Navigation Links
Gene variation is 'major genetic determinant of psoriasis'
Date:8/27/2009

(SALT LAKE CITY)A specific genetic region that has been increasingly identified as the strongest genetic link to psoriasis has an even more significant role in the chronic skin disease than has been suspected, University of Utah medical researchers show in a new study.

In the Aug. 13 issue of PLoS Genetics, researchers in the U School of Medicine's Department of Dermatology confirm that the presence of HLA-Cw*0602, a gene variation or allele on chromosome 6 found to be associated with psoriasis by numerous investigators, is the "major genetic determinant" of psoriasis, but that other nearby genetic variations also play an independent role in contributing to the disease

"The HLA-Cw*0602 gene variation stands alone as a high risk for psoriasis," said Gerald G. Krueger, M.D., professor of dermatology, Benning Presidential Endowed Chair holder, and a co-author on the study. "A major question has been: are there other genetic variations in this region that associate with psoriasis?"

The study reported in PLoS Genetics identifies two other genetic variations on chromosome 6 that also have significant association with psoriasis. People who have all three genetic variations are nearly nine times more at risk for psoriasis.

Psoriasis is a chronic disease that causes red scaly patches on the skin and affects up to 7.5 million people in the United States. About 25 percent of subjects with the disease also develop a painful inflammation of the joints called psoriatic arthritis.

University researchers, led by first author Bing-Jian Feng, Ph.D., postdoctoral fellow, and senior author David E. Goldgar, Ph.D., research professor of dermatology in the U of U School of Medicine, reached their conclusion after an expanded analysis of data from a study published earlier this year by investigators at Utah in collaboration with colleagues from the University of Michigan and Washington University.

That study (
'/>"/>

Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Common variation in gene linked to structural changes in the brain
2. Genetic Variation Associated With Survival Advantage in African Americans With HIV
3. New Map of Genomic Variation Will Enable Disease Research
4. Global Testing Shows No Variation in Swine Flu Virus
5. New Study Reveals Wide Variations in Depression Diagnoses among Ethnic Groups
6. Discovery of variations in resistance to sulfadoxine across Africa
7. Study IDs Variations in Black, White Genomes
8. DNA Variations May Alter Risk of Hodgkins Disease
9. Taming Wide Variations in Spending Key to Health Reform - New England Journal of Medicine Commentary from Dartmouth Atlas Project
10. Variations in Gene DNA Boost Drinkers Cancer Risk
11. St. Jude finds more than 100 gene variations linked with response to leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... metastasize? Think of Sparta. , Ancient Greek warriors were ... the demands of battle on distant fields. Cancer cells ... a new study revealing previously unknown differences between cancer ... site, and those that travel to other organs. , ... is the primary cause of cancer-related death, understanding how ...
(Date:9/21/2014)... NY (PRWEB) September 21, 2014 ... develops, implements and supports electronic medical records (EMR) ... benefited from federal healthcare legislation during the past ... do so during the five years to 2019. ... Clinical Health Act established Medicare and Medicaid incentives ...
(Date:9/21/2014)... September 21, 2014 Originally approved ... 1996, GSK’s Flovent (fluticasone propionate) is a synthetic ... used for the maintenance treatment of asthma prophylactically ... in two formulations, Diskus and HFA, which received ... Flovent’s active ingredient, fluticasone propionate, can bind to ...
(Date:9/21/2014)... (PRWEB) September 21, 2014 More ... have been added over the past month to ... allege serious cardiovascular injuries caused by the dialysis ... List updated on September 15th shows 2,089 cases ... U.S. District Court, District of Massachusetts. These claims ...
(Date:9/21/2014)... September 21, 2014 Developers and plugin ... have announced a new transition plugin entitled Transpack Vol. ... delivers high quality transitions that will add a level ... Austin, CEO of Pixel Film Studios. “Blurring the line ... definite game changer.” , Transpack Vol. 3 returns with ...
Breaking Medicine News(10 mins):Health News:Cancer cells adapt energy needs to spread illness to other organs 2Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 3Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 4Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 2Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 3Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 4Health News:Federal GranuFlo Litigation Adds Dozens of Cases Alleging Serious Cardiovascular Injuries, Bernstein Liebhard LLP Reports 2Health News:Federal GranuFlo Litigation Adds Dozens of Cases Alleging Serious Cardiovascular Injuries, Bernstein Liebhard LLP Reports 3Health News:Federal GranuFlo Litigation Adds Dozens of Cases Alleging Serious Cardiovascular Injuries, Bernstein Liebhard LLP Reports 4Health News:Pixel Film Studios Released Transpack Vol. 3 Plugin Exclusively for Final Cut Pro X 2
... , , , ... design competition offering the chance to combine creativity with passion for a ... Oct. 26, 2009, participants can enter Passionately Pink-inspired T-shirt designs with messages ... drawing for a $100 Hanes gift card. In addition, a ...
... , RICHMOND, Calif., Aug. 18 ... announced plans to reduce operating expenses by eliminating certain staff ... Purdue Pharmaceutical Products to commercialize Intermezzo ((R) )(zolpidem tartrate ... , Glenn A. Oclassen, President and Chief Executive ...
... SAN DIEGO, Aug. 18 Aethlon Medical, Inc. ... at today,s 14th Annual Southern California Investor Conference being ... The conference is hosted by California Equity Research and ... life science, technology, media, and real estate/financial organizations. ...
... ... announced that the hemostatic HemCon Patch™ and HemCon® Bandage were ... Premier Purchasing Partners L.P., the group purchasing unit of Premier Inc. ... The agreement makes HemCon dressings available at pre-negotiated terms to all ...
... , , INDIANAPOLIS, ... as those relating to smoke and fire, there would be a ... special operations for the Alameda County Fire Department in California. "The ... addressing the problem adequately. A 2006 NFPA study reveals 87-percent of ...
... ... States Health Alliance Admitted to Talent Management Organization , ... Atkins, VA (PRWEB) August 18, 2009 -- The ... world-class companies, has two new members, Qwest, headquartered in Denver, Colorado, and Mountain States ...
Cached Medicine News:Health News:Hanes(R) and Susan G. Komen for the Cure(R) Inspire Creativity for a Cause 2Health News:Hanes(R) and Susan G. Komen for the Cure(R) Inspire Creativity for a Cause 3Health News:Hanes(R) and Susan G. Komen for the Cure(R) Inspire Creativity for a Cause 4Health News:Transcept Announces Plans to Reduce Expenses by Decreasing Staff Following Recent Completion of Purdue U.S. License and Collaboration Agreement 2Health News:Transcept Announces Plans to Reduce Expenses by Decreasing Staff Following Recent Completion of Purdue U.S. License and Collaboration Agreement 3Health News:Transcept Announces Plans to Reduce Expenses by Decreasing Staff Following Recent Completion of Purdue U.S. License and Collaboration Agreement 4Health News:Transcept Announces Plans to Reduce Expenses by Decreasing Staff Following Recent Completion of Purdue U.S. License and Collaboration Agreement 5Health News:Aethlon Medical to Present at Today's Southern California Investor Conference 2Health News:Hemostatic HemCon Dressings Selected by the Premier Healthcare Alliance for Hemostasis Products Contract 2Health News:Hemostatic HemCon Dressings Selected by the Premier Healthcare Alliance for Hemostasis Products Contract 3Health News:Cyanide Toxicity in Smoke Inhalation Victims - a Deadly but Treatable Poison 2Health News:Cyanide Toxicity in Smoke Inhalation Victims - a Deadly but Treatable Poison 3Health News:Leading Communications and Healthcare Firms Join TEDS Consortium 2Health News:Leading Communications and Healthcare Firms Join TEDS Consortium 3Health News:Leading Communications and Healthcare Firms Join TEDS Consortium 4
(Date:9/19/2014)... 2014 /PRNewswire-iReach/ -- "United States General ... key market data on the United ... report provides value, in millions of ... within market categories – Bronchoscopes, Laryngoscopes, ... Gastroscopes, Duodenoscopes, Laparoscopes, Hysteroscopes, Sinuscopes, Resectoscopes, ...
(Date:9/19/2014)... 19, 2014 According to ... (Cryotherapy, Heat, therapy, Hydrotherapy), Accessories (Posture Mirror, Exercise Ball), ... technologies - Global Forecast to 2019" published by ... reach $19,786.3 Million by 2019 from $14,240.0 Million ... 2014 to 2019. Browse 74 market ...
(Date:9/19/2014)... Merck (NYSE: MRK ), known as MSD outside ... , is teaming with celebrity chef and cookbook author Leticia Moreinos ... educational program encouraging Hispanics with type 2 diabetes to achieve better ... help reduce the risk of serious health problems. Hispanics in ... for developing type 2 diabetes than non-Hispanic white adults, and it ...
Breaking Medicine Technology:United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 4United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 5Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5
... patients will be tested,to determine the prevalence of ... major cooperative effort between the Alpha-1 Foundation,and the ... principal investigator is Robert A. Sandhaus, MD, PhD, ... and Research Center,in Denver. Sandhaus is also the ...
... Dec. 6 DURECT Corporation,(Nasdaq: DRRX ... III trial for Remoxy,had successfully met its ... the U.S. Food and Drug Administration (FDA) ... investigational drug based on,DURECT,s patented ORADUR(TM) technology, ...
Cached Medicine Technology:Alpha-1 Foundation, AARC Cooperate on Study to Test 5,000 COPD Patients for Alpha-1 2Alpha-1 Foundation, AARC Cooperate on Study to Test 5,000 COPD Patients for Alpha-1 3Primary Endpoint of Pivotal Phase III Clinical Trial Achieved for Remoxy(TM) 2Primary Endpoint of Pivotal Phase III Clinical Trial Achieved for Remoxy(TM) 3Primary Endpoint of Pivotal Phase III Clinical Trial Achieved for Remoxy(TM) 4
... The FASTak Suture Anchor is a fully ... is inserted directly into bone without predrilling using ... Tear Drop Handle and Keyless Chuck. This implant ... well as other small anchor indications with very ...
... one step fixation of soft tissue to bone. ... cuff repair in one simple insertion maneuver. The ... of 5 mm and a small 2 mm ... hold a thin, bioabsorbable PLLA disc 5 mm ...
... The Bio-Corkscrews with NeedlePunch Needles are ... NeedlePunch instrument. The NeedlePunch Needles are preloaded ... housed inside the driver shaft. As the ... line is adjacent to the tissue before ...
... The Bio-FASTak is a 3 mm x 14 ... indications in the shoulder, knee, elbow and ankle. ... into the body of the anchor and provides ... metal anchors. This unique eyelet design allows the ...
Medicine Products: