Navigation Links
Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
Date:6/19/2009

Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds phosphates to a variety of protein substrates to modify their functions. CaMKII alpha is enriched in the hippocampus, the memory center of the brain, and is believed to be an essential mediator of activity-dependent synaptic plasticity and memory functions. However, the causative role of the enzymatic activity of CaMKII alpha in such processes has not been demonstrated yet, because this enzyme has multiple protein functions other than the kinase activity. A Japanese research group, led by Dr Yoko Yamagata of the National Institute for Physiological Sciences, Japan, has successfully generated a novel kinase-dead mutant mouse of the CaMKII alpha gene that completely and exclusively lacks its kinase activity. They examined hippocampal synaptic plasticity and behavioral learning of the mouse, and found a severe deficit in both processes. They reported their findings in the Journal of Neuroscience, published on June 10, 2009.

The research group successfully generated a novel CaMKII alpha (K42R) knock-in mouse that completely lacks the kinase activity of CaMKII alpha, and examined the effects on structural, functional, and behavioral expression of synaptic memory. In the K42R brain, tetanus-induced long-term potentiation (LTP), a proposed cellular mechanism of memory, and sustained postsynaptic spine enlargement, a structural basis for LTP, were both impaired, whereas dynamic postsynaptic movement of CaMKII alpha protein was preserved. In addition, the K42R mouse showed a severe deficit in inhibitory avoidance learning, a form of memory dependent on the hippocampus. The research group concluded that the mutant mouse could not form memories and did not remember the events that had just happened.

"We demonstrated that the mutant mouse has a severe memory deficit because of the lack of the kinase activity of CaMKII alpha. This finding supports the idea that
'/>"/>

Contact: Dr. Yoko Yamagata
yamagata@nips.ac.jp
81-564-595-887
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Next Generation Waters - Nuu
2. Abbott Initiates Trial of Next-Generation XIENCE PRIME(TM) Drug Eluting Stent, Building Upon Superior Outcomes from SPIRIT Family of Trials
3. Abbott Announces Launch of Next-Generation Embolic Protection System
4. Purity Products Partners with Leading Vitamin D Expert to Create Next-Generation D3 Complex
5. San Francisco Symposium Provides Training for Communities Looking to Develop Arts Programs That Unite Generations
6. RainEarth Applies for Patent for Second Generation Blood Dialysis Equipment
7. Nonin Medical Introduces Next-Generation Regional Oximeter at Euroanaesthesia 2009
8. ZigBee Selected by Continua Health Alliance for Next Generation Guidelines
9. Compressus Delivers Imaging Productivity & Efficiency Improvements in Next Generation MEDxConnect(TM) Workflow Management Solution
10. First heart patients implanted with next-generation mechanical heart pump
11. AARP to Host Cross-Generational Life Festival in Chicago, June 5-6
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... be aware of the needs of non-religious people. A unique ... Research Council (ESRC) provides a snapshot of a defining aspect ... death is one of the most important incidents that all ... School of Economics. "I wanted to look at how, in ...
... , WEDNESDAY, May 16 (HealthDay News) -- ... factors for a common heart rhythm disorder called atrial ... a person,s risk of heart attack, stroke and death. ... a risk factor for atrial fibrillation, but, according to ...
... TUESDAY, May 15 (HealthDay News) -- Black and Hispanic Americans ... polyps, a new study finds. Researchers analyzed data from ... who had a first-time colonoscopy screening at New York-Presbyterian Hospital/Columbia ... 2010. None of the patients had signs or symptoms of ...
... -- Asthma continues to take its toll on Americans, with ... in 2010, according to a report released Tuesday by the ... analysis also found that more than 29 million (almost 13 ... some point in their lifetime. Children are also being ...
... DETROIT Older, sicker, high-risk patients who undergo one ... better results in larger, busier hospitals, according to new ... the same research showed the experience level of the ... hospital setting. The results, based on data gathered ...
... educated women are opting for families, according to a national ... Shang, an assistant professor at UB, says the study uncovers ... educated women. She says it is still too early ... for older, highly educated women since the 1990s. (Fertility is ...
Cached Medicine News:Health News:Humanist funerals 2Health News:Palpitations May Signal Future Heart Rhythm Problem 2Health News:Blacks, Hispanics Have Higher Colon Polyp Risk Than Previously Thought 2Health News:Asthma Cases Continue to Rise in U.S., Affecting Millions 2Health News:Asthma Cases Continue to Rise in U.S., Affecting Millions 3Health News:Higher hospital volume more important than surgeon experience in outcome of prostate cancer surgery 2Health News:For highly educated women, families are an increasingly popular option 2
(Date:12/24/2014)... -- The International Trade Commission (ITC) issued its final decision in ... a notice issued on December 23, the ITC ruled in ... humidifier was invalid. BMC President, James Xu ... excited with the ITC,s decision in this case. This victory ... the very beginning on the key patents in the case. ...
(Date:12/24/2014)... LONDON , December 24, 2014 ... to grow at an average rate of 8.1%. The ... volume. Hip, knee and spine surgeries are the common ... economies they have a lower penetration. Increased number of ... of composites. Non-metallic orthopedic devices have gained popularity in ...
(Date:12/24/2014)... ResMed (NYSE: RMD ) today announced ... medical device manufacturer BMC Medical Co., Ltd. ... listed below infringe ResMed,s patents, and entered an order prohibiting ... the United States : , iVolve ... Willow nasal pillows mask , iVolve full face mask ...
Breaking Medicine Technology:ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2
... Ga., Dec. 23, 2010 MiMedx Group, ... integrated developer, manufacturer and marketer of patent protected biomaterial-based ... the Class III certification for a European product using ... certification for "post surgical adhesion inhibiting barriers" is in ...
... Pa., Dec. 23, 2010 Cephalon, Inc. (Nasdaq: ... appointed J. Kevin Buchi as Chief Executive Officer and a ... role of company Chairman in the future. William P. Egan ... "Kevin is an experienced pharmaceutical executive who has been ...
Cached Medicine Technology:MiMedx Receives Additional CE Certification for Its HydroFix™ Technology 2MiMedx Receives Additional CE Certification for Its HydroFix™ Technology 3MiMedx Receives Additional CE Certification for Its HydroFix™ Technology 4Cephalon Appoints J. Kevin Buchi as Chief Executive Officer and Member of Cephalon Board of Directors 2Cephalon Appoints J. Kevin Buchi as Chief Executive Officer and Member of Cephalon Board of Directors 3Cephalon Appoints J. Kevin Buchi as Chief Executive Officer and Member of Cephalon Board of Directors 4
... Finnpipette Focus from Thermo Labsystems ... ergonomics with uncompromising performance. ... offers a custom fit for ... shorter tip cones allow easier ...
... pipette is ideal for repeated ... Fixed volume FInnpipettes offer the ... other Finnpipette Digital pipettes: ... (1-40ul), Soft-touch tip ejection, Safety ...
This fixed-volume digital micropipet is used to accurately measure and transfer 5 microliters of solution....
5L...
Medicine Products: