Navigation Links
Gene variation is 'major genetic determinant of psoriasis'
Date:8/27/2009

(SALT LAKE CITY)A specific genetic region that has been increasingly identified as the strongest genetic link to psoriasis has an even more significant role in the chronic skin disease than has been suspected, University of Utah medical researchers show in a new study.

In the Aug. 13 issue of PLoS Genetics, researchers in the U School of Medicine's Department of Dermatology confirm that the presence of HLA-Cw*0602, a gene variation or allele on chromosome 6 found to be associated with psoriasis by numerous investigators, is the "major genetic determinant" of psoriasis, but that other nearby genetic variations also play an independent role in contributing to the disease

"The HLA-Cw*0602 gene variation stands alone as a high risk for psoriasis," said Gerald G. Krueger, M.D., professor of dermatology, Benning Presidential Endowed Chair holder, and a co-author on the study. "A major question has been: are there other genetic variations in this region that associate with psoriasis?"

The study reported in PLoS Genetics identifies two other genetic variations on chromosome 6 that also have significant association with psoriasis. People who have all three genetic variations are nearly nine times more at risk for psoriasis.

Psoriasis is a chronic disease that causes red scaly patches on the skin and affects up to 7.5 million people in the United States. About 25 percent of subjects with the disease also develop a painful inflammation of the joints called psoriatic arthritis.

University researchers, led by first author Bing-Jian Feng, Ph.D., postdoctoral fellow, and senior author David E. Goldgar, Ph.D., research professor of dermatology in the U of U School of Medicine, reached their conclusion after an expanded analysis of data from a study published earlier this year by investigators at Utah in collaboration with colleagues from the University of Michigan and Washington University.

That study (
'/>"/>

Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Common variation in gene linked to structural changes in the brain
2. Genetic Variation Associated With Survival Advantage in African Americans With HIV
3. New Map of Genomic Variation Will Enable Disease Research
4. Global Testing Shows No Variation in Swine Flu Virus
5. New Study Reveals Wide Variations in Depression Diagnoses among Ethnic Groups
6. Discovery of variations in resistance to sulfadoxine across Africa
7. Study IDs Variations in Black, White Genomes
8. DNA Variations May Alter Risk of Hodgkins Disease
9. Taming Wide Variations in Spending Key to Health Reform - New England Journal of Medicine Commentary from Dartmouth Atlas Project
10. Variations in Gene DNA Boost Drinkers Cancer Risk
11. St. Jude finds more than 100 gene variations linked with response to leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... Menopause can cause symptoms similar to ... women, menopause can trigger debilitating fluctuations in hormone ... major depressive disorder. These include intense feelings ... and fatigue. While hormone therapies are helpful ... cost make them an unsuitable treatment for many ...
(Date:9/23/2014)... Mirena IUD lawsuits ( http://www.themirenalawsuitcenter.com/ ) ... of the birth control device continue to mount in ... to court documents dated September 18th, an Iowa woman ... IUD outside of the uterus caused the device to ... now pending in the U.S. District Court, Northern District ...
(Date:9/23/2014)... 2014 Mel Frank, also known as ... and harvesting marijuana. He is perhaps one of the ... he’ll be leading a special elective course on growing ... pm at Oaksterdam University in Oakland, California. ... nomenclature, harvesting and manicuring, and identifying preflowers and outdoor ...
(Date:9/23/2014)... ZEPHYRHILLS, FL (PRWEB) September 23, 2014 ... opening of the newly renovated Women’s Health Center ... square feet of space, the specially designed center ... women in East Pasco County. The Women’s Health ... and pelvic floor health, labor and delivery through ...
(Date:9/23/2014)... PATHWAYS TO PREVENTION WORKSHOP: ROLE OF OPIOIDS IN THE ... The National Institutes of Health is convening a Pathways ... on the long-term effectiveness and potential risks of opioids ... nation,s top experts in the field of pain control ... key NIH scientists who focus on pain related research. ...
Breaking Medicine News(10 mins):Health News:Pristiq Discounts Now Available from MedicationDiscountCard.com To Help Ease Menopause Symptoms 2Health News:Mirena IUD Lawsuit News: New Complaint Filed On Behalf of Iowa Woman Claims Mirena Migrated to Her Rectum, Bernstein Liebhard LLP Reports 2Health News:Mirena IUD Lawsuit News: New Complaint Filed On Behalf of Iowa Woman Claims Mirena Migrated to Her Rectum, Bernstein Liebhard LLP Reports 3Health News:Mirena IUD Lawsuit News: New Complaint Filed On Behalf of Iowa Woman Claims Mirena Migrated to Her Rectum, Bernstein Liebhard LLP Reports 4Health News:Special Elective Course Added to Oaksterdam University Schedule; Unique Opportunity to Learn From the “Godfather of Cannabis” Mel Frank on September 27, 2014 2Health News:Florida Hospital Zephyrhills Celebrates Grand Opening of Women’s Health Center 2Health News:Florida Hospital Zephyrhills Celebrates Grand Opening of Women’s Health Center 3Health News:NIH Pathways to Prevention Workshop: The Role of Opioids in the Treatment of Chronic Pain 2Health News:NIH Pathways to Prevention Workshop: The Role of Opioids in the Treatment of Chronic Pain 3
... (January, 13 2008) University of Minnesota researchers have created ... a process called whole organ decellularization, scientists from the University ... by taking dead rat and pig hearts and reseeding them ... published online in the January 13 issue of Nature Medicine., ...
... injected into ,skeleton, of animal organ was beating in ... -- An organ-building biotechnology that could create transplantable hearts ... important laboratory tests, researchers report. , The technique, called ... heart tissue, according to a report in the Jan. ...
... notMYkid, I,wouldn,t be here today," says James, a ClearChoices ... as long as I was at dinner each,night... they ... story,with kids today and prevent them from going through ... a partnership between Chrysler LLC and,Barrett- Jackson will allow ...
... Promise to Deliver ... 12 Hala Moddelmog, president and CEO of,Susan G. Komen ... end breast,cancer forever, today was recognized for her leadership in ... a ,High Heels in High,Places, award. The Trumpet Awards Foundation, ...
... Company Reaffirms Fiscal 2008 Revenue Guidance, FORT LAUDERDALE, ... today announced the resignation of Chief Financial,Officer Robert Hamilton. ... accepted the Chief Financial Officer position at a privately ... transitional,matters., The Company has retained a search firm ...
... N.C., Jan. 11 Today,s top-level,pharmaceutical companies devise ... will carry out the plan as early as ... pharmaceutical research firm, Best,Practices, LLC., As the ... invest people and money earlier in the product,research ...
Cached Medicine News:Health News:U of M researchers create beating heart in laboratory 2Health News:Biotechnology Builds a New Heart 2Health News:Biotechnology Builds a New Heart 3Health News:First in Nation: notMYkid Educational Center Is Now a Reality Thanks to a Partnership Between Chrysler, Barrett-Jackson and notMYkid 2Health News:Susan G. Komen for the Cure's CEO Hala Moddelmog Earns 'High Heels in High Places' Recognition at 2008 Trumpet Awards 2Health News:Susan G. Komen for the Cure's CEO Hala Moddelmog Earns 'High Heels in High Places' Recognition at 2008 Trumpet Awards 3Health News:eDiets.com, Inc. Announces Resignation of Robert Hamilton, Chief Financial Officer 2Health News:eDiets.com, Inc. Announces Resignation of Robert Hamilton, Chief Financial Officer 3Health News:Global Pharmaceutical Launches: Best Practices for Winning Product Launch Successes 2
(Date:9/23/2014)... , Sept. 23, 2014 Report Details ... brand new report shows you potential revenues to 2024, ... 208-page report provides 160 tables, charts, and graphs. Our ... in the prostate cancer therapeutics market, showing their prospects ... industry and the future market prospects. Our new study ...
(Date:9/23/2014)...   LabStyle Innovations Corp . (OTCQB: DRIO), ... announced that it has closed a $4.2 million ... stock and warrants.  No placement agent was used ... expects to secure net proceeds of approximately $4.1 ... intends to use the net proceeds from the ...
(Date:9/23/2014)... 23, 2014  Global Discovery Biosciences, a laboratory dedicated ... the biggest healthcare challenges, announces their collaboration with IPMD, ... test for the early detection of lung cancer. ... death. Typically, the symptoms and subsequent diagnosis of lung ... the chance of a cure has already passed. Early ...
Breaking Medicine Technology:The Prostate Cancer Therapeutics Market Forecast 2014-2024 : Opportunities for Leading Companies 2The Prostate Cancer Therapeutics Market Forecast 2014-2024 : Opportunities for Leading Companies 3The Prostate Cancer Therapeutics Market Forecast 2014-2024 : Opportunities for Leading Companies 4The Prostate Cancer Therapeutics Market Forecast 2014-2024 : Opportunities for Leading Companies 5LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 2LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 3LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 4LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 5Global Discovery Biosciences Announces Collaboration with IPMD, Inc. to Develop Innovative Aptamer-Based Blood Test for the Early Detection of Lung Cancer 2
... THOUSAND OAKS, Calif., Nov. 10, 2010 Amgen Inc. ... of results from the first open-label study to compare ... therapies (SOC) in non-splenectomized adult patients with chronic immune ... in the New England Journal of Medicine ...
... -- HealthWarehouse.com, Inc . (OTC Bulletin ... retail mail-order pharmacy, announced today that it has placed ... debt with independent investors. The investment will ... while upgrading its technology infrastructure to keep pace with ...
Cached Medicine Technology:Study Published in New England Journal of Medicine Shows Nplate® Significantly Reduces Treatment Failure and Splenectomy Rate in Patients With Chronic ITP 2Study Published in New England Journal of Medicine Shows Nplate® Significantly Reduces Treatment Failure and Splenectomy Rate in Patients With Chronic ITP 3Study Published in New England Journal of Medicine Shows Nplate® Significantly Reduces Treatment Failure and Splenectomy Rate in Patients With Chronic ITP 4Study Published in New England Journal of Medicine Shows Nplate® Significantly Reduces Treatment Failure and Splenectomy Rate in Patients With Chronic ITP 5Study Published in New England Journal of Medicine Shows Nplate® Significantly Reduces Treatment Failure and Splenectomy Rate in Patients With Chronic ITP 6Study Published in New England Journal of Medicine Shows Nplate® Significantly Reduces Treatment Failure and Splenectomy Rate in Patients With Chronic ITP 7Study Published in New England Journal of Medicine Shows Nplate® Significantly Reduces Treatment Failure and Splenectomy Rate in Patients With Chronic ITP 8Study Published in New England Journal of Medicine Shows Nplate® Significantly Reduces Treatment Failure and Splenectomy Rate in Patients With Chronic ITP 9Study Published in New England Journal of Medicine Shows Nplate® Significantly Reduces Treatment Failure and Splenectomy Rate in Patients With Chronic ITP 10Study Published in New England Journal of Medicine Shows Nplate® Significantly Reduces Treatment Failure and Splenectomy Rate in Patients With Chronic ITP 11HealthWarehouse.com Places $3.3 Million in Preferred Stock and $1 Million in Convertible Debt 2HealthWarehouse.com Places $3.3 Million in Preferred Stock and $1 Million in Convertible Debt 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: