Navigation Links
Gene signature may predict patient response to therapy for gastrointestinal stromal tumors
Date:5/14/2009

ORLANDO (May 14, 2009)Researchers at Fox Chase Cancer Center uncovered a genetic pattern that may help predict how gastrointestinal stromal tumor (GIST) patients respond to the targeted therapy imatinib mesylate (Gleevec). Moreover, their findings point to genes that could be suppressed in order to make these tumors respond more readily to imatinib.

Lori Rink, PhD, a postdoctoral fellow in the laboratory of Andrew K. Godwin, PhD, at Fox Chase, presents their findings at the 2009 Annual Meeting of the American Society of Clinical Oncology. The study uses tumor specimens collected as part of a Phase II trial on the use of the drug before surgical resection for GIST, which is led by the Radiation Therapy Oncology Group, a national clinical cooperative group funded by the National Cancer Institute.

"Imatinib has been the first drug that has really made a dent in GIST progression up to 80 percent response yet some GIST patients have little or no response to the drug," says Rink. "We are looking to see how we can help clinicians make better decisions in applying imatinib or additional therapies to their GIST patients."

Rink and her colleagues followed 63 GIST patients in the RTOG trial, who were given imatinib before surgery for primary or recurrent tumors. Using tumor samples collected before and after the patients were given the drug, the researchers studied which genes were active in the tumors and then compared these profiles of gene expression to how well the tumors responded to short-term imatinib treatment.

According to Rink, they found a selection of 38 genes that were expressed higher in tumors that did not respond well to imatinib. Of these, they identified 20 KRAB-zinc finger genes that encode for proteins that typically act as transcriptional repressors of other genes. Ten of these genes, Rink says, are located to a single section of Chromosome 19.

"Our data indicate that if we can alter the activity o
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gene signature spells poor outcome
2. APHA Urges President Bush Not To Veto CHIP; Were Only One Signature Away from Protecting the Health of Our Children
3. New neuroimaging study identifies brain signature for cigarette cravings
4. Hays AG Integrates Authentidate(R) Signature Solution for Electronic Invoicing
5. Emmy(R)- and Golden Globe(R)-Nominated Actress Marcia Cross and Lifetime Television Deliver 20 Million Online Petition Signatures to Capitol Hill to Urge Congress to Stop Drive-Through Mastectomies
6. Avamere Health Systems Announces New President of Signature Home Health
7. Chemical signature of manic depression discovered by scientists
8. 24 Hour Fitness Partners With Derek Jeter to Launch Signature Sports Clubs in New York City
9. Gene Signature May Predict Recurrence of Lung Cancer
10. Determining genetic signature of lung tumors can help guide treatment
11. After Collecting 22 Million Petition Signatures on myLifetime.com, Bipartisan Breast Cancer Patient Protection Act Gets First Congressional Hearing in 12 Years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... (PRWEB) July 28, 2014 As health ... are looking to private exchanges. “Private Exchange Strategies ... 6 webinar from Atlantic Information Services, will provide answers ... exchange strategies for the future. , Barbara Gniewek, Jonathan ... with extensive experience in the private exchange sector — ...
(Date:7/28/2014)... According to the Heartburn No More PDF review recently ... help people get rid of acid reflux naturally. ... heartburn and acid reflux. In addition, inside this book, people ... factors for reflux disease. , Vkool informs in its ... symptoms of reflux disease naturally without medications. The book also ...
(Date:7/28/2014)... 28, 2014 Building a sense of ... important. Where personal outdoor space is not possible, ... enjoy fun and exercise outside is important. That’s ... in quality commercial playground equipment from APCPLAY. , Old ... Midlothian, Virginia. It is an historic tourist location of ...
(Date:7/28/2014)... Calif., July 27, 2014 - (PRWEB) July 28, 2014 ... in 12 months by earning the Masters Champion title at ... proving that age is no obstacle for this athlete. She ... at the event hosted by the International Pole Sports Federation ... 63, traveling from 30 countries, took part in the competition. ...
(Date:7/28/2014)... Dr. Alan Xenakis, MD announced today the ... Feelings.” The new book, DOC X MD Funny Feelings ... story telling style with humor and medical accuracy. The book ... will find answers to those age-old questions that most folks ... pee? Why do mosquitoes bite some and not others? Why ...
Breaking Medicine News(10 mins):Health News:Three PwC Consultants to Offer Insurers Successful Strategies for Private Exchanges 2Health News:Heartburn No More Pdf Review Exposes Jeff Martin's Guide For Treating Heartburn – Vkool.com 2Health News:Heartburn No More Pdf Review Exposes Jeff Martin's Guide For Treating Heartburn – Vkool.com 3Health News:Playground Creates Outdoor Fun for Community at Old Buckingham Station at Midlothian Village (VA) with APCPLAY© 2Health News:Inspiring Senior Athlete Lands Third World Title in One Year 2Health News:New Book by Alan P. Xenakis, MD Reveals Mind and Body Mysteries 2
... Texas Pesticides and pollutants are related to an alarming ... anencephaly in rural China, according to scientists at The University ... of the pesticides found in high concentrations in the placentas ... Endosulfan is only now being phased out in the United ...
... Steven Reinberg HealthDay Reporter , TUESDAY, Oct. ... friends tend to have areas of the brain that ... with fewer friends, British researchers say. "We were ... in them is reflected in brain structure and function," ...
... cardiac arrest is the leading cause of death in the ... initial collapse. In addition, fewer than half of the small ... the hospital, because they often suffer irreversible brain damage. A ... Neurology provides guidance to physicians using therapeutic cooling to ...
... flushes and night sweats years after the menopause finds a new ... and Gynaecology . Hot flushes and night sweats (HF/NS) are ... severity and duration vary considerably. The average age of ... it is generally assumed that HF/NS last between 2 to 5 ...
... Spanish . Researchers from Massachusetts General ... cell mechanism activated by a protein HOXB9 that becomes an ... world continue to focus their research on breast cancer. As ... growing, as well as of their interactions with the microenvironment. ...
... Duke University Medical Center researchers have verified data that ... a patient who has been under anesthesia for an operation. ... first year after surgery if a patient has low values ... patients whose values are all normal. The three ...
Cached Medicine News:Health News:Study links pollutants to a 450 percent increase in risk of birth defects 2Health News:Study links pollutants to a 450 percent increase in risk of birth defects 3Health News:More Facebook Friends, More Gray Matter in Brain? 2Health News:More Facebook Friends, More Gray Matter in Brain? 3Health News:Mayo Clinic study guides physicians using therapeutic cooling to treat cardiac arrest patients 2Health News:Older women still suffer from hot flushes and night sweats years after the menopause finds study 2Health News:Discovery of a cell mechanism that reduces effectiveness of breast cancer treatment 2Health News:3 factors could point to your fate after surgery 2
(Date:7/25/2014)... , July 25, 2014  Depomed, Inc. (NASDAQ: ... second quarter fiscal year 2014 financial results after the ... host a conference call beginning at 4:30 pm EDT, 1:30 ... access the call by dialing 877-317-6789 ( United ... will also be available via a live webcast on ...
(Date:7/25/2014)... July 25, 2014 GrowBLOX Sciences, Inc. (OTCQB: GBLX) ... of Understanding ("MOU") with LaurelCo, LLC, an Illinois ... of both cultivation and dispensary medical marijuana licenses in the ... MOU, GBLX will acquire a 20% equity interest in LaurelCo, ... TM growing chambers, as well as all technology related ...
(Date:7/25/2014)... July 25, 2014 According to ... "Global and China Insulin Market (Rapid-Acting, Short-Acting, Intermediate-Acting, Long-Acting, ... Share, Growth, Trends and Forecast (Value and Volume), 2013 ... USD 19.99 billion in 2012 and is expected to ... 2019 to reach USD 32.24 billion in 2019. ...
Breaking Medicine Technology:Depomed To Report Second Quarter Fiscal Year 2014 Financial Results On Wednesday, August 6, 2014 2GrowBLOX Sciences, Inc. Partners with LaurelCo, LLC to Obtain Licenses to Cultivate and Dispense Medical Marijuana in Illinois 2GrowBLOX Sciences, Inc. Partners with LaurelCo, LLC to Obtain Licenses to Cultivate and Dispense Medical Marijuana in Illinois 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 2Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 4
... Helen Londe, M.D. Contributing Editor The first human case of ... occurred in Kansas in late June. The CDC has ... being 2005's first documented incidence of the mosquito borne disease ... about 11 kb. It primarily infects birds and mosquitoes, ...
... lipids, comprised of triglycerides and cholesterols, vary with genetic ... factors contribute to serum cholesterol and triglyceride levels and ... events. Perhaps no other commonly determined medical laboratory values ... levels of good, bad, and total cholesterol, making the ...
Cached Medicine Technology:West Nile Virus Screening and Diagnostics Technology Emerges In Step with North American Outbreak 2West Nile Virus Screening and Diagnostics Technology Emerges In Step with North American Outbreak 3West Nile Virus Screening and Diagnostics Technology Emerges In Step with North American Outbreak 4Analyzers Offer Point-of-Care Lipid Panels 2Analyzers Offer Point-of-Care Lipid Panels 3
... The proper gel is essential ... when working with pH catheters ... specific chloride ion concentration in ... required for proper function of ...
The WaveMax is one of the most flexible stainless steel stents due to its unique wave design and has the lowest effective profile, accommodating a 6F sheath up to 7 mm....
... its specifically designed reagents, allows to ... sample, multiple analytes. This unique technology ... laboratories willing to simplify and standardize ... as well as to reduce as ...
... a variety of applications across a broad ... is suitable for any laboratory demanding high ... mixed-mode throughput exceeding 95 PT/aPTT/Fibrinogen per hour ... range of chromogenics, the AMAX DestinyPlus is ...
Medicine Products: