Vice President of North American ... Hill will be responsible for leading the sales team in the commercialization of the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Collagen Matrix, Inc., ("Collagen Matrix") the driving ... collagen and mineral based medical devices for tissue ... Messer has joined the company as Vice ... growing portfolio of oral surgery, neurosurgery, orthopaedic and ... the Collagen Matrix executive team as an accomplished ...
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
Breaking Medicine Technology: