Navigation Links
Gene may help identify risk of Alzheimer's in African Americans, Mayo Clinic says
Date:4/12/2013

JACKSONVILLE, Fla. Researchers at Mayo Clinic in Florida participated in a nationwide study that found minor differences between genes that contribute to late-onset Alzheimer's disease in African-Americans and in Caucasians.

The study, published April 10 in The Journal of the American Medical Association, was the first to look at the genetics of a large number of African-Americans diagnosed with this common form of Alzheimer's disease (1,968 patients) compared to 3,928 normal elderly African-American control participants.

The Alzheimer's Disease Genetics Consortium conducted the study, which included Mayo Clinic in Florida investigators Neill R. Graff-Radford, M.D., and Nilufer Ertekin-Taner, M.D., Ph.D. They provided genetic samples and data from their Alzheimer's disease databank.

The study found that the most common risk factor in these African-American patients was the APOE gene, which is also true for Caucasians with the disorder. In addition, another gene, ABCA7, which was discovered to be a risk locus for Caucasians, was also a significant risk factor in African-American patients.

The study concluded that association with variants at the ABCA7 gene increased the risk for late-onset Alzheimer's disease approximately 1.8-fold in these African-American patients compared to 1.1-fold to 1.2-fold in individuals of European ancestry, although the biologic implications of this difference remains to be established.

Still, these differences may not fully explain the genetic basis for development of Alzheimer's disease, the researchers say. The disorder is believed to arise from a number of different genes along with environmental influences.

"While they require replication in an independent African-American cohort, these findings imply that at least some of the genetic factors that lead to late-onset Alzheimer's disease are shared between the two ethnic groups," says Dr. Ertekin-Taner.

But the researchers also acknowledge that the seemingly greater influence of ABCA7 gene in African-Americans might contribute in some important, and as yet unknown, way to the disease, and it may have implications for developing targets for genetic testing, prevention, and treatment.

"These are early days in our understanding of Alzheimer's disease in this group, and in others," says Dr. Neill Graff-Radford. Dr. Ertekin-Taner adds: "It should be noted that these genetic association studies cannot identify the actual variant within the ABCA7 gene that causes the actual biologic change which ultimately confers risk for Alzheimer's disease. Thus, further studies are needed to determine whether the same functional variants or different ones are operating in these two ethnic groups. This knowledge may be critical in drug and biomarker development efforts."

"The importance of this study is that it is proof-of-principle study in this under-studied population and may pave the wave for future larger studies in African-Americans, as well as encourage similar studies in other non-Caucasian ethnic groups," says Dr. Ertekin-Taner.


'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Voices Against Brain Cancer Responds to Research Identifying Contributing Factor in Brain Tumors
2. Singapore clinician-scientists identify new type of deadly lymphoma
3. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Improves the My Diet Doc Health Questionnaire; Better Identifying Internal Factors that May Hinder Fast Weight Loss
4. Scientists identify brains molecular memory switch
5. Pathologists identify patterns of mutations to help inform design of future trials
6. Scientists identify gene that is consistently altered in obese individuals
7. Lung Cancer Asbestos Victims Center Now Urges Families To Help Them Identify A Nonsmoker Loved One Who Had Exposure To Asbestos In The Workplace And Now Has Lung Cancer
8. NIH-supported researchers identify new class of malaria compounds
9. University of Maryland researchers identify fish protein that may inhibit cancer metastasis
10. Researchers identify a promising target for multiple sclerosis treatments
11. Genetic testing may be used to identify BPH patients with increased risk of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a missionary ... Journey: From the Mountains to the Mission Field” is the creation of published author, ... ages and currently teaches a class of ladies at her church, which she has ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... IRVING, Texas , Oct. 6, 2017   ... industry with more than $100 billion in purchasing power, ... industry news and information. The Newsroom is ... chain and industry trends, infographics, expert bios, news releases, ... Besides having access to a wealth of resources at ...
(Date:10/2/2017)... 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... and Consulting, LLC , and named its founder as ... in Tennessee , will operate under ... EnvoyHealth,s service offerings for health care partners to include ... "In an interoperable world, technology delivers ...
(Date:9/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will host ... webcast on Friday, November 3, 2017, beginning at 7:00 ... approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... performance and guidance for 2018, Hill-Rom executives will also ... performance, and long-range financial outlook through 2020. ...
Breaking Medicine Technology: