Navigation Links
Genes May Boost Harm to Kids From Secondhand Smoke
Date:3/26/2009

Certain variants weaken lungs' defenses against free radicals, researchers say

THURSDAY, March 26 (HealthDay News) -- Variations in several genes can influence children's lung growth and function, as well as how vulnerable they are to secondhand smoke, say University of Southern California researchers.

"Many factors can affect lung function and growth, including genetic variation and environmental exposures such as tobacco smoke and air pollutants," study lead author Carrie Breton said in a USC news release.

"We wanted to determine whether specific gene variations would have measurable and predictable effects on lung function growth and susceptibility to environmental insults," she said. "We looked at a class of genes known to be involved in antioxidant defense, the glutathione-s transferase (GST) genes. Overall, we found that variation in several of the GST genes was important. This was particularly true for children of mothers who had smoked during pregnancy."

Breton and colleagues analyzed eight years' worth of lung function and genotyping data from more than 2,100 children. They identified three specific halotypes (patterns of genetic variation within genes) that had a significant effect on lung function. These halotypes were found in the genes GSTM2, GSTM3 and GSTM4.

The gene variants may not alter lung development, the researchers explained, but they may change the ability of the lungs to defend against damage caused by free radicals, such as those found in smoke.

"The GST genes are important to the detoxification of reactive oxygen species, including carcinogens and environmental exposures, such as cigarette smoke. We speculate that the patterns of genetic variation we investigated may alter this process, thereby reducing the lung's ability to detoxify harmful agents and causing a cascade of other events that promote inflammation, bronchial constriction, airway hyper-responsiveness and asthma-like symptoms," Breton said.

The study is in the first April issue of the American Journal of Respiratory and Critical Care Medicine.

"The next step would be to investigate how these genes interact with one another to jointly affect lung development," Breton said. "Future studies should also investigate the timing and quality of tobacco smoke exposure during pregnancy in combination with variation in these genes to further understand how they jointly affect fetal lung development."

More information

The American Lung Association has more about secondhand smoke and children.



-- Robert Preidt



SOURCE: American Thoracic Society, news release, March 26, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Right warfarin dose determined by 3 genes
2. Genes May Decide Which Smokers Get Lung Disease
3. Rearrangements of multifunctional genes cause cancer in children and young people
4. CFO of Genesis Pharmaceuticals Gives Live Interview on Bloomberg TV Asia
5. Cardiogenesis Corporation to Report 2008 Fourth Quarter and Year-End Results on March 31st
6. Study sheds light on angiogenesis inhibitors, points to limitations, solutions
7. Thermogenesis Technology Products Surpass Processing of More Than One Million Units of Cord Blood Stem Cells at 10-Year Milestone
8. Genes May Help Drive Rotator Cuff Injury
9. Genes That Control Bodys Salt Levels Are Identified
10. Empathy Might Be in the Genes
11. Genes Help Cancer-Linked Viruses Elude Immune System
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes May Boost Harm to Kids From Secondhand Smoke
(Date:6/23/2017)... ... , ... 21 Middle East and South Asia Leaders Selected as Eisenhower Fellows ... and civil society in 11 countries across the Middle East and South Asia to ... exchange of knowledge and ideas with the leading minds in their fields. , ...
(Date:6/23/2017)... ... 23, 2017 , ... PureLife Dental is pleased to announce that California Dental ... As part of the amalgam separator endorsement, all CDA members may purchase an ECO ... the retail value. This partnership between PureLife and CDA is especially timely as it ...
(Date:6/23/2017)... ... June 23, 2017 , ... American Farmer, will feature Chr. ... is slated to air fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET on ... Danish pharmacist, founded Chr. Hansen in Denmark in 1874 after a groundbreaking discovery of ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... management, financial planning, and related services to families and business owners in and ... charity drive to benefit senior citizens in the area. , Meals on Wheels ...
(Date:6/23/2017)... ... , ... All-Star Insurance, a family managed agency that offers insurance management assistance ... the launch of a new charity drive to benefit women in the area diagnosed ... that an estimated 252, 710 new cases of invasive or high risk breast cancer ...
Breaking Medicine News(10 mins):
(Date:6/2/2017)... LAWRENCE, Mass. , June 2, 2017  NxStage ... advancing renal care, today announced new findings demonstrating positive ... NxStage ® System One™. The data will be ... 2017, in Madrid, Spain . ... Knowledge to Improve Home Dialysis Network in ...
(Date:5/29/2017)... TEL AVIV, Israel, May 29, 2017  Cellect Biotechnology ... of innovative technology which enables the functional selection of ... financial results for the first quarter ended March 31 ... pleased with our accomplishments in the first quarter of ... the first quarter, we announced the treatment of the ...
(Date:5/22/2017)... , May 22, 2017  Lilac Corp, ... Gene-Eden-VIR/Novirin, announces the launch of a new ... the results of a clinical study that showed ... treatment with Gene-Eden-VIR/Novirin in individuals suffering from HPV ... note that there are no other treatments that ...
Breaking Medicine Technology: