Navigation Links
Genes Help Cancer-Linked Viruses Elude Immune System

Pathogens such as HPV tweak their DNA to escape detection, study suggests

TUESDAY, Feb. 10 (HealthDay News) -- The DNA of cancer-related viruses may actually change to disguise themselves from the immune system, a new study has found.

An international team of scientists studied the entire genomes of three common viruses -- Epstein-Barr, the human papilloma virus (HPV) and hepatitis B. Each of these pathogens can progress into cancer -- for example, HPV is strongly linked to cervical tumors, and hepatitis B has been tied to liver cancer. About 15 percent of all cancer cases worldwide are linked to a viral infection.

The researchers found that the genomes were generally similar between people who had the virus but no symptoms, those with the disease caused by the virus, and those who developed the virus-related cancer. However, the epigenome -- a layer of biochemical reactions that turns genes on and off -- appeared much different, with the virus increasingly experiencing methylation in patients who had developed cancer.

According to the researchers, methylation (an enzyme-mediated modification to DNA) may prove to be a type of camouflage to help the virus elude the body's natural defense system.

The findings were published online in Genome Research.

"This a very exciting result that can explain why some of these viruses can survive for such prolonged times in our body," senior author Manel Esteller, of the Bellvitge Institute for Biomedical Research (IDIBELL) in Barcelona, said in a news release issued by the journal.

DNA methylation could possible serve as a disease biomarker or as a route to attack the viruses and their associated diseases, Esteller said.

More information

The U.S. National Library of Medicine has more about the Human Genome Project .

-- Kevin McKeever

SOURCE: Genome Research, news release, Feb. 9, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Database to Help Speed Search for Bipolar Disorder Genes
4. Is Perfect Pitch All in the Genes?
5. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
6. Genes Boost Risk for Rheumatoid Arthritis, Lupus
7. The genes involved in rheumatoid arthritis identified
8. If you think cancer genes are simple, you dont know JAK
9. Test for lung cancer looks for discomforting quiet among protective genes
10. Hushed Genes Might Mean Higher Lung Cancer Risk
11. EURYI project to understand how the brain wires during embryogenesis
Post Your Comments:
Related Image:
Genes Help Cancer-Linked Viruses Elude Immune System
(Date:11/26/2015)... ... November 26, 2015 , ... Health-E-minds ... collaborated with Women’s Web – an online resource for Indian women looking ... and emotional well-being relationship, life balance, stress, professional development, and lifestyle. Health-E-minds ...
(Date:11/25/2015)... ... 25, 2015 , ... The holiday season is jam-packed with ... palates of attendees is of the utmost importance. Whether you are cooking at ... these recipes a try this holiday season. , Turkey Croquettes , ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dr. John Pierce, Medical Director at the Ageless ... treatment with the Capillus272™ Pro laser therapy cap. FDA cleared for safety and efficacy, ... without the need for surgery, prescription pills, or topical foams. , “Capillus272™ Pro ...
(Date:11/25/2015)... ... 25, 2015 , ... According to an article published November 10th ... widely heralded as a breakthrough for performing hernia repairs. The article explains that the ... is that it can greatly reduce the pain that a patient might otherwise experience ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... athletic programs, launches new Wimbledon Athletics Facebook page to educate the ... for unsuspected cardiac abnormalities. About 2,000 people under the age of 25 die ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ( ... "Advanced Wound Care Market by Type (Dressings, Therapy Devices, ... (In-Patient Facility, Out-Patient Facility), and Geography - Global Forecast ... --> --> The purpose ... and forecast of the global advanced wound care market. ...
(Date:11/26/2015)... India , November 26, 2015 ... --> adds ... Report" and "Investigation Report on China ... and 2021 forecasts data and information ... . ...
(Date:11/26/2015)... , Nov. 26, 2015 Research ... addition of the "2016 Future Horizons and ... (TDM) Market: Supplier Shares, Country Segment Forecasts, Competitive ... --> --> ... analysis of the Italian therapeutic drug monitoring market, ...
Breaking Medicine Technology: