Navigation Links
Gene therapy prevents memory problems in mice with Alzheimer's disease
Date:11/28/2010

SAN FRANCISCO, CANovember 21, 2010 Scientists at the Gladstone Institute of Neurological Disease (GIND) in San Francisco have discovered a new strategy to prevent memory deficits in a mouse model of Alzheimer's disease (AD). Humans with AD and mice genetically engineered to simulate the disease have abnormally low levels of an enzyme called EphB2 in memory centers of the brain. Improving EphB2 levels in such mice by gene therapy completely fixed their memory problems. The findings will be published in the November 28 issue of the journal Nature.

In both humans and mice, learning and memory requires effective communication between brain cells called neurons. This communication involves the release of chemicals from neurons that stimulate cell surface receptors on other neurons. This important process, called neurotransmission, is impaired by amyloid proteins, which build up to abnormally high levels in brains of AD patients and are widely thought to cause the disease. But how exactly these poisonous proteins disrupt neurotransmission is unknown.

"EphB2 is a really cool molecule that acts as both a receptor and an enzyme," said Moustapha Cisse, PhD, lead author of the study. "We thought it might be involved in memory problems of AD because it is a master regulator of neurotransmission and its brain levels are decreased in the disease."

To determine if low EphB2 levels actually contribute to the development of memory problems, the investigators used gene therapy to experimentally alter EphB2 levels in memory centers of mice. Reducing EphB2 levels in normal healthy mice disrupted neurotransmission and gave them memory problems similar to those seen in AD. This finding suggests that the reduced EphB2 levels in AD brains contribute to the memory problems that characterize this condition.

"What we were most curious about, of course, was whether normalizing EphB2 levels could fix memory problems caused by amyloid proteins
'/>"/>

Contact: Gary Howard
ghoward@gladstone.ucsf.edu
415-734-2044
Gladstone Institutes
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gene therapy for metastatic melanoma in mice produces complete remission
2. Neuralstem files FDA application for first drug therapy
3. Combination therapy improves survival time for patients with advanced liver cancer
4. Gene Therapy Shows Potential Against Heart Failure
5. Hearing loss common following radiation therapy for head and neck cancer
6. Targeted therapy reactivates guardian of the genome in resistant cancer
7. GUMC: fMRI predicts outcome to talk therapy in children with an anxiety disorder
8. Colorectal cancer risk increases in prostate cancer patients on androgen deprivation therapy
9. Fracture Risk Seen With Hormone Therapy for Prostate Cancer
10. Menopausal hormone therapy may increase risk of ovarian cancer
11. Side effects of hormonal breast cancer therapy increased; may affect treatment adherence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... The University of California, Davis, and Academia Sinica, ... China (Taiwan), have entered into a collaborative agreement ... program that couples cutting-edge research with opportunities to ... new companies. , The agreement was signed Sept.12 ... research at UC Davis and President Chi-Huey Wong ...
(Date:9/23/2014)... Dallas, TX (PRWEB) September 23, 2014 ... be taken before making a purchase. It’s difficult to ... and it’s easy for them to manipulate their customers ... mitigate this dilemma, but they tend to lack in ... Consumer Health Reports was founded to fix this ...
(Date:9/23/2014)... TUESDAY, Sept. 23, 2014 (HealthDay News) -- A test used ... geographic regions where certain lung infections are more common, a ... lung cancer is through the use of what,s known as ... imaging called FDG-PET is used, according to the study authors. ... do parts of the lungs that don,t have ...
(Date:9/23/2014)... DC (PRWEB) September 23, 2014 ... care? The National Quality Forum (NQF) released ... ( http://www.qualityforum.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID=77687 ), and an infographic ( http://bit.ly/1tX3lzA ... rising cost of healthcare, how patients define affordability, ... consumers to get the best possible healthcare at ...
(Date:9/23/2014)... TUESDAY, Sept. 23, 2014 (HealthDay News) -- The ... unapproved prescription drugs is growing, so doctors need ... Food and Drug Administration warned Tuesday. In ... so widespread that it has launched a program ... and administrators about proper drug purchasing procedures. The ...
Breaking Medicine News(10 mins):Health News:Academia Sinica, UC Davis sign agreement on exchanges and tech transfer 2Health News:Consumer Health Reports Debuts Revolutionary Review Website 2Health News:Lung Infections May Hamper Ability to Detect Lung Cancer 2Health News:Finding Affordable Care: Asking the Right Question is Key 2
... Laura Rogers, project director for the Pew Campaign ... following statement regarding the U.S. Food and Drug Administration,s ... of certain antibiotics in animal agriculture: , ... animal agriculture helps fuel the increase in antibiotic-resistant infections ...
... Insurance,Company (John Hancock) is reinforcing its commitment to ... requirements through an,affiliation with the ClearCert Clearinghouse. ... the year and effective January 1, 2009,will only ... Since beginning ...
... (The Dignity of a Person), an Instruction from the Vatican ... issues arising from biomedical research, provides guidance on how to ... age, said Cardinal Francis George of Chicago, president of the ... , "We welcome the Instruction as theologians, medical ...
... calcium and vitamin D in fight against osteoporosis, study finds ... of protein and cereal grains causes excess acid production in ... result in weakened bones. , However, a new study finds ... plenty of fruits and vegetables can strengthen bones. , The ...
... 12 Bionovo, Inc.,(Nasdaq: BNVI ) will ... agent BN108 at the 31st Annual San Antonio Breast ... Center, San Antonio TX,December 10-14, 2008. , ... the pathway for cancer cell,apoptosis (cell death) induced by ...
... Chronic Hepatitis and Liver Diseases for not only treatment & diagnosis ... , ... (PRWEB) December 12, 2008 -- This year, from ... held the 2008 International Symposium on Chronic Hepatitis and ...
Cached Medicine News:Health News:Statement From The Pew Charitable Trusts on the U.S. Food and Drug Administration's Reversal on Antibiotics Safeguards in Animal Farming 2Health News:John Hancock Expands LTC Training Effort with ClearCert High Usage By Producers and Streamlines Process for Insurers 2Health News:John Hancock Expands LTC Training Effort with ClearCert High Usage By Producers and Streamlines Process for Insurers 3Health News:Dignitas Personae, Vatican Instruction on Bioethics, Welcomed for Guidance on Issues of Procreation, Medical Research 2Health News:Dignitas Personae, Vatican Instruction on Bioethics, Welcomed for Guidance on Issues of Procreation, Medical Research 3Health News:Dignitas Personae, Vatican Instruction on Bioethics, Welcomed for Guidance on Issues of Procreation, Medical Research 4Health News:Fruits and Veggies May Strengthen Bones 2Health News:Bionovo to Present Recent Findings of BN108, its Anticancer Agent, at the 31st Annual San Antonio Breast Cancer Symposium 2Health News:ITRI: Taiwan Focuses on C Liver Medic's R&D to Reach USD 6 Billion Potential Market in the World 2Health News:ITRI: Taiwan Focuses on C Liver Medic's R&D to Reach USD 6 Billion Potential Market in the World 3Health News:ITRI: Taiwan Focuses on C Liver Medic's R&D to Reach USD 6 Billion Potential Market in the World 4
(Date:9/23/2014)... -- This test can detect HIV infection if used 3 ... activities that can transfer body fluids from one person to ... needles. , An in-vitro diagnostic home-use test for ... works by looking for your body,s response to fighting the ... patients to learn their status in a single visit and ...
(Date:9/23/2014)... Research and Markets ( ... the  "Large Volume Wearable Injectors - 2nd ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... potential for the future. From the conventional ... the modern-day pre-filled syringes, pen-injectors, needle free ...
(Date:9/23/2014)... Rising health concerns, growing ... number of foreign and domestic players in the market ... India   The India Probiotic ... growth potential markets worldwide due to multiple factors such ... youth, changing food consumption patterns, increasing diabetic population, growing ...
Breaking Medicine Technology:WholeHealth Products announces the release of the FDA Cleared "HIV 1&2" Rapid Diagnostic Test for Professional and Retail 2Large Volume Wearable Injectors - 2nd Edition 2Large Volume Wearable Injectors - 2nd Edition 3Large Volume Wearable Injectors - 2nd Edition 4Large Volume Wearable Injectors - 2nd Edition 5India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 2India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 3
... Zimmer Holdings, Inc. (NYSE and SIX: ZMH) announced today that ... notes. The Company intends to use the ... of the outstanding borrowings under its credit facility and for ... Smith Incorporated, BNP Paribas Securities Corp. and RBS Securities Inc. ...
... 7, 2011 Vermillion, Inc. (NASDAQ: ... to present at the Stephens Fall Investment Conference. The conference ... New York City on November 15-16, 2011. Vermillion,s ... Wednesday, November 16, 2011 at 10:30 a.m. Eastern time, with ...
Cached Medicine Technology:Zimmer Holdings, Inc. Announces Offering of Senior Notes 2Vermillion to Present at Stephens Fall Investment Conference on November 16, 2011 2
... Sleepscan VISION ensures flexibility in system configuration ... VISION utilizes the powerful Netlink amplifier system, ... standard Ethernet connection. Only computer industry components ... Sleepscan VISION to take advantage of the ...
... From the Pioneer in Digital EEG ... Digital EEG system presents the latest ... the Ceegraph VISION. This innovative system ... remote communications and information management to ...
... MOBEE headboxes are ... XLTEK's line of portable ... with a robust new ... latest software, XLTEK's standard ...
... Slit Lamp is an all-in-one instrument for observation, ... also allows the SL 130 to be used ... the possibility of operating the slit projector in ... right hand. The instrument configuration allows you to ...
Medicine Products: