Navigation Links
Genes Influence Whether Psych Drugs Lead to Weight Gain
Date:7/20/2012

FRIDAY, July 20 (HealthDay News) -- Researchers have discovered two genetic variants associated with substantial, rapid weight gain in people taking antipsychotic medications.

The researchers said the findings could eventually be used by doctors to identify which patients have the variations so they can be treated without the risk of weight gain, which can lead to obesity and health problems including diabetes and heart disease.

"Weight gain occurs in up to 40 percent of patients taking medications called second-generation or atypical antipsychotics, which are used because they're effective in controlling the major symptoms of schizophrenia," Dr. James Kennedy, of the Center for Addiction and Mental Health, in Toronto, said in a center news release.

Kennedy, senior author of a study published online recently in the journal Archives of General Psychiatry, pinpointed a variation near the melanocortin-4 receptor gene, which is known to be linked to obesity.

The study of patients in Europe and the United States being treated with atypical antipsychotics found that those with two copies of the variant gained about three times as much weight as those with one or no copies -- about 13 pounds vs. 4 pounds.

"The weight gain was associated with this genetic variation in all these groups, which included pediatric patients with severe behavior or mood problems, and patients with schizophrenia experiencing a first episode or who did not respond to other antipsychotic treatments," Dr. Daniel Muller, study co-author and Center for Addiction and Mental Health scientist, said in the news release.

"The results from our genetic analysis combined with this diverse set of patients provide compelling evidence for the role of this [melanocortin-4 receptor] variant," Muller said. "Our research group has discovered other gene variants associated with antipsychotic-induced weight gain in the past, but this one appears to be the most compelling finding thus far."

Kennedy and Muller also were involved in another study that identified a different variation near the melanocortin-4 receptor gene that was associated with weight gain in patients taking antipsychotic drugs. The study was published earlier this year in The Pharmacogenomics Journal.

Although the researchers found that the melanocortin-4 receptor gene variant was associated with rapid weight gain, the study did not prove a cause-and-effect relationship.

More information

The U.S. National Institute of Mental Health has more about mental-health medications.

-- Robert Preidt

SOURCE: Center for Addiction and Mental Health, news release, July 17, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. More Genes Linked to Osteoarthritis Identified
2. Study finds genes associated with hippocampal atrophy
3. New mechanism of bacterial pathogenesis discovered
4. Genes May Influence Reactions to Painkillers
5. Genes Might Help Some Smokers Kick the Habit
6. Genes predict if medication can help you quit smoking
7. Obesity genes may influence food choices, eating patterns
8. Study Ties Genes to Lower Urinary Tract Symptoms, Prostate Cancer Risk
9. Strategy discovered to activate genes that suppress tumors and inhibit cancer
10. Genes Might Be Key to Parkinsons Spread
11. Living longer - variability in infection-fighting genes can be a boon for male survival
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Influence Whether Psych Drugs Lead to Weight Gain
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a ... centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile ... the struggle to reverse the tide of prescription drug addiction. ... regulating their medicine intake and stepping down their dosage in ... to launch in December 2017; the first 100,000 people to ... more at http://www.rebound-solution.com/ ...
(Date:9/27/2017)... Sept. 27, 2017  Commended for their devotion to personalized ... Ranked as number one in the South Florida Business Journal,s ... Inc. 5000 yearly list, the national specialty pharmacy has found ... Bardisa will soon be honored by SFBJ as the ... Set to receive his award in October, Bardisa ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
Breaking Medicine Technology: