Navigation Links
Gene therapy increases survival for end-stage head and neck cancer
Date:5/28/2008

HOUSTON - A gene therapy invented at The University of Texas M. D. Anderson Cancer Center is the first to succeed in a U.S. phase III clinical trial for cancer, as announced today at the American Society of Gene Therapy annual meeting in Boston.

Introgen Therapeutics, Inc., reported results of its phase III trial of Advexin(r), a modified adenovirus that expresses the tumor-suppressing gene p53, for end-stage head and neck cancer.

"Cells become cancerous because p53 no longer functions. Restoring p53 works unlike any current cancer treatment because it treats the cancer genome," said Jack Roth, M.D., professor in M. D. Anderson's Department of Thoracic & Cardiovascular Surgery, who invented the drug and co-founded Introgen. He remains a shareholder and paid consultant to Introgen, and the University of Texas System is also a shareholder in Introgen.

The p53 gene is inactivated in many types of cancer. Its normal role is to halt the division of a defective cell and then force the cell to kill itself.

The trial showed that p53 expression in the patient's tumor before treatment is a reliable biomarker for how to treat head and neck cancer. Patients with a favorable p53 profile who received Advexin(r) had a median survival of 7.2 months, compared with 2.7 months for those whose tumor expressed high levels of mutant p53 before treatment. Patients with this unfavorable profile were better off taking the chemotherapy drug methotrexate, resulting in median survival of 5.9 months.

"The important finding is that patients who benefit from treatment can be identified with the p53 biomarker. The biomarker will enable physicians to personalize treatment," said Roth, who also directs M. D. Anderson's W.M. Keck Center for Innovative Cancer Therapies.

Detailed results of the 123-patient clinical trial, led by John Nemunaitis, M.D., executive director of the Mary Crowley Medical Research Center at Baylor-Charles A. Sa
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Vision restoration therapy shown to improve brain activity in brain injured patients
2. HIV therapy in pregnancy-data support WHO recommendations
3. Family-based treatment more effective than supportive psychotherapy in treating bulimia
4. Trial to Test Gene Therapy for Angina in Women
5. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
6. Aromatherapy Gift Line Sheds Humorous Light on Modern Therapy
7. Chemotherapy may be culprit for fatigue in breast cancer survivors
8. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
9. New Drug No Substitute for Standard Blood-Clot Therapy
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene therapy increases survival for end-stage head and neck cancer
(Date:4/21/2015)... 2015 My Patriot Supply is proud ... latest innovation in home water filtration: Alexapure Pro™ ... that makes existing gravity-fed filters obsolete. An unprecedented advancement ... industry standards for water filtration. With an optimized flow ... typical household. , The Alexapure Pro™ takes a unique, ...
(Date:4/21/2015)... Sinking Spring, PA (PRWEB) April 21, 2015 ... neighboring Berks County commercial printer, Offset Impressions. ... with its full line of printing capabilities and knowledgeable ... Grafika. “This acquisition allows us to offer an ... addition to the labeling, packaging, and specialty services we ...
(Date:4/21/2015)... The California Healthcare Institute (CHI), ... sciences organizations, released the following statement by CHI ... Assembly Bill (AB) 463: , “As innovators in ... of treatments and cures for patients with serious ... AB 463, the so-called Pharmaceutical Cost Transparency Act ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 Information is the ... Kevin Ryan, MD, FACP, empowers patients and their families with ... is the Rumor and Cancer is the Answer" and ... and informative language to guide patients from diagnosis through treatment ... patients active participants in their treatment, at home and in ...
(Date:4/21/2015)... 2015 The report “Dermatitis ... analysis on the therapeutic development for Dermatitis. ... identifying new targets and MOAs to produce ... TOC is available @ http://www.rnrmarketresearch.com/dermatitis-pipeline-review-h1-2015-market-report.html ... players involved in the therapeutic development for ...
Breaking Medicine News(10 mins):Health News:Preparedness Leader My Patriot Supply Unveils the New Alexapure Pro™ Water Filter 2Health News:California Healthcare Institute Statement on AB 463 2Health News:California Healthcare Institute Statement on AB 463 3Health News:Authoritative guide and new accompanying therapeutic web portal bridge information gaps in cancer treatment 2Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 2Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 3Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 4
... Sept. 30 Heartland Information Services, a national provider ... Himes to President and Chief Executive Officer. Previously Chief ... the President and CEO position immediately. , Himes will ... who has accepted a new position with Reichert, Inc. ...
... NEW YORK (Sept. 30, 2009) -- New research by ... ways parents and peers influence teenagers to smoke, drink ... toward smoking influenced teenagers, use of multiple drugs (smoking, ... in boys and girls. For girls, friends were ...
... system made of billions of neurons and thousands of ... of the strongest emotions, fear. Most neurological fear studies ... Missouri researchers have started using computational models of the ... Guoshi Li, an electrical and computer engineering doctoral student, ...
... a third of U.S. victims were also infected with pneumococcus ... News) -- Bacterial co-infections are common among people who have ... probably contributed to their deaths, according to a new federal ... Control and Prevention analyzed lung tissue samples from 77 people ...
... U.S. Food and Drug Administration today announced the availability ... Evaluation and Mitigation Strategies or REMS, which are required ... http://www.newscom.com/cgi-bin/prnh/20090824/FDALOGO ) , The Food and Drug ... the authority to require the submission and implementation of ...
... ARLINGTON, Va. and BOSTON, Sept. 30 On November 16, ... GO! and Boston creative group CloudKid, invite early elementary school ... and friends in FIZZY,S LUNCH LAB ( PBSKIDSGO.org/lunchlab ... good and bad food, and learn what happens once the ...
Cached Medicine News:Health News:Heartland Information Services Appoints New Chief Executive Officer 2Health News:Teen attitudes toward smoking linked to likelihood of drinking and using drugs 2Health News:Researchers use computational models to study fear 2Health News:CDC Links Infections With Swine Flu Deaths 2Health News:CDC Links Infections With Swine Flu Deaths 3Health News:FDA Issues Draft Guidance on Risk Evaluation and Mitigation Strategies 2Health News:Video: Laughter is the Key Ingredient in 'FIZZY'S LUNCH LAB,' a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org 2Health News:Video: Laughter is the Key Ingredient in 'FIZZY'S LUNCH LAB,' a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org 3Health News:Video: Laughter is the Key Ingredient in 'FIZZY'S LUNCH LAB,' a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org 4Health News:Video: Laughter is the Key Ingredient in 'FIZZY'S LUNCH LAB,' a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org 5Health News:Video: Laughter is the Key Ingredient in 'FIZZY'S LUNCH LAB,' a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org 6
(Date:4/21/2015)... -- A groundbreaking new, minimally invasive outpatient treatment option ... is now readily available to the estimated 1 million ... who suffer from this condition. ... leading practitioner of this safe, effective, Federal Drug Administration-approved ... new Los Angeles -area medical centers ...
(Date:4/21/2015)... 2015 Oxfordshire ... more than doubled its overseas sales in just 4 ... winning the Queen,s Award for Enterprise, for Outstanding Achievement ... first HealthScience Communications consultancy, helping its clients bring new ... Having more than doubled its exports in just 4 ...
(Date:4/21/2015)... Cardiologists at Henry Ford Hospital have implanted a ... an irregular heartbeat. With only handful of hospitals ... is able to add another option to its arsenal of ... heart,s ability to pump. "This is a ... Watchman implant at a non-clinical trial site," says cardiologist ...
Breaking Medicine Technology:New Minimally Invasive Treatment for Uterine Fibroids Offers Life-Changing Relief, Without a Hysterectomy, to 1 Million Southern California Women 2New Minimally Invasive Treatment for Uterine Fibroids Offers Life-Changing Relief, Without a Hysterectomy, to 1 Million Southern California Women 3New Minimally Invasive Treatment for Uterine Fibroids Offers Life-Changing Relief, Without a Hysterectomy, to 1 Million Southern California Women 4Queen's Award Crowns Achievements of Local Consultancy 2Queen's Award Crowns Achievements of Local Consultancy 3Queen's Award Crowns Achievements of Local Consultancy 4Queen's Award Crowns Achievements of Local Consultancy 5Stroke Risk Caused by Abnormal Heart Rhythm Reduced Without Blood Thinners 2Stroke Risk Caused by Abnormal Heart Rhythm Reduced Without Blood Thinners 3
... has been approved for use as an ... seizures in adults and adolescents over 12 ... that are refractory to antiepileptic medications. This ... controlled, clinical trials. Efficacy, measured as median ...
... Electrodes share similar characteristics with ... difference is that all of ... to assist you intraoperatively. In ... for use with either our ...
State-of-the-art sleep recording and analysis...
... workstation is a medical device designed to ... video capability, and archiving demands of the ... A framework that helps organize workflow and ... A centralized database and powerful search capability ...
Medicine Products: