Navigation Links
Genes Influence Whether Psych Drugs Lead to Weight Gain
Date:7/20/2012

FRIDAY, July 20 (HealthDay News) -- Researchers have discovered two genetic variants associated with substantial, rapid weight gain in people taking antipsychotic medications.

The researchers said the findings could eventually be used by doctors to identify which patients have the variations so they can be treated without the risk of weight gain, which can lead to obesity and health problems including diabetes and heart disease.

"Weight gain occurs in up to 40 percent of patients taking medications called second-generation or atypical antipsychotics, which are used because they're effective in controlling the major symptoms of schizophrenia," Dr. James Kennedy, of the Center for Addiction and Mental Health, in Toronto, said in a center news release.

Kennedy, senior author of a study published online recently in the journal Archives of General Psychiatry, pinpointed a variation near the melanocortin-4 receptor gene, which is known to be linked to obesity.

The study of patients in Europe and the United States being treated with atypical antipsychotics found that those with two copies of the variant gained about three times as much weight as those with one or no copies -- about 13 pounds vs. 4 pounds.

"The weight gain was associated with this genetic variation in all these groups, which included pediatric patients with severe behavior or mood problems, and patients with schizophrenia experiencing a first episode or who did not respond to other antipsychotic treatments," Dr. Daniel Muller, study co-author and Center for Addiction and Mental Health scientist, said in the news release.

"The results from our genetic analysis combined with this diverse set of patients provide compelling evidence for the role of this [melanocortin-4 receptor] variant," Muller said. "Our research group has discovered other gene variants associated with antipsychotic-induced weight gain in the past, but this one appears to be the most compelling finding thus far."

Kennedy and Muller also were involved in another study that identified a different variation near the melanocortin-4 receptor gene that was associated with weight gain in patients taking antipsychotic drugs. The study was published earlier this year in The Pharmacogenomics Journal.

Although the researchers found that the melanocortin-4 receptor gene variant was associated with rapid weight gain, the study did not prove a cause-and-effect relationship.

More information

The U.S. National Institute of Mental Health has more about mental-health medications.

-- Robert Preidt

SOURCE: Center for Addiction and Mental Health, news release, July 17, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. More Genes Linked to Osteoarthritis Identified
2. Study finds genes associated with hippocampal atrophy
3. New mechanism of bacterial pathogenesis discovered
4. Genes May Influence Reactions to Painkillers
5. Genes Might Help Some Smokers Kick the Habit
6. Genes predict if medication can help you quit smoking
7. Obesity genes may influence food choices, eating patterns
8. Study Ties Genes to Lower Urinary Tract Symptoms, Prostate Cancer Risk
9. Strategy discovered to activate genes that suppress tumors and inhibit cancer
10. Genes Might Be Key to Parkinsons Spread
11. Living longer - variability in infection-fighting genes can be a boon for male survival
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Influence Whether Psych Drugs Lead to Weight Gain
(Date:1/21/2017)... ... January 21, 2017 , ... In the United States, 20 million women ... of recovery, they often feel shame for having struggled with an eating disorder as ... the workshop, “Rising Strong in Life After an Eating Disorder” -- to be featured ...
(Date:1/20/2017)... ... January 20, 2017 , ... Source Vitál Apothecary, a skin and body care ... announced the company had a successful visit to the 2017 ECRM Diet, Vitamin & ... that work in the nutritional, sports and health industries a chance to meet in ...
(Date:1/20/2017)... ... 20, 2017 , ... International Protein, a company based out of Australia that ... the January ECRM trade show in Hilton Head, SC. , International Protein was ... create a line of products that would elevate her fitness regime. At this ECRM ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Angel”: a heartwarming ... set out for each of his children. “The Angel” is the creation of published ... in New York City, and impassioned writer. , When asked of her new book, ...
(Date:1/20/2017)... ... , ... “Journey to Christmas:” a beautiful and enchanting tale that teaches children the true meaning ... of three in Oklahoma City, and a devoted woman of faith. , “Becoming a ... in the back of my mind for years, but actually doing it might have been ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Jan. 19, 2017 The global immunomodulators ... by 2025, according to a new study by ... to be predominantly driven by high R&D investments ... large-scale production of new and therapeutically advanced drugs. ... drugs at an unprecedented rate into the immunomodulators ...
(Date:1/19/2017)... , Jan. 19, 2017 Report Details ... ... for Leading Companies – our new study reveals trends, ... issues and events affecting the Alzheimer,s disease therapeutics and ... answer these key questions: - How is the Alzheimer,s ...
(Date:1/19/2017)... -- According to a study conducted by Persistence Market ... a CAGR of 6.5% during the forecast period 2016-2024. According to ... be the leading market for cryotherapy globally during the forecast period  ... Highlights from the ... and adequate supply of gas in order to provide smoother maintenance ...
Breaking Medicine Technology: