Navigation Links
Gene linked to pancreatic cancer growth, U-M study finds
Date:1/31/2012

ANN ARBOR, Mich. A mutant protein found in nearly all pancreatic cancers plays a role not only in the cancer's development but in its continued growth, according to a new study from University of Michigan Comprehensive Cancer Center researchers. The finding suggests a possible target for developing new ways to treat this deadly disease.

Researchers have known that mutations in the Kras gene are what cause pancreatic cancer to develop. These mutations are frequently seen in common precancerous lesions, suggesting it has an early role in pancreatic cancer.

The new study, published in the February Journal of Clinical Investigation, finds that in mice, mutant Kras also keeps the tumor growing and helps precancerous tumors grow into invasive cancer. When the researchers turned off Kras, the tumors disappeared and showed no signs of recurring.

The researchers were able to manipulate Kras in a mouse model that they designed to look at Kras at various points in pancreatic cancer development. In the precancerous lesions, turning off Kras eliminated the tumors in mice and the pancreas tissue returned to normal, with no signs of the cancer returning. With invasive cancer, inactivating Kras killed off the cancer but left the pancreas with fibrous areas similar to scar tissue. Tumors did not recur.

Researchers hope this finding provides the basis for future drug development.

"Right now no drugs specifically target Kras, but there are drugs that target the cellular processes downstream of Kras. We next need to figure out which of these downstream effectors of Kras are important in pancreatic cancer," says study author Marina Pasca di Magliano, Ph.D., assistant professor of surgery and of cell and developmental biology at the U-M Medical School.

Kras is also known to play a role in lung and colon cancer. But it is likely the biggest player in pancreatic cancer, where more than 90 percent of all tumors have m
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Molecular pathways linked to sex, age affect outcomes in lung cancer
2. Physical Changes in Brain Linked to Altered Spirituality
3. Migraine Linked to Increased Heart Attack Risk
4. First Gene Variants Linked to Stuttering Discovered
5. Flat Head Syndrome Linked to Developmental Delays
6. Untreated poor vision in elderly linked to dementia, University of Michigan study shows
7. Genetic Mutation Linked to Prostate Cancer in Blacks
8. Sleep More, Lose Weight – Sleeplessness Linked to Obesity
9. Antibodies linked to cardiovascular disease increase in patients with active lupus
10. High Hormone Level Linked to Cancer Death in Older Men
11. Hormone replacement therapy linked to increased lung cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene linked to pancreatic cancer growth, U-M study finds
(Date:7/26/2014)... “Healthy teeth are important, and having your teeth cleaned regularly ... Health Center of Snohomish County (CHC) in their article, “ ... integration of medical and dental care is the best way ... encourage regular cleanings and checkups not only with a family ... adults will find knowledgeable and friendly staff that ...
(Date:7/26/2014)... 26, 2014 Another DePuy Pinnacle hip lawsuit ... has been filed by Wright & Schulte LLC. This ... behalf of an Erie County, Ohio man who alleges that ... and groin since receiving his Pinnacle Hip implant in 2008. ... be forced to undergo a complex and risky revision surgery ...
(Date:7/26/2014)... (PRWEB) July 26, 2014 As ... chocolate, the true vision of Xoçai ... through its exclusive and healthy chocolate products. One ... blend of cacao, açaí berries and blueberries, an ... exclusive high-antioxidant blend is utilized in all of ...
(Date:7/25/2014)... TX (PRWEB) July 26, 2014 ... Laser Scanning Confocal Microscope Industry” is a ... Laser Scanning Confocal Microscope market. The report ... including Laser Scanning Confocal Microscope definition, classification, ... industry overview. This research covers international market analysis, ...
(Date:7/25/2014)... USA (PRWEB) July 25, 2014 As reported ... Battlefield in War On Heroin (7/20), police in Salem, ... seriously crack down on the recent heroin epidemic that has ... article focuses on one heroin-related overdose case in which police ... in the victim's cell phone. By pretending to be the ...
Breaking Medicine News(10 mins):Health News:Common Dental Care Questions Answered by Community Health Center of Snohomish County in Recent Article 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Recipient Who Faces Surgery To Replace Artificial Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Recipient Who Faces Surgery To Replace Artificial Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Recipient Who Faces Surgery To Replace Artificial Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Recipient Who Faces Surgery To Replace Artificial Hip Implant 5Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 2Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 3Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 4Health News:Laser Scanning Confocal Microscope Market: 2014 Global, China Manufacturing Bases Analysis Now at DeepResearchReports.com 2Health News:Laser Scanning Confocal Microscope Market: 2014 Global, China Manufacturing Bases Analysis Now at DeepResearchReports.com 3Health News:Laser Scanning Confocal Microscope Market: 2014 Global, China Manufacturing Bases Analysis Now at DeepResearchReports.com 4Health News:Multiple States Crack Down on Heroin Epidemic 2
... has entered into a collaboration with the Indian Council of ... cervical cancer drug, Gardasil.// ,This is the first public-private ... trials will be conducted for a human pappiloma virus (HPV) ... been developed by Merck and will be tried on 30 ...
... outbreak of flu and it is presumed that this year it ... In Texas and Colorado the flu case increased greatly in number ... Georgia the State Health Department reports to the press that they've ... Centers for Disease Control and Prevention in Atlanta cautions the need ...
... adolescents and 8.5 million American adults are becoming overweight, ... Americans have been // getting less and less exercise ... ,However the new nationwide study of over 5,300 Americans ... researchers found a significant proportion of US teenagers and ...
... the right to fight for receiving the new breast cancer drug, ... breast cancer and wants to make sure that it does not ... its early stage has meant that the primary care trust is ... recourse for the same. Even Patricia Hewitt, the Health Secretary has ...
... In Canada questions have arisen about the best approach whether ... out to be that more people want public services offering ... the London’s public Queen Elizabeth Hospital is an example financial ... the US a study reveals that the health care provided ...
... beneficial effects of physical activities such as running, jogging on ... has now been found by neuroscientists from Germany that running ... boost of memory. // ,The study ... sessions per week followed by which they had to take ...
Cached Medicine News:Health News:Merck, ICMR to conduct joint trials on cervical cancer vaccine 2
(Date:7/25/2014)... NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, ... OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE ... JURISDICTION AbbVie (NYSE: ABBV ) today announced financial ... "This was another very strong quarter for AbbVie, ... original guidance and announced plans to merge with Shire, a ...
(Date:7/24/2014)... OVERLAND PARK, Kan. , July 24, 2014 ... licensing of two compounds that will be added ... agreement with Australian-based CIMTECH Pty Ltd, a biotechnology ... and PAR 122 have shown promise in bone ... a license to develop the compounds for the ...
(Date:7/24/2014)... Germany , and MARSEILLE, France ... , Exclusive global license from University of Tokyo ... next-generation sequencing (NGS) gene panels, for blood cancers  ... new test, indicate favorable prognosis for patients with bone ... sees potential for developing companion diagnostics to guide treatment ...
Breaking Medicine Technology:AbbVie Reports Second-Quarter 2014 Financial Results 2AbbVie Reports Second-Quarter 2014 Financial Results 3AbbVie Reports Second-Quarter 2014 Financial Results 4AbbVie Reports Second-Quarter 2014 Financial Results 5AbbVie Reports Second-Quarter 2014 Financial Results 6AbbVie Reports Second-Quarter 2014 Financial Results 7AbbVie Reports Second-Quarter 2014 Financial Results 8AbbVie Reports Second-Quarter 2014 Financial Results 9AbbVie Reports Second-Quarter 2014 Financial Results 10AbbVie Reports Second-Quarter 2014 Financial Results 11AbbVie Reports Second-Quarter 2014 Financial Results 12AbbVie Reports Second-Quarter 2014 Financial Results 13AbbVie Reports Second-Quarter 2014 Financial Results 14AbbVie Reports Second-Quarter 2014 Financial Results 15AbbVie Reports Second-Quarter 2014 Financial Results 16AbbVie Reports Second-Quarter 2014 Financial Results 17AbbVie Reports Second-Quarter 2014 Financial Results 18AbbVie Reports Second-Quarter 2014 Financial Results 19AbbVie Reports Second-Quarter 2014 Financial Results 20AbbVie Reports Second-Quarter 2014 Financial Results 21AbbVie Reports Second-Quarter 2014 Financial Results 22AbbVie Reports Second-Quarter 2014 Financial Results 23AbbVie Reports Second-Quarter 2014 Financial Results 24AbbVie Reports Second-Quarter 2014 Financial Results 25AbbVie Reports Second-Quarter 2014 Financial Results 26AbbVie Reports Second-Quarter 2014 Financial Results 27AbbVie Reports Second-Quarter 2014 Financial Results 28AbbVie Reports Second-Quarter 2014 Financial Results 29AbbVie Reports Second-Quarter 2014 Financial Results 30AbbVie Reports Second-Quarter 2014 Financial Results 31AbbVie Reports Second-Quarter 2014 Financial Results 32AbbVie Reports Second-Quarter 2014 Financial Results 33AbbVie Reports Second-Quarter 2014 Financial Results 34AbbVie Reports Second-Quarter 2014 Financial Results 35AbbVie Reports Second-Quarter 2014 Financial Results 36
... May 15, 2012 Reportlinker.com ... research report is available in ... Global ... Marketing Spend and Sales Strategies ...
... May 15, 2012  Reportlinker.com announces that ... available in its catalogue: ... China Market Analysis, Size, Trends And ... In 2009, the global Osteoporosis drug ...
Cached Medicine Technology:Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 2Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 3Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 4Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 5Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 6Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 7Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 8Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 9Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 10Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 11Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 12Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 13Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 14Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 15Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 16Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 17Global Pharmaceutical Survey 2012-2013: Market Trends, Marketing Spend and Sales Strategies in the Global Pharmaceutical Industry 18Osteoporosis Drug Market- Global And China Market Analysis, Size, Trends And Forecast (2010-2015) 2Osteoporosis Drug Market- Global And China Market Analysis, Size, Trends And Forecast (2010-2015) 3Osteoporosis Drug Market- Global And China Market Analysis, Size, Trends And Forecast (2010-2015) 4
The applicator is designed for a smooth delivery of the solution for surgical procedures....
... Avaulta™ BioSynthetic Mesh ... mesh coated in the ... absorbable, hydrophilic film of ... segments of the Avaulta™ ...
The Repliform Tissue Regeneration Matrix is an acellular human dermal allograft that when surgically implanted is intended to function as a template, facilitating the body's fibroblasts to regenerate...
... Pelvicol® Acellular Collagen Matrix delivers the ... exceptional strength, versatility, and durability in ... the effectiveness of site-specific defect repair ... sterile, biocompatible, crosslinked porcine dermal collagen ...
Medicine Products: