Navigation Links
Gene loss causes leukemia
Date:5/17/2010

What is leukemia or bone cancer?

In patients with leukemia, the formation of white blood cells in the bone marrow is disrupted. This makes leukemia patients particularly susceptible to infections, because properly functioning white blood cells ensure protection against intruders such as viruses and bacteria. In the US alone, every year around 50.000 adults and children develop leukemia.

T-ALL is caused by interplay of various factors

Leukemia occurs in various forms, one of which is T-cell acute lymphoblastic leukemia (T-ALL). Cells that normally develop into white blood cells, start to divide in an uncontrolled way, giving rise to a huge number of immature cells. Until now, few factors have been associated with an increased risk of developing T-ALL, but it is clear that T-ALL develops when errors occur in several genes simultaneously. Therefore, it is not only important to identify genes that underlie T-ALL, but also to unravel what combinations give rise to the disease. This is a crucial element in the development of future specific combination therapies, promising to be more effective than therapies that focus only on one target.

PTPN2 has a tumor suppressor role

Maria Kleppe and Jan Cools of VIB-K.U.Leuven, together with Peter Vandenberghe of the Centre for Human Genetics and Jean Soulier of the Hpital Saint-Louis in Paris, now identified the gene PTPN2 as another major player. In the DNA of the cells of some leukemia patients, they noticed that the PTPN2 gene was lost, causing proliferation of the cancerous cells. In addition, PTPN2 was identified as a negative regulator of the activity of a specific kinase. The study provides genetic and functional evidence for a tumor suppressor role of PTPN2.

Kinases and phosphatases in cancer development

Beyond the specific findings for T-ALL, this study provides new insights into cancer development in general. Errors in kinases and phosphatases, enzymes able to switch specific cellular functions on of and off, have long been known as potential causes of cancer, but this study now shows that when these errors occur together, the carcinogenic effects can reinforce each other. Furthermore, they can make the cells more resistant to kinase inhibitors, therapeutic substances currently used for cancer treatment.


'/>"/>

Contact: Joris Gansemans
joris.gansemans@vib.be
32-472-594-067
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Related medicine news :

1. No Surprise to David Perecman And Other Personal Injury Attorneys, Vehicles Lead All Causes of Injury at New York Hospital
2. How sunlight causes skin cells to turn cancerous
3. Economic Crisis Causes Acute Demand for Affordable Drug Addiction Treatment
4. Childhood Lead Exposure Causes Permanent Damage: Study
5. Childhood lead exposure causes permanent brain damage
6. Childhood Lead Exposure Causes Permanent Brain Damage
7. Genetic studies reveal new causes of severe obesity in childhood
8. Popular nanoparticle causes toxicity in fish, study shows
9. EPA's New Lead-Based Paint (LBP) Renovation, Repair and Painting Rule (RRP) Causes Headaches for Contractors and Property Owners Alike
10. Play Putty Blooms New Fundraising Opportunities for Schools and Causes in Need
11. What Causes A Person To Be Mentally Ill? Author Who Has Spent Decades Researching Topic Says He Has the Answer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
(Date:6/24/2016)... ... , ... Comfort Keepers® of San Diego, CA is excited to announce they ... to drive cancer patients to and from their cancer treatments. Comfort Keepers provides ... life and ongoing independence. Getting to and from medical treatments is one of ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB ... Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards ... in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, LLC (SCP) ... obtaining investment capital for emerging technology companies. SCP has delivered investment events ... in more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... Research and Markets has ... 2015-2025: Applications, Technologies, Forecasts" report to their ... Electronics, Smart Skin, Structural Health Monitoring, Composite Smart ... electronics involves electronic and/or electrical components and circuits ... structures such as vehicle bodies or conformally placed ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology: