Navigation Links
Genes Associated With Autism Also Related to Schizophrenia
Date:4/19/2012

THURSDAY, April 19 (HealthDay News) -- Scientists have identified 33 genes associated with autism and related disorders, and they say several of the genes also appear to be altered in people with schizophrenia.

Of the 33 genes, 22 were identified as associated with autism for the first time, according to the study, which currently appears online and is scheduled for publication in the April 27 print issue of the journal Cell.

"By sequencing the genomes of a group of children with neurodevelopmental abnormalities, including autism, who were also known to have abnormal chromosomes, we identified the precise points where the DNA strands are disrupted and segments exchanged within or between chromosomes," senior study author James Gusella, director of the Massachusetts General Hospital Center for Human Genetic Research, said in a hospital news release. "As a result, we were able to discover a series of genes that have a strong individual impact on these disorders."

"We also found that many of these genes play a role in diverse clinical situations -- from severe intellectual disability to adult-onset schizophrenia -- leading to the conclusion that these genes are very sensitive to even subtle perturbations," Gusella added.

The researchers screened the genomes of 38 people with autism or other neurodevelopmental disorders. A significant number of the genes linked with autism also appear to be associated with schizophrenia and other psychiatric disorders.

"The theory that schizophrenia is a neurodevelopmental disorder has long been hypothesized, but we are just now beginning to uncover specific portions of the genetic underpinnings that may support that theory," study author Michael Talkowski, also of Massachusetts General Hospital, said in the news release.

"We also found that different gene variations -- deletion, duplication or inactivation -- can result in very similar effects, while two similar changes at the same site might have very different neurodevelopmental manifestations," Talkowski said. "We suspected that the genetic causes of autism and other neurodevelopmental abnormalities are complex and likely to involve many genes, and our data support this."

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about autism.

-- Robert Preidt

SOURCE: Massachusetts General Hospital, news release, April 19, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. 2 repressor genes identified as essential for placental development
2. Researchers ID Genes That May Determine Mental Illness
3. Brisk Daily Walk Could Counter Obesity Genes
4. Genes Play a Role in Drug Abuse Risk Among Adopted Kids: Study
5. Study finds new genes that cause Baraitser-Winter syndrome, a brain malformation
6. Researchers Spot Genes Behind Macular Degeneration
7. When your left hand mimics what your right hand does: Its in the genes
8. 4 New Genes Linked to Type 2 Diabetes
9. Same Genes Key to Early & Late-Onset Alzheimers: Study
10. Genes linked to cancer could be easier to detect with liquid lasers
11. Mutations in 2 Genes Linked to Rare Autism-Related Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Associated With Autism Also Related to Schizophrenia
(Date:3/23/2017)... ... March 23, 2017 , ... PAINWeekEnd (PWE) Oklahoma City, on ... Avenue, will be an educational and exciting program providing busy clinicians and allied ... chronic pain. , Oklahoma is in a healthcare crisis. The state ranks 46th ...
(Date:3/23/2017)... ... 2017 , ... 82% of adults are unaware of the dangers that infectious bacteria play in ... minimum two times a day that dentists recommend. The ramifications of improper oral upkeep go ... and adults missing 164 million hours of work each year due to dental issues. That ...
(Date:3/23/2017)... ... March 23, 2017 , ... Benefits ... an innovative mobile app and centralized benefits dashboard solving one of the top ... from multiple locations. For the first time, employees can access up-to-date information and ...
(Date:3/23/2017)... ... March 23, 2017 , ... The Wound ... by HMP Communications Holdings, LLC, today announced that RestorixHealth® has officially ... of wound centers interested in becoming Certified Wound Specialist Physicians (CWSP®). , ...
(Date:3/23/2017)... ... March 23, 2017 , ... March 23, 2017 ... organizations to easily reprint customer invoices, bills, statements and other correspondence when they ... steps needed to retrieve and print the documents and batch them for efficient ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 2017  Ethicon* today announced the completion of ... held medical device company that manufactures and markets ... treatment of Gastroesophageal Reflux Disease (GERD). This acquisition ... portfolio of minimally invasive options for patients suffering ... of the transaction have not been disclosed. ...
(Date:3/23/2017)... YORK , March 23, 2017 ... sample preparation market is expected to reach USD 7.2 billion ... of 7.1%. Sample preparation is a procedure in which a ... crucial step in most analytical procedures since the methods are ... preparation is one of the most shared procedures in the ...
(Date:3/23/2017)... 2017  Drug diversion is a significant contributing ... overdoses. A new oral fluid monitoring test, announced ... reports more detailed and actionable information to clinicians ... therapy adherence, patient safety, and help to identify ... fluid Rx Evaluation (CORE) system is the first ...
Breaking Medicine Technology: