Gene plays 'Jekyll and Hyde' in br...(. This is because STAT3 acts as a tumor ...),Health
Navigation Links
Gene plays 'Jekyll and Hyde' in brain cancer
Date:2/6/2008
. This is because STAT3 acts as a tumor suppressor normally in astrocytes. However, as more PTEN becomes disabled, a cascade of molecular events is set in motion with the express purpose of inhibiting STAT3 function and thus turning the tide in the cells toward tumor formation.
The researchers confirmed these findings in human glioblastoma tumors as well.
The belief that STAT3 can only be an oncogene has been a pretty entrenched dogma in the field, says Bonni, so we performed many, many experiments to make sure this was correct. It took some very persistent investigators in my lab to get the job done. As a result, were convinced of our data.
While glioblastoma tends to be uncommon, STAT3 has also been implicated in prostate and breast cancers, so these results may translate to other types of tumors as well.
In addition, the findings contribute to the growing body of evidence for personalized medicine, showing that many types of cancers contain subgroups that require different treatments.
'/>"/>
| Contact: David Cameron david_cameron@hms.harvard.edu 617-432-0441 Harvard Medical School Source:Eurekalert |
Related medicine news :
1. Laboratory at UI plays major role in diagnosing cancer
2. Environment plays key role in childrens readiness for school
3. Gene Plays Role in Risk of Autism
4. Heart-Shaped Light Displays on Blue Cross Blue Shield of Michigan Building Show Support for American Heart Month, National Wear Red Day
5. Study Spots Gene That Plays Role in Infertility
6. One Million PLAYSTATION(R)3 Users Participate in Folding@home Research Project
7. Former Congressman Hyde Awarded Presidential Medal of Freedom While Receiving Medical Rehabilitation at Marianjoy
8. Draining away brains toxic protein to stop Alzheimers
9. Vision restoration therapy shown to improve brain activity in brain injured patients
10. Clinical depression linked to abnormal emotional brain circuits
11. Brain imaging reveals breakdown of normal emotional processing
Post Your Comments:
(Date:11/23/2009)...ers from Virginia Commonwealth University Medical ... oxidation of polyunsaturated fatty acids (PUFA) i...fatty liver (NAFL) to nonalcoholic steatohepatitis...er plasma monounsaturated fatty acids in the blood...pear in the December issue of Hepatology , a jour...
(Date:11/23/2009)... from women,s hair loss for almost ten years, Zsan...ng her progress and the secret behind her success ...of her video diaries which include a direct compar... , (PRWeb UK) November 23,...klosi has released the video diaries that document...
(Date:11/23/2009)...sintheRecommendedPriorityGroups ,, HARRISBURG,P...fHealthannouncedtodaytheywillconductthreeadditiona...Delaware,Lancaster,andLehighcountiesonTuesday,Nov....teredforfreetoindividualsintherecommendedtargetgro...artmentasksthatonlyindividualsinthefollowinggroups...
(Date:11/23/2009)...ls enjoy a pay raise for a job well done. But in s...e performance may actually backfire. , A new ...ings for 25 medical groups across California impro...ide pay-for-performance program in 2004 but not w... , Reporting in the December edition of the Jo...
(Date:11/23/2009)...the agency, said lives could be at risk , ...t from last week,s controversial recommendation th...ing for breast cancer continues, with a former hea...ng women to ignore the guidelines. , "I,m sayin...ly this will increase the number of women dying of...
Breaking Medicine News(10 mins):Health News:Metobolomics uncovers key indicators of nonalcoholic fatty liver disease 2Health News:Women's Hair Loss Treatment Results Captured on Video to Inspire Others 2Health News:Women's Hair Loss Treatment Results Captured on Video to Inspire Others 3Health News:Pennsylvania Department of Health Announces Additional H1N1 Vaccination Clinics in Delaware, Lancaster, Lehigh Counties 2Health News:Medical 'pay for performance' programs help improve care -- but not always, study finds 2Health News:Medical 'pay for performance' programs help improve care -- but not always, study finds 3Health News:Women Should Ignore New Mammogram Guideline, Ex-NIH Chief Says 2Health News:Women Should Ignore New Mammogram Guideline, Ex-NIH Chief Says 3[0] Metobolomics uncovers key indicators of nonalcoholic fatty liver disease[1] Women's Hair Loss Treatment Results Captured on Video to Inspire Others[0] Pennsylvania Department of Health Announces Additional H1N1 Vaccination Clinics in Delaware, Lancaster, Lehigh Counties[0] Medical 'pay for performance' programs help improve care -- but not always, study finds[1] Women Should Ignore New Mammogram Guideline, Ex-NIH Chief Says
...pulations at Greatest Risk for Developing End Stag...currently suffer from Kidney Disease, WASHINGTON,...wide coalition of patient advocates, dialysis,prof...e (CKD), today at an educational briefing on Capit...
... A Major Overhaul of Medicare, LEBANON, N.H., Apr... doctors more than the most efficient and effectiv...l people, yet gets worse,results, according to a n...d-standard health care systems such as the Mayo Cl...
...ood vessels that lose their ability to protect the...velopment of amyotrophic lateral sclerosis, better... research published in the April issue of Nature N...e unexpected finding opens up a new front in studi...
...RANCISCO, Calif., April 7, 2008 Hyperion,Therapeu...pany, today,announced that Lota S. Zoth has been e...th formerly served as Senior Vice President and Ch...n/prnh/20070905/AQW076LOGO ), In discussing her a...
... Calif., April 7, 2008 Exponent,Inc. (Nasdaq: EX...ial,results for the first quarter ended March 28, ...t on Monday, April 14, 2008. The Company will host...cer, and Richard Schlenker, Chief Financial Office...
...ce You are Willing to Pay, HUNTINGTON BEACH, Cali...uxury in the best or worst of times. "Make no mist...eir appearance with cosmetic,surgery "says Angela ...ue for the investment they are making in themselve...
Other Medicine News:Health News:Kidney Community Gathers on Capitol Hill to Ask Congress to Support Legislation for Increased Kidney Care Education, Updates for Kidney Dialysis Benefit 2Health News:Kidney Community Gathers on Capitol Hill to Ask Congress to Support Legislation for Increased Kidney Care Education, Updates for Kidney Dialysis Benefit 3Health News:Chronically Ill Patients Get More Care, Less Quality, Says Latest Dartmouth Atlas 2Health News:Chronically Ill Patients Get More Care, Less Quality, Says Latest Dartmouth Atlas 3Health News:Chronically Ill Patients Get More Care, Less Quality, Says Latest Dartmouth Atlas 4Health News:Chronically Ill Patients Get More Care, Less Quality, Says Latest Dartmouth Atlas 5Health News:Chronically Ill Patients Get More Care, Less Quality, Says Latest Dartmouth Atlas 6Health News:Leaky blood vessels open up nerve cells to toxic assault in Lou Gehrig's disease 2Health News:Leaky blood vessels open up nerve cells to toxic assault in Lou Gehrig's disease 3Health News:Leaky blood vessels open up nerve cells to toxic assault in Lou Gehrig's disease 4Health News:Hyperion Therapeutics Elects Lota Zoth to Board of Directors 2Health News:5 Ways to Get the Plastic Surgery That You Want 2Kidney Community Gathers on Capitol Hill to Ask Congress to Support Legislation for Increased Kidney Care Education, Updates for Kidney Dialysis BenefitChronically Ill Patients Get More Care, Less Quality, Says Latest Dartmouth AtlasLeaky blood vessels open up nerve cells to toxic assault in Lou Gehrig's diseaseHyperion Therapeutics Elects Lota Zoth to Board of DirectorsExponent to Report First Quarter Fiscal 2008 Results5 Ways to Get the Plastic Surgery That You Want
(Date:11/23/2009)...DAapprovalsoftwonewtherapiesforNon-Hodgkin,sLympho...ncludeofatumumab(Azerra(TM),GlaxoSmithKline)asathe...a(CLL)andromidepsin(Istodax(R),GloucesterPharmaceu...usT-celllymphoma(CTCL). ,, FORTWASHINGTON,Pa.,N...shavepromptedtheNationalComprehensiveCancerNetwork...
(Date:11/23/2009)...3/PRNewswire/--Reportlinker.comannouncesthatanewma... HolterMonitoringSystems-AGlobalMarketReview ,...onitoring-Systems---A-Global-Market-Review.html#ut...aign=prnewswire ,, Cardiovascularmonitoring...atientsneedtobecontinuouslymonitoredduringdiagnost...
(Date:11/23/2009)...ov.23/PRNewswire/--BridgePointMedicalannouncedtoda...foritscoronaryandperipheralChronicTotalOcclusion(C...ssingCatheterandtheStingray®CTORe-EntrySystem...etersthataredesignedtonavigatehighlydiseasedarteri...tyandstenting. ,, TheNationalHeart,LungandBlood...
Breaking Medicine Technology:NCCN Updates NHL Guidelines to Incorporate FDA Approvals of New Treatment Options 2NCCN Updates NHL Guidelines to Incorporate FDA Approvals of New Treatment Options 3Reportlinker Adds Holter Monitoring Systems - A Global Market Review 2Reportlinker Adds Holter Monitoring Systems - A Global Market Review 3Reportlinker Adds Holter Monitoring Systems - A Global Market Review 4Reportlinker Adds Holter Monitoring Systems - A Global Market Review 5BridgePoint Medical(R) Receives European CE Mark for Stingray(R) and CrossBoss(TM) for Opening Completely Blocked Arteries 2Micromet to Present at the 16th Annual NewsMakers in the Biotech Industry Conference on September 16 2009 14063 1Micromet to Present at the 16th Annual NewsMakers in the Biotech Industry Conference on September 16 2009 14063 2Micromet to Present at the 16th Annual NewsMakers in the Biotech Industry Conference on September 16 2009 14063 3Brains response to seeing food may be linked to weight loss maintenance 57213 1Brains response to seeing food may be linked to weight loss maintenance 57213 2University of Toronto study shows disparity of effect of climate change on UV radiation 9934 1University of Toronto study shows disparity of effect of climate change on UV radiation 9934 2...ion of Phase I/IIa Trial to 9 mg Dosage,Level, HOP...l/ --,Boston Life Sciences announced today that cl...rin(R), were presented in the Neurotrauma,and Crit...eting of,the American Association of Neurological ...entation, "Results of the Cethrin Phase I/IIa,Pros...
...ent Planned for Second Half of 2007 -, BRISBANE, A...,Progen Pharmaceuticals Limited today announced th...-88 in patients who had,previously undergone surgi...nstrated that 160 mg of PI-88 showed an improvemen...5 percent and,prolonged the time to tumour recurre...
Other Medicine Technology:Boston Life Sciences, Inc. Announces Presentation of Cethrin Phase,I/IIa 6-Month Results at 75th Annual Meeting of the American,Association of Neurological Surgeons 2Boston Life Sciences, Inc. Announces Presentation of Cethrin Phase,I/IIa 6-Month Results at 75th Annual Meeting of the American,Association of Neurological Surgeons 3Boston Life Sciences, Inc. Announces Presentation of Cethrin Phase,I/IIa 6-Month Results at 75th Annual Meeting of the American,Association of Neurological Surgeons 4Progen's Phase 2 Liver Cancer Trial Exceeds Efficacy Objective 2Progen's Phase 2 Liver Cancer Trial Exceeds Efficacy Objective 3| Copyright © 2003-2009 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |