Navigation Links
Genes' Link to Certain Cancers Questioned
Date:5/27/2010

Because of their small size, studies tying genes to common tumors may be invalid, researchers say

THURSDAY, May 27 (HealthDay News) -- Small sample sizes may undercut the reliability of recent genome studies that seemingly uncovered genetic underpinnings for cancer risk, a Greek-American analysis cautions.

The observation is the result of a review of 45 studies that had harnessed technological innovations in so-called "whole genome sequencing" to attempt to identify specific genetic risk factors and link them to the risk for developing a range of cancers.

All the analyzed studies, published between 2007 and 2010, were listed in the National Human Genome Research Institute catalog.

The research team, led by Dr. John P.A. Ioannidis of the department of hygiene and epidemiology at the University of Ioannina School of Medicine in Athens, said their review of studies identified 92 genetic associations linked to the risk for developing various cancers.

More than half the highlighted genetic links concerned prostate, colorectal and/or breast cancer, they noted.

But the authors concluded that the explanatory power to predict individual cancer risk is "limited," they noted in a news release.

Ioannidis' team specifically noted that although the reviewed evidence for genetic roots to cancer risk was generally of statistical significance, the observed connections were relatively weak. They further noted that "almost all of them would also have small or very small effects."

Their findings are published in the May 26 online issue of The Journal of the National Cancer Institute.

More information

For more on genetics and cancer risk, visit the American Cancer Society.



SOURCE: Oxford Journals, May 26, 2010, news release


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists ID a protein that splices and dices genes
2. Genes May Influence Preterm Births
3. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
4. Genes of pregnant women and their fetuses can increase the risk of preterm labor
5. NIH scientists identify maternal and fetal genes that increase preterm birth risk
6. Very Obese People May Be Missing Genes
7. Scientists map out regulatory regions of genome, hot spots for diabetes genes
8. Mutating Genes May Lead to Premature Births
9. ThermoGenesis Corp. Names Healthcare Industry Executive Craig Moore to Board of Directors
10. Genes, Diet Offer New Clues to Parkinsons Disease
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... PALM CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... of cold therapy products, announced today the introduction of an innovative new design of ... the multipurpose pad so you get maximum comfort while controlling your pain while using ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a ... health care, have expanded their existing home health joint venture through an agreement, ... been operating a joint venture home health company with Asante, delivering clinically integrated ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. ... recently contributed a medical article to the newly revamped Cosmetic Town journal ... spotlights the hair transplant procedure known as Follicular Unit Extraction (FUE). ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... for the 49th Congress of the International Society of Paediatric Oncology (SIOP) ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. ...
(Date:10/12/2017)... ... 12, 2017 , ... Women-owned and Grand Rapids-based workplace wellness ... in Wellness® by Best and Brightest. OnSite Wellness will be honored at the ... 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located at ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 The Rebound mobile app is poised to ... the tide of prescription drug addiction. The app empowers users ... and stepping down their dosage in a safe, controlled manner ... 2017; the first 100,000 people to sign up will enjoy ... ...
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017  DarioHealth ... and big data solutions, today announced that its MyDario product is expected ... local TV listings for when The Dr. Oz Show airs in your ... The nine-time Emmy ... ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest Obamacare ... Bill Cassidy (R-LA) and Lindsey Graham ... that the medical device industry is in an odd ... tax, the 2.3% excise tax on medical device sales ... also want covered patients, increased visits and hospital customers ...
Breaking Medicine Technology: