Navigation Links
General Anesthesia Boosts Post-Op Pain
Date:6/23/2008

Study helps confirm what many patients, doctors suspected

MONDAY, June 23 (HealthDay News) -- Most general anesthetics -- used to put patients to sleep during surgery -- can increase the discomfort patients feel when they wake up, according to Georgetown University Medical Center researchers.

This finding, the first to scientifically explain anecdotal observations, may lead to increased use of general anesthetics that do not have this side effect or to the development of new anesthetics, the researchers said.

They found that "noxious" anesthesia drugs -- which most general anesthetics are -- activate and then sensitize specific receptors on neurons in the peripheral nervous system. These sensory nerves in the inflammation and pain pathway aren't affected by general anesthesia drugs that target the central nervous system (brain and spinal cord).

"The choice of anesthetic appears to be an important determinant of post-operative pain. We hope these findings are ultimately helpful in providing more comfort to patients," lead investigator Gerard Ahern, an assistant professor in the department of pharmacology, said in a prepared statement.

It was known that general anesthetics cause irritation at the infusion site or in the airways when inhaled and that they can activate pain-sensing nerve cells in the peripheral nervous system, Ahern explained.

But the specific mechanism by which anesthetics affect sensory neurons wasn't known, nor the fact that anesthetics can continue to cause pain and inflammation even as they're used during surgery.

Ahern and colleagues found that the noxious effects of anesthetic drugs are caused by their effect on the nerve cell receptor TRPA1. They also found that nerve-mediated inflammation was greater when pungent (chemical irritants) versus non-pungent inhaled general anesthetics were used on patients.

Both findings suggest that sensory nerve stimulation throughout the body just before and after surgery contributes to the pain felt by patients when they wake up after surgery.

"This is a provocative finding in terms of the clinical setting, because it was not really recognized that use of these drugs results in release of lots of chemicals that recruit immune cells to the nerves, which causes more pain or inflammation," Ahern said.

While some general anesthetics don't activate the TRPA1 receptor, they may not be as effective in other ways.

"This tells us that there is room for improvement in these drugs," Ahern said.

The study was published in the June 23 issue of the journal Proceedings of the National Academy of Sciences.

More information

The National Institute of General Medical Sciences has more about anesthesia.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, June 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Glades General Hospital First in Palm Beach County to Provide On-Site Electronic Birth Registration
2. Academy of General Dentistry Launches Campaign to Focus on Tooth Erosion
3. VIDEO from Medialink and General Motors: On and Off the Track
4. New lung cancer guidelines oppose general CT screening
5. New Lung Cancer Guidelines Oppose General CT Screening
6. Medina General Hospital and University Hospitals Agree to Pursue Affiliation
7. Keith Taft Named General Manager of UltraTape Industries
8. Acting Surgeon General Announces National Initiatives to Protect Children by Reducing Exposure to Secondhand Smoke
9. General Colin Powell Speaks Out for Prostate Cancer Prevention
10. LMS integrated obstetrics solution achieves general availability
11. VIDEO from Medialink and General Mills: Digestive Health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
General Anesthesia Boosts Post-Op Pain
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered ... Latin America . ... ... ... ...
(Date:6/23/2016)... 2016  Guerbet announced today that it has been ... Award . One of 12 suppliers to ... its support of Premier members through exceptional local customer ... commitment to lower costs. ... our outstanding customer service from Premier," says Massimo ...
(Date:6/23/2016)... Research and Markets has announced ... Analysis (United States, China, Japan, Brazil, United Kingdom, Germany, ... offering. Surgical Procedure ... planners, provides surgical procedure volume data in a geographic ... in-depth analysis of growth drivers and inhibitors, including world ...
Breaking Medicine Technology: