Navigation Links
Gene variant predicts medication response in patients with alcohol dependence
Date:2/7/2008

Patients with a certain gene variant drank less and experienced better overall clinical outcomes than patients without the variant while taking the medication naltrexone, according to an analysis of participants in the National Institutes of Health's 2001-2004 COMBINE (Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence) Study. About 87 percent of patients with the variant who received naltrexone. experienced good outcomes, compared with about 49 percent of those who received a placebo. About 55 percent of patients without the variant experienced a good outcome regardless of whether they received naltrexone or placebo. Good outcome was defined as abstinence or moderate drinking without related problems, according to an article in the Feb. 4 issue of the Archives of General Psychiatry (http://archpsyc.ama-assn.org/cgi/content/abstract/65/2/135).

Drinking alcohol increases the release of endogenous opioids, compounds that originate in the body and promote a sense of pleasure or well-being. An opioid antagonist, naltrexone blocks brain receptors for endogenous opioids, making it easier for patients to remain abstinent or stop quickly in the event of a slip. In clinical studies, naltrexone has been shown to reduce relapse and craving for alcohol in some but not all treated patients. Earlier studies had suggested that a specific DNA variant of the opioid receptor gene (OPRM1) might have role in patients' response to naltrexone.

"Analysis of the large COMBINE patient population increases confidence that the OPRM1 variant is in part responsible for positive responses to naltrexone. This study points to the promise of research on gene-medication interactions to refine treatment selection, improve clinical results, and inform ongoing medications development," said National Institute on Alcohol Abuse and Alcoholism (NIAAA) director Ting-Kai Li, M.D.
'/>"/>

Contact: Ann Bradley
abradley@mail.nih.gov
301-443-0595
NIH/National Institute on Alcohol Abuse and Alcoholism
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Gene variant linked to moderated symptoms of beta-thalassemia
2. Gene Variant Tied to More Aggressive Prostate Cancer
3. Gene Variant Doubles Risk of Prostate Cancer in Black Men
4. Scientists discover genetic variant associated with prostate cancer in African Americans
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Gene predicts heart attack response and cardiac damage
7. Genetic difference predicts antidepressant response
8. U.S. Preventive Medicine(R) Predicts Robust Growth Ahead
9. UQ research predicts type 2 diabetes explosion
10. Simple test accurately predicts risk of serious jaundice in newborns
11. Medical Services International Predicts Revenues for the Second Half of the Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... July 30, 2014 Calling all runners in ... to announce it will host a monthly Runner’s Injury ... 2231 Old Brick Road the second Monday of each month ... 8, October 13, November 10 and December 8. , ... Participants, who should wear running shoes and attire, will receive ...
(Date:7/30/2014)... CareSource, a nonprofit, Ohio-based health plan, ... CEO, Wright-Patt Credit Union, to the CareSource Ohio Board ... CEO with an extensive background in leading credit unions. ... chief operating officer at Wright-Patt Credit Union (WPCU) in ... Wright-Patt Credit Union that has realized more than seven ...
(Date:7/30/2014)... July 30, 2014 Park Cities ... instituted company-wide staff meetings this month to reinforce best ... Ms. White chose to institute the meetings when ... and amongst staff has become over the past decade. ... her business that allow for quicker processing of customer ...
(Date:7/30/2014)... of traumatic events experienced during deployment, returning National ... drinking problem if faced with civilian life setbacks, ... financial and legal problemsall commonplace in military families. ... University,s Mailman School of Public Health are published ... Medicine . , Alcohol abuse is a major ...
(Date:7/30/2014)... who are born with severe combined immunodeficiency (SCID) can ... cells, according to experts led by Memorial Sloan Kettering,s ... development of transplant protocols. Their review will be published ... England Journal of Medicine . , SCID is a ... to severely malfunction. When this breakdown occurs, babies no ...
Breaking Medicine News(10 mins):Health News:Tidewater Physical Therapy to Host Monthly Runner’s Injury Clinic at 3 Sports Glen Allen Location 2Health News:Tidewater Physical Therapy to Host Monthly Runner’s Injury Clinic at 3 Sports Glen Allen Location 3Health News:Dallas-Based Park Cities Pet Sitter Stresses the Importance of Mindful Communication in This Month’s Staff Meetings, In Addition to Teaching the Signs of Burnout 2Health News:Dallas-Based Park Cities Pet Sitter Stresses the Importance of Mindful Communication in This Month’s Staff Meetings, In Addition to Teaching the Signs of Burnout 3Health News:Dallas-Based Park Cities Pet Sitter Stresses the Importance of Mindful Communication in This Month’s Staff Meetings, In Addition to Teaching the Signs of Burnout 4Health News:Vets' alcohol problems linked to stress on the home front 2Health News:Transplantation shown to be highly effective in treating immune deficiency in children 2
... Wis. , March 15 National Alliance of ... Association,s Institute for Quality and Patient Safety and the New ... they are sponsoring an initiative to expand the number of ... Jersey Wound Care Certification Initiative. This new initiative was borne ...
... FORT WORTH, Texas , March 15 ... a growing  provider of specialty medical products, announced today ... the DFCon 10 Global Diabetic Foot Conference in ... is more than 1000 physicians, clinicians, researchers, scientists, and ...
... naltrexone improves odds of not drinking, researchers say , ... the antidepressant Zoloft (sertraline) and the alcoholism drug naltrexone ... and alcohol dependence will be able to stop drinking, ... patients found that 54 percent of those who received ...
... A potent new inhibitor of HIV, derived from bananas, ... transmission of HIV, according to a University of Michigan Medical ... emerging interest in lectins, naturally occurring chemicals in plants, because ... leads to a variety of infections. In laboratory ...
... HONG KONG , March 15 /PRNewswire-Asia/ -- ... Code: 801), China,s leading,integrated healthcare device and ... shareholders (the "Shareholders") have approved at an,Extraordinary General Meeting ... the board of directors ("the Board") to change the ...
... nurse specialist at the Christiana Care Breast Center at the Helen F. Graham Cancer Center, is the 2010 recipient of the Pearl Moore Making a Difference Award from the ... ... ... ...
Cached Medicine News:Health News:New Jersey Approves Initiative to Expand the Number of Wound Care Certified Professionals 2Health News:New Jersey Approves Initiative to Expand the Number of Wound Care Certified Professionals 3Health News:New Jersey Approves Initiative to Expand the Number of Wound Care Certified Professionals 4Health News:New Jersey Approves Initiative to Expand the Number of Wound Care Certified Professionals 5Health News:Wound Management Technologies, Inc. Announces Conference Plans and Clinical Data Presentation at Leading Diabetic Foot Conference 2Health News:Wound Management Technologies, Inc. Announces Conference Plans and Clinical Data Presentation at Leading Diabetic Foot Conference 3Health News:Wound Management Technologies, Inc. Announces Conference Plans and Clinical Data Presentation at Leading Diabetic Foot Conference 4Health News:Wound Management Technologies, Inc. Announces Conference Plans and Clinical Data Presentation at Leading Diabetic Foot Conference 5Health News:University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection 2Health News:Golden Meditech Shareholders Approves of Name Change 2Health News:Golden Meditech Shareholders Approves of Name Change 3Health News:Christiana Care Health System's Darcy Burbage Receives Oncology Nursing Society Award 2Health News:Christiana Care Health System's Darcy Burbage Receives Oncology Nursing Society Award 3
(Date:7/30/2014)... SAN ANTONIO , July 30, 2014 /PRNewswire/ ... technology company focused on innovating lifesaving devices and ... closed $4.5 million in Series A financing, which ... .  Proceeds from the deal will allow Bluegrass ... Inside-Out Access Catheter System, enhance manufacturing capabilities, and ...
(Date:7/30/2014)... , July 30, 2014 ... and CUDA programming expertise to big data, aerospace ... eInfochips, a leading engineering R&D services ... to develop NVIDIA GPU-powered solutions for aerospace ... high-performance computing (HPC), industrial , and ...
(Date:7/29/2014)... , July 29, 2014 /PRNewswire-iReach/ -- The global ... of products, methods, applications, end users, and geographies. ... in the microbial identification market. This favorable growth ... (per test) and the time required for microbial ... technological advancements. Furthermore, genotypic methods have high applications ...
Breaking Medicine Technology:Bluegrass Vascular Technologies Raises $4.5M Series A Financing Led By Targeted Technology Funds 2eInfochips to Develop NVIDIA GPU-powered Solutions for Aerospace and Defense, Medical Imaging, HPC and Visual Computing 2Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 2Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 3Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 4Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 5Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 6
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Escherichia coli - For the qualitative detection of Escherichia coli 0157 and 0157:H7 in food products Accessories BinaxNOW EH E.coli 0157 & 0157:H7 Control Swab Pack (510-000) ...
... the qualitative differential detection ... antigen and an antigen that ... species of malaria:plasmodium falciparum (P.f), ... (P.o) and Plasmodium malariae (P.m) ...
For the qualitative detection of antibodies to Treponema pallidum in human serum, plasma and whole blood specimens...
Medicine Products: