Navigation Links
Genes Linked to Spread of Breast Cancer
Date:5/6/2009

Study identifies three genetic ties to brain metastasis,,,,

WEDNESDAY, May 6 (HealthDay News) -- Three genes linked to the spread of breast cancer to the brain have been identified by U.S. researchers, who say the finding could help lead to new treatments.

The spread, or metastasis, of breast cancer to the brain typically occurs years after a breast tumor has been removed. Experts say this suggests that the cancer cells initially lack the ability to penetrate the blood-brain barrier, which prevents the entry of circulating cells and regulates the transport of molecules into the brain tissue.

The new study found that two genes, COX2 and HB-EGF, are prime breast cancer cells for entrance into the brain. Another gene, ST6GALNAC5 -- which is normally active only in brain tissue -- causes a chemical reaction that creates a coating on the surface of breast cancer cells that enhances their ability to breach the blood-brain barrier.

"Our results draw attention to the role of the cell surface coating as a previously unrecognized participant in brain metastasis, and to the possibility of using drugs to disrupt its interactions," Joan Massague, chair of the Cancer Biology and Genetics Program at Memorial Sloan-Kettering Cancer Center in New York City and a Howard Hughes Medical Institute investigator, said in a news release from the cancer center.

The study appears online in the journal Nature.

Previous research found that COX2 and HB-EGF are involved in the spread of breast cancer to the lungs. The new finding, that the genes also play a role in its spread to the brain, might explain the association of brain and lung relapse in breast cancer patients, the researchers said.

More information

Breastcancer.org has more about recurrent and metastatic breast cancer.



-- Robert Preidt



SOURCE: Memorial Sloan-Kettering Cancer Center, news release, May 6, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. ThermoGenesis Corp. to Announce Third Quarter Fiscal 2009 Results on May 6, 2009
2. Genesis Pharmaceuticals Changes its Name to Jiangbo Pharmaceuticals, Inc. to Reflect its Brand Name
3. Genes May Alter Alcohols Effect on Fetus
4. Genesis Pharmaceuticals Announces the Launch of Three TCM Products
5. Genes Hike Melanoma Risk Even in Those Who Tan Well
6. Dark hair? Dont burn? Your genes may still put you at risk for melanoma
7. Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth
8. Scientists Spot Stroke Genes
9. Genesis Pharmaceuticals Affirms Operating Income Guidance, Adjusts Revenue Guidance for Fiscal 2009
10. Cardiogenesis Reports Fourth Quarter and Fiscal Year 2008 Results
11. New Directions in Angioedema: A Focus on Pathogenesis and Classification
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Linked to Spread of Breast Cancer
(Date:2/7/2016)... ... February 07, 2016 , ... HealthSmart Holdings, ... and organizations with the tools and information to lower the costs, and increase ... the cost of providing employee healthcare benefits by as much as 22%:, + ...
(Date:2/7/2016)... Scottsdale, AZ (PRWEB) , ... February 07, 2016 ... ... & Neck and Facial Plastics, has added Kybella® to his medical and surgical ... is a newly approved FDA injectable medication used as a non-surgical alternative for ...
(Date:2/6/2016)... , ... February 06, 2016 ... ... 303-368-6225 , MEDIA ADVISORY: 5000 PERIOPERATIVE NURSES EXPECTED AT AORN SURGICAL CONFERENCE ... perioperative nurses in the world with an estimated 5000 perioperative nurses in ...
(Date:2/6/2016)... ... February 06, 2016 , ... US Sports Camps is ... (YUCC) . This event brings together top non-profit leaders, ultimate organizations, and coaches from ... Ultimate”. Valerio Iani, Bay Area Disc Program Director of Youth and Education, describes this ...
(Date:2/6/2016)... Viejo, CA (PRWEB) , ... February 06, 2016 , ... ... quickly and easily add warm color grades to their footage. A LUT is a ... every pixel's color to the corresponding color indicated by the table. By manipulating each ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  Patients in Alabama ... focused ultrasound (HIFU) therapy no longer have to travel out ... its partnership with Urology Centers of Alabama to ... FDA-cleared procedure for qualifying patients. Alabama ... in the treatment of prostate cancer using many different modalities. ...
(Date:2/5/2016)... 5, 2016 Aethlon Medical, Inc. (Nasdaq: AEMD ... CEO, will be presenting at Source Capital Group,s 2016 Disruptive ... at 2:15 p.m. ET on Wednesday, February 10, ... discussion taking place at 3:15 p.m. ET. http://www.aethlonmedical.com ... hour after the conclusion of the live event. The panel ...
(Date:2/5/2016)... 5, 2016 Dehaier Medical Systems Ltd. ... "Company"), which develops, markets and sells medical devices ... China and international markets, today announced ... to concentrate the Company,s resources to develop its ... and to focus more on its major businesses. ...
Breaking Medicine Technology: