Navigation Links
Gene 'switch' reverses cancer in common childhood leukaemia
Date:6/17/2014

ight on the function of Pax5, which was one of about 100 genes known to 'suppress' human tumours. "When these tumour suppressor genes are inactivated by changes to the DNA, cancers start to develop," Dr Dickins said.

"This work shows how inactivating the tumour suppressor gene Pax5 contributes to B-ALL development and how leukaemia cells become 'addicted' to low Pax5 levels to continue proliferating. Even though the B-ALL cells have multiple genetic mutations, simply reactivating Pax5 causes tumour cells to resume normal development and lose their cancerous properties."

Dr Dickins said forcing B-ALL cells to resume their normal development could provide a new strategy for treating leukaemia. "While B-ALL has a relatively good prognosis compared with other cancers, current treatments can last years and have major side-effects. By understanding how specific genetic changes drive B-ALL, it may be possible to develop more specific treatments that act faster with fewer side-effects."

However Dr Dickins said that genes that are lost in tumour cells are not traditionally drug targets. "It is very difficult to develop drugs that restore the function of genes that are lost during cancer development," Dr Dickins said. "However by understanding the mechanisms by which Pax5 loss causes leukaemia, we can begin to look at ways of developing drugs that could have the same effect as restoring Pax5 function."

The genetic switch technology used to study Pax5 could also be used to understand 'tumour suppressor' genes in other cancers, he said.


'/>"/>
Contact: Liz Williams
williams@wehi.edu.au
61-428-034-089
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Tugging on the malignant switch
2. Team finds on-off switch to burning stored fat
3. Cancers potential on-off switch
4. Vascular simulation research reveals new mechanism that switches in disease
5. Our brain has switch board to guide behavior in response to external stimuli
6. Short circuit in molecular switch intensifies pain
7. Bariatric Surgeon in Mexico Dr. Jose A. Castaneda Introduces New Duodenal Switch With Single Anastomosis
8. Supercomputers help ORNL researchers identify key molecular switch that controls cell behavior
9. NetPlus® Leads in Security as the only Telecommunications Management System Certified by JITC on all Unified Communications and Legacy Switches
10. Victoria Staley, AMTC Aluma, Gets Lead Role in Switching Lanes Coming Out in 2014 and in Current Film Prisoners
11. X-ES Announces Fully Packaged Rugged Ethernet Switching and Routing Solutions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene 'switch' reverses cancer in common childhood leukaemia
(Date:4/25/2015)... York New York (PRWEB) April 25, 2015 ... that Dr. Jerry Blaivas has been chosen by the New ... for his contributions to medicine in the field of Urology. ... the best in his speciality, Genito-Urinary diseases. He was ... specifically in the field of urology. Not only did ...
(Date:4/25/2015)... (PRWEB) April 25, 2015 On Friday, ... of RFID Journal’s annual Best Implementation Award. This ... demonstrated the best use of RFID technology to improve ... is the company that best demonstrates how RFID is ... presented at RFID Journal Live! 2015 in San Diego, ...
(Date:4/24/2015)... 24, 2015 Bird B Gone, the leader ... now offers a complete line of bird control solutions to ... , New Flu Strains Threaten Pacific, Central and Mississippi Farms ... , a number of highly pathogenic avian flus in ... is often spread when wild birds enter poultry farms. The ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Multi Customer ... septic tank pumping ( http://www.zeitersseptics.com/multi-customer-discount.html ) of 1000-1500 gallons ... start the program. This does not include any Dig ... Save $25-$65 per person. If someone is part of ... two tanks totaling approximately 2500 gallons or more, the ...
(Date:4/24/2015)... 2015 Ryadon is a leading manufacturer ... capabilities and services to complement any custom hardware requirements ... Program will be offered on all heavy duty drawer ... Receive 10% discount - Order 20+: Receive 20% discount ... Slides Products, Furniture ,Drawer ...
Breaking Medicine News(10 mins):Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 3Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 3Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 4Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 3Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3
... N.Y., JAN. 5, 2009 Only 17 percent of ... are taking a multivitamin containing folic acid daily, according ... to focus on this population. , Folic acid ... of the brain and spine such as spina bifida ...
... Jan. 5 Only 17 percent of Spanish-speaking women ... a multivitamin containing folic acid daily, according to the ... on this population. Folic acid can prevent neural tube ... spine such as spina bifida and anencephaly, which are ...
... Volcano Corporation,(Nasdaq: VOLC ), a leader ... diagnosis and treatment of coronary and peripheral artery,disease, will ... to,discuss its acquisition of Axsun Technologies, Inc., that was ... The teleconference call and webcast will begin at 1 ...
... Conference on Cell Therapy for Cardiovascular Disease (IC3D) will ... organ injury. The session will include new data on ... cells for stroke patients, and treating Parkinson,s disease with ... include the first human data using special bone marrow ...
... Newswire Staff Volunteer Time As Part of ... Jan. 5 Ronald McDonald House of Cleveland ... non-profit organizations serving the Cleveland community, were the ... from PR Newswire,s Cleveland staff in 2008, PR ...
... OF THE AMERICAN SOCIETY OF PLASTIC SURGEONSARLINGTON HEIGHTS, Ill., ... the American Society of Plastic Surgeons:Can The US Really ... that while health care is one of the strongest ... sustainable reduction is US health care spending is not ...
Cached Medicine News:Health News:Folic acid survey of Spanish-speaking women finds most are missing benefits, March of Dimes says 2Health News:First Nationwide Folic Acid Survey of Spanish-Speaking Women Finds Most Are Missing Benefits, March of Dimes Says 2Health News:First Nationwide Folic Acid Survey of Spanish-Speaking Women Finds Most Are Missing Benefits, March of Dimes Says 3Health News:Reminder: Volcano Corporation Schedules Conference Call, Webcast to Discuss Axsun Transaction 2Health News:Conference on cell therapy includes new session on stem cells for non-cardiac organ injury 2Health News:PR Newswire Provides Grant to Ronald McDonald House and Habitat for Humanity in Cleveland 2Health News:PR Newswire Provides Grant to Ronald McDonald House and Habitat for Humanity in Cleveland 3Health News:PR Newswire Provides Grant to Ronald McDonald House and Habitat for Humanity in Cleveland 4Health News:PR Newswire Provides Grant to Ronald McDonald House and Habitat for Humanity in Cleveland 5Health News:Plastic and Reconstructive Surgery...In Brief 2Health News:Plastic and Reconstructive Surgery...In Brief 3
(Date:4/24/2015)... DUBLIN , April 24, 2015  Perrigo Company ... announced its rejection of the unsolicited offer from Mylan ... of the outstanding shares of Perrigo for $60.00 per ... each ordinary Perrigo share (the "Offer").  ... $205.00 per share significantly undervalued the Company and its ...
(Date:4/24/2015)... , April 24, 2015  A new study shows ... costs of drugs used to slow the progression of multiple ... study led by researchers at Oregon Health & Science University ... increase in the number of MS drugs in the marketplace ... lower or stabilized costs for patients who use those drugs. ...
(Date:4/24/2015)... 24, 2015 In today,s ever-changing and ... around the world to access diverse skill sets, ... there are many areas to misstep in the ... best practices are necessary and beneficial in order ... According to research by benchmarking firm, Best Practices, ...
Breaking Medicine Technology:Perrigo Rejects Mylan Unsolicited Offer 2Perrigo Rejects Mylan Unsolicited Offer 3Perrigo Rejects Mylan Unsolicited Offer 4Researchers find alarming rise in cost of MS drugs over past two decades 2Researchers find alarming rise in cost of MS drugs over past two decades 3Researchers find alarming rise in cost of MS drugs over past two decades 4Work Around the Clock: Building Effective Global Capabilities 2
... has published a,new report in its oncology series ... to provide critical strategic insight for,pharma and biotech ... diagnostics and,treatments in non-small cell and small cell ... recent American Society of Clinical Oncology (ASCO),meeting was ...
... Sciences, Inc., a privately,held biopharmaceutical company that ... prescription ophthalmic,pharmaceuticals, today reported the interim month ... human pharmacokinetic (PK) study of Medidur(TM) FA,which ... tradename Iluvien(TM),if approved by the U.S. Food ...
Cached Medicine Technology:Landscape for Lung Cancer Therapies is Focus of New Post-ASCO MedPredict Report 2Alimera Reports Results From the Three-Month Interim Readout of the Human PK Medidur(TM) FA Study 2Alimera Reports Results From the Three-Month Interim Readout of the Human PK Medidur(TM) FA Study 3
HME w/CO2 Sampling Port 22mm od/15mm od...
... T helps provide protection to the exposed airway ... extremely lightweight making it ideal for active young ... rate of heat and moisture recovery, it ensures ... HMEs and filters have ISO standard tapered ends ...
... provide protection to the exposed airway of the ... making it ideal for active young children as ... heat and moisture recovery, it ensures patient comfort ... filters have ISO standard tapered ends to assure ...
The Secretion Solution., ,Available Configurations: , Straight Flex Tube, Poppel Flex Tube, MDI Adaptor ...
Medicine Products: