Navigation Links
Gene therapy improves survival and quality of life of dogs with cancer
Date:6/16/2008

A new gene therapy has helped pet dogs with cancer live longer and could potentially improve the quality of life and survival of people with cancer, said the therapy's developers. The results of the animal study will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.

The single treatment works by increasing muscle strength and correcting common complications of cancer such as weakness, weight loss and anemia, said principal investigator Ruxandra Draghia-Akli, MD, PhD, researcher, VGX Pharmaceuticals Inc., The Woodlands, Tex.

Such complications occur in more than 50 percent of patients with cancer and, along with loss of appetite and fatigue, result in poor quality of life, she said. If cachexiamuscle wasting and severe weight lossdevelops, it can prevent cancer-specific therapy from being given and may be a direct cause of death.

"With our type of gene therapy," Draghia-Akli said, "we can 'trick' certain types of cells in the body to naturally produce specific hormones." These hormones have a muscle-building, or anabolic, effect.

The therapy uses a nonviral DNA molecule, called a plasmid, which encodes for growth hormone-releasing hormone (GHRH). This stimulates the endogenous growth hormone and another growth substance, insulin-like growth factor-1 (IFG-1), which have anabolic effects.

The therapeutic process involves injecting the DNA fragment into a muscle and applying electroporationshort, mild, controlled electric fieldsin the area of the injection. It opens the cell membrane pores and traps the DNA inside the cells, which allows the production of GHRH. This thwarts the body's natural process of eliminating a foreign body, in this case the DNA molecule, Draghia-Akli explained.

The researchers tested the gene therapy in 55 companion dogs that had cancer and anemia and were receiving cancer treatment. Three months after the injection, 54 percent of the dogs had responded to gene therapy, as apparent on blood testing. Dogs that responded to therapy survived 84 percent longer, compared with dogs that did not respond to gene therapy and untreated control dogs that received a placebo injection. Although the response rate dropped to 47 percent at 4 months, it was still 22 percent higher than in control dogs.

Also, study data showed quality of life, especially appetite, dramatically improved with the gene therapy, and complications of chemotherapy, such as vomiting and diarrhea were greatly reduced,


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Vision restoration therapy shown to improve brain activity in brain injured patients
2. HIV therapy in pregnancy-data support WHO recommendations
3. Family-based treatment more effective than supportive psychotherapy in treating bulimia
4. Trial to Test Gene Therapy for Angina in Women
5. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
6. Aromatherapy Gift Line Sheds Humorous Light on Modern Therapy
7. Chemotherapy may be culprit for fatigue in breast cancer survivors
8. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
9. New Drug No Substitute for Standard Blood-Clot Therapy
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... ... , ... Ellevate Network, the leading network for professional women, brought together some ... at their inaugural Summit in New York City in June. The event was livestreamed ... over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/13/2017)... ... , ... “America On The Brink”: the Christian history of the United States ... creation of published author, William Nowers. Captain Nowers and his wife, Millie, have ... thirty years in the Navy. Following his career as a naval aviator and ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... Oct. 6, 2017   Provista, a proven ... $100 billion in purchasing power, today announced a new ... The Newsroom is the online home for ... infographics, expert bios, news releases, slideshows and events. ... a wealth of resources at their fingertips, viewers can ...
(Date:10/2/2017)... 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... and Consulting, LLC , and named its founder as ... in Tennessee , will operate under ... EnvoyHealth,s service offerings for health care partners to include ... "In an interoperable world, technology delivers ...
(Date:9/28/2017)... CHICAGO , Sept. 28, 2017 Hill-Rom ... quarter 2017 earnings conference call and webcast on Friday, ... 8:00 a.m. (EDT) and ending at approximately 8:30 a.m. ... to discussing the company,s 2017 financial performance and guidance ... growth opportunities, initiatives to enhance operational performance, and long-range ...
Breaking Medicine Technology: