Navigation Links
Gene pattern may identify kidney transplant recipients who don't need life-long anti-rejection drugs
Date:5/24/2010

Researchers have identified a distinct pattern of gene expression in the largest reported group of kidney transplant recipients who have not rejected the transplant kidneys even though they stopped taking anti-rejection drugs. This finding may help identify other transplant recipients who could safely reduce or end use of immunosuppressive therapy. In 2008, more than 80,000 people in the United States were living with a kidney transplant.

The findings come from the Immune Tolerance Network (ITN), an international research consortium supported by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Diabetes and Digestive and Kidney Diseases, of the National Institutes of Health, and the Juvenile Diabetes Research Foundation International. The research team included three lead investigators, Kenneth Newell, M.D., Ph.D., of Emory University in Atlanta; Laurence Turka, M.D., of Beth Israel Deaconess Medical Center and Harvard Medical School in Boston; and Vicki Seyfert-Margolis, Ph.D., the former Chief Scientific Officer of ITN and currently at the Food and Drug Administration. Their report appears online in the Journal of Clinical Investigation.

"The immunosuppressive therapy regimens that organ transplant recipients must endure have toxic side effects and increase the recipients' vulnerability to infections and cancer," says NIAID Director Anthony S. Fauci, M.D. "This study holds promise for identifying kidney transplant recipients who might be able to minimize or withdraw from their use of anti-rejection drugs. However, large, prospective studies will be necessary to determine if the same biomarkers identified in the current study are reliable predictors of immune tolerance."

Following a kidney transplant, recipients must be placed on immunosuppressive therapy or their immune systems will reject the transplanted organ. However, these drugs suppress the entire immune system, reducing an
'/>"/>

Contact: Julie Wu
wujuli@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Genetic Pattern May Predict Leukemia Relapse
2. Genetic pattern that predicts leukemia relapse discovered
3. Research identifies patterns of CD24, a novel biomarker for non-small cell lung carcinomas
4. Study Offers Insights Into Male Pattern Baldness
5. Bees Can Be Trained to Recognize Face-Like Patterns
6. New Paperback Dating Advice Book, Love in 90 Days, Reveals 16 Men's Dead-End Dating Patterns and What To Do About Them
7. Researchers find new patterns in H1N1 deaths
8. Wistar-led research team discovers genetic pattern that indicates early-stage lung cancer
9. Australian researchers identify a new disease
10. McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
11. Simple Test May Identify Breast Cancer Subtypes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... As reported by WKMS.com in the article ... municipal court drug has come up with a new strategy ... as the presiding judge in a Southeastern Ohio municipal court ... a medicated treatment option that can literally prevent them from ... Vivitrol, which blocks receptors in the brain that would normally ...
(Date:8/29/2014)... by the Frederick News Post in the article Run For ... the Frederick County Drug Treatment Court has found a new way ... graduate, Korey Shorb, put together a race called Run For Recovery ... donate the proceeds of the event to the program he graduated ... graduated in 2008, admitted that he would probably be in jail ...
(Date:8/29/2014)... Healthpointe is proud to welcome to ... will be practicing out of Healthpointe’s newest office directly ... Healthpointe’s orthopedic team, Dr. Rodas is board-certified ... in occupational medicine. , Among Dr. Rodas’ many ... of Raytheon, the world-class defense and aerospace company. Additionally, ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Healthpointe ... Chapman University Physical Therapy students via Clinical Rotations. ... University will be shadowing Healthpointe providers and specialists ... them to develop clinical experience and learn professional ... students will gain insight into several patient care ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Pursuing its ... is set to unveil a stunning new design that ... company figures, the highly notable surrogacy platform has witnessed ... With over 13,000 visitors a month, the FindSurrogateMother.com community ... working toward one common goal — the precious gift ...
Breaking Medicine News(10 mins):Health News:Ohio Judge Pushes for Addiction Recovery Tool 2Health News:Ohio Judge Pushes for Addiction Recovery Tool 3Health News:Drug Court Grad Brings More Life to Drug Court Program 2Health News:Drug Court Grad Brings More Life to Drug Court Program 3Health News:Dr. Anthony G. Rodas Joins Healthpointe Team at LAX Office 2Health News:Healthpointe is Now Offering Clinical Rotations for Chapman University Physical Therapy Students 2Health News:FindSurrogateMother.com Set to Unveil Stunning New Design as Member Sign-ups Increase by 42% since January 2Health News:FindSurrogateMother.com Set to Unveil Stunning New Design as Member Sign-ups Increase by 42% since January 3
... Executive says that almost 25 percent of cancer patients in ... the targeted time of two months. //The current data is ... ,The report said that just about 75 percent of all ... fell to 60 percent for bowel cancer patients and those ...
... Gripp and his team from DuPont Hospital studied genetic ... scientists found that the gene mutation occured in germline ... of the parents of the affected patients. The researchers ... Interscience. The researchers identified mutations in codon 12 or ...
... can be triggered by exposure to endotoxins in the ... Critical Care Medicine study. Humidifiers, pests, dust, pets, and ... according to the University of Iowa’s Dr. Peter S. ... homes selected to represent the demographic characteristics of the ...
... Centre International de Recherches Médicales de Franceville has identified ... of infection by the deadly Ebola virus // . ... are eaten in Central Africa by local Congolese and ... the infection is contracted through the eating habits of ...
... hope regarding the DNA vaccine trials conducted against the ... have already been completed among 40 HIV- negative // ... in the area of vaccine biology. It involves direct ... antigens into the human body. These vaccines precipitate an ...
... women who have had vaginal deliveries prior to their menopause ... their sisters who have never given birth // . In ... to their counterparts. ,Over 10 million people worldwide ... the other. It is a major health issue that ...
Cached Medicine News:Health News:DNA Vaccine Trials Against HIV Virus In Sweden Nurture Hope 2Health News:Urinary Stress Incontinence Not Related To Childbirth 2
(Date:8/29/2014)... -- According to the new research ... Reagent, Primer, Probe, Custom Oligos), End-User (Research, Pharmaceutical ... NGS, DNA, RNAi) - Global Forecast to 2019" ... is expected to reach $1,712.1 Million by 2019 ... CAGR of 9.8% from 2014 to 2019.. ...
(Date:8/29/2014)... YORK, Pa. , Aug. 29, 2014  Unilife ...  ASX: UNS) announced today that it intends to release ... and year ended June 30, 2014 after market trading ... Management has scheduled a conference call for 4:30 p.m. ... 10, 2014 at 6:30 a.m. AEST), to review the Company,s ...
(Date:8/29/2014)... Aug. 29, 2014 Research and Markets ... Multiple Sclerosis Drugs Market 2014-2018" report to their ... inflammatory medical condition that results in demyelination, axonal transection, ... an abnormal response by the immune system, which targets ... a potentially debilitating disease in which the damage of ...
Breaking Medicine Technology:Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4Unilife Corporation to Announce Financial Results for Fiscal Year 2014 Fourth Quarter and Year End on Tuesday, September 9, 2014 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3
... Diagnostics (SIX: RO, ROG; OTCQX: RHHBY) announced today that ... for cardiac biomarker testing on the cobas ® ... labs with medium testing volumes. With a 9-minute duration, ... tests currently available on an integrated platform and enable ...
... and MYSTIC, Conn., Sept. 16 Amarin Corporation plc (Nasdaq: ... Financial Officer, is scheduled to present on Amarin,s behalf at ... 2010 at 12:30 pm. This conference will be held at ... Stewart, recently appointed as President and Chief Executive Officer, will ...
Cached Medicine Technology:Roche Diagnostics Introduces Full Line of 9-Minute STAT Assays for Cardiac Biomarker Testing on cobas 6000 Analyzer Series 2Roche Diagnostics Introduces Full Line of 9-Minute STAT Assays for Cardiac Biomarker Testing on cobas 6000 Analyzer Series 3Amarin to Present at UBS Life Sciences Conference 2
... TOX/See™ is a 1-step, hand-held, point-of-care device for ... in human urine. The TOX/See device can ... abused drugs in 3 to 8 minutes and ... TOX/See cassette is individually packaged to maximize convenience ...
... point-of-care device for the qualitative detection of drug ... TOX/See device can detect up to nine of ... 8 minutes and requires only a few drops ... to maximize convenience and ease of use. TOX/See ...
... device for the qualitative detection of drug or ... device can detect up to nine of the ... minutes and requires only a few drops of ... maximize convenience and ease of use. TOX/See features ...
... TOX/See™ is a 1-step, hand-held, point-of-care device for ... in human urine. The TOX/See device can ... abused drugs in 3 to 8 minutes and ... TOX/See cassette is individually packaged to maximize convenience ...
Medicine Products: