Navigation Links
Genes Give Clues to Newborn Lung Disease
Date:10/4/2007

Bronchopulmonary dysplasia causes long-term respiratory trouble, researchers note

THURSDAY, Oct. 4 (HealthDay News) -- Using gene-chip (microarray) analysis, researchers at Children's Hospital Boston have found new information that may help predict and treat bronchopulmonary dysplasia (BPD), a lung disease that affects premature newborns

Little is known about how to predict, prevent or treat BPD, which can cause long-term breathing problems, according to background information in the study, published online Oct. 4 in the journal Genome Biology.

In this study -- one of the first to use gene-chip analysis to investigate diseases of premature newborns -- researchers analyzed gene activity in samples from the umbilical cords of 54 infants born at less than 28 weeks gestation. Of those, 20 developed BPD, and 34 did not.

"In the infants who went on to have BPD, we were surprised and intrigued to find a difference in a biochemical pathway (the chromatin remodeling pathway) that's also disrupted in adult chronic obstructive pulmonary disease (COPD)," senior author Dr. Isaac Kohane, director of the Children's Hospital Informatics Program, said in a prepared statement.

A group of drugs (histone deacetylase inhibitors) being developed to treat COPD may also prevent or treat BPD, he suggested.

"If you can prevent that pathway from being switched on and chewing away the lung, you might prevent BPD and perhaps improve the rocky clinical course of premature infants," Kohane said.

The researchers plan further genetic research of BPD in premature infants.

More information

The U.S. National Heart, Lung, and Blood Institute has more about BPD.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, Oct. 3, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Genes for lung disease
3. Genesis of SUPAC
4. Cirrhosis linked to genes
5. Altering genes through calories
6. Predictable genes
7. Genes for Vision discovered
8. Endometriosis coalesced with genes
9. Birth weight may be influenced by genes
10. New breast cancer genes discovered
11. Altitude sickness connected to genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
Breaking Medicine Technology: