Navigation Links
Gene linked to worsening kidney disease in African-Americans

In African Americans with kidney disease related to hypertension (high blood pressure), a common gene variant is associated with a sharply increased risk of progressive kidney disease, according to a study presented at the American Society of Nephrology's 43rd Annual Meeting and Scientific Exposition. End Stage Renal Disease (ESRD) associated with hypertension occurs in the African American population at a rate 13.1 times greater than that of their white counterparts.

"We found that individuals with the common genotype were approximately 1.5 times more likely to have progressive kidney disease than those with other genotypes," comments Brad C. Astor, PhD (Johns Hopkins Bloomberg School of Public Health, Baltimore). The variant genefound in more than half of patients in the studycould contribute to the high rate of ESRD among African Americans.

The researchers performed genetic studies to identify variant forms of the gene MYH9 in 706 African Americans with kidney disease related to high blood pressure (hypertensive nephrosclerosis). The patients were drawn from a larger study, the African American Study of Kidney Disease and Hypertension (AASK).

"African Americans are at much higher risk of ESRD compared to white Americans, but the reasons for this discrepancy are unknown," Astor explains. "A genetic variation of the MYH9 gene, common in African Americans, was recently found to be associated with ESRD in individuals without diabetes. We examined the association between this genetic variation and progression of kidney disease in African Americans with hypertensive nephrosclerosis."

In the AASK patients, several MYH9 gene variants were related to the risk of decreased kidney function or ESRD. Participants with one MYH9 variant were likely to have other variants as well.

The same MYH9 gene variant previously linked to nondiabetic ESRD was also associated with an increased risk of progressive kidney disease in the AASK patients. The risk of death, ESRD, or a significant drop in kidney function was 50 percent higher than in those without the variant gene.

The variant MYH9 gene was very common, present in 55 percent of the AASK study participants. Its association with progressive kidney disease was independent of age, sex, or treatment for high blood pressure. The same variants are present in many African Americans without kidney disease, however.

The results add new evidence linking MYH9 variants to racial differences in kidney disease rates and outcomes. "Associations between specific genetic variations and outcomes can help us understand the pathophysiologic processes involved in progressive kidney disease and may lead to areas of research to slow or prevent progressive kidney disease," says Astor.

Meanwhile, newer studies raise questions about the significance of the MYH9 variants.* Those studies suggest that a neighboring gene, called APOL1, may actually be the causal gene for non-diabetic ESRD/CKD in African Americans. MYH9 may simply be a marker of the causal gene. Further studies are needed to dissect the contribution of APOL1 and MYH9 in CKD in African Americans and to determine the utility of the APOL1/MYH9 locus in diagnosis and patient management.

Astor points out that the AASK study, designed to test different blood pressure medications and blood pressure goals, had strict inclusion and exclusion criteria. "The results in this study may not be generalizable to other populations," he notes.


Contact: Shari Leventhal
American Society of Nephrology

Related medicine news :

1. UH physicists study behavior of enzyme linked to Alzheimers, cancer
2. Depression linked to HIV risk among South African young people, study shows
3. Prostate cancer treatment linked to higher rate of colon cancer, study finds
4. Use of AEDs in hospitals for cardiac arrest not linked with improved survival
5. Antibody Linked to Allergies on the Rise
6. Gene Variation Linked to Altruism
7. Low Vitamin D Linked to Deterioration in Certain Leukemia Patients
8. Yogas ability to improve mood and lessen anxiety is linked to increased levels of a critical brain chemical
9. Common Eye Condition Linked to Elevated Eye Pressure
10. Childhood Abuse Linked to Diabetes Risk in Adult Women
11. Higher Statin Doses Linked to Fewer Heart Attacks, Stroke
Post Your Comments:
(Date:11/27/2015)... ... 2015 , ... An inventor, from Hopkinsville, Ky., thought there ... home, so he invented the patent-pending ELECTRONIC M.D. , The ELECTRONIC M.D. provides ... so, it could help to prevent potential overdose situations. As a result, it ...
(Date:11/27/2015)... Aliso Viejo, CA (PRWEB) , ... November 27, 2015 , ... ... exclusively for use in Final Cut Pro X. With ProSidebar: Fasion, video editors ... banners, or use ProSidebar as a minimalist title opener. Utilize presets featuring self-animating ...
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television ... an interesting show that delves into an array of issues that are presently affecting ... benefit from open dialogue, this show is changing the subjects consumers focus on, one ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and ... nonprofit healthcare organizations in the country. They have overseen financial turnarounds, shown commitment ... advance the healthcare industry as a whole through their advocacy and professional efforts. ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity Point ... come together on Thanksgiving Day to share the things that they are most ... Serenity Point YouTube channel, patients displayed what they wrote on index cards, describing ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... 2015  Lannett Company, Inc. (NYSE: LCI ... acquisition of Kremers Urban Pharmaceuticals Inc. (KU), the ... company UCB S.A. (Euronext: UCB). ... KU from UCB for total consideration of approximately ... customary working capital adjustment, a deduction of certain ...
(Date:11/27/2015)... 26, 2015 ... the "2016 Global Tumor Marker Testing ... and Sales Segment Forecasts, Innovative Technologies, Instrumentation ... to their offering. --> ... "2016 Global Tumor Marker Testing Market: ...
(Date:11/26/2015)... Un nuevo enfoque combina la ... cáncer avanzado.   --> Un nuevo ... Bremachlorin para el cáncer avanzado.   --> ... la terapia fotodinámica de Bremachlorin para el cáncer avanzado. ... --> Clinical Cancer Research . --> ...
Breaking Medicine Technology: