Navigation Links
Gene therapy prevents memory problems in mice with Alzheimer's disease
Date:11/28/2010

," said Lennart Mucke, MD, director of the GIND and senior author of the study. "We were absolutely thrilled to discover that it did."

Increasing EphB2 levels in neurons of mice engineered to produce high levels of human amyloid proteins in the brain prevented their neurotransmission deficits, memory problems and behavioral abnormalities. The scientists also discovered that amyloid proteins directly bind to EphB2 and cause its degradation, which helps explain why EphB2 levels are reduced in AD and related mouse models.

"Based on our results, we think that blocking amyloid proteins from binding to EphB2 and enhancing EphB2 levels or functions with drugs might be of benefit in AD." said Mucke. "We are excited about these possibilities and look forward to pursuing them in future studies."


'/>"/>

Contact: Gary Howard
ghoward@gladstone.ucsf.edu
415-734-2044
Gladstone Institutes
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gene therapy for metastatic melanoma in mice produces complete remission
2. Neuralstem files FDA application for first drug therapy
3. Combination therapy improves survival time for patients with advanced liver cancer
4. Gene Therapy Shows Potential Against Heart Failure
5. Hearing loss common following radiation therapy for head and neck cancer
6. Targeted therapy reactivates guardian of the genome in resistant cancer
7. GUMC: fMRI predicts outcome to talk therapy in children with an anxiety disorder
8. Colorectal cancer risk increases in prostate cancer patients on androgen deprivation therapy
9. Fracture Risk Seen With Hormone Therapy for Prostate Cancer
10. Menopausal hormone therapy may increase risk of ovarian cancer
11. Side effects of hormonal breast cancer therapy increased; may affect treatment adherence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... ... June 30, 2015 , ... AvePoint, the established leader in ... new apps – AvePoint Watermark, AvePoint MyWorld, and AvePoint ... apps, workers can better streamline everyday business operations and take advantage of the latest ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... Intellitec Solutions ... Microsoft 2015 update to Dynamics CRM. With the enhanced changes and new procedures involved ... , The agenda will feature a look at the new user interface and what ...
(Date:6/30/2015)... , ... June 30, 2015 , ... ... launching MEDFLOW 2.0 EHR, a SaaS electronic health records system from the company ... evolution in software, Medflow 2.0 delivers an intuitive state-of-the-art solution combining modern cloud ...
(Date:6/30/2015)... ... June 30, 2015 , ... Curly Hair Solutions™ is honoured to attend Cosmoprof ... the US, featuring products from all over the world. For the first time ever, ... line of hair styling products focused entirely on meeting the needs of all ...
(Date:6/29/2015)... MA (PRWEB) , ... June 30, 2015 , ... ... Connecticut in early November at one of the industry’s premier thought leadership symposiums, ... 250 administrators, directors of nursing, rehabilitation managers and other management and corporate personnel ...
Breaking Medicine News(10 mins):Health News:AvePoint Enhances Workforce Productivity and Document Protection on Microsoft Office 365 with the Release of Three New Apps 2Health News:AvePoint Enhances Workforce Productivity and Document Protection on Microsoft Office 365 with the Release of Three New Apps 3Health News:AvePoint Enhances Workforce Productivity and Document Protection on Microsoft Office 365 with the Release of Three New Apps 4Health News:Intellitec Solutions to Host Microsoft CRM 2015 Update Webinar 2Health News:Medflow Launches MEDFLOW 2.0 EHR – The Cloud-Based Ophthalmology EHR 2Health News:Curly Hair Solutions™ Showcases Entire Curl Keeper™ Collection at Cosmoprof Las Vegas July 12 - 14 2Health News:Gov. Mark Parkinson, President and CEO of AHCA/NCAL to Give Keynote Address at Harmony 2015 2Health News:Gov. Mark Parkinson, President and CEO of AHCA/NCAL to Give Keynote Address at Harmony 2015 3
... UC Irvine neuroscientists have received $2 million to ... findings could lead to clinical research and treatment of ... UCI scientists hope to gain a greater understanding of ... the auditory cortex. , "We still don,t know how ...
... a new imprint devoted to the relationships between men and ... HOME. AFRAID TO GO HOME, a 420 page paperback, is ... advantage of at work by the Good Ol, Boys, and ... herself and her children from at home."One of the reasons ...
... to Consumer Reports Health News for health and ... issues pertaining to the efficacy and safety of ... health, diet and nutrition, food safety, and fitness. ... the effectiveness and affordability of prescription drugs, and ...
... Abnormal Heart RhythmsAUSTIN, Texas, March 3 On ... Institute at St. David,s Medical Center became the ... long-awaited NaviStar(R) RMT ThermoCool(R) Catheter to treat abnormal ... received FDA approval on Friday, Feb. 27, 2009.The ...
... effectiveness of the only tuberculosis vaccine approved for humans ... pre-clinical test, report scientists at The University of Texas ... ,s Advance Online Publication March 1. Their findings resulted ... the National Institutes of Health (NIH). , Bacille ...
... to zero, saves nearly $2 millionCARY, Ill., March 3 ... or immobilized are at a higher risk for the ... conditions that can significantly reduce quality of life. Establishment ... of heel protectors resulted in 100 percent prevention of ...
Cached Medicine News:Health News:AFRAID TO GO HOME, A Novel About Violence Against Women, Released By Tristan/Isolde Publishing 2Health News:Consumer Reports Health News 2Health News:Consumer Reports Health News 3Health News:Texas Cardiac Arrhythmia Institute at St. David's Medical Center First in Nation to Use NaviStar(R) RMT ThermoCool(R) Catheter Since Technology Received FDA Approval 2Health News:Texas Cardiac Arrhythmia Institute at St. David's Medical Center First in Nation to Use NaviStar(R) RMT ThermoCool(R) Catheter Since Technology Received FDA Approval 3Health News:TB breakthrough could lead to stronger vaccine 2Health News:TB breakthrough could lead to stronger vaccine 3Health News:Clinical Intervention Eliminates Heel Ulcer Incidents in ICU 2
(Date:6/29/2015)... June 29, 2015 ... (Troitsk) und Strand Life Sciences, weltweiter Marktführer ... Medizin, haben eine Kooperationsvereinbarung unterzeichnet. Laut Vereinbarung ... entwickeln, basierend auf NGS (Next-Generation Sequencing), für ... Formen von Epilepsie und primären Immundefizenz (PI)-Erkrankungen. ...
(Date:6/29/2015)... N.Y. and EWING, N.J. ...  (Nasdaq: CPXX ) today announced that The Leukemia ... a portion of the final payment linked to the ... lead product candidate, for the treatment of patients with ... moved forward payment of $400,000 originally attached to the ...
(Date:6/29/2015)... MOSCOW , June 29, 2015 /PRNewswire/ ... nanocenter TECHNOSPARK (Troitsk), and Strand Life Sciences, the ... personalized medicine, have signed a cooperation memorandum. According ... develop affordable tests based on next-generation sequencing (NGS) ... hereditary forms of epilepsy and primary immunodeficiency disorders ...
Breaking Medicine Technology:Das Genomic Center of Nanocenters 'Technospark' und 'Dubna', Russland und Strand Life Sciences, Indien werden gemeinsam Tests zur Diagnose von Erbkrankheiten entwickeln 2Das Genomic Center of Nanocenters 'Technospark' und 'Dubna', Russland und Strand Life Sciences, Indien werden gemeinsam Tests zur Diagnose von Erbkrankheiten entwickeln 3The Leukemia & Lymphoma Society Accelerates Milestone Payment Associated with the Phase 3 Study of CPX-351 in High Risk (Secondary) AML 2The Leukemia & Lymphoma Society Accelerates Milestone Payment Associated with the Phase 3 Study of CPX-351 in High Risk (Secondary) AML 3The Leukemia & Lymphoma Society Accelerates Milestone Payment Associated with the Phase 3 Study of CPX-351 in High Risk (Secondary) AML 4The Leukemia & Lymphoma Society Accelerates Milestone Payment Associated with the Phase 3 Study of CPX-351 in High Risk (Secondary) AML 5The Leukemia & Lymphoma Society Accelerates Milestone Payment Associated with the Phase 3 Study of CPX-351 in High Risk (Secondary) AML 6The Genomic Center of Nanocenters 'Technospark' and 'Dubna', Russia and Strand Life Sciences, India to Co-develop Tests for Diagnosis of Inherited Diseases 2The Genomic Center of Nanocenters 'Technospark' and 'Dubna', Russia and Strand Life Sciences, India to Co-develop Tests for Diagnosis of Inherited Diseases 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: