Navigation Links
Gene pattern may identify kidney transplant recipients who don't need life-long anti-rejection drugs
Date:5/24/2010

ls (Tregs). Work in animal models indicates that B cells also may help promote immune tolerance.

"We expected to find a difference between the tolerant and immunosuppression groups in the genes associated with Tregs," says Dr. Newell. "However, we were surprised that our data showed that B cell genes may play an important role in maintaining and possibly inducing tolerance to transplanted organs."

According to Dr. Turka, identifying potential biomarkers of immune tolerance is the first step in identifying transplant recipients whose immunosuppression therapy could be reduced. "If we could develop a reliable tolerance signaturea pattern of gene expression that indicates that someone will not reject a transplantthen we could find patients who would make good candidates for supervised drug withdrawal," he said.

The study team stresses that transplant patients should never consider reducing or changing their medication regimen unless under the direct supervision of their physician. According to Drs. Newell and Turka, doing so would "almost certainly result in the rejection of the kidney, leaving the patient in need of another transplant."

Follow-up studies of this gene pattern are being planned. Similar findings already have been provided by a European group, led by King's College in London, that conducted a comparable study in kidney transplant patients. Their results appear in the same issue of the Journal of Clinical Investigation.

"The goal of ITN is to understand how immune tolerance can be induced or achieved in a variety of settings, including allergy, autoimmune disease and transplantation," says Daniel Rotrosen, M.D., director of the Division of Allergy, Immunology and Transplantation at NIAID. "Potentially, a biomarker for tolerance in kidney transplant recipients may predict tolerance in individuals following transplantation of other organs or with other immune-mediated diseases. Having a cooperative p
'/>"/>

Contact: Julie Wu
wujuli@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Genetic Pattern May Predict Leukemia Relapse
2. Genetic pattern that predicts leukemia relapse discovered
3. Research identifies patterns of CD24, a novel biomarker for non-small cell lung carcinomas
4. Study Offers Insights Into Male Pattern Baldness
5. Bees Can Be Trained to Recognize Face-Like Patterns
6. New Paperback Dating Advice Book, Love in 90 Days, Reveals 16 Men's Dead-End Dating Patterns and What To Do About Them
7. Researchers find new patterns in H1N1 deaths
8. Wistar-led research team discovers genetic pattern that indicates early-stage lung cancer
9. Australian researchers identify a new disease
10. McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
11. Simple Test May Identify Breast Cancer Subtypes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... ... August 31, 2015 , ... The acknowledgement from Caribbean Journal comes after Grace ... 2015. The island of Providenciales itself received a TripAdvisor Traveller's Choice Award in ... Bay is offering a special promotion for newlyweds and honeymooners to celebrate this amazing ...
(Date:8/30/2015)... ... August 31, 2015 , ... ChopChop Kids, ... for Kids , recently elected two new officers to serve on the organization’s ... mission of inspiring and teaching kids to cook real food with their families ...
(Date:8/30/2015)... CA (PRWEB) , ... August 30, 2015 , ... ... announced a back to school special. The company is currently offering lice head checks ... In addition, the company is offering a 10% discount on their lice treatment products. ...
(Date:8/30/2015)... ... August 30, 2015 , ... Certified Nutrition Businessman Reid Eckert agrees to ... InHealth media is a global sales and communications firm that offers U.S. brands a ... our business relationship with Mr. Reid Eckert, as his interpretation of the nutritional needs ...
(Date:8/29/2015)... Tempe, AZ (PRWEB) , ... August 30, 2015 , ... ... of David O’Shea to serve as the college’s Vice President of Strategic Initiatives and ... years, is eager to help the college expand its reach and impact through innovative ...
Breaking Medicine News(10 mins):Health News:Grace Bay Beach Named a Top Beach Destination for Weddings 2Health News:ChopChop Kids Appoints New Chair and Vice-Chair to Board of Directors 2Health News:ChopChop Kids Appoints New Chair and Vice-Chair to Board of Directors 3Health News:Lizzie’s Lice Pickers Announces Back to School Head Check Special and Discounted Lice Treatment Products 2Health News:Nutrition Guru Continues Relationship With Renowned Health and Wellness Company 2Health News:Rio Salado College Appoints New Vice President of Strategic Initiatives and Information Services 2
... By Steven Reinberg HealthDay Reporter , MONDAY, Oct. ... appear to reduce the risk of having a baby with a ... or palette, a new study suggests. Neural tube birth ... are known to decrease when pregnant women take supplements of folic ...
... strength of its synapses -- the connections between neurons -- ... discovery that challenges conventional wisdom on the brain mechanisms of ... "rhythm," or frequency, for changing synaptic strength. And further, like ... a different optimal frequency for learning. The ...
... Mount Sinai School of Medicine have found that $6.7 billion ... unnecessary medications in primary care, with 86 percent of that ... high cholesterol. The findings are published in a research letter ... of Internal Medicine , one of the JAMA/Archives journals. ...
... By Amanda Gardner HealthDay Reporter , MONDAY, ... 10 parents don,t follow recommended vaccination guidelines for their ... involve skipping doses or delaying shots. And parents ... move toward an alternative schedule, according to new research. ...
... , MONDAY, Oct. 3 (HealthDay News) -- Among patients ... of sedation was not linked to an increased risk ... Swedish researchers report. "Neither duration of anesthesia nor ... with an increased risk for new malignant disease within ...
... whether or not to treat an ill resident on-site or send ... status. A new study out this month shows that on ... be sent to the hospital than individuals with private insurance ... health outcomes. "Nursing homes have an incentive to ...
Cached Medicine News:Health News:Mom's Healthy Diet Might Cut Birth Defect Risk 2Health News:Mom's Healthy Diet Might Cut Birth Defect Risk 3Health News:How the brain makes memories: Rhythmically! 2Health News:How the brain makes memories: Rhythmically! 3Health News:New research shows $6.7 billion spent on unnecessary tests and treatments in one year 2Health News:Some U.S. Parents Ignoring Vaccination Guidelines 2Health News:Some U.S. Parents Ignoring Vaccination Guidelines 3Health News:General Anesthesia Does Not Boost Cancer Risk, Study Finds 2Health News:Nursing home hospitalizations often driven by payer status 2Health News:Nursing home hospitalizations often driven by payer status 3Health News:Nursing home hospitalizations often driven by payer status 4
(Date:8/28/2015)... -- Perrigo Company plc ("Perrigo") (NYSE: PRGO ; TASE) ... leading OTC brands from GSK in an all cash ... clear demonstration of Perrigo,s unique ability to maximize brand ... 36 countries.  Perrigo Chairman, President and ... excited to complete this transaction, which clearly demonstrates our ...
(Date:8/28/2015)... LONDRES, 28 de agosto de 2015   ... su participación en el  Congreso de la ESC ... más recientes y novedosas, entre ellas HeartModel A.I. ... las personas y la tecnología con los protocolos ... guiar los tratamientos y permitir atención en el ...
(Date:8/27/2015)... CUPERTINO, Calif. , Aug. 27, 2015 ... management is scheduled to present at three upcoming healthcare ... , President and CEO, will present at the Rodman ... 10:00 a.m. Eastern time. The conference is being held ... York City . A live audio webcast of ...
Breaking Medicine Technology:Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 4Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 2Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 3Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 4Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 5DURECT to Participate in Upcoming Healthcare Conferences 2
... THE WOODLANDS, Texas, Dec. 7, 2010 Community-based oncology practices ... iKnowMed PM. iKnowMed PM is offered by US Oncology, ... accessible via the Internet and customizable for community-based oncology practices. ... and can interface with a variety of other EHRs already ...
... Dec. 7, 2010 MedAvante, Inc., the leader in ... disorders, announced that Cipher Pharmaceuticals is using MedAvante Centralized ... Cipher recently announced the completion of the ... every patient is interviewed by a qualified MedAvante mental ...
Cached Medicine Technology:Community-Based Oncology Practices Have a New Affordable Practice Management System Offering by US Oncology 2Community-Based Oncology Practices Have a New Affordable Practice Management System Offering by US Oncology 3Community-Based Oncology Practices Have a New Affordable Practice Management System Offering by US Oncology 4Cipher Pharmaceuticals Using MedAvante Centralized Ratings in Phase 3 Study 2Cipher Pharmaceuticals Using MedAvante Centralized Ratings in Phase 3 Study 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: