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Gene silencer and quantum dots reduce protein production to a whisper
Date:6/23/2008

vious techniques is, however, still a mystery.

"We believe the improvement is caused by the endosome escape, and the ability of the quantum dots to separate from the siRNA," Gao said.

Quantum dots are not yet approved for use in humans. The authors are now transferring their techniques to particles of iron oxide, several types of which have been approved by the Food and Drug Administration for use in humans. They are also working to target cancer cells by attaching to specific markers on the cells' surface. "Looking forward, this work will have important implications in in-vivo siRNA therapeutics, which will require the use of nontoxic iron oxide and biodegradable polymeric carriers rather than quantum dots," Nie said.


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Contact: Hannah Hickey
hickeyh@u.washington.edu
206-543-2580
University of Washington
Source:Eurekalert  

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