Navigation Links
Gene variation is 'major genetic determinant of psoriasis'
Date:8/27/2009

(SALT LAKE CITY)A specific genetic region that has been increasingly identified as the strongest genetic link to psoriasis has an even more significant role in the chronic skin disease than has been suspected, University of Utah medical researchers show in a new study.

In the Aug. 13 issue of PLoS Genetics, researchers in the U School of Medicine's Department of Dermatology confirm that the presence of HLA-Cw*0602, a gene variation or allele on chromosome 6 found to be associated with psoriasis by numerous investigators, is the "major genetic determinant" of psoriasis, but that other nearby genetic variations also play an independent role in contributing to the disease

"The HLA-Cw*0602 gene variation stands alone as a high risk for psoriasis," said Gerald G. Krueger, M.D., professor of dermatology, Benning Presidential Endowed Chair holder, and a co-author on the study. "A major question has been: are there other genetic variations in this region that associate with psoriasis?"

The study reported in PLoS Genetics identifies two other genetic variations on chromosome 6 that also have significant association with psoriasis. People who have all three genetic variations are nearly nine times more at risk for psoriasis.

Psoriasis is a chronic disease that causes red scaly patches on the skin and affects up to 7.5 million people in the United States. About 25 percent of subjects with the disease also develop a painful inflammation of the joints called psoriatic arthritis.

University researchers, led by first author Bing-Jian Feng, Ph.D., postdoctoral fellow, and senior author David E. Goldgar, Ph.D., research professor of dermatology in the U of U School of Medicine, reached their conclusion after an expanded analysis of data from a study published earlier this year by investigators at Utah in collaboration with colleagues from the University of Michigan and Washington University.

That study (
'/>"/>

Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Common variation in gene linked to structural changes in the brain
2. Genetic Variation Associated With Survival Advantage in African Americans With HIV
3. New Map of Genomic Variation Will Enable Disease Research
4. Global Testing Shows No Variation in Swine Flu Virus
5. New Study Reveals Wide Variations in Depression Diagnoses among Ethnic Groups
6. Discovery of variations in resistance to sulfadoxine across Africa
7. Study IDs Variations in Black, White Genomes
8. DNA Variations May Alter Risk of Hodgkins Disease
9. Taming Wide Variations in Spending Key to Health Reform - New England Journal of Medicine Commentary from Dartmouth Atlas Project
10. Variations in Gene DNA Boost Drinkers Cancer Risk
11. St. Jude finds more than 100 gene variations linked with response to leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... (PRWEB) July 28, 2014 ... "McDonald’s continues to market to a disadvantaged ... Hispanic. They use proven, often offensive, ethnically-slanted ... of people." ('The Tainted Burger." Amazon: ... with Anna Lappe', author and activist who ...
(Date:7/27/2014)... (PRWEB) July 28, 2014 Zensah®, the leader ... offering to include a wrist support . The wrist ... the wrist area. , Lateral and Medial Epicondylitis, more commonly ... condition in which there is inflammation of the tendons attached ... unrelated to wrist pain, the muscles that work the wrist ...
(Date:7/27/2014)... a reliable online supplier of women’s special occasion outfits, has ... on its website. Now, all these charming gowns are provided ... are pleased to add the new fabulous prom dress collection ... who are in need of fashionable special occasion outfits. Each ... our clients will love them. Ladies, just visit our online ...
(Date:7/27/2014)... Bags underneath the eyes is one condition that both ... a range of new products now available from Internet retailers. ... serum review that is now posted for adults to access ... with baggy eyes and how the natural ingredients in some ... also provides a detailed overview of the creams and oils ...
(Date:7/27/2014)... virus (HEV) transmission by blood components indicates that about ... their plasma. The findings, published in The Lancet ... red cells, platelets, and fresh frozen plasma) are likely ... The study retrospectively screened 225 000 individual blood donations ... Sept, 2013 for HEV RNA. 79 donors were found ...
Breaking Medicine News(10 mins):Health News:The Tainted Burger- McDonalds's Franchise Owner's Tale by Author Michael B. Potts Says McDonald's Disproportionately Markets to Minorities--Tedx Video Supports Claim 2Health News:Zensah® Releases New Wrist Support 2Health News:Wdsshop.de Unveils New Prom Dresses To Expand The Online Market 2Health News:Baggy Eyes Serum Review Posted for Men and Women at Cherry News Website 2Health News:The Lancet: 1 in 3000 blood donors in England infected with hepatitis E 2
... Feb. 3 The Ensign Group, Inc. (Nasdaq: ... into Colorado by acquiring four long-term care facilities in ... a 35-bed skilled nursing facility in Littleton, Arvada Nursing ... Temple Center, a 128-bed skilled nursing facility in Englewood, ...
... DEL MAR, Calif., Feb. 3 Plastic & ... the field, published the remarkable safety record of ... killer blood clots to the lungs (pulmonary embolism ... over the past 16 years! This series included ...
... for online vacuum cleaner reviews. , ... Boise, Idaho (PRWEB) February 3, ... will collaborate with The Carpet and Rug Institute (CRI) to ... "Seal of Approval" designation. , , , , ,The new series seeks ...
... web based user self service & identity management software solution that allows ... accounts easily and securely via a web browser, and ends the need ... ... 3, 2009 -- SysOp Tools, Inc. announced that Password Reset PRO, a ...
... Feb. 3 Beneficiaries enrolled in Medicare Part D ... as the "doughnut hole" were much less likely to ... according to a University of Pittsburgh Graduate School of ... 3 online issue of Health Affairs , raise ...
... in the February issue of the Journal of the ... to 20 minutes with simple surgical exercises prior to an ... skills in surgeons of all experience levels. The researchers found ... surgeons, alertness to a higher level for surgical procedures and ...
Cached Medicine News:Health News:The Ensign Group Expands into Colorado 2Health News:Cosmetic Surgery - No Killer Blood Clots to the Lungs Sans GA, PK Anesthesia Can Save the Day 2Health News:The Housekeeping Channel (HC) and The Carpet and Rug Institute (CRI) Partner on Vacuum Cleaner Reviews 2Health News:The Housekeeping Channel (HC) and The Carpet and Rug Institute (CRI) Partner on Vacuum Cleaner Reviews 3Health News:New Web-Based User Self Service & Identity Management Software for Active Directory takes Security, User Convenience to a Whole New Level 2Health News:New Web-Based User Self Service & Identity Management Software for Active Directory takes Security, User Convenience to a Whole New Level 3Health News:Seniors in Medicare's doughnut hole decrease use of meds 2Health News:Journal of American College of Surgeons study finds warm-up helps surgeons improve performance 2
(Date:7/25/2014)... 2014  Depomed, Inc. (NASDAQ: DEPO ) ... year 2014 financial results after the market closes on Wednesday, ... call beginning at 4:30 pm EDT, 1:30 pm PDT to discuss ... by dialing 877-317-6789 ( United States ) ... available via a live webcast on the investor relations ...
(Date:7/25/2014)... MISSION, Kan. , July 25, 2014 /PRNewswire-iReach/ ... , and TCGRx, of Powers Lake, ... exclusive partners in a distribution and co-marketing agreement ... to retail pharmacies throughout the United ... of robotics-based pharmacy management and workflow systems to ...
(Date:7/25/2014)... WOONSOCKET, R.I. , July 25, 2014  CVS ... holding a conference call on Tuesday, August 5, 2014, ... discuss its second quarter 2014 financial results. ... broadcast simultaneously through the Investor Relations portion of the ... the webcast, visit http://info.cvscaremark.com/investors . This webcast will ...
Breaking Medicine Technology:Depomed To Report Second Quarter Fiscal Year 2014 Financial Results On Wednesday, August 6, 2014 2ScriptPro and TCGRx Integrate Pharmacy Automation Technologies 2ScriptPro and TCGRx Integrate Pharmacy Automation Technologies 3
... YORK , June 21 Pfizer Inc. (NYSE: ... and Drug Administration (FDA), it will be discontinuing commercial availability of Mylotarg® ... leukemia (AML)) in the United States and that it will ... October 15, 2010 . , , ...
... , MONTEREY, Calif. , June 21 ... Cayston delivered by the Altera Nebulizer System versus tobramycin ... aeruginosa , the co-primary endpoint of non-inferiority for mean ... (FEV(1)) percent predicted after 28 days of treatment was ...
Cached Medicine Technology:Pfizer Prepares for Voluntary Withdrawal of U.S. New Drug Application and for Discontinuation of Commercial Availability of Mylotarg® 2Pfizer Prepares for Voluntary Withdrawal of U.S. New Drug Application and for Discontinuation of Commercial Availability of Mylotarg® 3Pfizer Prepares for Voluntary Withdrawal of U.S. New Drug Application and for Discontinuation of Commercial Availability of Mylotarg® 4Pfizer Prepares for Voluntary Withdrawal of U.S. New Drug Application and for Discontinuation of Commercial Availability of Mylotarg® 5Pfizer Prepares for Voluntary Withdrawal of U.S. New Drug Application and for Discontinuation of Commercial Availability of Mylotarg® 6PARI Pharma's Altera Delivers Gilead's Cayston in Head-to-Head Study With Tobramycin Inhalation Solution 2PARI Pharma's Altera Delivers Gilead's Cayston in Head-to-Head Study With Tobramycin Inhalation Solution 3PARI Pharma's Altera Delivers Gilead's Cayston in Head-to-Head Study With Tobramycin Inhalation Solution 4
... the most advanced visual electrodiagnostic system ... of retinal and optic nerve function. ... drives this powerful computer-controlled instrument. With ... pattern stimulation, rapid Ganzfeld flash rate ...
... The Universal Biomedical Amplifier (UBA-4204) ... true DC signal amplification and ... commonly seen amplifier problems of ... saturation. These features make the ...
The STALIF stand-alone anterior lumbar fusion cage is the latest product development from Surgicraft. STALIF is the natural evolution of the Hartshill Horseshoe, which has over 10 years clinical suc...
... PACHETTE 3 will enable eye care professionals ... utilizing improved ultrasound technology. The PACHETT 3 ... algorithm used in all the DGH pachymeters ... DGH Model 555 PACHETTE 3 is capable ...
Medicine Products: