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Gene mutation identifies colorectal cancer patients who live longer with aspirin therapy
Date:10/25/2012

That led researchers to hypothesize that aspirin could be especially effective against colorectal cancers in which the PIK3CA gene which provides a subunit of PI3K is mutated.

To conduct the study, investigators obtained data on 964 patients with rectal or colon cancer from the Nurses' Health Study and the Health Professionals Follow-up Study long-term tracking studies of the health of tens of thousands of people. The data included information on the patients' use of aspirin after diagnosis and the presence or absence of PIK3CA mutations in their tumor tissue.

The study, which combines the study of disease-related genes and research into large populations of individuals, represents a new, hybrid field which Ogino has termed molecular pathology epidemiology. "The field may help us bring together information from two frontiers of cancer research at both the molecular and population levels in ways that are beneficial to patients," he said.


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Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-5665
Dana-Farber Cancer Institute
Source:Eurekalert  

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Gene mutation identifies colorectal cancer patients who live longer with aspirin therapy
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