Navigation Links
Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
Date:6/19/2009

Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds phosphates to a variety of protein substrates to modify their functions. CaMKII alpha is enriched in the hippocampus, the memory center of the brain, and is believed to be an essential mediator of activity-dependent synaptic plasticity and memory functions. However, the causative role of the enzymatic activity of CaMKII alpha in such processes has not been demonstrated yet, because this enzyme has multiple protein functions other than the kinase activity. A Japanese research group, led by Dr Yoko Yamagata of the National Institute for Physiological Sciences, Japan, has successfully generated a novel kinase-dead mutant mouse of the CaMKII alpha gene that completely and exclusively lacks its kinase activity. They examined hippocampal synaptic plasticity and behavioral learning of the mouse, and found a severe deficit in both processes. They reported their findings in the Journal of Neuroscience, published on June 10, 2009.

The research group successfully generated a novel CaMKII alpha (K42R) knock-in mouse that completely lacks the kinase activity of CaMKII alpha, and examined the effects on structural, functional, and behavioral expression of synaptic memory. In the K42R brain, tetanus-induced long-term potentiation (LTP), a proposed cellular mechanism of memory, and sustained postsynaptic spine enlargement, a structural basis for LTP, were both impaired, whereas dynamic postsynaptic movement of CaMKII alpha protein was preserved. In addition, the K42R mouse showed a severe deficit in inhibitory avoidance learning, a form of memory dependent on the hippocampus. The research group concluded that the mutant mouse could not form memories and did not remember the events that had just happened.

"We demonstrated that the mutant mouse has a severe memory deficit because of the lack of the kinase activity of CaMKII alpha. This finding supports the idea that
'/>"/>

Contact: Dr. Yoko Yamagata
yamagata@nips.ac.jp
81-564-595-887
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Next Generation Waters - Nuu
2. Abbott Initiates Trial of Next-Generation XIENCE PRIME(TM) Drug Eluting Stent, Building Upon Superior Outcomes from SPIRIT Family of Trials
3. Abbott Announces Launch of Next-Generation Embolic Protection System
4. Purity Products Partners with Leading Vitamin D Expert to Create Next-Generation D3 Complex
5. San Francisco Symposium Provides Training for Communities Looking to Develop Arts Programs That Unite Generations
6. RainEarth Applies for Patent for Second Generation Blood Dialysis Equipment
7. Nonin Medical Introduces Next-Generation Regional Oximeter at Euroanaesthesia 2009
8. ZigBee Selected by Continua Health Alliance for Next Generation Guidelines
9. Compressus Delivers Imaging Productivity & Efficiency Improvements in Next Generation MEDxConnect(TM) Workflow Management Solution
10. First heart patients implanted with next-generation mechanical heart pump
11. AARP to Host Cross-Generational Life Festival in Chicago, June 5-6
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... 2015 Atlantic Information Services, Inc. ... Medicare-Medicaid Dual Eligibles Database, a brand-new, continually updated ... to the more than 9 million Medicare-Medicaid dual ... than $300 billion in annual health care spending. ... team that also creates the industry-leading AIS’s Directory ...
(Date:4/21/2015)... One of the most difficult aspects ... food cravings. Many diets end badly due to dieters’ ... Some attempt to eat more often throughout the day, ... regular intervals. While this approach does work for many, ... after a meal. For those who are having trouble ...
(Date:4/21/2015)... April 21, 2015 Pharmacy point ... attend this year's Independent Pharmacy Cooperative trade show, to ... Fontainebleau Miami Beach. , Retail Management Solutions recently became ... according to Mike Gross, VP of Sales and Marketing. ... exclusive independent pharmacy trade shows in the country -- ...
(Date:4/21/2015)... On May 12, 2015, West ... its Center for Graduate Studies, located near Los ... campus recently completed a stunning renovation, but the ... has administrators and students abuzz. , The ... of Science in Nursing, Post-Master’s Family Nurse Practitioner ...
(Date:4/21/2015)... Hills, CA (PRWEB) April 21, 2015 Dr. ... has just released an interesting infographic that takes a close ... millennials. , The new infographic, which appears on both Dr. ... The Rise of Plastic Surgery in the Age of the ... surgery in Beverly Hills to a variety of A-list ...
Breaking Medicine News(10 mins):Health News:New AIS Database Tracks All Programs, Plans Serving the Dual-Eligible Community 2Health News:Diet Doc Introduces New Neuro Balance, A Proprietary Diet Aid to Help Dieters Eliminate Food Cravings 2Health News:Diet Doc Introduces New Neuro Balance, A Proprietary Diet Aid to Help Dieters Eliminate Food Cravings 3Health News:Retail Management Solutions to Attend Upcoming Independent Pharmacy Cooperative Trade Show 2Health News:Retail Management Solutions to Attend Upcoming Independent Pharmacy Cooperative Trade Show 3Health News:West Coast University Opens a Center for Graduate Studies 2Health News:West Coast University Opens a Center for Graduate Studies 3Health News:Beverly Hills Plastic Surgery Expert Dr. Zain Kadri Releases Thought-Provoking New Infographic 2
... Heroes, WATERTOWN, Mass., Oct. 28 Bright ... child care,early education, and work/life solutions, salutes its ... Companies" by Working Mother magazine.,Nine out of the ... the critical role high-quality child care plays in ...
... #7720, PATIENTS, HOME PHOTOS HELP IDENTIFY ASTHMA TRIGGERS , ... of in-home photography may be a more cost-effective alternative ... Researchers from Truman Medical Center and the University of ... persistent asthma to take photos of a predetermined list ...
... MONDAY, OCTOBER 27 , #7720, PATIENTS, HOME PHOTOS ... EST), The use of in-home photography may be a ... and allergy triggers. Researchers from Truman Medical Center and ... adult subjects with persistent asthma to take photos of ...
... 28 URAC,s Board of,Directors has approved ... Workers, Compensation and Property and Casualty Pharmacy ... to URAC,s Pharmacy Quality,Management(R) suite of products., ... All standards within this suite of programs ...
... Calif., Oct. 28 Inspired by San ... Beautiful Plastic Surgery in,Encinitas and Carlsbad, CA ... creates a more sensuous, sculpted, fit appearance ... advanced,methods that shape surface contour to suggest ...
... Group, is Early Adopter in U.S., DENVER, ... or the "Company") (OTC Bulletin Board: GLOB), an,international ... Wyndgate Technologies(R) ("Wyndgate") division has,licensed its SafeTrace Tx(R) ... in Brevard County, Florida. The system is now,live ...
Cached Medicine News:Health News:Bright Horizons Congratulates 76 Clients Named to Working Mother's 100 Best 2Health News:New research about chronic lung disease presented at CHEST 2008 2Health News:New research about chronic lung disease presented at CHEST 2008 3Health News:New research about chronic lung disease presented at CHEST 2008 4Health News:New research about chronic lung disease presented at CHEST 2008 5Health News:New research about chronic lung disease presented at CHEST 2008 6Health News:New research about chronic lung disease presented at CHEST 2008 7Health News:CHEST 2008: Featured abstracts 2Health News:CHEST 2008: Featured abstracts 3Health News:CHEST 2008: Featured abstracts 4Health News:CHEST 2008: Featured abstracts 5Health News:CHEST 2008: Featured abstracts 6Health News:CHEST 2008: Featured abstracts 7Health News:CHEST 2008: Featured abstracts 8Health News:CHEST 2008: Featured abstracts 9Health News:CHEST 2008: Featured abstracts 10Health News:CHEST 2008: Featured abstracts 11Health News:CHEST 2008: Featured abstracts 12Health News:CHEST 2008: Featured abstracts 13Health News:CHEST 2008: Featured abstracts 14Health News:CHEST 2008: Featured abstracts 15Health News:CHEST 2008: Featured abstracts 16Health News:CHEST 2008: Featured abstracts 17Health News:CHEST 2008: Featured abstracts 18Health News:URAC Introduces New Pharmacy Benefit Management Accreditation for Workers' Compensation and Property and Casualty Programs 2Health News:New Tummy Tuck Technique Increases Sensuality 2Health News:Global Med Technologies(R), Inc. Implements Transfusion Management System in Large Private Physician Owned Laboratory 2Health News:Global Med Technologies(R), Inc. Implements Transfusion Management System in Large Private Physician Owned Laboratory 3Health News:Global Med Technologies(R), Inc. Implements Transfusion Management System in Large Private Physician Owned Laboratory 4
(Date:4/20/2015)... Mass. , April 20, 2015 ... and final clinical results for the Phase 1 ... in HER2-positive metastatic breast cancer.  The results were ... clinical trials plenary oral session at the 2015 ... in Philadelphia, PA. Data ...
(Date:4/20/2015)... , April 20, 2015  Sigma-Aldrich Corporation ... Corporate Responsibility (CR) Magazine,s list of the 100 ... on outstanding corporate responsibility performance.  Sigma-Aldrich ranked fifth, ... appearance on the list. "We are ... corporate responsibility efforts and we are extremely pleased ...
(Date:4/20/2015)... , April 20, 2015 The preclinical contract research ... testing of drugs and safety testing of medical devices, announces ... at this week,s workshop " Drug Transporters in ADME: From ... MD . The title of Dr. Hidalgo,s talk is ... a session entitled "Transporter Tools of the Future." ...
Breaking Medicine Technology:Merrimack Announces Final Clinical Results for MM-302 Phase 1 Study Demonstrating Robust Activity in Heavily Pre-Treated Patients with HER2-Positive Metastatic Breast Cancer 2Merrimack Announces Final Clinical Results for MM-302 Phase 1 Study Demonstrating Robust Activity in Heavily Pre-Treated Patients with HER2-Positive Metastatic Breast Cancer 3Merrimack Announces Final Clinical Results for MM-302 Phase 1 Study Demonstrating Robust Activity in Heavily Pre-Treated Patients with HER2-Positive Metastatic Breast Cancer 4Merrimack Announces Final Clinical Results for MM-302 Phase 1 Study Demonstrating Robust Activity in Heavily Pre-Treated Patients with HER2-Positive Metastatic Breast Cancer 5Sigma-Aldrich Named to CR Magazine's 100 Best Corporate Citizens List 2Absorption Systems Chief Scientist Ismael Hidalgo to Present at International Workshop on Drug Transporters 2
... , , , IRVINE, Calif., Dec. 9 ... CO-Oximetry and Measure-Through Motion and Low Perfusion pulse oximetry, announced ... equipment and service excellence from the American Association of ... Congress in San Antonio, Texas. Masimo Rainbow SET Acoustic ...
... FALL RIVER, Mass., Dec. 9 Millstone Medical Outsourcing ... professionals to head the leadership of the Memphis, TN, ... the Fall River, MA, headquarters, recently relocated to Memphis ... Millstone Memphis and provide management of operations and program ...
Cached Medicine Technology:Masimo Receives 2009 Zenith Award at the American Association of Respiratory Care Congress 2Masimo Receives 2009 Zenith Award at the American Association of Respiratory Care Congress 3Masimo Receives 2009 Zenith Award at the American Association of Respiratory Care Congress 4Masimo Receives 2009 Zenith Award at the American Association of Respiratory Care Congress 5Millstone Medical Outsourcing Appoints New Leadership of Memphis Facility 2
... This is the comprehensive, simple and ... has a compact, bench-top design, but ... previously only found in high-volume systems. ... cost-effective solution and can also be ...
... KeraCel Ophthalmic Products are ... formulation of lint-free MEROCEL polyvinyl ... configured to be beneficial to ... being absorbent, and yet firm ...
... infant heelstick device uses a highly sharpened surgical ... gentle arc. The incision produced is carefully controlled ... most nerve fibers are located, but through the ... quality blood sample with significantly less pain and ...
Available in 5 different models to accommodate your blood sampling needs....
Medicine Products: