Navigation Links
Genes Could Highlight Plavix Users at Clot Risk After Stent
Date:10/25/2011

By Amanda Gardner
HealthDay Reporter

TUESDAY, Oct. 25 (HealthDay News) -- Scientists have identified mutations in three genes that make certain patients more likely to have a potentially fatal blood clot after undergoing heart stent placement.

The genes are involved in metabolism of the drug Plavix (clopidogrel), a widely used blood thinner, and in platelet formation, according to a study published in the Oct. 26 issue of the Journal of the American Medical Association.

"This goes back to the idea of tailored medicine but [gene testing] is not feasible to do on everybody," said Dr. John Gassler, associate professor of medicine at the University of Rochester Medical Center, who was not involved with the research. "This study is very strongly thought-provoking but I don't think it can alter practice until it's been evaluated [further]."

The authors of the study also reported that a higher initial dose of Plavix reduced the risk of stent thrombosis (blood clot formation), while using proton pump inhibitors -- common drugs to treat gastroesophageal reflux disease (GERD) and stomach ulcers -- upped the risk.

People who get stents to prop open blocked arteries routinely receive two different blood thinners to reduce the risk of stent thrombosis. This has cut the rate of stent thrombosis tremendously, but up to 4 percent of patients still end up with this devastating complication, according to background information in the study.

The study authors analyzed 23 gene variants in 15 genes in 123 patients who had undergone percutaneous coronary intervention in France and who had experienced stent thrombosis.

These patients were compared to 246 similar patients who had not had stent thrombosis.

Three genotypes and two clinical factors -- Plavix loading (initial) dose and use of proton pump inhibitors -- all affected the risk of stent thrombosis.

When the investigators combined the
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Linking of mutations in 12 genes to ovarian cancer may lead to more effective prevention
2. Happy Kids a Product of Genes, Parenting, Study Finds
3. New Genes Revealed for Type 1 Diabetes
4. Scientists ID More Genes Linked to Heart Disease
5. Genes May Explain Blacks Bleaker Prostate Cancer Stats
6. Key regulatory genes often amplified in aggressive childhood tumor of the brainstem
7. Family Heart Disease Risk Linked to Genes, Not Lifestyle
8. Intelligence Largely Rooted in the Genes
9. Johns Hopkins scientists map genes for common form of brain cancer
10. Genes, Not Healthy Living, Get Most to Age 100
11. Researchers Find 3 Genes Linked to Esophagus Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Could Highlight Plavix Users at Clot Risk After Stent
(Date:5/22/2015)... Omar Ahmad Barrada, a junior at ... the 2015 Congress of Future Medical Leaders in Boston, ... of “America’s highest achieving high school students.” , “I’m ... new goals and learn better study habits,” said Omar. ... which we can ask the surgeons questions.” , The ...
(Date:5/22/2015)... NY (PRWEB) May 22, 2015 Hands ... that June 17, 2015, the Annual One Day Sale ... Since 2007, Hands On HCMT offers drastically reduced certificates one ... and estheticians have enough sessions, through what used to be ... is wonderful for the community as well. This once a ...
(Date:5/22/2015)... 22, 2015 Family, friends, students, colleagues, ... surgical oncologist, Dr. LaSalle D. Leffall, on Monday, May ... began after Grand Rounds in the hospital’s Tower Auditorium. ... outside the auditorium, trying to keep the secret. “I’d ... he sees me, he’ll know something is up,” she ...
(Date:5/22/2015)... May 22, 2015 Coordinating care ... difficult process. Historically providers have not been reimbursed ... Starting in 2015, Medicare has paved the way ... Thanks to the launch of Oculus Health ... health systems using the platform will now be ...
(Date:5/22/2015)... According to a new Aegis Living Study on ... likely to worry about what will happen to their memory ... 69% Silent Generation), which may help explain why nearly half ... particularly Millennials (47%), Gen X’ers (51%), and Boomers (43%). The ... among more than 2,000 U.S. adults ages 18+. , ...
Breaking Medicine News(10 mins):Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 3Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2Health News:Oculus Health Care Coordination Platform Officially Launched 2Health News:Oculus Health Care Coordination Platform Officially Launched 3Health News:Oculus Health Care Coordination Platform Officially Launched 4Health News:New Study Reveals America’s Fear of Aging 2Health News:New Study Reveals America’s Fear of Aging 3
... for heart disease, 56% risk of ischemic stroke, study finds ... secondhand smoke at home or in the workplace had a ... to women who weren,t exposed, a new study says. , ... of secondhand smoke on peripheral artery disease in women," lead ...
... are uncovering more evidence that a virus they recently discovered ... deadly form of skin cancer. , The findings, published in ... the National Academy of Sciences, put to rest the ... that were the case, the virus would be a passenger ...
... help women to,take control of their health and improve ... Women today placed the first,bilingual, touch-activated Women,s Wellness Guide ... This is the first of 13 kiosks to ... tendency to care for everyone else but themselves and,their ...
... Sept. 22 Biomoda, Inc.,(OTC Bulletin Board: BMOD) ... expanded its intellectual property portfolio,with approval from the ... and CyPath(R)., "We are pleased to receive ... portfolio," said John Cousins, Biomoda president. "It is ...
... Ill. September 22, 2008 A study appearing ... Journal of Medicine shows that among individuals with no ... risk of colorectal cancer is extremely low. The data provides ... longer after a normal colonoscopic examination. , "This research is ...
... patients who receive stereotactic radiosurgery (SRS) and whole brain ... tumors have more than twice the risk of developing ... alone, according to new research from The University of ... of the phase III randomized trial were presented at ...
Cached Medicine News:Health News:Women's Peripheral Artery Disease Tied to Secondhand Smoke 2Health News:Pitt research indicates new virus is culprit, not bystander, in deadly skin cancer 2Health News:Pennsylvania Commission for Women Delivers First Women's Wellness Guide Kiosk to Allegheny County Jail 2Health News:U.S. Patent Office Grants Biomoda Registration for Trademarks 2Health News:Risk of colorectal cancer extremely low 5 years after a normal colonoscopy screening 2Health News:Whole brain radiation increases risk of learning and memory problems in cancer patients 2Health News:Whole brain radiation increases risk of learning and memory problems in cancer patients 3
(Date:5/22/2015)... InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" or the "Company"), ... that its CGuard TM Embolic Prevention System reported positive ... Musialek , at the EuroPCR conference on May ... PARADIGM, an investigator-initiated P rospective evaluation of ... revascularization I n symptomatic and increased-risk asymptomatic carotid artery ...
(Date:5/22/2015)... 2015 AcelRx Pharmaceuticals, Inc. (Nasdaq: ACRX ... and commercialization of innovative therapies for the treatment of ... executive officer Howie Rosen will be presenting ... Tim Morris will be presenting at JMP ... are as follows: Jefferies 2015 Healthcare Conference ...
(Date:5/21/2015)... , May 21, 2015 ... announced the addition of the "Market Assessment ... Europe" report to their offering. ,     (Logo: ... of the respiratory imaging diagnostics market in ... Europe . The service provides detailed ...
Breaking Medicine Technology:InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4AcelRx Pharmaceuticals to Present at Two Upcoming Investor Conferences In June 2United States and Europe Respiratory Diagnostics Market Assessment 2015 2
Greenberg micro instrument holder is a flexbar arm used to hold micro instruments used repeatedly within retracted fields. Holds instruments with shafts up to 1/8 in diameter....
Greenberg universal retractor case, with four compartments to hold various components....
Length-9 (229 mm) Tapered retractor blades....
Kit is supplied with four secondary bars. Secondary bars attach to primary bar. Length 12 (305 mm)....
Medicine Products: