Navigation Links
Gene signature spells poor outcome

Other than visually inspecting the disease, doctors have no genetic blueprint to classify melanomas, a lethal form of skin cancer. Tumors generally are ranked by how deeply the growth has invaded underlying skin tissue. The deeper it burrows into the skin, the more lethal the cancer, but some patients defy the odds and survive with thick tumors or die from thin ones. Two melanoma patients with cancers of the same invasion depth and appearance under the microscope can have completely different outcomes, says Rhoda Alani, M.D., associate professor of oncology, dermatology and molecular biology and genetics at Hopkins Kimmel Cancer Center.

Alani says the way genes turn their protein-manufacturing machinery on and off in each cancer may help create a signature that can be used to identify tumors that are more prone to kill. These so-called expression patterns can be different from one stage of cancer to the next.

Her research team charted the level of gene expression in melanoma cell lines. Three of the lines mimic the least aggressive type, which grows along the uppermost surface of the skin, called radial growth phase. Four of the cell lines are typical of so-called vertical growth phase cancers, which invade inner skin layers, and another three represent the most lethal form -metastatic melanomas.

Two vertical growth phase cell lines had gene expression patterns similar to radial growth cancers, indicating that these cells were less aggressive, according to the scientists. The remaining two vertical growth cell lines contained patterns in 18 genes that paralleled metastatic cancer cell lines, the most aggressive form. Alani and her colleagues believe that within this group of 18 genes is a signature for aggressive melanomas.

Many of the genes described in the Hopkins report, published online on July 4 in PLoS One, were previously identified as associated with aggressive cancers by scientists at Johns Hopkins and elsewhere, but Alani says her study brings them all together for melanoma and links them to an aggressive profile.

Alanis team is validating these results in human tissue samples and evaluating gene correlations with patient outcomes. Funding for the study was provided by the National Cancer Institute. With further study, the genes could be used in tests that predict a patients prognosis and as targets for tailored therapies, she says.

Contact: Vanessa Wasta
Johns Hopkins Medical Institutions

Related medicine news :

1. Predicting Breast Cancer Recurrence By Understanding Gene Signature
2. Signature Campaign: Striking doctors take to the streets
3. Attention! Spells of momentary blindness following visual disturbance
4. Uncontrolled Diabetes Spells Doom for Dental Implants
5. Lip Service : Indiscriminate Kissing Spells Doom
6. Medicare Bulk Billing Spells Ill Health For The Health System
7. Community Health Shake-up Spells Trouble for Nurses
8. Heat Spells Trouble in South Carolina
9. The DNA That Spells Double Risk of Heart Attack
10. The DNA That Spells Double Risk of Heart Attack
11. Antifever drug betters stroke outcome
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Altec ... their Title Sponsorship of Synergy 2015. The annual WennSoft KEY2ACT user conference will ... Ranch and will unite customers, partners, WennSoft team members and sponsors to facilitate ...
(Date:10/13/2015)... ... 13, 2015 , ... Georgia Partnership for TeleHealth ... Georgia, along with affiliate organizations, Alabama Partnership for Telehalth (ATP) and Florida Partnership ... Fall 2015. , Each of the three conferences share this year’s conference ...
(Date:10/13/2015)... ... October 13, 2015 , ... Local Gold’s Gym franchise owner, Bryce Berry, received ... 26. Berry, who owns and operates Gold's Gym Cheyenne in Cheyenne, Wyoming, ... in the United States. A brand leader in global fitness, Gold’s Gyms are located ...
(Date:10/13/2015)... ... October 13, 2015 , ... With Fall weather approaching ... tool for this month’s Facebook Hair Styler Contest. , Enter to win! , How ... Answering: What Is Your Favorite Hair Style? , 3. Follow us on Instagram ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... home furnishings and décor, today announced it closed on a $20.5 million funding ... will be used to support the Company’s continued rapid growth and expansion, broaden ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015   Rosa & Co. ... in Quantitative Systems Pharmacology (QSP)/ PhysioPD™ , today announced ... lead a workshop at the QSP Congress Meeting ... Boston, MA.  The conference focuses on ... development.  Dr. Friedrich,s workshop is entitled "Using Mechanistic Physiological ...
(Date:10/13/2015)... World Thrombosis Day Interactive Infographic ...   --> World Thrombosis Day Interactive ... promote vital global awareness of thrombosis, its causes, ... the formation of potentially deadly blood clots in ... thromboembolism (VTE) - or the artery (arterial thrombosis) [1] ...
(Date:10/12/2015)... Apheresis is an invasive process that involves ... other components from whole blood. In this procedure, the blood ... apheresis machine or a blood cell separator. The apheresis equipment ... blood components. A selected part of the blood is removed, ... the patient. It involves the use of devices and disposables ...
Breaking Medicine Technology: