Navigation Links
Genes Give Clues to Newborn Lung Disease
Date:10/4/2007

Bronchopulmonary dysplasia causes long-term respiratory trouble, researchers note

THURSDAY, Oct. 4 (HealthDay News) -- Using gene-chip (microarray) analysis, researchers at Children's Hospital Boston have found new information that may help predict and treat bronchopulmonary dysplasia (BPD), a lung disease that affects premature newborns

Little is known about how to predict, prevent or treat BPD, which can cause long-term breathing problems, according to background information in the study, published online Oct. 4 in the journal Genome Biology.

In this study -- one of the first to use gene-chip analysis to investigate diseases of premature newborns -- researchers analyzed gene activity in samples from the umbilical cords of 54 infants born at less than 28 weeks gestation. Of those, 20 developed BPD, and 34 did not.

"In the infants who went on to have BPD, we were surprised and intrigued to find a difference in a biochemical pathway (the chromatin remodeling pathway) that's also disrupted in adult chronic obstructive pulmonary disease (COPD)," senior author Dr. Isaac Kohane, director of the Children's Hospital Informatics Program, said in a prepared statement.

A group of drugs (histone deacetylase inhibitors) being developed to treat COPD may also prevent or treat BPD, he suggested.

"If you can prevent that pathway from being switched on and chewing away the lung, you might prevent BPD and perhaps improve the rocky clinical course of premature infants," Kohane said.

The researchers plan further genetic research of BPD in premature infants.

More information

The U.S. National Heart, Lung, and Blood Institute has more about BPD.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, Oct. 3, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Genes for lung disease
3. Genesis of SUPAC
4. Cirrhosis linked to genes
5. Altering genes through calories
6. Predictable genes
7. Genes for Vision discovered
8. Endometriosis coalesced with genes
9. Birth weight may be influenced by genes
10. New breast cancer genes discovered
11. Altitude sickness connected to genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... , ... STAT courier is pleased to announce that due to customer demand, ... expanding their presence in Dallas. One of the most exciting parts for STAT is ... the Dallas and Forth Worth market. STAT takes pride in treating their employees with ...
(Date:12/8/2016)... ... December 08, 2016 , ... Vida Health, the digital health ... led by Canvas Ventures . Other investors include Nokia Growth Partners (NGP) and ... to serve more consumers who are managing chronic conditions or simply want ...
(Date:12/8/2016)... ... December 08, 2016 , ... Peter Zipp Insurance, an ... around the greater Phoenix metropolitan region, is announcing a charity event to provide ... the Homeless Youth Connection is to promote community awareness of the ongoing needs ...
(Date:12/8/2016)... ... 08, 2016 , ... Bill Mull Agencies, a Wichita-based firm ... around central Kansas, is joining the Youth Horizons organization for a charity event ... in Wichita, Youth Horizons works to empower area children from unstable, troubled, or ...
(Date:12/7/2016)... ... , ... Kenall Manufacturing, a leader in sealed healthcare lighting for more than ... multi-function, sealed, LED luminaire that meets the needs of everyone in the patient room ... , A 2’ x 4’ model features four modes: reading, ambient, standard and ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 8, 2016  Boehringer Ingelheim announced today that it ... (CEI). This is the ninth time that the company ... a Best Place to Work for LGBT Equality. Administered ... a national benchmarking report on corporate policies and practices ... transgender (LGBT) employees. "We are committed ...
(Date:12/8/2016)... , December 8, 2016 ... "Sugar-Based Excipients Market by Product (Actual Sugars, Sugar ... (Filler & Diluent, Tonicity Agents), Formulation (Oral, Topical, ... MarketsandMarkets, the market has witnessed healthy growth during ... at a CAGR of 4.3% between 2016 and ...
(Date:12/8/2016)... 2016 According to a new market research report ... Therapeutic (Pain, Insulin)), End Use (Sports, Fitness, RPM), Type (Smart watch, Patch), ... global market, in terms of value, is projected to reach 12.14 Billion ... 18.0% during the forecast period. Continue Reading ... ...
Breaking Medicine Technology: