Navigation Links
Gene markers located for hereditary prostate cancer
Date:1/16/2008

nvestigators found 16 SNPs in five different regions of human chromosomes 8 and 17 that were more common to men with prostate cancer than those without the disease. The individual changes were ones previously linked to prostate cancer and other diseases, a good indication, the scientists say, that they were on the right track.

To create their panel, the scientists chose the best SNPs from each of the five regions and tested their cumulative effect on prostate cancer risk. As the number of associated SNPs increased, so did risk. Men with four or more of these SNPs were nearly 4.5 times more likely to have prostate cancer.

This work strongly suggests that because of the combination of polymorphisms we inherit, one man may be more on the path to developing prostate cancer than another, says Isaacs, who is the William Thomas Gerrard, Mario Anthony Duhon and Jennifer and John Chalsty Professor of Urology at the Brady Urological Institute and professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

Add to that a family history of prostate cancer and the risk doubles. Men with all five SNPs plus a family history of prostate cancer were nearly 9.5 times more likely to have the disease. Further analysis revealed that 46 percent of prostate cancer cases in this population were due to these risk factors. But the scientists estimate that almost 90 percent of the Swedish population carries one or more of the five SNPs, elevating their risk for prostate cancer relative to men who carry none of these factors.

Swedish populations are relatively homogenous, tending to marry other Swedes and well suited for such genetic studies because genetic variation is somewhat more limited than in larger, heterogeneous groups. Socialized medicine in Sweden also enables access to robust registries of patient data.

In addition, Swedes suffer from higher-grade prostate and other cancers, and deaths among their Cauca
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UCLA researchers identify markers that may predict diabetes in still-healthy people
2. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
3. Study makes progress in zoning in on biomarkers for better colon cancer treatment
4. Study shows blood markers can help choose best dose for antiangiogenic drugs
5. Biomarkers predict risk for invasive breast cancer years before the tumor develops
6. 2 proteins may be survival markers in some breast cancers
7. JDRF and Lilly partner to fund research to identify beta cell biomarkers
8. Biomarkers for Alzheimers disease can be trusted in clinical trials
9. New developments in biomarkers for epithelial ovarian cancer
10. Biological markers of prostate cancer shed light on cancer burden faced by African-American men
11. Blood Markers Might Predict Clotting Risk With HRT
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... Rapids, MI (PRWEB) , ... July 31, 2015 ... ... Pure Essential Oils are 100% organic, natural, therapeutic-grade oils from ingredients sourced all ... Ashley Eilers, explains that “With considerable effort, we have developed the highest-quality oils ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... Types " from NBC talked about a woman’s unfortunate experience having cosmetic skin ... on her face, which resulted in blistering, swelling, bruising, and pain. This woman’s ...
(Date:7/31/2015)... Georgia (PRWEB) , ... July 31, 2015 , ... Super-Sod ... Houzz.com with a Super-Sod Pro Page as the perfect fit for such ... via pictures and articles. The social website is a dynamic site that spreads home ...
(Date:7/31/2015)... ... July 31, 2015 , ... Nutritional ... variety of nutritional and wellness products, announced the addition of Vincent Aquilino to ... therapy, active isolated stretching and the prevention and rehabilitation of injuries, has spent ...
(Date:7/31/2015)... ... July 31, 2015 , ... India Network Foundation sponsors ... work, study or family visit for the past 25 years. As India Network offers ... able to travel and spend time with their children and grand children. India ...
Breaking Medicine News(10 mins):Health News:Living Pure Essential Oils takes Therepeutic Essential Oil Market by Storm 2Health News:Dermatologists Discuss Rise in Unqualified Practitioners of Cosmetic Dermatology 2Health News:Dermatologists Discuss Rise in Unqualified Practitioners of Cosmetic Dermatology 3Health News:Super-Sod Created a Landscape Profile on Houzz.com for Home Garden Design 2Health News:NPI Welcomes Vincent Aquilino to Board of Directors 2Health News:India Network Visitor Health Insurance Announces Completion of Food Grains Distribution to Godavari Pushkaram Visitors, Andhra Pradesh, India 2Health News:India Network Visitor Health Insurance Announces Completion of Food Grains Distribution to Godavari Pushkaram Visitors, Andhra Pradesh, India 3
... lawyers' access to a high-profile detainee at Guantanamo Bay, ... security secrets" whose revelation could "cause extremely grave damage", ... prisoners at secret CIA prisons must not be allowed ... - even to their lawyers, the Post reported.,A lawyer ...
... Researchers want doctors to be ready to handle medical problems ... it. //In the present state, what happens when a person ... get back to normal conditions for treatment in time simply ... findings from a UF study show there is little difference ...
... the trans-fat controversy for quite a while, has decided to ... oils! This is perhaps the last nail in the coffin! ... have already communicated their intention of banishing trans fats from ... Government to bring in a law that would entail manufacturers ...
... leading economic think tank has urged policymakers to ensure ... women to reduce their// economic and social vulnerability., ... disproportionately affected by HIV and AIDS get equal opportunities ... Economic Research (NCAER) in a report on 'Gender impact ...
... against time to prevent HIV, the virus that causes AIDS, ... in// the number of prostitutes and lack of safe sex ... three-year programme to encourage the use of condoms and voluntary ... UNAIDS estimates 500 HIV-infected people in Bhutan, a country of ...
... battled off the infection appear to be shielded from ... Canadian study.// ,WebMD.com said that Drug users ... British Columbia researchers for presence of Hepatitis C antibodies ... C mainly through their habit of sharing needles during ...
Cached Medicine News:Health News:Researchers explore medicine in space 2Health News:Researchers explore medicine in space 3Health News:Equal Opportunities For HIV-Positive Women Urged 2Health News:HIV/AIDS Epidemic Scare In Bhutan 2
(Date:7/30/2015)... China , July 30, 2015 Tianyin ... a pharmaceutical company that specializes in the patented biopharmaceutical, ... pharmaceutical ingredients (API), provided updates regarding the notice it ... LLC (the "Exchange") indicating that the Company was below ... forth in Sections 134 and 1101 of the NYSE ...
(Date:7/30/2015)... N.J. , July 30, 2015 Eisai ... in the United States , European ... FDA, EMA and MHLW, respectively) for eribulin, for the ... who have received prior chemotherapy for advanced or metastatic ... on data from a pivotal global Phase 3 clinical ...
(Date:7/30/2015)... York , July 30, 2015 ... its latest report titled, "Continuous Glucose Monitoring Systems Market: ... According to the report, the global continuous glucose monitoring ... 2014 and is expected to reach US$ 788.4 Mn ... forecast period, 2015 to 2020. Global continuous ...
Breaking Medicine Technology:TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 3Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 4Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 5Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 4
... 2011 Cumberland Pharmaceuticals Inc. ... on hospital acute care and gastroenterology markets, today announced that ... has been appointed Chief Financial Officer, effective Tuesday, October 18. ... since April of this year. Mr. Greene ...
... HILL, N.C., Oct. 12, 2011 Cempra Holdings, LLC, ... announced that it has filed a registration statement on ... (SEC) relating to its proposed initial public offering. ... and Company are serving as joint book-running managers for ...
Cached Medicine Technology:Cumberland Pharmaceuticals Appoints Rick S. Greene Chief Financial Officer 2Cumberland Pharmaceuticals Appoints Rick S. Greene Chief Financial Officer 3Cempra Holdings, LLC Files Registration Statement for Proposed Initial Public Offering 2
The Storz Protege is an anterior segment unit only....
... phaco system has all the features of ... dependable engineering means minimal maintenance. Small, light ... site to site. Lowest cost reusable tubing ... No longer is there a price objection ...
... The Horizon Phacoemulsification System ... segment surgical system. Lightweight ... high-end performance and features ... It also provides all ...
CataRhex PRO the portable cataract extraction system with automated capsulotomy....
Medicine Products: