Navigation Links
Gene variant predicts medication response in patients with alcohol dependence
Date:2/7/2008

Patients with a certain gene variant drank less and experienced better overall clinical outcomes than patients without the variant while taking the medication naltrexone, according to an analysis of participants in the National Institutes of Health's 2001-2004 COMBINE (Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence) Study. About 87 percent of patients with the variant who received naltrexone. experienced good outcomes, compared with about 49 percent of those who received a placebo. About 55 percent of patients without the variant experienced a good outcome regardless of whether they received naltrexone or placebo. Good outcome was defined as abstinence or moderate drinking without related problems, according to an article in the Feb. 4 issue of the Archives of General Psychiatry (http://archpsyc.ama-assn.org/cgi/content/abstract/65/2/135).

Drinking alcohol increases the release of endogenous opioids, compounds that originate in the body and promote a sense of pleasure or well-being. An opioid antagonist, naltrexone blocks brain receptors for endogenous opioids, making it easier for patients to remain abstinent or stop quickly in the event of a slip. In clinical studies, naltrexone has been shown to reduce relapse and craving for alcohol in some but not all treated patients. Earlier studies had suggested that a specific DNA variant of the opioid receptor gene (OPRM1) might have role in patients' response to naltrexone.

"Analysis of the large COMBINE patient population increases confidence that the OPRM1 variant is in part responsible for positive responses to naltrexone. This study points to the promise of research on gene-medication interactions to refine treatment selection, improve clinical results, and inform ongoing medications development," said National Institute on Alcohol Abuse and Alcoholism (NIAAA) director Ting-Kai Li, M.D.
'/>"/>

Contact: Ann Bradley
abradley@mail.nih.gov
301-443-0595
NIH/National Institute on Alcohol Abuse and Alcoholism
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Gene variant linked to moderated symptoms of beta-thalassemia
2. Gene Variant Tied to More Aggressive Prostate Cancer
3. Gene Variant Doubles Risk of Prostate Cancer in Black Men
4. Scientists discover genetic variant associated with prostate cancer in African Americans
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Gene predicts heart attack response and cardiac damage
7. Genetic difference predicts antidepressant response
8. U.S. Preventive Medicine(R) Predicts Robust Growth Ahead
9. UQ research predicts type 2 diabetes explosion
10. Simple test accurately predicts risk of serious jaundice in newborns
11. Medical Services International Predicts Revenues for the Second Half of the Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... Molecules from cone snail venom and African plants are being ... oral drug to treat chronic pain. , Professor David ... Bioscience have received $218,275 from the National Health and Medical ... a product available for Australians to use. , Studies ...
... severe symptom reported by middle-aged women when their periods change ... study in the April issue of the UK-based Journal of ... of Nursing, USA, spoke to 110 women entering the menopause ... at longer or shorter intervals. Their average age was 49 ...
... RuiTai International Holdings Co., Ltd. (OTC Bulletin Board: ... and distributor,of cellulose ether products in the People,s ... for the fiscal year ended December,31, 2007., ... increased 36.7% to $38.4 million -- Gross ...
... Executive brings extensive experience in both healthcare and human ... ... 16 Precyse Solutions, the leader in,driving peak performance within Health ... Corporate,Vice President of Human Resources. She joins Precyse from Pegasus,Communications where ...
... next President to focus more on improving their,standard ... of jobs overseas than making it easier for ... to the latest "America At Work" national,opinion survey ... The workplace-issues poll, based on a sampling of ...
... It may produce chemicals that protect the brain, ... -- Regular physical exercise may help protect against ... study. , People with mild cognitive impairment can ... details of conversations, events and upcoming appointments. Most, ...
Cached Medicine News:Health News:Cone snails and plants used to develop oral drug for pain 2Health News:Getting a good night's sleep is the biggest problem for women entering the menopause 2Health News:Getting a good night's sleep is the biggest problem for women entering the menopause 3Health News:China RuiTai Reports Fiscal Year 2007 Financial Results 2Health News:China RuiTai Reports Fiscal Year 2007 Financial Results 3Health News:China RuiTai Reports Fiscal Year 2007 Financial Results 4Health News:China RuiTai Reports Fiscal Year 2007 Financial Results 5Health News:China RuiTai Reports Fiscal Year 2007 Financial Results 6Health News:China RuiTai Reports Fiscal Year 2007 Financial Results 7Health News:China RuiTai Reports Fiscal Year 2007 Financial Results 8Health News:China RuiTai Reports Fiscal Year 2007 Financial Results 9Health News:Precyse Solutions Appoints Karen Heisler as New Corporate Vice President, Human Resources 2Health News:Americans Want Next President to Focus More on Saving U.S. Jobs and Healthcare; Less on Immigration Reform 2Health News:Americans Want Next President to Focus More on Saving U.S. Jobs and Healthcare; Less on Immigration Reform 3Health News:Exercise Could Cut Risk of Mild Cognitive Impairment 2
(Date:12/24/2014)... 2014  Lockton Dunning Benefits, the ... the addition of Vice President Kim Foerster ... Pharmacy Consulting team, Excelsior Solutions. ... to the position.  Most recently, she worked as ... Specialty Pharmacy, where she has held various managerial ...
(Date:12/24/2014)... N.C. , Dec. 23, 2014  Endo Pharmaceuticals ... ENDP ) (TSX: ENL), and BioDelivery Sciences International, ... they have submitted a New Drug Application (NDA) for ... Drug Administration (FDA).  Buprenorphine HCl Buccal Film is under ... require daily, around-the-clock, long-term opioid treatment and for which ...
(Date:12/22/2014)... Dec. 22, 2014 Apnea Sciences ( www.apneasciences.com ... in Aliso Viejo , California.  ... the tremendous growth and worldwide expansion, a new facility ... SnoreRx, the anti snore cure have exceeded our expectations ... "We are now in 23 countries and will be ...
Breaking Medicine Technology:Kim Foerster Joins Lockton Companies 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5
... Custom Spine, a company dedicated to offering advanced spinal ... North American Spine Society,s (NASS) annual meeting being held ... a unique articulating vertebral interbody device, which consists of ... the disc space. The interbody is inserted in ...
... CardioGenics Holdings Inc. (OTC Bulletin Board: CGNH), a developer ... the IVD testing market, was featured in Medical ... article by Amanda Petersen, titled "CardioGenics aims to offer ... Yahia Gawad, MD regarding the company,s point-of-care (POC) cardiac ...
Cached Medicine Technology:Custom Spine Launches Pathway AVID and Regent ACP at NASS 2CardioGenics Holdings Inc. Featured in Medical Device Daily 2CardioGenics Holdings Inc. Featured in Medical Device Daily 3
The Vitatron Excellence S+ lead series are endocardial leads providing excellent reliability and optimal pacing characteristics....
The family of Passive Plus DX passive-fixation leads features a 5 mm tip, designed to increase current density and pacing impedance, and a tine fixation, offering versatility and security in lead pla...
... The IsoFlex S lead's small ... ease implantation and lower the ... smaller, more tortuous vessels. Atrial ... and fixation options combine to ...
Unipolar Atrial "J" Lead...
Medicine Products: