Navigation Links
Gene variant identified as a heart disease risk factor for women
Date:7/22/2014

When it comes to heart disease, Dr. Ross Feldman says women are often in the dark. Historically, it was thought that heart disease was a men's-only disease, however, data has shown that post-menopausal women are just as likely as men to get heart disease and are less likely to be adequately diagnosed and treated. New research from Western University published online this week in the British Journal of Clinical Pharmacology brings to light a genetic basis for heart disease in women and helps to identify which women are more prone to heart disease.

The study, led by Dr. Feldman, a clinical pharmacologist at London Health Sciences Centre and a researcher at the Schulich School of Medicine & Dentistry's Robarts Research Institute, identifies a common gene variant in women for the G-protein coupled estrogen receptor 30 (GPER) that makes them significantly more likely to have high blood pressure, the single biggest risk factor for heart attack and stroke.

GPER, when functioning normally, is activated in part by the hormone estrogen and has been previously shown to relax the blood vessels, and in turn, lower blood pressure. This new study demonstrates that many women have a less functional form of GPER, increasing their risk of developing high blood pressure.

The research looked at the effect of expression of the GPER gene variant versus the normal GPER gene in the vascular smooth muscle cells as well as its association with blood pressure in humans. It also looked at the frequency of the gene variant in a group of women referred a tertiary care clinic at London Health Sciences Centre. The study found that women, but not men, carrying the GPER gene variant had higher blood pressure, and almost half of women who attended a hard-to-treat blood pressure clinic, where Dr. Feldman is a physician, expressed the variant. Twice as many women than men with hard to treat hypertension carried the gene.

"This is one step in understanding
'/>"/>

Contact: Crystal Mackay
crystal.mackay@schulich.uwo.ca
519-661-2111 x80387
University of Western Ontario
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Common gene variants account for most of the genetic risk for autism
2. Splice variants reveal connections among autism genes
3. Certain genetic variants may identify patients at higher risk of bladder cancer recurrence
4. Gene variants protect against relapse after treatment for hepatitis C
5. Researchers identify genomic variant associated with sun sensitivity, freckles
6. Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers
7. Noodles Box launches variants in serving size
8. Gene variant ID could lead to better fatty liver disease diagnosis
9. Common gene variants explain 42 percent of antidepressant response
10. An international study identifies new DNA variants that increase the risk for cancer
11. eVariant Welcomes Advocate Health Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Alabama (PRWEB) October 31, 2014 ... emergency physician, knows all too well the chaos that ... for the end-of-life. “The vast majority of Americans who ... their own lives are completely unprepared for the moment ... the ListStuffFast app can serve as a catalyst for ...
(Date:10/31/2014)... Energy Textiles has recently added a new ... now available online, and Energy Textile is providing their ... athletic gear over compression gear. , The Boston ... signed for Under Armour to provide team gear for ... In light of this decision, Energy Textiles contemplates whether ...
(Date:10/31/2014)... suggests that insomnia is a major contributor to deaths ... injuries. The results underscore the importance of the "Sleep ... Awareness Project. , Results show that the risk of ... the number of insomnia symptoms present. People with all ... to die from a fatal injury than those with ...
(Date:10/31/2014)... October 31, 2014 North Shore Eye ... Garden City, Long Island and the addition of leading ... staff, according to North Shore Eye Care Medical Director, ... Acting Chairman of the Department of Ophthalmology of Winthrop-University ... in Garden City for more than 30 years. He ...
(Date:10/31/2014)... October 31, 2014 In an effort to ... Dr. Majid Jamali announced he will soon offer orthodontics at ... the end of November. , To build upon the ... of New York has become known for, Dr. Jamali is ... from such top learning institutions as UCLA, Stanford and UCSF. ...
Breaking Medicine News(10 mins):Health News:This Thanksgiving or Christmas Family Gathering, Use The New App ListStuffFast to Start "The Conversation" With a Parent That Has No Plan For End-of-Life 2Health News:This Thanksgiving or Christmas Family Gathering, Use The New App ListStuffFast to Start "The Conversation" With a Parent That Has No Plan For End-of-Life 3Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4Health News:Insomnia increases risk of motor vehicle deaths, other fatal injuries 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 3Health News:Oral & Maxillofacial Surgery of New York Adds Orthodontic Patient Services 2Health News:Oral & Maxillofacial Surgery of New York Adds Orthodontic Patient Services 3
... Medical Center have successfully accomplished the removal of an extremely ... ,They removed one of his two left arms ... second left arm is further up his shoulder. ... were formed just as they would be for a normal ...
... The World Health Organisation has ruled out human-to-human transmission ... nurses tending patients with the disease // , easing ... to spread more readily among humans. ,'The negative ... that the virus is not spreading efficiently or sustainably ...
... myeloid leukemia has shown to improve the survival rates in ... for health and Clinical Excellence (NICE), which regulates drug approvals ... advanced cases, but the drug has not proved itself in ... blood cancer, which arises due to a defect in the ...
... high life in Mumbai with both Rahul Mahajan, now being ... suspected to have supplied// him drugs, being known faces in ... commonly known as lifestyle drugs,are a rage with the rich ... abuse is rampant in party circuits or private,functions here," said ...
... a bird flu exercise Tuesday in which all ... to a human,influenza pandemic. ,Senior officials from ... a hypothetical scenario in the "APEC Pandemic Response,Exercise ... a series that will prepare the,emergency management sector ...
... Overweight children are likely to suffer from fractures ... ,Researchers led by Jack Yanovski //from the National ... and 128 normal,weight children. The overweight children reported ... ,The study found that overweight children ...
Cached Medicine News:Health News:Drugs Part of Mumbai High Life 2Health News:APEC Launches Bird Flu Exercise 2
(Date:10/31/2014)... -- AbbVie (NYSE: ABBV ) today announced ... 30, 2014. "Our third-quarter results ... double-digit growth from HUMIRA and several other key ... in the quarter excluding lipids," said Richard A. ... exceeded our outlook for the quarter and have ...
(Date:10/30/2014)... Oct. 30, 2014 WuXi PharmaTech (Cayman) Inc. (NYSE: ... and technology platform company serving the pharmaceutical, biotechnology, and ... and the United States ... in the Tel Aviv area ... promote WuXi,s broad platform of integrated R&D services to ...
(Date:10/30/2014)... -- The number of retail health clinics in ... to drug store chains, according to Kalorama Information.  In ... retail clinic growth had been at a standstill, but ... of retail clinics reached nearly 1,600 according to the ... and 2014 Consumer Survey Results .  More ...
Breaking Medicine Technology:AbbVie Reports Third-Quarter 2014 Financial Results 2AbbVie Reports Third-Quarter 2014 Financial Results 3AbbVie Reports Third-Quarter 2014 Financial Results 4AbbVie Reports Third-Quarter 2014 Financial Results 5AbbVie Reports Third-Quarter 2014 Financial Results 6AbbVie Reports Third-Quarter 2014 Financial Results 7AbbVie Reports Third-Quarter 2014 Financial Results 8AbbVie Reports Third-Quarter 2014 Financial Results 9AbbVie Reports Third-Quarter 2014 Financial Results 10AbbVie Reports Third-Quarter 2014 Financial Results 11AbbVie Reports Third-Quarter 2014 Financial Results 12AbbVie Reports Third-Quarter 2014 Financial Results 13AbbVie Reports Third-Quarter 2014 Financial Results 14AbbVie Reports Third-Quarter 2014 Financial Results 15AbbVie Reports Third-Quarter 2014 Financial Results 16AbbVie Reports Third-Quarter 2014 Financial Results 17AbbVie Reports Third-Quarter 2014 Financial Results 18AbbVie Reports Third-Quarter 2014 Financial Results 19AbbVie Reports Third-Quarter 2014 Financial Results 20AbbVie Reports Third-Quarter 2014 Financial Results 21AbbVie Reports Third-Quarter 2014 Financial Results 22AbbVie Reports Third-Quarter 2014 Financial Results 23AbbVie Reports Third-Quarter 2014 Financial Results 24WuXi AppTec Launches Representative Office in Israel, Forms Strategic Collaboration with Pontifax 2Report: Drugstore Chains Drive Retail Clinic Growth 2Report: Drugstore Chains Drive Retail Clinic Growth 3
... Reportlinker.com announces that a new market ... Medical Devices - Asia ... This package contains 15 medical device ... Azerbaijan, China, India, Indonesia, Iran, Japan, Jordan, ...
... Nov. 29, 2011 When compared to mammography and ... Breast Imaging (MBI), has greater sensitivity and comparable specificity ... at the 2011 Radiological Society of North America (RSNA) ... through Dec. 2, 2011. BSGI/MBI also proved to be ...
Cached Medicine Technology:Medical Devices - Asia 2BSGI/MBI Shows Greater Sensitivity and Comparable Specificity When Compared to Ultrasound and Mammography 2
... designed to optimize the accuracy and precision ... products is widely recognized by customers throughout ... extended over the years and now covers ... tips including filter tips, certified pure tips, ...
... Finntip Filters are ideal for ... or for any work where ... are designed for pipetting DNA/RNA ... and other. For applications requiring ...
... ART Aerosol Resistant Tips offer a ... ART Tips are designed for applications such ... studies. In addition, ART Tips are excellent ... and forensic studies. ART Tips prevent aerosol ...
Inquire...
Medicine Products: