Navigation Links
Gene variants linked to metabolic syndrome and HDL cholesterol levels
Date:6/17/2008

e.

The investigators who included M. Alan Permutt, M.D., professor of medicine and of cell biology and physiology; Rosalind J. Neuman, Ph.D., professor of mathematics in psychiatry; and Samuel Klein, M.D., the Danforth Professor of Medicine and Nutritional Science and director of the Center for Human Nutrition focused on 36 small genetic variations, called single nucleotide polymorphisms (SNPs), in the CD36 gene. A SNP involves a single base-pair change in the DNA.

The team evaluated DNA taken from more than 2,000 African-Americans because variations in the gene are more common in individuals of African and Asian descent than in other racial groups. The researchers expect, however, that these findings also will be applicable in other populations.

"The idea was to look at the different variations in the gene and see whether they were more prevalent in people who also had elevated cholesterol, abnormal blood glucose or the other components of the metabolic syndrome," says first author Latisha Love-Gregory, Ph.D., research instructor in the Division of Geriatrics and Nutritional Science.

Love-Gregory says the research team demonstrated an association between SNPs in the gene and metabolic syndrome.

"There is additional work to do to determine if the function of these genetic variants actually contributes to the development of type 2 diabetes or heart disease," she explains. "We do expect that a number of different changes, in both CD36 and other genes, will be related to these diseases. What we'd like to learn, however, is whether the changes identified in the gene alter the CD36 protein in ways that change its function to make a person more vulnerable."

The team determined that five of the SNPs they examined are more common in people who have symptoms of metabolic syndrome, but a sixth seemed to have a more favorable metabolic effect. The "protective" SNP makes people produce lower amounts of CD36 protein.


'/>"/>
Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Gene Variants Linked to Lung Cancer Identified
2. Gene Variants Can Predict Threat of Heart Disease
3. Hot flashes underreported and linked to forgetfulness
4. Poor sleep linked to suicidal behavior among children and adolescents with depressive episodes
5. Frequent self-cutting linked to risky sexual behavior in teens
6. Disturbed rest, activity linked to mortality in older men
7. Sleep Apnea Linked to Memory Loss
8. Normal sleep linked to successful aging
9. Memory loss linked to common sleep disorder
10. Common bowel problem linked to chili pepper pain receptor
11. Sleep problems linked to obesity, lower quality of life in school-aged children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... the brain involved in multitasking and ways to train ... the IUGM Institut universitaire de griatrie de Montral and ... to better predict the effectiveness of this training. Cooking ... the Web, or driving while listening to a radio ... our daily lives. Unfortunately, it decreases with age, which ...
(Date:8/19/2014)... Recently, UWDress.com, a professional company of women’s dresses and related ... formal evening dresses . Additionally, the firm has launched a ... moment, all of them can be ordered at discounted rates, ... until August 27, 2014. , The company puts much ... that women of all shapes can be graceful and charming. ...
(Date:8/19/2014)... August 19, 2014 “ Inbox Blueprint ... course designed to provide users with the tools necessary ... marketing techniques and strategies. The course which was ... of excitement throughout the internet marketing world. The commotion ... HonestyFirstReviews.com's Tiffany Hendricks prompting an updated review of the ...
(Date:8/19/2014)... NV (PRWEB) August 19, 2014 The ... the 2nd Annual Southwest CannaBusiness Symposium on ... Plaza Hotel & Casino in Las Vegas. , Featuring ... State Senator Tick Segerblom (D-Las Vegas), the event will ... practices, and the work NCIA is doing federally to ...
(Date:8/19/2014)... Grande Naturals, LLC is proud ... the 2014 Independent Cosmetics Manufacturers & Distributors Award ... position in “Product Innovation; Product Color Cosmetic” for ... includes a lash enhancement serum, GrandeLINER™. GrandeLINER™ ... , This all-new eyeliner is a ...
Breaking Medicine News(10 mins):Health News:Targeted brain training may help you multitask better 2Health News:Cheap Plus Size Formal Evening Dresses Announced By UWDress.com 2Health News:Anik Singal’s “Inbox Blueprint” Review Released By HonestyFirstReviews.com 2Health News:SATURDAY IN LAS VEGAS: U.S. Rep. Dina Titus, State Sen. Tick Segerblom Keynote National Cannabis Industry Association Southwest CannaBusiness Symposium 2Health News:GrandeLINER™ Wins Independent Cosmetics Manufacturers & Distributors Award 2Health News:GrandeLINER™ Wins Independent Cosmetics Manufacturers & Distributors Award 3
... ... are turning to unexpected sources for natural remedies and ways to conserve. Humidifiers , ... and relieving symptoms of colds and the flu through proper humidification. As a result ... ...
... ... advisory committee in pain management, , ... Maywood NJ (PRWEB) October 13, 2009 -- Advanced Data Systems (ADS) welcomes ... is a Managing Partner of Pain Centers of America, PA specializing in interventional pain management. ...
... ... of his new state-of-the-art website designed to provide comprehensive information on gastric sleeve surgery, ... obese men and women lose significant amounts of weight and reduce the risk of ... ...
... ... quality EMS bags and backpacks and other trauma bags for medical professionals. The updated website ... meet the growing demands of their customers in the medical community. , ... (PRWEB) October 13, 2009 -- Colorado Cases ...
... ... 15 to Dec. 31—for Medicare-eligible individuals to evaluate and choose the plan that best ... ... seniors and people with disabilities will be required to choose new healthcare coverage during ...
... team of scientists at the National Cancer Institute (NCI) in ... yield valuable information on how to diagnose and treat human ... team discusses an ongoing initiative in which spontaneously occurring cancers ... of new cancer drugs, devices and imaging strategies for human ...
Cached Medicine News:Health News:Humidifiers -- Not Just for Children Anymore -- AchooAllergy.com Announces All New Humidifiers Offering 2Health News:Humidifiers -- Not Just for Children Anymore -- AchooAllergy.com Announces All New Humidifiers Offering 3Health News:ADSC's Pain Management Reinforcement 2Health News:Dallas, Texas Lap-Band Surgeon Announces New Website to Educate Patients on the Lap-Band System and Other Advanced Weight Loss Solutions 2Health News:Dallas, Texas Lap-Band Surgeon Announces New Website to Educate Patients on the Lap-Band System and Other Advanced Weight Loss Solutions 3Health News:Colorado Cases Launches New Website to Add More Custom Cases for Medical Professionals and Expand Services 2Health News:Colorado Cases Launches New Website to Add More Custom Cases for Medical Professionals and Expand Services 3Health News:Healthcare Reform, Coverage Changes Highlight Key Questions for Medicare Annual Enrollment Season, Allsup Says 2Health News:Healthcare Reform, Coverage Changes Highlight Key Questions for Medicare Annual Enrollment Season, Allsup Says 3Health News:Healthcare Reform, Coverage Changes Highlight Key Questions for Medicare Annual Enrollment Season, Allsup Says 4Health News:Healthcare Reform, Coverage Changes Highlight Key Questions for Medicare Annual Enrollment Season, Allsup Says 5
(Date:8/19/2014)... BETHESDA, Md. , Aug. 19, 2014  Northwest ... biotechnology company developing DCVax® personalized immune therapies for solid ... note offering announced last Thursday, August 14, 2014, has ... and are convertible at $7.30 per share of common ... 3 months, to purchase up to an additional 30% ...
(Date:8/19/2014)... Aug. 19, 2014 Research and Markets ... Contract Manufacturing - Global Strategic Business Report" report ... the worldwide markets for Pharmaceutical Contract Manufacturing in US$ ... and IV solutions), Solid Dosage Forms (Tablets and Capsules), ... Creams & Ointments). The report provides separate ...
(Date:8/19/2014)... Research and Markets has announced the addition of ... Report" report to their offering. This ... in US$ Million by the following Brands: Humatrope, Norditropin, Genotropin, ... comprehensive analytics for the US, Canada , ... Asia-Pacific , and Rest of World. Annual ...
Breaking Medicine Technology:NW BIO COMPLETES THE CLOSING OF ITS $17.5 MILLION CONVERTIBLE NOTE OFFERING 2NW BIO COMPLETES THE CLOSING OF ITS $17.5 MILLION CONVERTIBLE NOTE OFFERING 3Global Pharmaceutical Contract Manufacturing - Strategic Business Report 2014 2Global Human Growth Hormone Drugs - Strategic Business Report 2014 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: