Navigation Links
Gene therapy improves survival and quality of life of dogs with cancer
Date:6/16/2008

A new gene therapy has helped pet dogs with cancer live longer and could potentially improve the quality of life and survival of people with cancer, said the therapy's developers. The results of the animal study will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.

The single treatment works by increasing muscle strength and correcting common complications of cancer such as weakness, weight loss and anemia, said principal investigator Ruxandra Draghia-Akli, MD, PhD, researcher, VGX Pharmaceuticals Inc., The Woodlands, Tex.

Such complications occur in more than 50 percent of patients with cancer and, along with loss of appetite and fatigue, result in poor quality of life, she said. If cachexiamuscle wasting and severe weight lossdevelops, it can prevent cancer-specific therapy from being given and may be a direct cause of death.

"With our type of gene therapy," Draghia-Akli said, "we can 'trick' certain types of cells in the body to naturally produce specific hormones." These hormones have a muscle-building, or anabolic, effect.

The therapy uses a nonviral DNA molecule, called a plasmid, which encodes for growth hormone-releasing hormone (GHRH). This stimulates the endogenous growth hormone and another growth substance, insulin-like growth factor-1 (IFG-1), which have anabolic effects.

The therapeutic process involves injecting the DNA fragment into a muscle and applying electroporationshort, mild, controlled electric fieldsin the area of the injection. It opens the cell membrane pores and traps the DNA inside the cells, which allows the production of GHRH. This thwarts the body's natural process of eliminating a foreign body, in this case the DNA molecule, Draghia-Akli explained.

The researchers tested the gene therapy in 55 companion dogs that had cancer and anemia and were receiving cancer treatment. Three months after the injection, 54 percent of the dogs had responded to gene
'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Vision restoration therapy shown to improve brain activity in brain injured patients
2. HIV therapy in pregnancy-data support WHO recommendations
3. Family-based treatment more effective than supportive psychotherapy in treating bulimia
4. Trial to Test Gene Therapy for Angina in Women
5. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
6. Aromatherapy Gift Line Sheds Humorous Light on Modern Therapy
7. Chemotherapy may be culprit for fatigue in breast cancer survivors
8. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
9. New Drug No Substitute for Standard Blood-Clot Therapy
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... (PRWEB) April 18, 2015 Lowcostcarinsuranceprice.com has ... theft rates have on auto insurance prices . ... high rates of vehicle theft may have to pay ... Some liability auto insurance policies can also offer protection ... can now be compared online on a single website: ...
(Date:4/18/2015)... April 18, 2015 Patients who undergo ... developing mesothelioma later in life, but the disease is ... that is unrelated to radiation. Surviving Mesothelioma has just ... website. Click here to read it now. ... the cases of 45 patients who had both a ...
(Date:4/18/2015)... In the past few weeks, TheBeautyPlace.com has been ... had to run maintenance on our shipping facilities to ... the PR Director. "It disrupted our regular shipping schedule ... back on track after having completed the maintenance." , ... systems which has not allowed some calls to come ...
(Date:4/18/2015)... On April 14th, 2015, Symantec released Volume 20 ... “exposes a tactical shift by cyberattackers.” With everything from frightening ... 2014 - almost a million a day - to how ... and patched by prominent manufacturers – as long as 204 ... a digital world can be fraught with peril, and that ...
(Date:4/18/2015)... “ ArcAngel ” was featured on NewsWatch as part ... latest and coolest applications on the market for ... and technology expert, conducted the app review and shared with ... In a turbulent world, people may find themselves in dangerous ... their first move, but some situations can be avoided if ...
Breaking Medicine News(10 mins):Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2Health News:New Study Examines Relationship Between Radiation for Hematologic Cancers and Development of Mesothelioma, According to Surviving Mesothelioma 2Health News:TheBeautyPlace.com Temporary Number Available 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:A Personal Safety Application was Featured on NewsWatch Television 2
... DALLAS June 3, 2009 A simple magnetic resonance ... the best treatment for some cancer patients, report researchers at ... that the amount of oxygen present in a tumor can ... to treatment. Tumors with little oxygen tend to grow stronger ...
... 2 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical,Inc. ("China Sky ... ), a leading,fully integrated pharmaceutical company producing over-the-counter drugs ... it obtained,approval from the State Food and Drug Administration ... drops. The document number for the drug is,2009S02063. , ...
... , This release is available in <A ... induce cells from pigs to transform into pluripotent stem ... capable of developing into any type of cell in ... world that this has been achieved using somatic cells ...
... than 25 years of experience to support growing demand ... June 2 Covance Inc. today announced Monte Jarvis ... for periapproval services. With more than 25 years ... global data management, Jarvis will oversee data management and ...
... June 2 The National Press Club Newsmaker ... Wednesday, June 3, with Argonne National Laboratory Director ... and cannot travel to Washington. , , ... ) , , The press conference ...
... Foundation,s Annual Salute to Service Award , , ... consecutive year, Jim Kerwin of Oxford Communications ( www.oxfordcommunications.bm ... that Oxford Communications will be the primary sponsor of ... Luncheon on June 17th and Celebrity Golf Tournament to ...
Cached Medicine News:Health News:Oxygen + MRI might help determine cancer therapy success, researchers find 2Health News:China Sky One Medical, Inc. Obtains SFDA Approval for Diclofenac Sodium Eye Drops 2Health News:China Sky One Medical, Inc. Obtains SFDA Approval for Diclofenac Sodium Eye Drops 3Health News:World first: Chinese scientists create pig stem cells 2Health News:World first: Chinese scientists create pig stem cells 3Health News:Covance Announces Monte Jarvis as Vice President of Global Data Management and Biostatistics for Periapproval Services 2Health News:Covance Announces Monte Jarvis as Vice President of Global Data Management and Biostatistics for Periapproval Services 3Health News:Jim Kerwin Announces Oxford Communications To Be the Title Sponsor of Bermuda Health Foundation Salute for the Second Year 2
(Date:4/17/2015)... ADELAIDE, Australia , April 17, 2015 ... the discovery and development of innovative therapeutics for the ... system, today announced the presentation of data from three ... American Association for Cancer Research (AACR) 106 th ... Philadelphia, PA USA. ...
(Date:4/16/2015)... , April 16, 2015  Hologic, Inc. ... cervical cancer screening study i published on-line ... peer-reviewed journal of the American Cancer Society. ... and the University of Pittsburgh Medical Center, supports current consensus ... recommend that women 30-65 years of age be ...
(Date:4/16/2015)... , April 16, 2015  Diplomat Pharmacy, Inc. ... Shannon Beltrand to their senior leadership team as ... be responsible for securing and properly monitoring Diplomat,s data, ... both internally and externally. Additionally, she will play key ... "We are very excited to have someone ...
Breaking Medicine Technology:Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 3Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 4Diplomat Names Shannon M. Beltrand as New CISO 2
... The Coolscope operates with a simple ... monitor display. Direct the mouse cursor ... macro image of the slide and ... The intuitive Graphic User Interface (GUI) ...
Advanced ergonomic design allows greater comfort even after long hours of use. The focus knob and stage handle are located equidistant from the operator, permitting one-handed operation in a natural ...
... laboratory microscope whose superior ergonomics, ... to make it the ideal ... designed to fit the user ... to fit the microscope. Optimized ...
Carbide drill bits, cutters, side cutting. Available in various sizes....
Medicine Products: