Navigation Links
Gene therapy increases survival for end-stage head and neck cancer
Date:5/28/2008

mmons Cancer Center in Dallas, are available at www.introgen.com.

Better Quality of Life

Patients treated with Advexin experienced far fewer harmful side effects such as pneumonia than those who received methotrexate. The incidence of inflammation of the mouth lining and a decrease in white blood cells, for example, both dropped to zero for those receiving Advexin.

"That certainly results in a better quality of life," Roth noted, which makes sense because p53 does not cause problems in normal cells.

Roth's lab has been developing gene therapy for cancer since 1990. "We wanted to go beyond conventional treatment, because most of those treatments were not very effective," Roth said. "Surgery and radiation are limited to the local tumor and once given, it's very hard to repeat those therapies. Chemotherapy inhibits DNA replication, but it also interferes with normal cells."

From idea to Phase I Trial at M. D. Anderson

All basic and preclinical work on the modified adenovirus was done at M. D. Anderson. The first phase I clinical trial was conducted by Gary Clayman, M.D., D.D.S., professor in M. D. Anderson's Department of head and neck surgery. Clayman also enrolled patients in the phase II and phase III clinical trials conducted by Introgen.

Roth and colleagues deleted an important region of the adenovirus' genome, preventing it from replicating. They installed a genomic segment that expresses p53. When injected into a tumor, the p53 adenovirus burrows into the cancer cell's nucleus. But instead of replicating in a typical viral manner, it expresses p53, resulting in cell death.

Clayman's phase I trial provided the first indicator that p53 expression in the tumor before treatment could be an accurate biomarker for p53 therapy. The concept was further developed retrospectively in Introgen's phase II trial, Roth said, and then it was applied prospe
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Vision restoration therapy shown to improve brain activity in brain injured patients
2. HIV therapy in pregnancy-data support WHO recommendations
3. Family-based treatment more effective than supportive psychotherapy in treating bulimia
4. Trial to Test Gene Therapy for Angina in Women
5. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
6. Aromatherapy Gift Line Sheds Humorous Light on Modern Therapy
7. Chemotherapy may be culprit for fatigue in breast cancer survivors
8. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
9. New Drug No Substitute for Standard Blood-Clot Therapy
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene therapy increases survival for end-stage head and neck cancer
(Date:7/22/2014)... Texas (PRWEB) July 22, 2014 ... progress in almost every sphere of human anatomy. ... brought forth advancements that rendered the possibility of ... samples, including blood and tissues, in order to ... concerning congenital abnormality. Essentially, In-vitro Diagnostics (IVD) have ...
(Date:7/22/2014)... People who suffer long-term sleep problems after a divorce ... a new study suggests. Previous research has linked ... but few studies have examined the reasons for this ... according to the University of Arizona investigators. Their ... divorced for about 16 weeks. They reported on the ...
(Date:7/22/2014)... Dennis Thompson HealthDay Reporter ... therapies for autism focus on the child, but new ... treatments designed specifically for them. Mothers of autistic ... found they connected better with their child and felt ... University, in Nashville. , , "Interventions have, for good ...
(Date:7/22/2014)... a cup of coffee and sit down to read People ... last before you reach for another cup? Would you need ... A new study in the Journal of Consumer Research ... as coffee and aspirin lose their effectiveness when they engage ... how long it takes for products to wear off. For ...
(Date:7/22/2014)... Medicine (BUSM) and Boston Medical Center (BMC) have ... Violence Intervention Advocacy Program (VIAP)--an interventional program targeting ... violently injured youthswere less likely to retaliate for ... connections to caring, steady, supportive adults who helped ... reported in the journal Academic Emergency Medicine ...
Breaking Medicine News(10 mins):Health News:Global Molecular Diagnostics Market Report 2014 Edition Now Available at MarketReportsOnline.com 2Health News:Global Molecular Diagnostics Market Report 2014 Edition Now Available at MarketReportsOnline.com 3Health News:Global Molecular Diagnostics Market Report 2014 Edition Now Available at MarketReportsOnline.com 4Health News:Sleepless Nights After Divorce May Be Tied to Blood Pressure Rise 2Health News:Parents of Children With Autism Need Help, Too 2Health News:Parents of Children With Autism Need Help, Too 3Health News:Why do challenging tasks make consumers believe drugs wear off faster? 2Health News:Clients of BMC's violence interventional advocacy program find experience supportive 2Health News:Clients of BMC's violence interventional advocacy program find experience supportive 3
... WASHINGTON, Aug. 31 As Congress prepares to return to ... least 102 rallies and other events in 20 states in ... insurance option. , , Events began Aug. ... returns to Washington, D.C.. They are taking place in California, ...
... , , , ... Diego-based MultiGEN Diagnostics Inc. has launched a novel multi-target DNA sequencing ... in molecular diagnostics. , , "Until now, lack ... market, forcing laboratories to adopt number of alternative methods such as ...
... , , VENTURA, Calif., Aug. 31 ... than to receive." However, when the gift one is giving is ... with more than 97 percent organic aloe vera, receiving and giving ... Founded by Rinaldo and Lalla Brutoco, owners of the manufacturer ...
... , , TORRANCE, ... not be top-of-mind for empty-nesters. But keeping with the spirit of ... on nutrition lessons, take stock of your medicine cabinet and challenge ... can still take advantage of summer,s fresh produce, ensuring a consistent ...
... need for meds, helped some lose weight compared to low-fat ... Mediterranean diet, long touted as a healthy eating plan, may ... medications, as well as help them lose weight and lower ... Italian researchers who found that while 70 percent of people ...
... rare autoimmune condition, new report finds , MONDAY, Aug. 31 ... Kennedy still exerts a pull on medical sleuths nearly 50 ... by a U.S. Navy physician claims that Kennedy suffered from ... was diagnosed with as a young man. , In the ...
Cached Medicine News:Health News:'Let's Get it Done!' From Coast to Coast, USAction Affiliates Rally This Week for Quality, Affordable Health Care 2Health News:Cost Effective Solution for Patient Testing: Introducing Comprehensive and Affordable Molecular Diagnosis With Verifiable Accuracy 2Health News:It's Better to Give Than to Receive 2Health News:It's Better to Give Than to Receive 3Health News:Change in Seasons: Ideal Time to Review Healthy Aging Habits 2Health News:Mediterranean Diet May Be Best for Type 2 Diabetes 2Health News:Mediterranean Diet May Be Best for Type 2 Diabetes 3Health News:JFK's Health Problems More Complex Than Thought 2Health News:JFK's Health Problems More Complex Than Thought 3
(Date:7/22/2014)... , July 22, 2014  ConvaTec, a privately-held medical ... Clerkin has been appointed chief financial officer of ... Clerkin was previously executive vice president and chief financial ... -based biotechnology company.  Mr. Clerkin was part of a ... Elan, culminating in its sale to Perrigo, a pharmaceutical ...
(Date:7/22/2014)... , July 22, 2014  UL (Underwriters ... that the U.S. Food and Drug Administration (FDA) ... consensus standards for medical devices incorporating lithium or ... - Standard for Household and Commercial Batteries, and ... Consensus standards are standards recognized ...
(Date:7/22/2014)... York , July 22, 2014 ... Partnerschaft für umfassenden Schutz von Pharmazeuten ... Österreich    Equashield ( ... Transfersystemen (Closed System Transfer Devices, CSTDs) für gefährliche ... einen Vertriebshändler und Hersteller von medizinischen ...
Breaking Medicine Technology:ConvaTec Names Nigel Clerkin Chief Financial Officer 2Two UL Battery Safety Standards Are now FDA Recognized Consensus Standards for Medical Devices 2Equashield ernennt Medikus zu seinem exklusiven österreichischen Vertriebspartner für seine geschlossenen Arzneimitteltransfersysteme 2
... CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 17, 2007 - Curis, ... novel targeted,medicines primarily for cancer treatment, today ... presentations at the 98th Annual Meeting,of the ... AACR, Curis also disclosed that its April ...
... 17, 2007 /PRNewswire-FirstCall/ --,Telik, Inc. announced the ... clinical trial of the triplet combination of ... the,first-line treatment of advanced non-small cell lung ... significant,improvement in both progression-free survival and overall ...
Cached Medicine Technology:Curis Announces Hedgehog and Wnt Antagonist Data Presentation at,AACR 2Curis Announces Hedgehog and Wnt Antagonist Data Presentation at,AACR 3Curis Announces Hedgehog and Wnt Antagonist Data Presentation at,AACR 4Telik Reports Positive Data Demonstrating Synergy in Combination,and Highly Statistically Significant Effect of Telcyta as,Maintenance Therapy in First-Line Non-Small Cell Lung Cancer 2Telik Reports Positive Data Demonstrating Synergy in Combination,and Highly Statistically Significant Effect of Telcyta as,Maintenance Therapy in First-Line Non-Small Cell Lung Cancer 3Telik Reports Positive Data Demonstrating Synergy in Combination,and Highly Statistically Significant Effect of Telcyta as,Maintenance Therapy in First-Line Non-Small Cell Lung Cancer 4
A patient care system tailored to your specific needs that supports current and previous-generation ICDs and pacemakers....
The Safire Bi-directional Ablation Catheter with ComfortGrip Handle is impeccably designed to provide superb comfort, usability, efficiency and adaptability. It is the perfect addition to your EP pro...
... new Guidant VASOVIEW® HemoPro™ EVH ... a new level of performance ... both the saphenous vein and ... capability, it lets you make ...
...
Medicine Products: