Navigation Links
Gene markers located for hereditary prostate cancer
Date:1/16/2008

Researchers at the Johns Hopkins Brady Urological Institute, Wake Forest University and the Karolinska Institute in Sweden have identified an array of gene markers for hereditary prostate cancer that, along with family history for the disease, appear to raise risk to more than nine times that of men without such markers. The panel, gleaned from a study of more than 4,000 Swedes, found that these markers are common and could account for nearly half of the prostate cancer cases in this study. Results are published online in the Jan. 16 edition of the New England Journal of Medicine.

The international research team plans to sample DNA from U.S. populations of men to determine if these genetic changes prevail outside of Sweden. And they caution that the panel of markers cannot tell how aggressive a potential cancer may be.

This information is not yet available as a genetic test for risk of prostate cancer, but efforts are under way to rapidly develop one, says William B. Isaacs, Ph.D., of the Johns Hopkins Brady Urological Institute, who participated in the study.

While these findings need to be validated and refined, its a step in the right direction to revealing the genetic-based reasons for this cancer that we have been looking for over the past 15 years, he added.

In the study, the scientists drew blood from 2,893 prostate cancer patients and 1,781 men without the disease. White blood cells are a good source of DNA that an individual is born with as opposed to DNA in cancer cells that gets altered by the environment or other means, according to the scientists.

Using DNA from blood cells, they sifted through variations in chemicals called nucleotides that pair up to form the rungs of a DNA ladder which carries genetic instructions. These so-called single nucleotide polymorphisms or SNPs, occur when one chemical base pair is swapped for another, altering the information in the DNA alphabet or sequence.

Investigators found 16 SNPs in five different regions of human chromosomes 8 and 17 that were more common to men with prostate cancer than those without the disease. The individual changes were ones previously linked to prostate cancer and other diseases, a good indication, the scientists say, that they were on the right track.

To create their panel, the scientists chose the best SNPs from each of the five regions and tested their cumulative effect on prostate cancer risk. As the number of associated SNPs increased, so did risk. Men with four or more of these SNPs were nearly 4.5 times more likely to have prostate cancer.

This work strongly suggests that because of the combination of polymorphisms we inherit, one man may be more on the path to developing prostate cancer than another, says Isaacs, who is the William Thomas Gerrard, Mario Anthony Duhon and Jennifer and John Chalsty Professor of Urology at the Brady Urological Institute and professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

Add to that a family history of prostate cancer and the risk doubles. Men with all five SNPs plus a family history of prostate cancer were nearly 9.5 times more likely to have the disease. Further analysis revealed that 46 percent of prostate cancer cases in this population were due to these risk factors. But the scientists estimate that almost 90 percent of the Swedish population carries one or more of the five SNPs, elevating their risk for prostate cancer relative to men who carry none of these factors.

Swedish populations are relatively homogenous, tending to marry other Swedes and well suited for such genetic studies because genetic variation is somewhat more limited than in larger, heterogeneous groups. Socialized medicine in Sweden also enables access to robust registries of patient data.

In addition, Swedes suffer from higher-grade prostate and other cancers, and deaths among their Caucasian populations are 10 to 20 percent higher than among American Caucasians, according to Henrik Gronberg, M.D., Ph.D., professor of epidemiology at the Karolinska Institute and a co-investigator on the study.

Isaacs and his team note that the SNPs may not in themselves lead to increased cancer risk, but could be markers linked to other changes that do so.

Wake Forest and Johns Hopkins Schools of Medicine have filed patent applications for the technology and results described in this study.


'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. UCLA researchers identify markers that may predict diabetes in still-healthy people
2. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
3. Study makes progress in zoning in on biomarkers for better colon cancer treatment
4. Study shows blood markers can help choose best dose for antiangiogenic drugs
5. Biomarkers predict risk for invasive breast cancer years before the tumor develops
6. 2 proteins may be survival markers in some breast cancers
7. JDRF and Lilly partner to fund research to identify beta cell biomarkers
8. Biomarkers for Alzheimers disease can be trusted in clinical trials
9. New developments in biomarkers for epithelial ovarian cancer
10. Biological markers of prostate cancer shed light on cancer burden faced by African-American men
11. Blood Markers Might Predict Clotting Risk With HRT
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
(Date:6/24/2016)... ... 24, 2016 , ... Puradigm® & Innovative Solutions today announced ... and processing operations at its production facility, and opened its first two dispensaries ... manufacturer of a complete system of proactive air and surface purification solutions for ...
(Date:6/24/2016)... ... ... recruitment firm Slone Partners is pleased to announce the placement of Suzanne ... of North American Capital Sales at HTG Molecular . , In ... commercialization of the HTG EdgeSeq system and associated reagents in North America. , Headquartered ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today that ... Supplier Horizon Award . One of ... was recognized for its support of Premier members through ... clinical excellence, and commitment to lower costs. ... this recognition of our outstanding customer service from Premier," ...
Breaking Medicine Technology: