Navigation Links
Genes, brain chemistry may dictate nicotine cravings, says CU-Boulder study
Date:11/6/2007

Individual brain chemistry and genes could be key to understanding why some people become addicted to nicotine and why the chemical compound's effects appear to diminish at night, University of Colorado at Boulder researchers say.

"The depth of a person's addiction to nicotine appears to depend on his or her unique internal chemistry and genetic make-up," said lead author Jerry Stitzel, an assistant professor in CU-Boulder's department of integrative physiology and researcher with CU-Boulder's Institute for Behavioral Genetics.

Stitzel presented his team's findings in San Diego on Monday at Neuroscience 2007, an annual scientific meeting that is taking place through Wednesday.

He and his team set out to evaluate the effects of nicotine over the course of a day by examining mice that could make and "recognize" melatonin, a powerful hormone and antioxidant, and others that could not. Scientists believe that melatonin, which is produced by darkness, tells our bodies when to sleep.

The CU researchers found that the reduced effects of nicotine at night were dependent on the mice's genetic make-up and whether their brains and bodies were able to recognize melatonin. They also found that the daytime effects of nicotine were greatest when levels of the stress hormone corticosterone were high.

The second finding could explain why many smokers report that the first cigarette of the day is the most satisfying. Cortisol, the human equivalent of corticosterone, is at peak levels in the early morning, Stitzel said.

"The negative health consequences of smoking have become well known, and a large majority of smokers say that they would like to quit," Stitzel said. "As such, we need to understand the interaction between smoking, genes and internal chemistry so we can target new therapies to those who have a hard time quitting."

While the team's research could shed light on why people smoke and how nicotine affects them, Stitzel says more research is needed to determine the role that melatonin plays in altering the effects of nicotine, and whether the correlation between higher corticosterone levels and nicotine sensitivity is a coincidence.


'/>"/>

Contact: Jerry Stitzel
jerry.stitzel@colorado.edu
303-859-9577
University of Colorado at Boulder
Source:Eurekalert

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Vision restoration therapy shown to improve brain activity in brain injured patients
3. Clinical depression linked to abnormal emotional brain circuits
4. Brain imaging reveals breakdown of normal emotional processing
5. Brain cells work differently than previously thought
6. Vaccine Stops Alzheimers Brain Tangles
7. Research may unlock mystery of autisms origin in the brain
8. Scientists Spot Brains Free Will Center
9. Free will takes flight: how our brains respond to an approaching menace
10. Alcoholics With Cirrhosis Have More Brain Damage
11. Brain Lesions Predict MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... For many artists, the act of blending paint ... it into a science. , Using the new, highly precise METTLER TOLEDO ML204T ... add depth and meaning to his works. What’s more, it has allowed him to ...
(Date:5/2/2016)... ... May 02, 2016 , ... The debilitating disease of arthritis can bring patients ... most patients must deal with prescription costs to treat arthritis over the course of ... savings at the pharmacy on many common prescriptions. , Arthritis , Although arthritis is ...
(Date:5/2/2016)... ... May 02, 2016 , ... Summit BHC (Summit), a ... of Twin Lakes Recovery Center. Located east of Atlanta in Monroe, Georgia, ... The residential facility is set on 34 acres of beautiful, secluded property that ...
(Date:5/2/2016)... ... May 02, 2016 , ... Marshall Votta, Josh Holmes and Laura ... development roles to drive RowdMap Inc.’s market growth across both health plans and provider ... order to succeed in value based care. , Marshall Votta joins RowdMap, Inc. as ...
(Date:5/1/2016)... , ... May 02, 2016 , ... ... for original 1968 Jimi Hendrix Merriweather Post Pavilion in Columbia, Maryland concert posters. ... concert poster. The concert was held on August 16. According to Hawley, “The ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...  Marking its one year anniversary since launching ... risk test, Color Genomics announced a ... impact the most common hereditary cancers affecting both ... analyzes hereditary cancer risks for breast, colorectal, melanoma, ... Color Test is physician ordered and includes genetic ...
(Date:4/28/2016)... YORK , April 28, 2016 ... online consumer insights on healthcare, announced today that it ... their report Cool Vendor in Life Sciences, 2016, ... April 15, 2016.  The report focuses on life-science- oriented ... gain insight from patients and doctors, confirm medication ingestion, ...
(Date:4/28/2016)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ( ... of oral drug delivery systems, announced today that the Company ... Joseph Gunnar & Co. LLC, taking place on ... Nadav Kidron , CEO of Oramed, will present a ...   PIONEERS 2016, presented by Joseph Gunnar ...
Breaking Medicine Technology: