Navigation Links
Gene variation makes alcoholism less likely in some survivors of sexual abuse
Date:2/2/2010

articipated in the Nicotine Addiction Genetics project. Originally, that study was set up to learn about nicotine addiction, but investigators also looked at related problems, including how much alcohol people drank and whether they met the diagnostic criteria for alcohol dependence.

Study subjects also were asked about sexual abuse in childhood. A total of 121 women and 35 men reported a history of sexual abuse beginning at around age 11. Nelson's group also had access to DNA samples from those evaluated in this study.

By identifying a handful of specific sites in the genome, it's possible to classify a person as having either the H1 or the H2 haplotype. One of the genes in the DNA region included in H1 and H2 is called corticotropin releasing hormone receptor type 1 (CRHR1). Nelson's group is focusing on that gene, which research in animals has implicated in risk for alcohol dependence.

Many past studies have focused on genes related to alcohol metabolism, but CRHR1 is not a metabolism gene. Nelson says it appears from animal studies, however, that the gene may be involved in risks associated with the effects of environmental stress. In the case of humans, he suspects variants of the gene may play a role in protecting against stresses caused by child sexual abuse.

"There are many different ways an individual can become alcoholic, some involving heavy genetic risks, some involving specific environmental factors, such as exposure to peers who drink heavily," Nelson says. "This particular pathway involving CRHR1 is interesting because it seems to play an extremely important role in animal models of alcohol consumption and dependence."

He says better understanding of how the gene works may help scientists understand the process by which people become alcoholics. As they attempt to clarify the possible role of the CRHR1 gene in protecting sexual abuse survivors from alcohol dependence, Nelson says it may be interesting to lo
'/>"/>

Contact: Diane Duke Williams
williamsdia@wustl.edu
314-286-0111
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Climatic variations influence the emergence of cholera in Africa
2. Study looks at mitochondrial variation in sperm traits and sperm competitive ability
3. Genetic variation affects smoking cessation treatment
4. Optherion Licenses Worldwide Rights to Develop Age-Related Macular Degeneration Diagnostics Based on Chromosome 10 Genetic Variations
5. Study questions impact of hemoglobin variations on mortality in dialysis patients
6. Human genetic variation -- Sciences Breakthrough of the Year
7. More Gene Variations Found That Raise Prostate Cancer Risk
8. Study Finds Variations in Doses of Radiation Therapy
9. New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland
10. Genetic variations raise lung cancer risk for smokers and ex-smokers
11. Study shows gene variations may predict risk of breast cancer in women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... DC (PRWEB) August 01, 2014 ... offer health plans and employers effective options to ... narrow networks argue that they can enhance formulary ... administrative fees. Consultants report that nearly all PBMs ... to requests for proposals. The Aug. 12 ...
(Date:8/1/2014)... 2014 Millions of women suffer with ... and in some cases the arms, causing an abnormal ... 17 million women in the U.S. alone are affected. ... the pain, embarrassment and discomfort caused by lipedema, it’s ... are unaware that this is a disease,” says Dr. David ...
(Date:8/1/2014)... August 01, 2014 Get the report ... with PitchBook presents the 3Q 2014 Private Equity Breakdown ... equity investment, exits and fundraising activity in the second ... help plan for private equity endeavors for the remainder ... to download it now. , About Merrill DataSite , ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 The ... important developments about chemical listings, appellate decisions, litigation ... that may affect compliance with California's Proposition 65. ... to the law, regulations, history and trends impacting ... the fourth installment of the series which adds ...
(Date:7/31/2014)... recently used birth control pills containing high-dose estrogen and ... breast cancer, whereas women using some other formulations did ... , a journal of the American Association for Cancer ... oral contraceptives [birth control pills] in the past year ... to never or former oral contraceptive use, and that ...
Breaking Medicine News(10 mins):Health News:Atlantic Information Services Webinar to Offer Health Plan, Employer Strategies for Implementing Narrow Pharma Networks 2Health News:Lipedema Centers Works With Insurers To Gain Coverage For Lipedema Treatment 2Health News:Register to Download Merrill DataSite's Report: PitchBook 3Q 2014 Private Equity Breakdown Report 2Health News:Save 25% on the Proposition 65 Handbook - 2013 Edition Through August 31 2Health News:Recent use of some birth control pills may increase breast cancer risk 2
... is a sad day for the American labor movement and ... the bottom up, rather than the top down.SEIU,s press release ... It also is predictable that Hearing Officer Ray Marshall, former ... Stern to conduct the hearing would do the job he ...
... 22 Novo Nordisk, a global healthcare company focusing on ... "100 Best Companies to Work For" awards issue. This is ... award -- one of the most influential business scorecards in ... For" are historically good performers in the marketplace for not ...
... 22 Missouri Congressman Roy Blunt today reflected on the ... v. Wade by speaking with the Missouri-Illinois Right to Life ... in sending a letter to President Barack Obama urging him ... "The last few years are the first time since I,ve ...
... preventable blindnessOAK BROOK, Ill., Jan. 22 The ... http://www.newscom.com/cgi-bin/prnh/20081014/DC38855LOGO ) Who: Former President ... Lions Clubs International President Albert Brandel; ... Dedication of the "Gift of Sight" statue, ...
... 22 Griffin Hospital has been honored with a 10th year ... Griffin ranked 62 on the 2009 list released today. Griffin is ... ten years.Griffin was first invited to apply for selection to the ... since. FORTUNE has issued the list of "100 Best Companies to ...
... announced today that,the physicians of Midwest Pulmonary and ... , The physicians are Susan ... Plumb, M.D. All are board-certified in pulmonology,and critical care ... the treatment of sleep disorders. , ...
Cached Medicine News:Health News:Statement by UHW on SEIU's Claims Regarding SEIU-Trusteeship Hearing Process Chaired by Ray Marshall 2Health News:Novo Nordisk Makes its Debut in FORTUNE's '100 Best Companies to Work For' 2Health News:Novo Nordisk Makes its Debut in FORTUNE's '100 Best Companies to Work For' 3Health News:Blunt Marks Anniversary of Roe v. Wade, Signs Letter in Defense of Pro-Life Legislation 2Health News:Blunt Marks Anniversary of Roe v. Wade, Signs Letter in Defense of Pro-Life Legislation 3Health News:Former President Jimmy Carter Dedicates 'Gift of Sight' Statue at Lions Club International Headquarters in Recognition of Lions' Blindness Prevention Efforts 2Health News:Griffin Honored with Tenth Year on FORTUNE Best Companies to Work for List 2Health News:Midwest Pulmonary and Critical Care Associates Will Join Aurora Medical Group 2
(Date:7/31/2014)... VIEW, Calif. , July 31, 2014 /PRNewswire/ ... today provided an update on its pipeline and ... 2014, Alexza expects to initiate a Phase 2a ... is being developed for the management of patients ... two new Staccato -based product candidates for ...
(Date:7/31/2014)... July 31, 2014  Decision Resources Group is launching ... product Marketrack to now include ChinaTrack; the new capabilities ... in an interactive dashboard providing detailed brand-level share tracking ... a hospital level. Other key capabilities of ... feed: In addition to end-user surveys of healthcare facilities, ...
(Date:7/31/2014)... , July 31, 2014 For its innovative ... California , Art,s-Way Scientific has earned a Modular ... With competition in over 30 categories, MBI,s contest is ... members, which include building manufacturers, dealers, and product and ... excellent example the capability of our team," said ...
Breaking Medicine Technology:Alexza Provides Pipeline Update 2Alexza Provides Pipeline Update 3Alexza Provides Pipeline Update 4Alexza Provides Pipeline Update 5Alexza Provides Pipeline Update 6Decision Resources Group Announces First Medical Device Account Targeting Tool in China 2Art's Way Scientific Earns Prestigious Modular Building Institute Award 2Art's Way Scientific Earns Prestigious Modular Building Institute Award 3Art's Way Scientific Earns Prestigious Modular Building Institute Award 4
... 29 Pfizer Inc. (NYSE: PFE ) invites investors and the general ... at 10 a.m. EDT on Tuesday, August 3, 2010 . The purpose ... company,s Second Quarter 2010 Performance Report, to be issued that morning. , ... (Logo: http://photos.prnewswire.com/prnh/20100416/PFIZERLOGO ) , , , ...
... , SUNNYVALE, Calif. , June 29 Accuray Incorporated ... announced today the appointment of Peter Fine as a member of ... replace board member Li Yu who has resigned effective June ... Fine currently serves ...
Cached Medicine Technology:Pfizer Invites Public to View and Listen to Webcast of August 3 Conference Call With Analysts 2Accuray Appoints Peter Fine to Board of Directors 2Accuray Appoints Peter Fine to Board of Directors 3Accuray Appoints Peter Fine to Board of Directors 4
A sturdy, robust stool. Gas operated height adjustment for convenience....
Lacrimal Cannulas, 19 g. shaft tapering to 23 g. cannula, straight. Overall length 37.5 mm. 5/box....
Viscoelastic Cannula, 27 g. Angled. 7 mm angled tip cannula with unique hub that facilitates flow of viscoelastic material. Overall length 23 mm. 5/box....
Anterior Chamber Needle, 27 g. Angled. 5 mm angled tip. Overall length 20 mm. 5/box....
Medicine Products: