Navigation Links
Gene linked to severity of autism's social dysfunction
Date:4/6/2011

h inhibitory and excitatory synapses, according to Wang.

Initially, looking under a microscope at normal mouse neurons and neurons with a mutant version of GRIP1, the investigators marked the receptor proteins with green fluorescence, added a chemical that promotes their "disappearance" deep inside a cell and timed the rates at which they disappeared leaving a cell unable to respond to signals from other cells. They also timed the reemergence of the protein back to the cell surface. With the GRIP1 mutant neurons, the receptors recycled to the surface twice as fast as in the normal neurons.

"If the receptors are recycling faster, the number of receptors on the surface is greater, so the cells are more sensitive to glutamate," Huganir explains. "The quicker the recycling, the more receptors on the surface and the stronger the excitatory transmission."

Even if just the excitatory synapses are affected, and the inhibitory ones don't change, that alone affects the relative balance of signaling, Huganir says.

Next, using 10 mice genetically engineered to lack both normal and mutant GRIP proteins, researchers watched what happened when each animal was put into a box where it could choose between spending time with a mouse it hadn't encountered before, or an inanimate object. They compared the behaviors of these mice with 10 normal mice put into the same social situation. Mice lacking both GRIP1 and GRIP2 spent twice as much time as wild-type (normal) mice interacting with other mice as they did with inanimate objects.

"These results support a role for GRIP1 in social behavior and implicate its variants in modulating autistic behavior," Wang says.

Finally, the team looked at the behavioral analyses of individuals in two families, each with two autistic brothers, and correlated their scores on standard diagnostic tests that assessed social interaction with their genotypes for GRIP1 variants.

In one family, th
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Weight Linked to Complications in Some Hysterectomy Patients
2. Researchers use zebrafish to identify new gene linked to melanoma
3. Poverty Linked to Anxiety, Mood Disorders
4. Could Pop Music Be Linked to Depression?
5. HPV Might Be Linked to Lung Cancer
6. Severe psoriasis linked to major adverse cardiovascular events
7. Monthly Aspirin Use Linked to Lower Pancreatic Cancer Risk
8. Genetic variation linked to longer telomeres and lower risk of bladder cancer
9. Antidepressants linked to thicker arteries
10. Common Birth Defect May Be Linked to Migraine With Aura
11. Fatal respiratory infections in endangered gorillas are linked to human contact
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... 2014 From embedded sensors and biometrics to ... technology will take center stage at the FitnessTech Summit ... the 2015 International CES® , January 6, 2015 in ... Bellini 2004). The bond between fitness and technology is stronger ... devices and more about the human body. , “Fitness technology ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 The ... its 12th annual International Symposium on Malignant Mesothelioma from ... Maryland. Daytime conference sessions will take place on the ... while dinners, including a community dinner and an awards ... , Sessions will cover a range of topics about ...
(Date:11/24/2014)... November 24, 2014 Residents of retirement ... in this year’s SENIORS GOT TALENT, an annual online ... From piano players to classic crooners, to seniors partying ... older adults are indeed living young. , “SENIORS GOT ... there’s a cash prize, has always been about highlighting ...
(Date:11/24/2014)... Recently, SweetDressy.com, a well-known dress supplier and ... of 2014 Evening Dresses. All these fresh items are ... marketing manager, the special offer is valid until Dec. ... Sweetdressy.com has been working well in the fashion industry ... designs. Their new dresses may be the best products ...
(Date:11/24/2014)... Mental health issues affect tens of ... families, ruin careers, and generally destroy lives. , ... suffer,” says Hardy Nutritionals® founder David ... specialized nutritional treatments can reverse these disorders naturally.” ... Matter”, the premiere episode of O2 Media’s new ...
Breaking Medicine News(10 mins):Health News:Next Wave Fitness Products Debut at FitnessTech Summit Living in Digital Times at the 2015 International CES 2Health News:Next Wave Fitness Products Debut at FitnessTech Summit Living in Digital Times at the 2015 International CES 3Health News:Next Wave Fitness Products Debut at FitnessTech Summit Living in Digital Times at the 2015 International CES 4Health News:2015 International Symposium on Malignant Mesothelioma Will Take Place at the National Institutes of Health Campus 2Health News:2015 International Symposium on Malignant Mesothelioma Will Take Place at the National Institutes of Health Campus 3Health News:Nursing Homes & Assisted Living Retirement Communities Enter Seniors Guide's Seniors Got Talent 2Health News:Nursing Homes & Assisted Living Retirement Communities Enter Seniors Guide's Seniors Got Talent 3Health News:SweetDressy.com Unveiled A New Selection Of Evening Dresses 2Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 2Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 3
... ... of Plantronics telephone headsets, has re-launched its blog to serve as a ... As headsets do more and telephone systems work more closely with computers, ... and the like. Headsets Direct,s blog posts answers to the top ...
... , SEATTLE, Aug. 25 While many debate ... confidently propose will fix health care. With input from doctors and consumers, ... care status quo. , , "The struggles with health ... CEO of Clarion Care. "First, put health care dollars back in the ...
... , , , SHERMAN OAKS, ... facility, a subsidiary of Prime Healthcare Services, Inc. (PHS), today is ... , The new Cardiac Cath. Lab helps to definitively ... in opening the clotted coronary arteries that cause heart attacks. ...
... , , DES MOINES, ... drugs through Iowa Drug Card since the launch of the free statewide ... to Iowa residents, was launched in June, 2008. Every resident of Iowa ... , Former Hawkeye,s Head Football Coach Hayden Fry has been ...
... Aug. 25 A symptomless blood disorder, monoclonal gammo ... not linked to as many serious diseases as previously thought. This finding ... study published in the August 2009 issue of Mayo Clinic ... MGUS has long been thought to be a precursor of serious ...
... ... Percentage of Proceeds to Inspire People to Sign Up to Donate Life - New CD ... ... quartet that scored an international smash with the song "I Swear," is returning to recording ...
Cached Medicine News:Health News:Headsets Direct Blog Becomes Real-Time Help Desk for Plantronics Headset Questions 2Health News:Headsets Direct Blog Becomes Real-Time Help Desk for Plantronics Headset Questions 3Health News:Seattle Software Firm Claims to Cure What Ails Health Care 2Health News:Sherman Oaks Hospital Opens New Cardiac Catheterization Laboratory and Reopens Behavioral Health Facility for Seniors 2Health News:Sherman Oaks Hospital Opens New Cardiac Catheterization Laboratory and Reopens Behavioral Health Facility for Seniors 3Health News:Iowa Drug Card a Huge Success With Iowans 2Health News:Mayo Clinic Proceedings: Common Blood Disorder May Not be Linked to as Many Serious Diseases, as Previously Thought 2Health News:Mayo Clinic Proceedings: Common Blood Disorder May Not be Linked to as Many Serious Diseases, as Previously Thought 3Health News:R&B / Pop Vocal Quartet All-4-One Makes 7-Year Comeback 2Health News:R&B / Pop Vocal Quartet All-4-One Makes 7-Year Comeback 3
(Date:11/23/2014)... Nov. 23, 2014 Anthera Pharmaceuticals, Inc. (Nasdaq: ... F. Truex , President and Chief Executive Officer, will ... Jaffray Healthcare Conference. Anthera will present ... Palace Hotel in New York City ... Anthera Pharmaceuticals is a biopharmaceutical company focused on developing ...
(Date:11/22/2014)... , 21 de noviembre de 2014 /PRNewswire/ ... ensayos clínicos externalizados y tecnologías eClinical, ha indicado ... de ,seguimiento inteligente, para el seguimiento basado en ... inteligente amplía el concepto del seguimiento basado en ... de las visitas de seguimiento o cambio de ...
(Date:11/22/2014)... Nov. 21, 2014 Research and Markets  has ... Drug Industry Report, 2014-2017" report to their offering. ... The Chinese recombinant protein drug market has been expanding ... ability and the like. During 2005-2013, sales of recombinant ... a CAGR of 19.1%, and it is projected that ...
Breaking Medicine Technology:Anthera Pharmaceuticals to Present at Annual Piper Jaffray Healthcare Conference 2El 'seguimiento inteligente' consigue un excelente momento 2El 'seguimiento inteligente' consigue un excelente momento 3China Recombinant Protein Drug Industry Report, 2014-2017 2China Recombinant Protein Drug Industry Report, 2014-2017 3
... , PRINCETON, N.J., Nov. 30 Covance ... present at the Piper Jaffray 21st Annual Health Care Conference on ... access a live webcast of the presentation at www.covance.com . ... log on 10 minutes early. , Covance, with headquarters in Princeton, ...
... , ... that a new market research report is available in ... Market Review , http://www.reportlinker.com/p0164331/Operating-Tables---A-World-Market-Review.html , Operating ... the best possible position for the surgeon to conduct ...
Cached Medicine Technology:Reportlinker Adds Operating Tables - A World Market Review 2Reportlinker Adds Operating Tables - A World Market Review 3Reportlinker Adds Operating Tables - A World Market Review 4Reportlinker Adds Operating Tables - A World Market Review 5
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
... cautery connector extending from the top of ... electrosurgery when properly attached to standard cautery ... Endo-Surgery provides disposable handheld instruments that provide ... instruments come in 5mm and 10mm sizes. ...
... The Featured Products ... at Mediflex and are ... modular in regular or ... come equipped with insulation, ...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
Medicine Products: