Navigation Links
General anesthetics lead to learning disabilities in animal models
Date:10/22/2009

ner said.

Turner and other neuroscientists began considering the potential effects of anesthesia on children after making the connection in animal studies that drugs such as MK801, which act in a similar manner to some general anesthetics by blocking the NMDA receptor, can cause brain injury in immature rodents.

Using rats equivalent in age to children in their last trimester of development through to two years old, the researchers injected MK801, blocking the NMDA receptor in the brain. Within hours, they noticed evidence of injury in many brain regions. The blocking of the receptor, and subsequent inhibition of calcium influx into the cells, caused changes in a variety of proteins critical to normal brain cell function in the rats, particularly communication.

"It's not just that cells are dying," Turner said, "but we have now identified other pathologies that follow from blocking the NMDA receptor. For example, we have found that blocking the receptor results in the turning off of the brain's ability to regenerate new cells, which means that the brain cannot compensate for the cells that die.

"Imagine all of this going on during the time the brain is still developing," Turner added. "With all of these changes, it's not surprising that certain brain functions are diminished as animals get older. For example, immature animals exposed to MK801 are later unable to respond to auditory cues in a way that would be considered normal. A lot of learning in all animals depends on being able to efficiently process auditory information."

These findings, Turner said, could also have implications for research on schizophrenia. Many of the molecular, cellular and behavioral changes seen in this disorder NMDA receptor blockade, changes in proteins important for cell-to-cell communication, auditory deficits, and developmental brain injury are key features of the animal model used by the Turner lab.

"For a long time, res
'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Glades General Hospital First in Palm Beach County to Provide On-Site Electronic Birth Registration
2. Academy of General Dentistry Launches Campaign to Focus on Tooth Erosion
3. VIDEO from Medialink and General Motors: On and Off the Track
4. New lung cancer guidelines oppose general CT screening
5. New Lung Cancer Guidelines Oppose General CT Screening
6. Medina General Hospital and University Hospitals Agree to Pursue Affiliation
7. Keith Taft Named General Manager of UltraTape Industries
8. Acting Surgeon General Announces National Initiatives to Protect Children by Reducing Exposure to Secondhand Smoke
9. General Colin Powell Speaks Out for Prostate Cancer Prevention
10. LMS integrated obstetrics solution achieves general availability
11. VIDEO from Medialink and General Mills: Digestive Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... July 31, 2014 ReputationChief.Com, a ... new online reputation management service named ‘Remove Pissed ... as organizations get rid of Pissed Consumer Complaints. ... of extensive research. ReputationChief.Com management assigned the responsibility ... those who are struggling in their social or ...
(Date:7/31/2014)... -- A new study by researchers at Sanford-Burnham Medical ... caerulein can convert existing cells in the pancreas into ... The study, published online July 31 in Cell ... treating the estimated 3 million people in the U.S., ... diabetes. , "We have found a promising technique for ...
(Date:7/31/2014)... La Mirada, CA (PRWEB) July 31, 2014 ... California’s leading healthcare providers, strives in maintaining the ... and employers. That is why Healthpointe is offering ... facility to surrounding employers, employees and patients. They ... from insurance carriers. , Healthpointe’s Occupational Medicine services ...
(Date:7/31/2014)... 31, 2014 Dallas Fit Body Boot ... Texas to 3821 Ross Avenue, also in Dallas, in an ... potential members to burn fat and get in great shape ... because he believes that the new space will help his ... results they want as well as accommodate new members interested ...
(Date:7/31/2014)... With a busy lifestyle, it is hard to relax. World ... but to ensure their mental health is equally in check. ... right is key to your body’s health. However, I want everyone ... healthy lifestyle,” expressed Chef Ravi, owner of World Gardens Cafe. Check ... , ", 1. Stop eating lunch at your desk or taking ...
Breaking Medicine News(10 mins):Health News:ReputationChief.Com Announces a New Online Reputation Management Service 2Health News:A new way to generate insulin-producing cells in Type 1 diabetes 2Health News:Occupational Medicine Services Available at Healthpointe’s Perris Facility 2Health News:Dallas Fit Body Boot Camp Moves to New Location, Announces Grand Opening Set for Saturday August 9th 2Health News:World Garden’s Cafe Launches ‘16 Simple Ways to Feel Connected to the World’ 2Health News:World Garden’s Cafe Launches ‘16 Simple Ways to Feel Connected to the World’ 3Health News:World Garden’s Cafe Launches ‘16 Simple Ways to Feel Connected to the World’ 4
... including physical activity and structured weight loss programs, can result ... adults, according to two reports that were posted online today ... were made available early online to coincide with the presentation ... the Obesity Society. The articles will appear in the ...
... FRIDAY, Oct. 8 (HealthDay News) -- A new diagnostic tool ... the lining of the cheek show some promise in preliminary ... screening approach functions as a kind of optical sweep of ... located far from the site of an actual tumor undergo ...
... Oct. 12, 2010 Researchers at UT Southwestern ... the small protein that forms plaques in the brain ... Alzheimer,s disease. Compared with similar so-called DNA ... animal study, the new experimental vaccine stimulated more than ...
... , FRIDAY, Oct. 8 (HealthDay News) -- Weight-loss surgery ... obese teenagers, particularly those who are beginning to show ... obesity has become a serious public health concern in ... one in every four teenagers is obese, according to ...
... and Infectious Diseases, part of the National Institutes of ... at the Virginia Bioinformatics Institute (VBI) and collaborators to ... by pathogens of the gut. The funding will be ... immune responses to gut pathogens. "The Center for ...
... are the most widely used medical tests in the world. ... continue to discover new uses for it, ranging from more ... complex, a sonographer,s skill level is even more important. ... one of the keys to becoming a successful sonographer: spatial ...
Cached Medicine News:Health News:Clinical trials demonstrate effective weight loss strategies for obese and overweight adults 2Health News:Clinical trials demonstrate effective weight loss strategies for obese and overweight adults 3Health News:New Tool Shows Promise for Early Lung Cancer Screening 2Health News:New Tool Shows Promise for Early Lung Cancer Screening 3Health News:UT Southwestern researchers create experimental vaccine against Alzheimer's 2Health News:Weight-Loss Surgery for Teens May Be Gaining Advocates 2Health News:Weight-Loss Surgery for Teens May Be Gaining Advocates 3Health News:Virginia Bioinformatics Institute to model immune responses to gut pathogens 2Health News:Virginia Bioinformatics Institute to model immune responses to gut pathogens 3Health News:Improving sonography requires improving sonography school admissions 2
(Date:7/31/2014)... July 31, 2014 MarketResearchreports.biz presents ... Insulin Market (Rapid-Acting, Short-Acting, Intermediate-Acting, Long-Acting, Premixed, And ... Growth, Trends and Forecast (Value and Volume), 2013 - ... Diabetes, growing at an exponential rate worldwide, has ... as a major cause of death of people between ...
(Date:7/30/2014)... 2014  There is still time to share ... 10th Annual Institute for Supply Management ® ... Supply Management is open for submissions.  The annual ... importance of supply management by recognizing supply management ... management practices.  Entries are due August 22, 2014. ...
(Date:7/30/2014)... July 30, 2014  Hologic, Inc. (NASDAQ: ... fiscal quarter ended June 28, 2014. Third ... increased 1.0% to $632.6 million, reflecting operational growth of ... to the same period in the prior year. ... segments. , Breast Health revenues grew 3.5%. , ...
Breaking Medicine Technology:The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 2The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 3The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 4The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 5The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 6The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 7The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 8Institute for Supply Management, Michigan State University to recognize companies with excellent supply management practices 2Hologic Announces Third Quarter Fiscal 2014 Operating Results 2Hologic Announces Third Quarter Fiscal 2014 Operating Results 3Hologic Announces Third Quarter Fiscal 2014 Operating Results 4Hologic Announces Third Quarter Fiscal 2014 Operating Results 5Hologic Announces Third Quarter Fiscal 2014 Operating Results 6Hologic Announces Third Quarter Fiscal 2014 Operating Results 7Hologic Announces Third Quarter Fiscal 2014 Operating Results 8Hologic Announces Third Quarter Fiscal 2014 Operating Results 9Hologic Announces Third Quarter Fiscal 2014 Operating Results 10Hologic Announces Third Quarter Fiscal 2014 Operating Results 11Hologic Announces Third Quarter Fiscal 2014 Operating Results 12Hologic Announces Third Quarter Fiscal 2014 Operating Results 13Hologic Announces Third Quarter Fiscal 2014 Operating Results 14Hologic Announces Third Quarter Fiscal 2014 Operating Results 15Hologic Announces Third Quarter Fiscal 2014 Operating Results 16Hologic Announces Third Quarter Fiscal 2014 Operating Results 17
... 30, 2011 Ampio Pharmaceuticals, Inc. (NASDAQ: ... discovers and develops new uses for previously approved drugs ... manuscript reporting the results of its phase III clinical ... dysfunction, premature ejaculation (PE), was accepted for publication in ...
... Accuray Incorporated (Nasdaq: ARAY ), ... in use of the CyberKnife® Robotic Radiosurgery System ... company experienced a 24 percent increase in worldwide prostate treatments ... 2011. Continued momentum in the adoption of CyberKnife prostate SBRT ...
Cached Medicine Technology:Zertane™ Clinical Results Published in the Journal European Urology 2Zertane™ Clinical Results Published in the Journal European Urology 3Accuray Drives Growth in Radiosurgery for Early-Stage Prostate Cancer 2Accuray Drives Growth in Radiosurgery for Early-Stage Prostate Cancer 3Accuray Drives Growth in Radiosurgery for Early-Stage Prostate Cancer 4Accuray Drives Growth in Radiosurgery for Early-Stage Prostate Cancer 5
The AGC Revision Knee, extends the AGC Family to include implants for severe primary knees or revision. Provides rotational freedom of +/- 2 and varus/valgus freedom of +/- 1.5....
The Performance Knee System is a wide and easy to use system that offers enough options to cover any indication for primary and revision knee surgery, and all this with extensive intraoperative flexi...
The NexGen CR femoral component is intended for patients who, in the physician's judgement, have good bone stock and whose ligaments provide adequate mediolateral, anteroposterior, and varus/valgus s...
Cruciate retaining, posterior stabilized and constrained components....
Medicine Products: