Navigation Links
Gene signature spells poor outcome
Date:8/30/2007

Other than visually inspecting the disease, doctors have no genetic blueprint to classify melanomas, a lethal form of skin cancer. Tumors generally are ranked by how deeply the growth has invaded underlying skin tissue. The deeper it burrows into the skin, the more lethal the cancer, but some patients defy the odds and survive with thick tumors or die from thin ones. Two melanoma patients with cancers of the same invasion depth and appearance under the microscope can have completely different outcomes, says Rhoda Alani, M.D., associate professor of oncology, dermatology and molecular biology and genetics at Hopkins Kimmel Cancer Center.

Alani says the way genes turn their protein-manufacturing machinery on and off in each cancer may help create a signature that can be used to identify tumors that are more prone to kill. These so-called expression patterns can be different from one stage of cancer to the next.

Her research team charted the level of gene expression in melanoma cell lines. Three of the lines mimic the least aggressive type, which grows along the uppermost surface of the skin, called radial growth phase. Four of the cell lines are typical of so-called vertical growth phase cancers, which invade inner skin layers, and another three represent the most lethal form -metastatic melanomas.

Two vertical growth phase cell lines had gene expression patterns similar to radial growth cancers, indicating that these cells were less aggressive, according to the scientists. The remaining two vertical growth cell lines contained patterns in 18 genes that paralleled metastatic cancer cell lines, the most aggressive form. Alani and her colleagues believe that within this group of 18 genes is a signature for aggressive melanomas.

Many of the genes described in the Hopkins report, published online on July 4 in PLoS One, were previously identified as associated with aggressive cancers by scientists at Johns Hopkins and else
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Predicting Breast Cancer Recurrence By Understanding Gene Signature
2. Signature Campaign: Striking doctors take to the streets
3. Attention! Spells of momentary blindness following visual disturbance
4. Uncontrolled Diabetes Spells Doom for Dental Implants
5. Lip Service : Indiscriminate Kissing Spells Doom
6. Medicare Bulk Billing Spells Ill Health For The Health System
7. Community Health Shake-up Spells Trouble for Nurses
8. Heat Spells Trouble in South Carolina
9. The DNA That Spells Double Risk of Heart Attack
10. The DNA That Spells Double Risk of Heart Attack
11. Antifever drug betters stroke outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... Previously, the crew members for Maplewood’s three fire ... Now, the department’s 53 part-time members “self-schedule” through the ... , “Scheduling our personnel with paper and pencil, and then ... track of when people could work, because they would say ... and we would have to try to figure out how ...
(Date:7/23/2014)... Controlling pain during childbirth and post delivery may reduce ... a Northwestern Medicine perinatal psychiatrist, in a July 23 ... Wisner,s editorial is based on a new Chinese study ... anesthesia during a vaginal delivery had a much lower ... the epidural. , "Maximizing pain control in labor and ...
(Date:7/22/2014)... July 22, 2014 Print Audit® ... Audit Facilities Manager web portal. Facilities Manager 3.1.0R ... of the software as well as numerous new ... Print Audit Facilities Manager is a powerful, easy ... remotely collect meter reads, automate supplies fulfillment and ...
(Date:7/22/2014)... Recently, iFitDress.com, a popular supplier of wedding dresses ... selection of white party dresses to its product ... are now available on its website. As a special offer, ... July can get a discounted rate, up to 54% off. ... international customers, so its marketing specialist believes the new white ...
(Date:7/22/2014)... (PRWEB) July 23, 2014 Provectus ... devices . From now on, in addition to working ... software solutions for Google Glass as well as the ... , A dynamic lifestyle requires special gadgets for ... Glass has found application in healthcare, logistics, travelling, sports, ...
Breaking Medicine News(10 mins):Health News:This Fire Department Allows Personnel to Schedule Themselves - Saving Administration Up To 60 Hours a Month 2Health News:This Fire Department Allows Personnel to Schedule Themselves - Saving Administration Up To 60 Hours a Month 3Health News:Controlling childbirth pain tied to lower depression risk 2Health News:Print Audit® Releases Facilities Manager 3.1.0R 2Health News:Elegant White Party Dresses Now Provided by Distinguished Company iFitDress.com 2Health News:Provectus Announces Development for Google Glass and Wearables 2
... A form of partial epilepsy associated with auditory ... disruption of brain development during early childhood, according to ... Medical Center (BIDMC). , Described in today,s Advance On-line ... provide the first genetic link between childhood brain development ...
... ... of Washington D.C. is business owner John Wahlquist of eMedicalSystems, Bremerton, Washington state. Author of ... unusual choice to retire his product and migrate his medical practices over to a new ... ...
... LOUISVILLE, Ky., Aug. 22 A top medical officer in the ... veterans service organizations can play a key role in suicide prevention ... coordinator, in pointing to the 5,000 self-inflicted deaths among veterans a ... to own up to that. There,s no reason any veteran in ...
... check-ups and communication with school staff , SATURDAY, Aug. 22 ... parents of children with asthma can prepare for flu season ... , "Good hygiene is the best and first line of ... frequent handwashing and covering your mouth when coughing or sneezing," ...
... CAESAREA, Israel, August 17 EndyMed Medical Ltd, an,innovative ... market, announced today the FDA clearance of the EndyMed,PRO(TM) ... rhytides. , The EndyMed PRO ... uses multiple, phase controlled sources, and is the,first product ...
... The nation,s home foreclosure epidemic may be taking its ... Nearly half of people studied while undergoing foreclosure reported ... major depression, according to new University of Pennsylvania School ... American Journal of Public Health. Many also ...
Cached Medicine News:Health News:Fragile period of childhood brain development could underlie epilepsy 2Health News:eMedical Systems, Inc. Selects MPMsoft as its Medical Billing Software Solution 2Health News:eMedical Systems, Inc. Selects MPMsoft as its Medical Billing Software Solution 3Health News:The American Legion Can Play Key Role in Vets' Suicide Prevention, Says VA 2Health News:Going Back to School With Asthma Takes Extra Work 2Health News:EndyMed Medical Receives FDA Clearance for Painless, Non-invasive Anti-Wrinkle Treatment System 2Health News:More than 1/3 of homeowners in foreclosure suffer from major depression, Penn study shows 2Health News:More than 1/3 of homeowners in foreclosure suffer from major depression, Penn study shows 3
(Date:7/22/2014)... , July 22, 2014 The number ... killing 45 people each day. Twenty-three percent of the ... Survey on Drug Use and Health, making opioid use ... are taking opioid painkillers at the correct dosage with ... Today, the National Safety Council ...
(Date:7/22/2014)... VIEW, Calif. , July 22, 2014 /PRNewswire/ ... resonance imaging (MRI) market, Frost & Sullivan recognizes ... for Product Leadership. Siemens Healthcare,s FREEZEit solution, which ... the need for robust and motion-insensitive imaging. The ... boosted the evolution of body MRI imaging in ...
(Date:7/22/2014)... -- Sanofi Pasteur, the vaccines division of Sanofi (EURONEXT: SAN ... first lots of Fluzone ® (Influenza Vaccine) for the ... U.S. Food and Drug Administration (FDA) for distribution. The lots ... at least 65 million doses of seasonal influenza vaccine manufactured ... care providers and pharmacies in August. The ...
Breaking Medicine Technology:5 things employers should know about prescription painkiller use 25 things employers should know about prescription painkiller use 3Frost & Sullivan Recognizes Siemens Healthcare with the Product Leadership Award for Innovative Techniques in Abdominal Imaging 2Frost & Sullivan Recognizes Siemens Healthcare with the Product Leadership Award for Innovative Techniques in Abdominal Imaging 3Frost & Sullivan Recognizes Siemens Healthcare with the Product Leadership Award for Innovative Techniques in Abdominal Imaging 4Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 2Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 3Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 4Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 5Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 6Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 7
... Personal Experience about Protecting Kids from a Deadly ... but Vaccine-Preventable Disease, ... (PKIDs) today announced the launch of its national educational,campaign "Silence ... To view the Multimedia News Release, go to:, http://www.prnewswire.com/mnr/pertussis/29579/ ...
... MIAMI, Oct. 16 Roger K. Khouri, M.D. ... a team of surgeons in a,clinical trial performing ... external expansion system and liposuctioned,micro-fat grafts primarily on ... or without radiation therapy. Typically, breast reconstruction ...
Cached Medicine Technology:Video: Actress and New Mom Keri Russell Joins PKIDs to Launch 'Silence the Sounds of Pertussis' Campaign 2Video: Actress and New Mom Keri Russell Joins PKIDs to Launch 'Silence the Sounds of Pertussis' Campaign 3New Minimally Invasive Breast Reconstructive Procedure for Breast Cancer Patients - Actively Recruiting Participants for Clinical Study 2
Full Handle Laseredge Implant Blade Knife, 3.2 mm round tip. Blade dimension: 14.4 mm x 3.2 mm x 3.8 mm x 1.65 mm....
Full Handle Laseredge Implant Blade Knife, 4.0 mm straight. Blade dimension: 15.2 mm x 4.0 mm x 3.0 mm x 1.6 mm....
Full Handle Laseredge Stab Blade Knife, 30 blade. Blade tip dimension: 10.5 mm x 1.9 mm x 3.4 mm....
19 Gauge. Reusable. Block of 4 each....
Medicine Products: