Navigation Links
Gene sequencing project identifies potential drug targets in common childhood brain tumor
Date:6/20/2012

Researchers studying the genetic roots of the most common malignant childhood brain tumor have discovered missteps in three of the four subtypes of the cancer that involve genes already targeted for drug development.

The most significant gene alterations are linked to subtypes of medulloblastoma that currently have the best and worst prognosis. They were among 41 genes associated for the first time to medulloblastoma by the St. Jude Children's Research Hospital Washington University Pediatric Cancer Genome Project.

"This study provides new direction for understanding what drives these tumors and uncovers totally unexpected new drug targets. There are drugs already in development against these targets aimed at treating adult cancers and other diseases," said Richard Gilbertson, M.D., Ph.D., St. Jude Comprehensive Cancer Center director. Gilbertson and Jinghui Zhang, Ph.D., an associate member of the St. Jude Department of Computational Biology, are the study's corresponding authors. The work appears in the June 20 advance online issue of the scientific journal Nature.

The results mark progress toward more targeted therapies against medulloblastoma and other cancers. While better use of existing drugs and improved supportive care have helped push long-term survival rates for childhood cancer to about 80 percent, drug development efforts have largely stalled for more than two decades, particularly against pediatric brain tumors.

"This study is a great example of the way whole-genome sequencing of cancer patients allows us to dig deep into the biology of certain tumors and catch a glimpse of their Achilles heel," said co-author Richard K. Wilson, Ph.D., director of The Genome Institute at Washington University School of Medicine in St. Louis. "These results help us better understand the disease and, as a result, we will be able to more effectively diagnose and treat these kids."

This study involved sequencing the
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. How the brains daily clock controls mood: A new project
2. Image share project gives patients and physicians anytime, anywhere access to medical images
3. Optogenetics project takes top NIDA Addiction Science Award
4. Leah Hoskins, F.I.L.M. Project Founder, Headed to Jail?
5. The W3 Project Receives Support from Doulton for Emergency Relief Efforts
6. New study identifies promising, achievable solutions to Nigerias childhood mortality crisis
7. Study identifies potential treatment for lethal childhood leukemia
8. New study identifies how information technology is used to solve global health challenges
9. Study identifies possible protective blood factors against Type 2 diabetes
10. Genetic test identifies eye cancer tumors likely to spread
11. 3-center study identifies main causes of unprofessional behavior among hospitalists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... September 19, 2014 A jacket is ... A jacket typically has sleeves, and fastens in the ... generally lighter, tighter-fitting, and less insulating than a coat, ... serve as protective clothing. Today, Fecbek, a well-known clothing ... of trendy men’s jackets; all these items are offered ...
(Date:9/18/2014)... Steven Reinberg HealthDay Reporter , THURSDAY, ... Ebola outbreak in West Africa is starting to spread faster than ... new cases of the deadly viral infection were reported in just ... more than 5,300, with roughly half of those reported in the ... of deaths now tops 2,600. WHO has estimated that as ...
(Date:9/18/2014)... 2014 One of the most capable ... industry, ShandsCair Flight Program’s new EC155 B1, ... (AHI) at the Air Medical Transport Conference (AMTC), Sept. ... placed into service ShandsCair EC155 and the Vanderbilt ... at AMTC highlight Airbus Helicopters broad, industry leading line-up ...
(Date:9/18/2014)... Norton HealthDay Reporter , THURSDAY, ... of a common antidepressant can quickly alter the way brain ... findings, reported online Sept. 18 in Current Biology ... to widely prescribed antidepressants. Experts said the hope is to ... likely to benefit from a drug -- and which people ...
(Date:9/18/2014)... In 2003, the government ... Barrio Adentro), which it hoped would increase ... Section 6.1.3.). In 2009, it invested VEF28 ... of Pharmaceutical Elaborations (Servicio Autónomo de Elaboraciones ... at a cheaper rate than private pharmaceutical ...
Breaking Medicine News(10 mins):Health News:Cool Jackets Are For Sale At Fecbek.com 2Health News:New Ebola Cases Top 700 in Just One Week, Officials Report 2Health News:New Ebola Cases Top 700 in Just One Week, Officials Report 3Health News:Airbus Helicopters Inc. Features Industry-leading Models at AMTC 2Health News:Airbus Helicopters Inc. Features Industry-leading Models at AMTC 3Health News:Airbus Helicopters Inc. Features Industry-leading Models at AMTC 4Health News:One Dose of Antidepressant Changes Brain Connections, Study Says 2Health News:One Dose of Antidepressant Changes Brain Connections, Study Says 3Health News:Venezuela Pharmaceutical Market worth $22.2 billion with 12% CAGR by 2020 Says a New Report Available at MarketOptimizer.org 2Health News:Venezuela Pharmaceutical Market worth $22.2 billion with 12% CAGR by 2020 Says a New Report Available at MarketOptimizer.org 3Health News:Venezuela Pharmaceutical Market worth $22.2 billion with 12% CAGR by 2020 Says a New Report Available at MarketOptimizer.org 4
... Calif., May 22 Setaram Inc., a ... analyzers,calorimeters, gas sorption and high pressure mass ... pleased to announce the,appointment of Bruce Jamieson ... the recent acquisition of Hy-Energy LLC (Newark, ...
... Minimally Invasive P3(TM) (Pioneer Peek-on-Peek) ... Technology Motion Preservation Device, DRIEBERGEN, ... announced the BacJac(TM),Interspinous Decompression System (IDS) will be market ... Switzerland., The BacJac system is designed to relieve ...
... May 22 HHS Secretary Mike,Leavitt today announced ... (FDA) and the Centers for Medicare & Medicaid ... patient safety and the quality,of medical care., ... to,monitor the use of medical products on the ...
... PA May 21, 2008 If you were ... works specifically for you" Or a treatment that prevents ... The emerging field of clinical and translational science provides ... patient-specific therapy. Deputy Editor, Scott A. Waldman, MD, PhD, ...
... Accenx Technologies, Inc.,announced today that it ... Program and is now part of Sun,s ... to the healthcare industry. From,this new relationship, ... its already robust client roster, develop a ...
... of today,s,congressional subcommittee hearing on animal-disease research on ... should serve several,purposes:, * Underscore the critical ... real and present threat of diseases that could,harm ... * Demonstrate the urgency of addressing foreign-animal diseases, ...
Cached Medicine News:Health News:Setaram Inc. Appoints New CEO/VP 2Health News:Pioneer(R) Surgical Technology Introduces the BacJac(TM) Interspinous Decompression System to the European Spine Market 2Health News:New Efforts to Help Improve Medical Products for Patient Safety and Quality of Medical Care 2Health News:New Efforts to Help Improve Medical Products for Patient Safety and Quality of Medical Care 3Health News:New Efforts to Help Improve Medical Products for Patient Safety and Quality of Medical Care 4Health News:Unlocking the promise of clinical and translational science 2Health News:Accenx Technologies Joins Sun's Authorized Subcontractor Program 2Health News:Tip Sheet: Kansas Responds to Congressional Hearing on Animal Disease Research 2
(Date:9/18/2014)...  KIYATEC announced today that it has been ... (SBIR) Phase II Contract from the National Cancer ... centers that comprise the National Institutes of Health ... award, KIYATEC will expand its 3D breast cancer ... of cancer therapy strategies: 1) cancer,s interaction with ...
(Date:9/18/2014)... Mass. , Sept. 18, 2014  Decision Resources ... anti-vascular endothelial growth factor (VEGF) agent for wet AMD, ... Medicare Advantage plans as Genentech,s Lucentis, which is the ... surveyed managed care organization (MCO) directors do not identify ... is slightly more likely than Lucentis to be listed ...
(Date:9/18/2014)... Sept. 18, 2014  ePharmaSolutions, the leading ... as the Disruptive Innovator of the Year ... eClinical platform. This solution includes an integrated ... file (eTMF), a remote monitoring application, eSource ... patient screening and matching technology. ...
Breaking Medicine Technology:National Cancer Institute Awards KIYATEC Nearly $2M to Advance Predictive Cancer Diagnostics 2National Cancer Institute Awards KIYATEC Nearly $2M to Advance Predictive Cancer Diagnostics 3Regeneron's Eylea and Genentech's Lucentis Are Equally Likely to be Covered on Commercial and Medicare Advantage Plans for Wet AMD 2Regeneron's Eylea and Genentech's Lucentis Are Equally Likely to be Covered on Commercial and Medicare Advantage Plans for Wet AMD 3ePharmaSolutions Named 2014 Disruptive Innovator of the Year for its ePharmaONE eClinical Platform 2ePharmaSolutions Named 2014 Disruptive Innovator of the Year for its ePharmaONE eClinical Platform 3
... YORK, Dec. 8, 2010 Reportlinker.com announces that ... its catalogue: Asia-Pacific Dental Devices ... http://www.reportlinker.com/p0336613/Asia-Pacific-Dental-Devices-Market-Outlook-to-2016.html Asia-Pacific Dental Devices ... new report, "Asia-Pacific Dental Devices Market Outlook to ...
... 2010 Reportlinker.com announces that a new market research ... China Pharmaceutical Market Overview http://www.reportlinker.com/p0337367/China-Pharmaceutical-Market-Overview.html ... pharma market generated sales of $22.9 billion in 2009, ... and 2009. Key growth drivers include China,s support of ...
Cached Medicine Technology:Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 2Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 3Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 4Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 5Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 6Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 7Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 8Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 9Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 10Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 11Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 12Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 13Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 14Reportlinker Adds Asia-Pacific Dental Devices Market Outlook to 2016 15Reportlinker Adds China Pharmaceutical Market Overview 2Reportlinker Adds China Pharmaceutical Market Overview 3Reportlinker Adds China Pharmaceutical Market Overview 4Reportlinker Adds China Pharmaceutical Market Overview 5Reportlinker Adds China Pharmaceutical Market Overview 6Reportlinker Adds China Pharmaceutical Market Overview 7Reportlinker Adds China Pharmaceutical Market Overview 8Reportlinker Adds China Pharmaceutical Market Overview 9Reportlinker Adds China Pharmaceutical Market Overview 10Reportlinker Adds China Pharmaceutical Market Overview 11Reportlinker Adds China Pharmaceutical Market Overview 12Reportlinker Adds China Pharmaceutical Market Overview 13Reportlinker Adds China Pharmaceutical Market Overview 14Reportlinker Adds China Pharmaceutical Market Overview 15Reportlinker Adds China Pharmaceutical Market Overview 16Reportlinker Adds China Pharmaceutical Market Overview 17
Span Diagnostics Limited...
Malaria ( P. Falciparum ) Whole Blood Strip / Cassette...
DiaMed OptiMAL-IT is an immuno-chromatographic test, using monoclonal antibodies against the metabolic enzyme pLDH (parasite lactate dehydrogenase) of Plasmodium spp. These Mabs are classified in t...
Core Malaria Pf is a rapid self performing, qualitative, two site sandwich immunoassay for the determination of P. falciparum specific histidine rich protein 2 (Pf HRP-2) in whole blood samples...
Medicine Products: