Navigation Links
Gene markers located for hereditary prostate cancer
Date:1/16/2008

nvestigators found 16 SNPs in five different regions of human chromosomes 8 and 17 that were more common to men with prostate cancer than those without the disease. The individual changes were ones previously linked to prostate cancer and other diseases, a good indication, the scientists say, that they were on the right track.

To create their panel, the scientists chose the best SNPs from each of the five regions and tested their cumulative effect on prostate cancer risk. As the number of associated SNPs increased, so did risk. Men with four or more of these SNPs were nearly 4.5 times more likely to have prostate cancer.

This work strongly suggests that because of the combination of polymorphisms we inherit, one man may be more on the path to developing prostate cancer than another, says Isaacs, who is the William Thomas Gerrard, Mario Anthony Duhon and Jennifer and John Chalsty Professor of Urology at the Brady Urological Institute and professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

Add to that a family history of prostate cancer and the risk doubles. Men with all five SNPs plus a family history of prostate cancer were nearly 9.5 times more likely to have the disease. Further analysis revealed that 46 percent of prostate cancer cases in this population were due to these risk factors. But the scientists estimate that almost 90 percent of the Swedish population carries one or more of the five SNPs, elevating their risk for prostate cancer relative to men who carry none of these factors.

Swedish populations are relatively homogenous, tending to marry other Swedes and well suited for such genetic studies because genetic variation is somewhat more limited than in larger, heterogeneous groups. Socialized medicine in Sweden also enables access to robust registries of patient data.

In addition, Swedes suffer from higher-grade prostate and other cancers, and deaths among their Cauca
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UCLA researchers identify markers that may predict diabetes in still-healthy people
2. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
3. Study makes progress in zoning in on biomarkers for better colon cancer treatment
4. Study shows blood markers can help choose best dose for antiangiogenic drugs
5. Biomarkers predict risk for invasive breast cancer years before the tumor develops
6. 2 proteins may be survival markers in some breast cancers
7. JDRF and Lilly partner to fund research to identify beta cell biomarkers
8. Biomarkers for Alzheimers disease can be trusted in clinical trials
9. New developments in biomarkers for epithelial ovarian cancer
10. Biological markers of prostate cancer shed light on cancer burden faced by African-American men
11. Blood Markers Might Predict Clotting Risk With HRT
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 2014 Dr. Svetlana Gomer, MGS Tewksbury ... nation gathered with US Marines on November 14, 2014 ... for the Toys for Tots Literacy Program. This ... new books and audio books for the Toys for ... this Christmas. It represents another major strike in the ...
(Date:12/24/2014)... The report offers details on the global sports ... such as the key trends, the orthopedic market, the ... U.S. sports medicine, the impact of the global economy ... by the market. , Browse report with table of ... provides an overview of the global as well as ...
(Date:12/24/2014)... GA (PRWEB) December 24, 2014 Verde Pointe ... comical than ever. "Last years homemade Christmas sweater lit ... uglier. The 2014 winner is Tandy Wilson for the ... ugly sweater enthusiast," says Kirk Kimmerling DDS. "She took pictures ... angels on the sweater." , "Every year I ...
(Date:12/24/2014)... FL (PRWEB) December 24, 2014 Dental ... solution for a tooth replacement. They offer the strongest ... several advantages over other forms of tooth replacement. They ... rely on the adjacent teeth for support, and they ... people have been told that they are not suitable ...
(Date:12/24/2014)... Attorneys handling talcum powder cancer lawsuits at ... website, the Talcum Powder Ovarian Cancer Center. ... action lawsuits and ovarian cancer claims. These baby powder ... at their website, which serves as a national public ... are not the same as class action lawsuits,” explains ...
Breaking Medicine News(10 mins):Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 2Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 3Health News:Sports Medicine Market Report 2014: Global Industry Analysis, Share, Size, Trends, Growth and Forecast report 2Health News:Verde Pointe Dental Associates Announces the 2014 Ugly Sweater Holiday Contest Winner 2Health News:Innovative Dental Implant Procedure to Gain Momentum in the New Year 2Health News:Talcum Powder Attorneys Explain Class Action Lawsuits 2Health News:Talcum Powder Attorneys Explain Class Action Lawsuits 3Health News:Talcum Powder Attorneys Explain Class Action Lawsuits 4
... (HealthDay News) -- Some HIV patients experience memory loss ... suggests that the reason why is because the virus ... of supporting brain cells called astrocytes. The blood-brain ... the brain from harmful chemicals and toxins. In healthy ...
... teaming up to offer one of the nation,s most ... Led by the University of Maryland and the ... will target the so-called short-haul "drayage" fleet that shuttles ... The effort seeks to double the impact of ...
... News) -- Cancer patients taking the drugs sunitinib and ... the drugs don,t cause as much damage to the ... small study included 40 volunteers in the Netherlands, including ... were treated with sorafenib. Seven patients with metastatic renal ...
... Kathleen Doheny HealthDay Reporter , TUESDAY, June 28 ... more than most experts have long believed, according to a ... follow-up of nearly three decades -- the longest ever -- ... clearer as the decades roll on. In fact, most ...
... 2011 Earl L. Smith III, O.D., dean of the ... received an award for his work in slowing the progression ... the endowed Greeman-Petty Professor chair, accepted the Donald Korb Award ... lens and cornea section of the American Optometric Association (AOA). ...
... & Science University have discovered a naturally occurring disease in ... a discovery that could have a major impact on ... The disease that the researchers discovered in monkeys at OHSU,s ... virus that could give significant clues into how multiple sclerosis ...
Cached Medicine News:Health News:Research Sheds Light on Cause of Brain Deficits in HIV Patients 2Health News:Mid-Atlantic states' unique plan to replace region's dirtiest trucks 2Health News:Mid-Atlantic states' unique plan to replace region's dirtiest trucks 3Health News:Certain Cancer Drugs Don't Interfere With Flu Vaccine: Study 2Health News:Longest Trial Ever Confirms Mammograms' Benefits 2Health News:Longest Trial Ever Confirms Mammograms' Benefits 3Health News:Work to slow progression of nearsightedness in children wins award 2Health News:Researchers at Oregon Health & Science University discover MS-like disease in monkeys 2
(Date:12/22/2014)... LAWRENCE, Mass. , Dec. 22, 2014 /PRNewswire/ ... a leading manufacturer of innovative dialysis products, announced ... (FDA) has cleared its System One™ to perform ... sleeping, known as home nocturnal hemodialysis. NxStage,s® System ... cleared by the FDA for this indication. ...
(Date:12/22/2014)... LUXEMBOURG , Dec. 22, 2014  ConvaTec, a ... Paul Moraviec has been appointed Interim Chief Executive Officer ... Mr. Moraviec succeeds Ken Berger .  "The Board ... service in leading ConvaTec over the past three years," ... Board of Directors.  "We are confident that the company ...
(Date:12/22/2014)... , Dec, 22, 2014  Eiger BioPharmaceuticals ... 2a study of lonafarnib in patients with chronic ... conducted at the National Institutes of Health (NIH) ... .  The double-blinded, randomized, placebo-controlled, dose ascending study ... daily and 200 mg twice daily for 28 ...
Breaking Medicine Technology:NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 2Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 3
... , a leading provider of therapeutic drug monitoring and ... today the appointment of David Cohen to Chief Operating ... responsible for new business analysis and development to expand ... Millennium,s legislative initiatives and community outreach programs. ...
... Pharmaceuticals, Inc. (Nasdaq: ISIS ) announces the following webcast:What: ... presented at ESCWhen: , Wednesday, September 1, 2010 at 4:00 ... Live on the Internet.  Simply log onto our Web site listed ... a replay of the webcast will be available for a limited ...
Cached Medicine Technology:Millennium Laboratories Announces New Chief Operating Officer David Cohen 2
Polyester ribbons (3) impregnated with different OD values of conjugated Protein G...
Colloidal Gold Sol, 80 nm - 12 - 15 OD, 1 ml, Gold Sol Nanoparticles - not boiled, not centrifuged...
Colloidal Gold Sol, 20 nm - 12 - 15 OD, 1 ml, Gold Sol Nanoparticles - not boiled, not centrifuged...
... Pachymeter [i.e., PalmScan P2000] device is ... which incorporates A-mode pulsed-echo ultrasound,technology, and ... measure the corneal thickness (CT) and,epithelium ... P2000 includes two software user,interfaces; a ...
Medicine Products: