Navigation Links
Gene which protects against lung cancer identified

A study led by researchers at The University of Nottingham has identified a gene that protects the body from lung cancer.

The research, published in the journal Proceedings of the National Academy of Sciences, USA and funded by a 72,000 grant from the British Lung Foundation, has found that the tumour suppressor gene, LIMD1, is responsible for protecting the body from developing lung cancer paving the way for possible new treatments and early screening techniques.

Lead researcher Dr Tyson Sharp and his University of Nottingham team, together with US collaborator Dr Greg Longmore, set out to examine if loss of the LIMD1 gene correlated with lung cancer development.

The University of Nottingham team examined lung cancer tissue from patients with the disease and compared it to healthy lung tissue. They found that the LIMD1 gene was missing in the majority of lung cancer samples, indicating that the presence of the LIMD1 gene protects the body against lung cancer.

Dr Greg Longmore's team in the USA supported these findings, using a mouse without the LMID1 gene which developed lung cancer.

Dr Sharp said: "The LIMD1 gene studied in this research is located on part of chromosome 3, called 3p21.

"Chromosome 3p21 is often deleted very early on in the development of lung cancer due to the toxic chemicals in cigarettes, which implies that inactivation of LIMD1 could be a particularly important event in early stages of lung cancer development.

"We are now going to extend these finding by developing LIMD1 as a novel prognostic tool for detection of early stage lung cancer."

Lung cancer is the UK's biggest cancer killer, claiming around 33,600 lives a year. Ninety per cent of cases are caused by smoking. At present lung cancer is often detected late, meaning that 80 per cent of patients die within a year of being diagnosed.

Dame Helena Shovelton, Chief Executive of the British Lung Foundation said: "This is very exciting research which could lead to the development of early screening techniques and treatments for lung cancer. We are very proud to have made this breakthrough possible".


Contact: Dr. Tyson Sharp
University of Nottingham

Related medicine news :

1. The science behind the food we eat and the earth on which it grows
2. Which intervention would do the most to improve the health of the extreme poor?
3. Marlo Thomas and St. Jude Childrens Research Hospital(R) Announce Hitting The 50-Partner Milestone as They Kick Off the Fourth Annual Thanks and Giving(R) Campaign Which Asks America to Support St. Jude While Shopping This Holiday Season
4. The Polls are Open! America Votes to Decide Which Hospital is the Most Deserving of Siemens Newest MRI Technology
5. Which segments of the gastrointestinal tract does Salmonella enteritidis penetrate?
6. OxySure(R) Systems, Inc. Named to 2008 Worlds Best Technologies (WBT) List For its Unique, Safe and Easy to Use Portable Emergency Oxygen Generator, Which Provides Medical Oxygen Without the Need for Compressed Tanks
7. Study identifies which men are likely to have persistent prostate cancer
8. Bradmer announces Phase II results published in newly diagnosed glioblastoma which demonstrate improved survival and support upcoming Phase III study
9. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
10. Which came first, social dominance or big brains? Wasps may tell
11. Hats Off to the Red Hat Society, Which Turns 10 Today
Post Your Comments:
(Date:11/30/2015)... ... ... Bayco Products, Inc today announced the introduction of three Nightstick® brand LED traffic wands with ... colors; red ( NSP-1632 ), yellow ( NSP-1634 ) and blue ( NSP-1636 ), the ... or 27 hours in blinking strobe mode using a fresh set of 3 AAA cells ...
(Date:11/29/2015)... Metamora, Michigan (PRWEB) , ... ... ... is once again accredited by the American Institute of Ultrasound in Medicine! ... allows practices to demonstrate that they meet or exceed nationally recognized standards ...
(Date:11/29/2015)... ... November 29, 2015 , ... NewsWatch featured X-wing as ... available to consumers. Amanda Forstrom, a technology expert and special reporter for NewsWatch, conducted ... reality in the future. , It’s the future because flying cars are about to ...
(Date:11/29/2015)... , ... November 29, 2015 , ... Doctors who missed ... colleagues to recognize the signs of mesothelioma and push for a diagnosis, especially in ... its website. Click here to read it now. , Researchers at ...
(Date:11/29/2015)... ... November 29, 2015 , ... Key Housing, a top-rated ... announce their December, 2015, featured apartment community: Epic. In showcasing this featured apartment community ... the tight Bay Area rental market to efficiently find housing suitable to their needs ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... Iowa , Nov. 29, 2015 ... ultrasound guidance technology at the Radiological Society of ... in Chicago November 29 ... system is designed to offer customers unrivaled versatility, ... --> ...
(Date:11/27/2015)... 27, 2015 Ein neuer ... Krebs.   --> Ein neuer Kombinationsansatz ...   --> Ein neuer Kombinationsansatz ...   Clinical Cancer Research vom ... Cancer Research vom 6. November 2015 berichtet. ...
(Date:11/26/2015)... PUNE, India , November ... --> ... / personal emergency response system ... grow steadily for 5 years ... growing region expected to see ...
Breaking Medicine Technology: