Navigation Links
Gene variation makes alcoholism less likely in some survivors of sexual abuse
Date:2/2/2010

articipated in the Nicotine Addiction Genetics project. Originally, that study was set up to learn about nicotine addiction, but investigators also looked at related problems, including how much alcohol people drank and whether they met the diagnostic criteria for alcohol dependence.

Study subjects also were asked about sexual abuse in childhood. A total of 121 women and 35 men reported a history of sexual abuse beginning at around age 11. Nelson's group also had access to DNA samples from those evaluated in this study.

By identifying a handful of specific sites in the genome, it's possible to classify a person as having either the H1 or the H2 haplotype. One of the genes in the DNA region included in H1 and H2 is called corticotropin releasing hormone receptor type 1 (CRHR1). Nelson's group is focusing on that gene, which research in animals has implicated in risk for alcohol dependence.

Many past studies have focused on genes related to alcohol metabolism, but CRHR1 is not a metabolism gene. Nelson says it appears from animal studies, however, that the gene may be involved in risks associated with the effects of environmental stress. In the case of humans, he suspects variants of the gene may play a role in protecting against stresses caused by child sexual abuse.

"There are many different ways an individual can become alcoholic, some involving heavy genetic risks, some involving specific environmental factors, such as exposure to peers who drink heavily," Nelson says. "This particular pathway involving CRHR1 is interesting because it seems to play an extremely important role in animal models of alcohol consumption and dependence."

He says better understanding of how the gene works may help scientists understand the process by which people become alcoholics. As they attempt to clarify the possible role of the CRHR1 gene in protecting sexual abuse survivors from alcohol dependence, Nelson says it may be interesting to lo
'/>"/>

Contact: Diane Duke Williams
williamsdia@wustl.edu
314-286-0111
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Climatic variations influence the emergence of cholera in Africa
2. Study looks at mitochondrial variation in sperm traits and sperm competitive ability
3. Genetic variation affects smoking cessation treatment
4. Optherion Licenses Worldwide Rights to Develop Age-Related Macular Degeneration Diagnostics Based on Chromosome 10 Genetic Variations
5. Study questions impact of hemoglobin variations on mortality in dialysis patients
6. Human genetic variation -- Sciences Breakthrough of the Year
7. More Gene Variations Found That Raise Prostate Cancer Risk
8. Study Finds Variations in Doses of Radiation Therapy
9. New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland
10. Genetic variations raise lung cancer risk for smokers and ex-smokers
11. Study shows gene variations may predict risk of breast cancer in women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... NEW YORK (17 April 2014) Population Council scientists and ... is safe, stable, and can prevent the transmission of ... and rectum in animals: HIV, herpes simplex virus 2 ... provides the first data that the gel is effective ... of efficacy in the vagina against all three viruses ...
(Date:4/17/2014)... flow and alleviates muscle soreness after exercise, according ... of Illinois at Chicago. , The study, reported ... Archives of Physical Medicine and Rehabilitation , also ... who had not exercised, suggesting that massage has ... physical activity. , Improved circulation and relief of ...
(Date:4/17/2014)... TORONTO, April 17, 2014While 94 per cent of Canadians ... that screen newborns for a specific number of genetic ... willing to participate in screening that would sequence their ... prick test" in their first day or two of ... taken from their heels and tested for about five ...
(Date:4/17/2014)... lost its status as the leading weapon against the ... life, with new research indicating it simply needs to ... use of the cheap anti-malarial drug chloroquine in treating ... of more than half a million people each year ... has developed resistance to chloroquine, but research carried out ...
(Date:4/16/2014)... , PHOENIX, Ariz. April 15, 2014 The ... Arizona philanthropists at their annual Founders Dinner for their ... cancer. The event took place March 28 in Scottsdale. ... & Catherine Ivy Foundation, received TGen,s John S. McCain ...
Breaking Medicine News(10 mins):Health News:Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum 2Health News:Massage therapy improves circulation, eases muscle soreness 2Health News:Researcher looks at public perceptions around newborn testing 2Health News:Researcher looks at public perceptions around newborn testing 3Health News:Scientists find new way to fight malaria drug resistance 2Health News:TGen honors Catherine Ivy and Craig Jackson with Leadership; Collaborative Spirit awards 2
... Pa., June 1 Practice-Reps, LLC ( http://www.practice-reps.com ) ... to specialty medical practices along the East Coast. The ... a 16-year veteran of the practice marketing industry, to ... experienced marketing support on a part-time basis. , ...
... SAN FRANCISCO, Calif., June 1 Rigel Pharmaceuticals, Inc. ... oral Syk inhibitor, R788, is being evaluated in a ... the National Cancer Institute (NCI), part of the U.S. ... trial will include patients with advanced colorectal, thyroid, non-small ...
... , Collaboration Delivers Cost and Quality Benefits for Widespread ... June 1 SAFC(R) ( www.safcglobal.com ), a member ... and Cherokee Pharmaceuticals(TM) ( www.cherokee-pharma.com ... business, today announced an exclusive strategic partnership that encompasses ...
... , New Product Names for Recently Introduced MicroRNA-based Diagnostics ... Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic ... platform yesterday at the American Society of Clinical Oncology ... a presentation entitled "Profiling of Receptor Tyrosine Kinases (RTK) ...
... the mouth and periodontists to ask questions about heart health ... leading killer of men and women in the United States, ... each day. Periodontal disease, a chronic inflammatory disease that destroys ... 75 percent of Americans and is the major cause of ...
... program aimed at reducing criminal behavior in juvenile justice teens ... reducing the teens, rate of pregnancy, according to a new ... in the Department of Psychology at Oregon State University, and ... Learning Center, conducted the research, which will be published in ...
Cached Medicine News:Health News:Practice-Reps Brings Sales and Marketing to the Business of Medical Practice Management 2Health News:Rigel's R788 Evaluated in Phase 2 Trial in Multiple Cancers 2Health News:Rigel's R788 Evaluated in Phase 2 Trial in Multiple Cancers 3Health News:SAFC(R) & Cherokee Pharmaceuticals(TM) Pool Expertise and Resources With Strategic Partnership For U.S. Market 2Health News:SAFC(R) & Cherokee Pharmaceuticals(TM) Pool Expertise and Resources With Strategic Partnership For U.S. Market 3Health News:Prometheus Presents Proprietary Oncology Diagnostic Platform at ASCO Annual Meeting 2Health News:Prometheus Presents Proprietary Oncology Diagnostic Platform at ASCO Annual Meeting 3Health News:Healthy Gums and a Healthy Heart: The Perio-Cardio Connection 2Health News:Healthy Gums and a Healthy Heart: The Perio-Cardio Connection 3Health News:Healthy Gums and a Healthy Heart: The Perio-Cardio Connection 4Health News:Intervention reduces delinquent teenage pregancy rates 2Health News:Intervention reduces delinquent teenage pregancy rates 3
(Date:1/15/2014)... BreedIT Corp (OTC: BRDT), through its ... highly sophisticated agro-breeding solutions for plant breeders and researchers, ... board of directors appointed chemistry and pharmaceutical industry expert ... of the board. From 1975 to 2012, ...
(Date:1/15/2014)... Therapeutics, Inc. (Nasdaq: ECTE ) ("Echo"), a ... a non-invasive, wireless continuous glucose monitoring system, today announced ... Interim CEO of Echo Therapeutics, will present at "TEN", ... Mr. Doman will make a corporate presentation ...
(Date:1/15/2014)... 15, 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... offer by its indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ... stock of Solta Medical, Inc. (NASDAQ: SLTM ...
Breaking Medicine Technology:BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... Thomas, McNerney & Partners, LLC, a health care venture ... technology companies, will be relocating its West Coast office ... Pratik Shah, Ph.D. announced the move at BIOCOM,s first ... "Southern California is home to many top-tier scientific ...
... 2011 Healthpoint today announced the launch of a ... Biotherapeutics, along with an updated brandmark and corporate tagline, ... is designed to communicate the company,s commitment to scientific ... contribute to improved outcomes and quality of life for ...
Cached Medicine Technology:Thomas, McNerney & Partners Expands Team and Moves West Coast Office to San Diego 2Healthpoint Launches New Corporate Identity 2Healthpoint Launches New Corporate Identity 3
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features:Eppendorf "pipette/tip" system ensures utmost ...
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
... ergonomics, and value!, Comfortable feel ... non-slip, contoured handle , Finer control ... spring action , Completely autoclavable for ... need for recalibration , Easy-to-read precision ...
Inquire...
Medicine Products: