Navigation Links
Gene therapy reduces cocaine use in rats
Date:4/16/2008

UPTON, NY - Researchers at the U.S. Department of Energy's Brookhaven National Laboratory have shown that increasing the brain level of receptors for dopamine, a pleasure-related chemical, can reduce use of cocaine by 75 percent in rats trained to self-administer it. Earlier research by this team had similar findings for alcohol intake. Treatments that increase levels of these chemicals - dopamine D2 receptors -- may prove useful in treating addiction, according to the authors. The study will be published online April 16 and will appear in the July 2008 issue of Synapse.

"By increasing dopamine D2 receptor levels, we saw a dramatic drop in these rats' interest in cocaine," said lead author Panayotis (Peter) Thanos, a neuroscientist with Brookhaven Lab and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) Laboratory of Neuroimaging. "This provides new evidence that low levels of dopamine D2 receptors may play an important role in not just alcoholism but in cocaine abuse as well. It also shows a potential direction for addiction therapies."

The D2 receptor receives signals in the brain triggered by dopamine, a neurotransmitter needed to experience feelings of pleasure and reward. Without receptors for dopamine, these signals get "jammed" and the pleasure response is blunted. Previous studies at Brookhaven Lab have shown that chronic abuse of alcohol and other addictive drugs increases the brain's production of dopamine. Over time, however, these drugs deplete the brain's D2 receptors and rewire the brain so that normal pleasurable activities that stimulate these pathways no longer do - leaving the addictive drug as the only way to achieve this stimulation.

The current study suggests that cocaine-dependent individuals may have their need for cocaine decreased if their D2 levels are boosted. Thanos' lab previously demonstrated dramatic reductions in alcohol use in alcohol-preferring rats infused with dopamine D2 receptors (se
'/>"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Immunotherapy: enlisting the immune system to fight cancer
2. In blood vessel stents, innovative materials allow better control, delivery of gene therapy
3. Biomarker May Predict Response to Cancer Therapy
4. Penn researchers find targeted therapy combination overcomes treatment resistance in liver cancer
5. Rejuvasun(TM) With Omnilux(TM): Industry First to Feature FDA-Cleared, Clinically Proven Light Therapy Technology
6. Estrogen therapy increases benign breast disease risk
7. High-intensity chemotherapy does not improve survival in small cell lung cancer
8. Double binding sites on tumor target may provide future combination therapy
9. How Patients Can Meet the Criteria for Insulin Pump Therapy
10. New Legislation Would Expedite Medicare Patient Access to Physical Therapy
11. Stem cell research leads to potential new therapy for rare blood disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... 2014 This report studies the ... Handling Systems), Consumables (Tubes), Kits (Isolation, Purification), By ... - Global Forecast to 2018" This market was ... poised to grow at a CAGR of 5.9% ... by 2018. , Browse 98 market data Tables ...
(Date:8/22/2014)... Buying a policy for different life insurance products ... available coverage types by insurers in the U.S. The Quotes ... to the public using its sortable tool at http://quotespros.com/life-insurance.html ... and is expected to promote the discounts and special offerings ... U.S. The system is designed to help an adult locate ...
(Date:8/22/2014)... With the stage set for the ... Expo - which will be held in Boston August ... in its online opinion section, Podium. The op-ed ... co-authored by Steven C. Anderson, IOM, CAE, president & ... the MCPHS University School of Pharmacy – Worcester/Manchester. ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Japantown Dental ... a new teeth whitening technique. Air polishing is a ... appointments. , Dark teeth can be caused by a ... external stains and internal stains. External stains include coffee, ... be caused by certain medications, such as tetracycline, and ...
(Date:8/22/2014)... FL (PRWEB) August 22, 2014 Millennium Treatment ... marijuana, resulting in a high level of drug use among ... ages fight against drug addiction and work to minimize drug ... levels of alcohol and drug addiction in history. According to ... an estimated 23.9 million Americans aged 12 or older—or 9.2 ...
Breaking Medicine News(10 mins):Health News:Sample Preparation Market by Product and Application Worth $5,672 Million by 2018 - New Research Report by MarketsandMarkets 2Health News:Sample Preparation Market by Product and Application Worth $5,672 Million by 2018 - New Research Report by MarketsandMarkets 3Health News:Sample Preparation Market by Product and Application Worth $5,672 Million by 2018 - New Research Report by MarketsandMarkets 4Health News:Principal Life Insurance Policies Now Quoted for Adults at Insurance Website Online 2Health News:The Boston Globe Publishes Value of Pharmacy Op-ed as NACDS Total Store Expo Begins 2Health News:The Boston Globe Publishes Value of Pharmacy Op-ed as NACDS Total Store Expo Begins 3Health News:Japantown Dental Introduces Air Polishing 2Health News:Millennium Treatment Group Sees Increase in Marijuana Use Among Youth 2
... ... for health supplements, customers who want to reduce or reverse the signs of aging. ... ... -- Increased positive coverage by respected media outlets has helped clear up many of ...
... ... ... -- CMS Watch announced today that it has changed its name to The Real ... , , ,“The new name better reflects what we,ve been doing for nearly a decade: ...
... ... ... ... ...
... , ... ... ... ...
... ... ... ... ...
... Scientists from Sydney,s Garvan Institute of Medical Research have ... Biology , describing gene expression in a prostate cancer ... we could ever have imagined, even five years ago. ... cancer cell ,epigenome, (biochemical processes that target DNA and ...
Cached Medicine News:Health News:Sytropin HGH Shows Promising Anti-Aging Results 2Health News:CMS Watch Changes Name to The Real Story Group 2Health News:CMS Watch Changes Name to The Real Story Group 3Health News:Diabetics Twice as Likely to Have Hearing Loss; Massachusetts HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 2Health News:Diabetics Twice as Likely to Have Hearing Loss; Massachusetts HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 3Health News:Diabetics Twice as Likely to Have Hearing Loss; Massachusetts HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 4Health News:Diabetics Twice as Likely to Have Hearing Loss; Massachusetts HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 5Health News:ChildCare Education Institute Supports the First Lady's Efforts to Reduce Childhood Obesity 2Health News:ChildCare Education Institute Supports the First Lady's Efforts to Reduce Childhood Obesity 3Health News:ChildCare Education Institute Supports the First Lady's Efforts to Reduce Childhood Obesity 4Health News:ChildCare Education Institute Supports the First Lady's Efforts to Reduce Childhood Obesity 5Health News:Global Hospitals and Healthcare Suppliers Focus on Cutting Costs and Improving Quality at 2010 GHX Supply Chain Summit 2Health News:Global Hospitals and Healthcare Suppliers Focus on Cutting Costs and Improving Quality at 2010 GHX Supply Chain Summit 3Health News:Global Hospitals and Healthcare Suppliers Focus on Cutting Costs and Improving Quality at 2010 GHX Supply Chain Summit 4Health News:Global Hospitals and Healthcare Suppliers Focus on Cutting Costs and Improving Quality at 2010 GHX Supply Chain Summit 5Health News:What it might take to unravel the 'lean mean machine' that is cancer 2Health News:What it might take to unravel the 'lean mean machine' that is cancer 3
(Date:8/22/2014)... CHAPEL HILL, N.C. , Aug. 22, 2014 /PRNewswire/ ... pharmaceutical organizations and thought leaders in the healthcare sector. ... to evolve, the iPad is changing how Medical Science ... MSLs are using the tablet to ... physicians but also to better coordinate thought leader interactions ...
(Date:8/22/2014)... , August 22, 2014 ... Markets ( http://www.researchandmarkets.com/research/x34qgv/global_laboratory ) has announced the addition ... 2014-2018"  report to their offering.  ... is an essential instrument for any modern ... precise weighing of materials. It can be ...
(Date:8/22/2014)... Research and Markets ( ... the  "Global Operating Room Equipment Market 2014-2018" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,An operating room is ... a healthcare facility used to perform surgical ... equipment, which ensures patient care and enhanced ...
Breaking Medicine Technology:iPads Enhancing Medical Science Liaison Interactions with Thought Leaders, New Study Shows 2Global Laboratory Electronic Balance Market 2014-2018: Key Vendors are A&D Company, Mettler-Toledo, Sartorius and Thermo Fisher 2Global Operating Room Equipment Market 2014-2018: Key Vendors are Getinge, STERIS, Stykron and TRUMPF Medical Systems 2
... 2011 The Myth that physicians workload lessens ... with the New Year quickly approaching physicians are preparing for ... RNCOS depicts Healthcare IT spending by physicians and other healthcare ... this year, with most of it attributed to electronic health ...
... Therapeutics, Inc. (PTC) today announced the receipt of ... from the Wellcome Trust to support the development ... by multidrug-resistant (MDR) Gram-negative bacteria.  PTC previously received ... Trust to support its BMI1 oncology program. ...
Cached Medicine Technology:Medicalbillersandcoders.com Puts its Service Offers to Physicians Who Strive to Streamline Their Practice This Holiday Season! 2Medicalbillersandcoders.com Puts its Service Offers to Physicians Who Strive to Streamline Their Practice This Holiday Season! 3Medicalbillersandcoders.com Puts its Service Offers to Physicians Who Strive to Streamline Their Practice This Holiday Season! 4PTC Therapeutics' Antibacterial Program Receives $5 Million Award from the Wellcome Trust 2
... powder reagent once reconstituted offers the ... liquid stability to help maximize laboratory ... quick result turnaround time. The proprietary ... reagent provides a long shelf life ...
... AST (GOT) powder reagent once reconstituted offers ... liquid stability to help maximize laboratory productivity, ... turnaround time. The patented technology of the ... long shelf life and stability once reconstituted ...
LCD chart display...
... forceps are extremely delicate and if repairs ... they can easily be damaged beyond repair ... endoscopes. , On the other hand, with ... can have a virtually indefinite lifespan. The ...
Medicine Products: