Navigation Links
Gene therapy improves survival and quality of life of dogs with cancer
Date:6/16/2008

A new gene therapy has helped pet dogs with cancer live longer and could potentially improve the quality of life and survival of people with cancer, said the therapy's developers. The results of the animal study will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.

The single treatment works by increasing muscle strength and correcting common complications of cancer such as weakness, weight loss and anemia, said principal investigator Ruxandra Draghia-Akli, MD, PhD, researcher, VGX Pharmaceuticals Inc., The Woodlands, Tex.

Such complications occur in more than 50 percent of patients with cancer and, along with loss of appetite and fatigue, result in poor quality of life, she said. If cachexiamuscle wasting and severe weight lossdevelops, it can prevent cancer-specific therapy from being given and may be a direct cause of death.

"With our type of gene therapy," Draghia-Akli said, "we can 'trick' certain types of cells in the body to naturally produce specific hormones." These hormones have a muscle-building, or anabolic, effect.

The therapy uses a nonviral DNA molecule, called a plasmid, which encodes for growth hormone-releasing hormone (GHRH). This stimulates the endogenous growth hormone and another growth substance, insulin-like growth factor-1 (IFG-1), which have anabolic effects.

The therapeutic process involves injecting the DNA fragment into a muscle and applying electroporationshort, mild, controlled electric fieldsin the area of the injection. It opens the cell membrane pores and traps the DNA inside the cells, which allows the production of GHRH. This thwarts the body's natural process of eliminating a foreign body, in this case the DNA molecule, Draghia-Akli explained.

The researchers tested the gene therapy in 55 companion dogs that had cancer and anemia and were receiving cancer treatment. Three months after the injection, 54 percent of the dogs had responded to gene
'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Vision restoration therapy shown to improve brain activity in brain injured patients
2. HIV therapy in pregnancy-data support WHO recommendations
3. Family-based treatment more effective than supportive psychotherapy in treating bulimia
4. Trial to Test Gene Therapy for Angina in Women
5. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
6. Aromatherapy Gift Line Sheds Humorous Light on Modern Therapy
7. Chemotherapy may be culprit for fatigue in breast cancer survivors
8. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
9. New Drug No Substitute for Standard Blood-Clot Therapy
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... York (PRWEB) December 25, 2014 Thousands ... to move forward in a number of multidistrict litigations ... West Virginia, Bernstein Liebhard LLP reports. According to an ... scheduled to convene a Joint Status Conference in all ... a.m. Parties have been directed to submit a proposed ...
(Date:12/25/2014)... Phoenix, AZ (PRWEB) December 25, 2014 ... comes to outstanding customer service and affordable quality regarding ... metropolitan area announces recognition in 2014 by the “Queen ... and Sons has earned an impressive reputation over the ... pricing on a wide range of contractor services for ...
(Date:12/24/2014)... December 25, 2014 Recently, iFitDress.com, a famous ... of prom dresses under $150 . All these items are ... company’s website has already been updated with the new range ... been ordered so far. All iFitDress.com’s designs are made according ... on using great materials. Every outfit from the company is ...
(Date:12/24/2014)... Today, UWDress.com, the famous women’s dress supplier, has presented its ... site-wide wedding gown promotion. , For those who ... unexpected way, the collection should be a great choice. The ... and they are available with custom service. , Now, all ... up to 75% off; most of them come in hot ...
(Date:12/24/2014)... HealthDay Reporter TUESDAY, Dec. 23, 2014 ... sex for one year will be allowed to donate blood in ... a 31-year ban on donations from men who have sex with ... intention to release a new draft guidance in early 2015 that ... The FDA is changing its policy based on data from ...
Breaking Medicine News(10 mins):Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3Health News:Many Prom Dresses under 150 from Well-known Dress Manufacturer iFitDress.com 2Health News:Buy Cheap Long Sleeve Wedding Gowns At UWDress.com 2Health News:FDA to Lift Ban on Blood Donations by Gay Men 2Health News:FDA to Lift Ban on Blood Donations by Gay Men 3
... Ellex Medical Lasers,Limited (ASX: ELX) today announced another ... of a direct sales channel in Germany -- ... the European Society of Cataract and,Refractive Surgeons (ESCRS) ... will focus initially on sales of Ellex laser ...
... Bail-out from Family Members to Pay for ... Medical Bills, 30% of Consumers Receiving Care for a Critical ... ... women to,use credit cards to pay for major medical recovery expenses and both sexes,largely agree ...
... If a stressful day at,work finds you lunging ... of ice cream, you,re,not alone. Millions of Americans ... with The Vitamin Code(TM) Perfect Weight multivitamin (, ... with human,clinical research demonstrating its ability to help ...
... virtual shopping, www.personalcaredeals.com was recently launched to the online ... of their needs for those pampering moments. Pampering one,s self ... , ... (PRWEB) September 10, 2008 -- Premised upon ...
... publisher of online health information since ... [website for expectant parents, parents, ... birth to adolescence] to provide important ... website contains physician-developed and -monitored information ...
... September 10 ,Essilor is pursuing its growth strategy ... in Omega Optix. The company is a leading,operator ... prescription,laboratories generate total revenue of more than EUR10 ... viability of a recognized market,player, the acquisition will ...
Cached Medicine News:Health News:Ellex Commences Direct Sales in Germany 2Health News:Guardian Survey: Men are Twice as Likely as Women to Use Credit Cards to Pay for Major Health Expenses 2Health News:Guardian Survey: Men are Twice as Likely as Women to Use Credit Cards to Pay for Major Health Expenses 3Health News:Guardian Survey: Men are Twice as Likely as Women to Use Credit Cards to Pay for Major Health Expenses 4Health News:Guardian Survey: Men are Twice as Likely as Women to Use Credit Cards to Pay for Major Health Expenses 5Health News:Guardian Survey: Men are Twice as Likely as Women to Use Credit Cards to Pay for Major Health Expenses 6Health News:Stress-Related and Emotional Eating Can Be Curbed With the Vitamin Code(TM) Perfect Weight Formula 2Health News:Stress-Related and Emotional Eating Can Be Curbed With the Vitamin Code(TM) Perfect Weight Formula 3Health News:A One-Stop Online Shop For Personal Pampering Needs 2Health News:A One-Stop Online Shop For Personal Pampering Needs 3Health News:Pediatrichealthchannel.com - New Site for Parents Seeking Answers to Children's Health Questions 2Health News:Pediatrichealthchannel.com - New Site for Parents Seeking Answers to Children's Health Questions 3
(Date:12/24/2014)... Ohio , Dec. 23, 2014   ... treatment decision support to healthcare providers for behavioral ... it has secured $30 million in equity financing ... Virginia C. Drosos , President and Chief Executive ... clinical adoption and development of Assurex Health,s ...
(Date:12/24/2014)... RALEIGH, N.C. , Dec. 23, 2014 ... plc (NASDAQ: ENDP ) (TSX: ENL), and ... announced today that they have submitted a New Drug ... U.S. Food and Drug Administration (FDA).  Buprenorphine HCl Buccal ... severe enough to require daily, around-the-clock, long-term opioid treatment ...
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) ... Blood Glucose Market" report to their offering. ... market insight focuses on the developments in the self-monitoring ... . Reimbursement analysis and the effects of competitive ... than 73 SMBG meters have been performed, based on ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5US Self-monitoring Blood Glucose Market 2
The care package includes a spare motor, fuse, Spare Fluorescent Bulb, additional Vibratome Feather Blades, Specimen Adhesive, Specimen Mounting Blocks, and a Specimen Tray....
... (10 to 12) brain slices to be ... maintaining excellent viability. A mixture of 95% ... This initiates a circular flow and oxygen ... Slices remain viable for hours while awaiting ...
... provides a convenient reservoir of cooling water for the ... extended period of time or in a location which ... the hot side of the thermoelectric heat pump. ... is adequate to run the 900R for up to ...
Punch set for Advanced Tissue Arrayer, 0.6 mm...
Medicine Products: