Navigation Links
Genes Give Clues to Newborn Lung Disease
Date:10/4/2007

Bronchopulmonary dysplasia causes long-term respiratory trouble, researchers note

THURSDAY, Oct. 4 (HealthDay News) -- Using gene-chip (microarray) analysis, researchers at Children's Hospital Boston have found new information that may help predict and treat bronchopulmonary dysplasia (BPD), a lung disease that affects premature newborns

Little is known about how to predict, prevent or treat BPD, which can cause long-term breathing problems, according to background information in the study, published online Oct. 4 in the journal Genome Biology.

In this study -- one of the first to use gene-chip analysis to investigate diseases of premature newborns -- researchers analyzed gene activity in samples from the umbilical cords of 54 infants born at less than 28 weeks gestation. Of those, 20 developed BPD, and 34 did not.

"In the infants who went on to have BPD, we were surprised and intrigued to find a difference in a biochemical pathway (the chromatin remodeling pathway) that's also disrupted in adult chronic obstructive pulmonary disease (COPD)," senior author Dr. Isaac Kohane, director of the Children's Hospital Informatics Program, said in a prepared statement.

A group of drugs (histone deacetylase inhibitors) being developed to treat COPD may also prevent or treat BPD, he suggested.

"If you can prevent that pathway from being switched on and chewing away the lung, you might prevent BPD and perhaps improve the rocky clinical course of premature infants," Kohane said.

The researchers plan further genetic research of BPD in premature infants.

More information

The U.S. National Heart, Lung, and Blood Institute has more about BPD.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, Oct. 3, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Genes for lung disease
3. Genesis of SUPAC
4. Cirrhosis linked to genes
5. Altering genes through calories
6. Predictable genes
7. Genes for Vision discovered
8. Endometriosis coalesced with genes
9. Birth weight may be influenced by genes
10. New breast cancer genes discovered
11. Altitude sickness connected to genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... KS (PRWEB) , ... April 28, 2017 , ... ... have typically been previously exposed to more adverse experiences than children in the ... experienced trauma such as abuse, neglect or other family challenges. While no fault ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... and College of Urgent Care Medicine will host industry leaders for the annual ... will help those in the industry adapt to the issues currently affecting urgent ...
(Date:4/28/2017)... ... 2017 , ... People are starting to accept that hearing aids can be ... the stigma it had when great-grandpa wore his hearing aids years ago,” said Dr. ... North American Speaker Series (NASS) segment. “He probably wore an iPod-size hearing ...
(Date:4/28/2017)... ... ... Pastor and Overseer at The House of Yahweh in Abilene, Texas, has published a new ... not. Yisrayl says with so many titles and names for the Creator, it’s hard ... a little Scripture, backed with a lot of research, the truth is undeniable. , ...
(Date:4/28/2017)... UTAH (PRWEB) , ... April 28, 2017 , ... ... Account Manager for the North East region. Côté has 20+ years of experience ... Prior to Phytomer, Côté worked with an array of high-end cosmetic brands, retail ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... The Global Effective Microorganisms (EM) Market by Manufacturers, ... and analysed the potential of Global Effective Microorganisms (EM) Market ... growth factors. The report identifies and analyses the emerging trends ... market. ... and Figures, 6 Major Company Profiles, spread across 124 pages ...
(Date:4/19/2017)... , April 19, 2017 ... stimulate an immune response in pets such as ... products are of various types such as Attenuated ... Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated ... as virus or bacteria, which have been weakend ...
(Date:4/19/2017)... HANOVER, N.J. , April 19, 2017 /PRNewswire/ ... conducted by the National Heart, Lung, and Blood ... (NIH) demonstrating that 58% of patients with treatment-naïve ... six months when treated with eltrombopag at the ... 1 . The study evaluated three sequential treatment ...
Breaking Medicine Technology: