Navigation Links
Gene variations alter risk of esophageal cancer
Date:11/5/2008

HOUSTON - Variations in a common gene pathway may affect esophageal cancer risk, a dangerous and rapidly increasing type of cancer, according to research by scientists at The University of Texas M. D. Anderson Cancer Center.

Results of the study, which is the first to look at the association between variations in genes related to microRNAs (miRNAs) and esophageal cancer, are published in the November issue of Cancer Prevention Research, a journal of the American Association of Cancer Research.

"Previous research has shown miRNAs control approximately one-third of human genes and may play a part in cancer risk," said the study's lead author, Xifeng Wu, M.D., Ph.D., a professor in the Department of Epidemiology at M. D. Anderson. "But whether genetic variants of miRNA-related genes influence esophageal cancer has largely remained unknown."

To examine the potential roles of these variations in esophageal cancer, researchers looked at the relationships among 41 single-nucleotide polymorphisms (SNPs) in 26 miRNA-related genes and risk of esophageal cancer. SNPs are places in the human genome that vary by a single DNA chemical building block or nucleotide.

Seven genotypes were significantly associated with esophageal cancer risk, and four more showed at least a borderline significance. The risk of esophageal cancer became higher in correlation to an increase in the number of the unfavorable genotypes present.

"This research showed not only that a single gene contributes to the risk of esophageal cancer, but more importantly that the joint effect of several genetic elements can increase risk," said the study's first author, Yuanqing Ye, Ph.D., an instructor in the Department of Epidemiology at M. D. Anderson.

Esophageal cancer ranks sixth in cancer-related deaths worldwide, and it is becoming more common. According to the American Cancer Society, more than 16,000 people will be diagnosed and more than 14,000 people will die of the disease in the United States this year.

"Incidence of esophageal cancer has increased six-fold in the past three decades, and the survival rate is poor," Wu said. "MicroRNAs are exciting because they can modulate the expression of so many human genes."

Major risk factors for esophageal cancer include tobacco smoking, alcohol consumption and reflux disease. The high prevalence of these risk factors in the general population and rare occurrence of this disease provide a clue that genetic predisposition to the disease may play an important role.

Researchers recruited 346 people who were newly diagnosed with esophageal cancer at M. D. Anderson and matched them by age, gender and ethnicity to 346 people without cancer. Only results for Caucasians were reported because of the low numbers of other races that enrolled.

While patients tended to be current smokers and have higher body mass index (BMI), there was no difference between the two groups in alcohol consumption.

One of the most notable findings was a SNP in the mir423 region, which was associated with a significantly lower esophageal cancer risk. The protective effect was significant for smokers and nonsmokers 64 years old and younger, but not for older subjects.

Mir423 also is found in leukemia cells and is altered significantly in other diseases including heart disease and Alzheimer's disease.

Future large-scale, multi-center studies are necessary to confirm these findings, Wu said.

"Our ultimate goal is to construct a comprehensive risk prediction model that includes not only genetic factors, but epidemiological and clinical variables as well, in hopes of predicting the probability of developing esophageal cancer in general population," she said.


'/>"/>

Contact: Robin Davidson
rdavidson@mdanderson.org
713-794-1731
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Climatic variations influence the emergence of cholera in Africa
2. Optherion Licenses Worldwide Rights to Develop Age-Related Macular Degeneration Diagnostics Based on Chromosome 10 Genetic Variations
3. Study questions impact of hemoglobin variations on mortality in dialysis patients
4. More Gene Variations Found That Raise Prostate Cancer Risk
5. Study Finds Variations in Doses of Radiation Therapy
6. New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland
7. Genetic variations raise lung cancer risk for smokers and ex-smokers
8. Study shows gene variations may predict risk of breast cancer in women
9. Gene Variations May Predict Antidepressant Response
10. MYH9 gene variations help explain high rate of kidney disease in African-Americans
11. Data from Patient Subsets of e-HEALING, a Worldwide Registry, Support Use of OrbusNeichs Genous(TM) Bio-Engineered R Stent(TM) as Alternative to Drug- Eluting Stents
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene variations alter risk of esophageal cancer
(Date:6/27/2016)... , ... June 27, 2016 , ... ... mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... to the network of the Tennessee Counseling Association, adding exclusive benefits and promotional ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating ... Millions of individuals in the United States and Canada wear eyeglasses. Once considered to ... correct vision and make a fashion statement. Even celebrities use glasses as a way ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media ... give their videos a whole new perspective by using the title layers in ... Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
(Date:6/23/2016)... FRANKLIN, Tenn. , June 23, 2016 ... for automating, integrating and transforming the patient ... launch of several innovative new products and ... depth of its revenue cycle offerings. These ... establish more efficient workflows, remain compliant in ...
Breaking Medicine Technology: