Navigation Links
Genes Linked to Spread of Breast Cancer
Date:5/6/2009

Study identifies three genetic ties to brain metastasis,,,,

WEDNESDAY, May 6 (HealthDay News) -- Three genes linked to the spread of breast cancer to the brain have been identified by U.S. researchers, who say the finding could help lead to new treatments.

The spread, or metastasis, of breast cancer to the brain typically occurs years after a breast tumor has been removed. Experts say this suggests that the cancer cells initially lack the ability to penetrate the blood-brain barrier, which prevents the entry of circulating cells and regulates the transport of molecules into the brain tissue.

The new study found that two genes, COX2 and HB-EGF, are prime breast cancer cells for entrance into the brain. Another gene, ST6GALNAC5 -- which is normally active only in brain tissue -- causes a chemical reaction that creates a coating on the surface of breast cancer cells that enhances their ability to breach the blood-brain barrier.

"Our results draw attention to the role of the cell surface coating as a previously unrecognized participant in brain metastasis, and to the possibility of using drugs to disrupt its interactions," Joan Massague, chair of the Cancer Biology and Genetics Program at Memorial Sloan-Kettering Cancer Center in New York City and a Howard Hughes Medical Institute investigator, said in a news release from the cancer center.

The study appears online in the journal Nature.

Previous research found that COX2 and HB-EGF are involved in the spread of breast cancer to the lungs. The new finding, that the genes also play a role in its spread to the brain, might explain the association of brain and lung relapse in breast cancer patients, the researchers said.

More information

Breastcancer.org has more about recurrent and metastatic breast cancer.



-- Robert Preidt



SOURCE: Memorial Sloan-Kettering Cancer Center, news release, May 6, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. ThermoGenesis Corp. to Announce Third Quarter Fiscal 2009 Results on May 6, 2009
2. Genesis Pharmaceuticals Changes its Name to Jiangbo Pharmaceuticals, Inc. to Reflect its Brand Name
3. Genes May Alter Alcohols Effect on Fetus
4. Genesis Pharmaceuticals Announces the Launch of Three TCM Products
5. Genes Hike Melanoma Risk Even in Those Who Tan Well
6. Dark hair? Dont burn? Your genes may still put you at risk for melanoma
7. Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth
8. Scientists Spot Stroke Genes
9. Genesis Pharmaceuticals Affirms Operating Income Guidance, Adjusts Revenue Guidance for Fiscal 2009
10. Cardiogenesis Reports Fourth Quarter and Fiscal Year 2008 Results
11. New Directions in Angioedema: A Focus on Pathogenesis and Classification
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Linked to Spread of Breast Cancer
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor ... on sciatica in a new episode of "Success Files," which is an award-winning ... innovation and investigates each subject in-depth with passion and integrity. , Sciatica occurs ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), an ... showcase a range of technology and learning solutions at the 68th Annual American ... to be held October 14–18, 2017 at the Mandalay Bay Resort in Las ...
(Date:10/12/2017)... ... 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the ... new design of the shoulder pad. The shoulder pad provides optimal support and ... pain while using cold therapy. By utilizing ice and water that is circulated from ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform for ... the first annual edition of its Global CSR Risk and Performance Index. ... by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points ... ... ...
Breaking Medicine Technology: