Navigation Links
Gene variant ID could lead to better fatty liver disease diagnosis
Date:4/23/2013

More patients could be diagnosed earlier with non-alcoholic fatty liver disease (NAFLD) after a cohort study presented at the International Liver CongressTM 2013 identified variants within four genes significantly associated with the histological features of the disease.

NAFLD is caused by a fatty liver; when fat is deposited in the liver not due to the use of alcohol. The spectrum of the disease is broad, ranging from simple fat deposition without inflammation (steatosis), to liver inflammation (steatohepatitis), eventually accompanied by a variable degree of fibrosis. In case of severe fibrosis progession, cirrhosis may develop. NAFLD is currently regarded as a major cause of cirrhosis of the liver of unknown cause.

As NAFLD patients are typically asymptomatic, even in the presence of more severe liver lesions, patient diagnostic techniques to identify at-risk individuals would be very helpful to improve the management of the disease.

Previous genome-wide association studies (GWAS) have provided important insights into modifier genes which influence the pathology of steatosis. Using data drawn from a large GWAS of 1125, European and North American Caucasian patients with NAFLD, this study applied a candidate-gene approach to re-examine the broader validity of these associations.

Variants within four genes significantly associated with the histological features of NAFLD were identified including steatosis (PNPLA3 rs738409, GCKR rs780094, PPP1R3B rs11777327, TRIB1 rs2385114); steatohepatitis (PNPLA3, GCKR, TRIB1); and fibrosis (PNPLA3, GCKR, TRIB1).

This study has further established the overwhelming significance of the chromosome 22 PNPLA3 locus to all aspects of NAFLD and has, for the first time, demonstrated that some genetic variations previously associated with steatosis or mild biochemical abnormalities may in fact have broader pathological significance influencing inflammatory disease and progression to
'/>"/>

Contact: Dimple Natali
easlpressoffice@cohnwolfe.com
44-079-001-68904
European Association for the Study of the Liver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Common gene variants explain 42 percent of antidepressant response
2. An international study identifies new DNA variants that increase the risk for cancer
3. eVariant Welcomes Advocate Health Care
4. Gene variants found to affect human lifespan
5. Researchers Link 25 New Gene Variants to Autism
6. Carriers of gene variant appear less likely to develop heart disease
7. More Gene Variants Linked to Heart Trouble
8. Bigger human genome pool uncovers rarer variants
9. New gene variants raise risk of neuroblastoma, influence tumor progression
10. Mayo, UCSF team discovers genomic variant that increases risk of brain tumors
11. Moffitt Cancer Center study validates activity of rare genetic variant in glioma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... 12, 2014 Sean Francis, owner of the Kawartha ... challenges to his clients. He’s also known for his support of ... a way to combine the two and is excited to announce ... the Boys and Girls Club. , The funds are the result ... June 23rd. Francis sent out emails and asked his clients to ...
(Date:7/12/2014)... For those who are unfamiliar with enzymes, they are ... in food. The enzymes literally break up the vitamins and ... absorbed by human bodies. According Dr. Henry Balzani, Medical Consultant ... food is the cause of many gastrointestinal health issues. ... DelPresto, a mother of 3 who is passionate about fitness ...
(Date:7/12/2014)... Lake City, Utah (PRWEB) July 12, 2014 ... spotlighted two types of startups, with awards being bestowed ... new emphasis spotlighted Utah’s outstanding entrepreneur community with recognition ... proving a sustainable model with incoming revenue. , 25 ... from across the state that are under 5 years ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 Restore My ... Sen and Samantha Pearson, a couple boasting very impressive ... launch Restore My Vision Today as a way to ... ophthalmologists have become in their respective patients’ treatments ... privy to a “secret” trove of pertinent information relevant ...
(Date:7/11/2014)... Recently, MagicQuinceaneraDresses.com, the popular online supplier ... of 2014 Quinceanera dresses . The company’s new ... look fashionable without paying a large amount of money. ... 57% off. , The company’s online shop has become ... special occasion outfits. In addition to exquisite Quinceanera dresses, ...
Breaking Medicine News(10 mins):Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 3Health News:New Super Digestive Enzyme, DZ10, Supercharges The Digestion Process 2Health News:SquareHook is Recognized for UVEF 25 Businesses Under 5 Years-Watch Out 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2
... 1 When Madonna sets out to adopt a child, ... people are being introduced to Malawi -- a small impoverished ... orphaned children range from 500,000 to over a million, help ... are raised in nurturing homes, with a mother and siblings, ...
... Honors Award(TM)RIDGEFIELD, Conn., April 1 Boehringer ... Association of Diversity Councils with the organization,s ... award recognizes the outstanding contributions of the ... lead diversity processes in their organizations and ...
... Pro:Idiom , Enable MSOs to Conveniently Deliver HD ... R.L. Drake , an American cable TV equipment ... solutions for over 65 years, has checked in as ... cable operators in the United States and Canada. ...
... exchange technology gives patients initial breast cancer screening ... unit FARMERVILLE, La., April 1 A breakthrough ... first time to over-40 women who live in ... http://www.newscom.com/cgi-bin/prnh/20090401/NY92660 ) ...
... with vascular birthmarks around the eye, even partial blockage ... amblyopia. Now a simple test can detect early ... vision testing, reports a study in the April issue ... http://www.elsevier.com/locate/ajo ) published by Elsevier. , Led by Dr. ...
... it Takes to Form a New Habit; Lack of Motivation ... Conn., April 1 According to ... brand bottled water, the number one bottled water brand in ... months or longer to form a new habit. However, experts ...
Cached Medicine News:Health News:In Malawi, Adoption is Not Enough 2Health News:Boehringer Ingelheim Recognized For Diversity And Inclusion Efforts 2Health News:Drake Nabs 'Suite Deal' as Distributor of Pro:Idiom(R) Hospitality Solution to U.S. and Canadian Cable Operators 2Health News:New Mobile Mammography Unit Offers Residents of Rural Northern Louisiana First-Ever Access to Free Breast Cancer Screening Exams 2Health News:New Mobile Mammography Unit Offers Residents of Rural Northern Louisiana First-Ever Access to Free Breast Cancer Screening Exams 3Health News:New Mobile Mammography Unit Offers Residents of Rural Northern Louisiana First-Ever Access to Free Breast Cancer Screening Exams 4Health News:Test allows early detection of vision problems in infants with hemangiomas of eyelids 2Health News:Video: New Survey Reveals Misconceptions About Forming New Habits 2Health News:Video: New Survey Reveals Misconceptions About Forming New Habits 3Health News:Video: New Survey Reveals Misconceptions About Forming New Habits 4
(Date:7/10/2014)... 2014  Major advances in radiation therapy and ... highlighted in a three-day Oncology Summit taking place ... 2014.  Renowned national and international cancer experts from seven ... exchange knowledge on modern technologies making treatment for ... The Summit will address a wide ...
(Date:7/10/2014)... SAN DIEGO , July 10, 2014  RESMED INC. ... report its fourth quarter and fiscal year ended June 30, ... York Stock Exchange market close. A press release with ResMed,s ... and the company will host a webcast to discuss operating ... scheduled to begin at 1:30 p.m. US Pacific Time and ...
(Date:7/10/2014)...  Decision Resources Group finds that while more ... are willing to prescribe Durata,s Dalvance (dalbavancin) and ... OPAT, approximately two-thirds of the respondents reported a ... inpatients. However, our findings indicate that nearly two-thirds ... OPAT following hospital discharge, and most are discharged ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
... 2 Questcor Pharmaceuticals, Inc . (Nasdaq: QCOR ) announced ... on Thursday, June 10, 2010 at The Grand Hyatt Hotel in ... Chief Executive Officer, will discuss the Company,s business strategy and historical financial performance ... , , ...
... CUPERTINO, Calif. , June 1 DURECT Corporation (Nasdaq: DRRX ) ... be presenting at the Jefferies Global Life Sciences Conference on Thursday, June 10 ... the Grand Hyatt Hotel in New York .   , ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO ) , , ...
Cached Medicine Technology:Questcor to Present at the Jefferies 2010 Global Life Sciences Conference 2DURECT to Present at the Jefferies Global Life Sciences Conference 2
Double Ended Occluders...
Double Ended Occluders...
Designed to provide occlusion while permitting observation of the eye. Helpful to determine if only one eye is deviating. Approximately 9 inches long....
Short handle occluders are about 6 inches long....
Medicine Products: