Navigation Links
Genes Linked to Spread of Breast Cancer
Date:5/6/2009

Study identifies three genetic ties to brain metastasis,,,,

WEDNESDAY, May 6 (HealthDay News) -- Three genes linked to the spread of breast cancer to the brain have been identified by U.S. researchers, who say the finding could help lead to new treatments.

The spread, or metastasis, of breast cancer to the brain typically occurs years after a breast tumor has been removed. Experts say this suggests that the cancer cells initially lack the ability to penetrate the blood-brain barrier, which prevents the entry of circulating cells and regulates the transport of molecules into the brain tissue.

The new study found that two genes, COX2 and HB-EGF, are prime breast cancer cells for entrance into the brain. Another gene, ST6GALNAC5 -- which is normally active only in brain tissue -- causes a chemical reaction that creates a coating on the surface of breast cancer cells that enhances their ability to breach the blood-brain barrier.

"Our results draw attention to the role of the cell surface coating as a previously unrecognized participant in brain metastasis, and to the possibility of using drugs to disrupt its interactions," Joan Massague, chair of the Cancer Biology and Genetics Program at Memorial Sloan-Kettering Cancer Center in New York City and a Howard Hughes Medical Institute investigator, said in a news release from the cancer center.

The study appears online in the journal Nature.

Previous research found that COX2 and HB-EGF are involved in the spread of breast cancer to the lungs. The new finding, that the genes also play a role in its spread to the brain, might explain the association of brain and lung relapse in breast cancer patients, the researchers said.

More information

Breastcancer.org has more about recurrent and metastatic breast cancer.



-- Robert Preidt



SOURCE: Memorial Sloan-Kettering Cancer Center, news release, May 6, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. ThermoGenesis Corp. to Announce Third Quarter Fiscal 2009 Results on May 6, 2009
2. Genesis Pharmaceuticals Changes its Name to Jiangbo Pharmaceuticals, Inc. to Reflect its Brand Name
3. Genes May Alter Alcohols Effect on Fetus
4. Genesis Pharmaceuticals Announces the Launch of Three TCM Products
5. Genes Hike Melanoma Risk Even in Those Who Tan Well
6. Dark hair? Dont burn? Your genes may still put you at risk for melanoma
7. Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth
8. Scientists Spot Stroke Genes
9. Genesis Pharmaceuticals Affirms Operating Income Guidance, Adjusts Revenue Guidance for Fiscal 2009
10. Cardiogenesis Reports Fourth Quarter and Fiscal Year 2008 Results
11. New Directions in Angioedema: A Focus on Pathogenesis and Classification
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Linked to Spread of Breast Cancer
(Date:8/15/2017)... ... August 15, 2017 , ... Horizon ... John McCain said, “We are overwhelmed with gratitude for the very generous donation ... who need assistance to both get a job and keep it. This donation ...
(Date:8/15/2017)... ... August 15, 2017 , ... The V Foundation for Cancer ... V Foundation Wine Celebration raised nearly $9 million for cancer research during a ... “Fund-A-Need” donations to support the study of BRCA mutation research in laboratories and ...
(Date:8/15/2017)... ... August 15, 2017 , ... ... Snap-on Smile® consultations. Patients interested in orthodontics, dental crowns and teeth whitening ... Nash provides Snap-on Smile treatment at his state-of-the-art practice, Nash Family Dentistry, in ...
(Date:8/15/2017)... ... August 15, 2017 , ... Organizers today announced plans and ... maximize the value of events and activations held during UN General Assembly week and ... Global Goals. This year’s Global Goals Week will be held 16-23 September, with events ...
(Date:8/15/2017)... ... August 15, 2017 , ... ... leading selection of services. FDA-cleared CoolSculpting is the world’s most popular non-invasive fat ... or downtime, CoolSculpting can reduce fat cells in almost any area of the ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... SAN DIEGO , Aug. 3, 2017  Opioid ... crippling diseases driving up healthcare costs and threatening outcomes, ... the lab supply and IVD industry that support them, ... health care market researcher said that drugs of abuse, ... vendors and sessions at the organization,s 69th meeting in ...
(Date:8/2/2017)... Aug. 2, 2017 CaryRx, a next-generation full-service pharmacy, ... service for patients in the Washington D.C. ... pharmacy by providing delivery of medications through the convenience of ... delivery or delivered within one hour to any location in ... to bring this invaluable service to Washington D.C. ...
(Date:7/31/2017)... 31, 2017 7D Surgical, developer of ground breaking ... the 7D Surgical System to support its strategic sales plan ... and Virginia.  7D Surgical has entered into an ... the premier medical facilities within those markets. ... Spartan ...
Breaking Medicine Technology: