Navigation Links
Gene is linked to lung cancer development in never-smokers
Date:3/21/2010

two more GWAS scans in independent populations -- 328 never smoker lung cancer patients and 407 controls at MD Anderson Cancer Center, and 92 never smoker lung cancer patients and 161 controls at Harvard University. From this, the search was narrowed to just two hits. Both of these hits were adjacent to each other on the same gene, which the researchers then identified as a variant of GPC5.

In the third stage of the study, the researchers used a different method to perform genotyping from the method used in stages 1 and 2 to look at the difference between 91 never smoker lung cancer patients and 439 controls at UCLA. "We confirmed the variant-lung cancer association again," Dr. Yang says.

The final stage of the study involved understanding the function of the gene. "We had to understand whether these hits really represented the functional aspect of the gene, so we tested expression level of GPC5 and found it was significantly reduced," Dr. Yang says. They found that the GPC5 transcription level was twofold lower in adenocarcinoma compared to normal lung tissue. "Interestingly, this reduced transcript expression level was not found in lung carcinoid tumors," Dr. Yang says.

Then the researchers looked to see if this reduced expression led to tumor development, which it did in laboratory culture. "If reduction of expression of this gene leads to development of lung cancer, it suggests that this gene is normally a tumor suppressor," Dr. Yang says. "We believe it helps control the cell proliferation and division, but we need to prove its function in animal models."

They calculated that about one-third of never smoker lung cancer patients in this study had the same variation of the underperforming GPC5 gene. "We hypothesize that this is an important cancer trigger in these patients, and that something else is going on in the remaining two-thirds of never smokers," she says.

"We don't know what that is, but we now have 42 ot
'/>"/>

Contact: Karl Oestreich
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Agricultural Chemical Spray Linked to Birth Defect Risk
2. 3 brain diseases linked by toxic form of same neural protein
3. Bad Behavior as a Kid Linked to Early Death in Men
4. Sedation Linked to Longer Stay in ICU
5. Personal History Linked to Feelings of Betrayal
6. Improved air quality linked to fewer pediatric ear infections
7. Flame-Retardant Chemical Linked to Conception Problems
8. Common antidepressant drugs linked to lactation difficulties in moms
9. Vitamin D Linked to Survival in Lymphoma Patients
10. Poop dermatitis linked to fashionable toilet seats, harsh chemicals
11. Self-Image Linked to Activity in Frontal Lobe of Brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/7/2015)... May 07, 2015 When people think about ... consideration to their roofs than their basements. However, heavy rain ... in crawlspaces and basements. While flooding is an obvious problem ... crawlspaces and unfinished areas dry to avoid a musty ... Damp Basement, Even small amounts of water can cause foundation ...
(Date:5/7/2015)... 07, 2015 Five CHI Health ... Health Bergan Mercy, CHI Health Immanuel and CHI ... in Papillion, Neb.; and CHI Health Mercy in ... achieving high-quality standards of care by the Accreditation ... to best practices in cardiovascular care. The five ...
(Date:5/6/2015)... 2015 Device Patent Law Changes:, Six Key ... a.m. – 12:30 p.m. EDT, http://www.fdanews.com/DevicePatentLaw , Every ... lawsuits and claims that waste their time. , It ... could be prevented if devicemakers better understand the trouble spots ... and revisions to patent laws from all around the world. ...
(Date:5/6/2015)... the exclusive hospital of the Tampa Bay Buccaneers, Florida Hospital ... James Stadium for all the “Bucs Babies” celebrating their first ... the “Bucs Babies” program last year. , “It is ... those born at the Florida Hospitals here in our community, ... enjoyed my time participating in the festivities, interacting with the ...
(Date:5/6/2015)... 06, 2015 On April 27, 2015, ... Plastic Surgery ,” compiled quotes about cosmetic surgery from ... pop singer Iggy Azalea, and Gwyneth Paltrow. For the ... having plastic surgery themselves; only a couple ... its expectations of youth and beauty. (see: goo.gl/wSomih) , ...
Breaking Medicine News(10 mins):Health News:Spring Storms Bring Musty Smell Inside 2Health News:Spring Storms Bring Musty Smell Inside 3Health News:Five CHI Health Facilities in Nebraska, Iowa Recognized for High-Quality Care by Accreditation for Cardiovascular Excellence 2Health News:Five CHI Health Facilities in Nebraska, Iowa Recognized for High-Quality Care by Accreditation for Cardiovascular Excellence 3Health News:FDAnews Announces — Device Patent Law Changes: Six Key Areas of Concern Webinar, May 27, 2015 2Health News:FDAnews Announces — Device Patent Law Changes: Six Key Areas of Concern Webinar, May 27, 2015 3Health News:Florida Hospital and the Tampa Bay Buccaneers Celebrate “Bucs Babies” Who are Turning One this Month with a Party on the Pirate Ship 2Health News:Florida Hospital and the Tampa Bay Buccaneers Celebrate “Bucs Babies” Who are Turning One this Month with a Party on the Pirate Ship 3Health News:Plastic Surgery: Sixteen Celebrities Offer their Opinion about Going Under the Knife 2
... , , JACKSONVILLE, Fla., Sept. ... makers of ACUVUE(R) Brand Contact Lenses is offering movie fans a chance ... this October, for themselves and 50 friends. The grand prize also ... of ACUVUE(R) Brand Contact Lenses. , , Fans can ...
... Health Access Program Awards Minnesota Up to $35 Million Over Five ... , ST. PAUL, Minn., Sept. 22 Portico Healthnet, ... coverage for health care services, has been named as a partner ... announced effort to expand health care access to uninsured Minnesotans. The ...
... , MOUNTAIN VIEW, Calif., Sept. 22 ... publication of results from an in vitro study of ... the potential mechanism by which the pharmacokinetics (PK) and pharmacodynamics of ... dihydroergotamine (DHE). Results will be published in a manuscript titled ...
... , , , ... show hosted by cardiac surgeon and health expert Dr. Mehmet Oz, and the ... the Reliant Convention Center in Houston, Texas on Saturday September 26, 2009 to ... health insurance. Dr. Oz will participate in the event and will devote ...
... Departing Chicago via Vespa Scooter, Schaller to Ride Through Seven Western States ... Md., Sept. 22 Emily Schaller, a 27-year-old drummer with cystic fibrosis ... from Chicago to Burbank, California, in her quest to get on "The ... is to raise awareness about cystic fibrosis, has appeared in ...
... found that hormone therapy used to treat men with advanced ... various heart problems. Some choices of therapy appear, however, to ... biggest cancer congress, ECCO 15 ESMO 34 [1], in ... study, the largest and most comprehensive to date on the ...
Cached Medicine News:Health News:ACUVUE(R) Brand Contact Lenses Gives Movie Fans a Chance to Win a Hometown Screening of WHIP IT 2Health News:ACUVUE(R) Brand Contact Lenses Gives Movie Fans a Chance to Win a Hometown Screening of WHIP IT 3Health News:Portico Healthnet Named Partner in Increasing Health Care Access Via Federal Grant 2Health News:'Headache' Publication Describes Potential Mechanistic Rationale for LEVADEX(TM) Favorable Adverse Event Profile 2Health News:'Headache' Publication Describes Potential Mechanistic Rationale for LEVADEX(TM) Favorable Adverse Event Profile 3Health News:'Headache' Publication Describes Potential Mechanistic Rationale for LEVADEX(TM) Favorable Adverse Event Profile 4Health News:'The Dr. Oz Show' and the National Association of Free Clinics Host One Day Free Public Health Clinic at Houston's Reliant Convention Center on September 26 2Health News:'The Dr. Oz Show' and the National Association of Free Clinics Host One Day Free Public Health Clinic at Houston's Reliant Convention Center on September 26 3Health News:'The Dr. Oz Show' and the National Association of Free Clinics Host One Day Free Public Health Clinic at Houston's Reliant Convention Center on September 26 4Health News:'The Dr. Oz Show' and the National Association of Free Clinics Host One Day Free Public Health Clinic at Houston's Reliant Convention Center on September 26 5Health News:Cystic Fibrosis Patient Emily Schaller Begins 2,000-Mile Quest to Get on 'The Ellen DeGeneres Show' 2Health News:Prostate cancer patients on hormone therapy at increased risk for various heart diseases 2Health News:Prostate cancer patients on hormone therapy at increased risk for various heart diseases 3Health News:Prostate cancer patients on hormone therapy at increased risk for various heart diseases 4
(Date:5/6/2015)...  Membership in Medicare Supplement plans continued to ... Strategy report released by Mark Farrah Associates (MFA).  ... Med Supp plans, covered approximately 11.2 million seniors ... from 2013. Between 2013 and 2014, enrollment in ... Though UnitedHealth was the segment growth leader, many ...
(Date:5/6/2015)... , May 05, 2015 Research and Markets ... addition of the "Chromatography (Instruments and Reagents) ... to their offering. Chromatography is an ... the component of a complex mixture by differential ... decades the scientists have considered chromatography as an ...
(Date:5/6/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4fgrnh/asiapacific ) ... Internal Trauma Fixation Devices Market by Type & ... report to their offering. The ... to grow at a CAGR of 6.7% from ... rising incidences of road accidents, increasing aging population, ...
Breaking Medicine Technology:Continued Growth in Med Supp Market for 2014 according to Mark Farrah Associates 2Global Chromatography (Instruments and Reagents) Market 2015 - Forecasts to 2019 2Asia-Pacific Internal Trauma Fixation Devices (Internal Trauma Fixation Plates, Screws, Rod Wires & Pins, Fusion Nails) Market 2015 2
... , , ATLANTA , Feb. ... for Economic and Clinical Health (HITECH) Act, Elekta has expanded its ... advantage of the financial incentives available from the federal government. These ... certified EMR systems who are able to demonstrate meaningful use. , ...
... , PITTSBURGH , Feb. 4 Mylan ... by Pfizer in connection with the filing of an Abbreviated New ... for Amlodipine Besylate and Atorvastatin Calcium Tablets 2.5/10 mg, 2.5/20 mg, ... mg, 10/20 mg, 10/40 and 10/80 mg. This product is the ...
Cached Medicine Technology:Elekta Expands Consultative Services Program to Help MOSAIQ Customers Demonstrate Meaningful Use Guidelines 2Elekta Expands Consultative Services Program to Help MOSAIQ Customers Demonstrate Meaningful Use Guidelines 3Mylan Confirms First-to-File Patent Challenge Relating to Caduet(R) 2
Curved shafts with 2 mm angled platform. Wide serrated handle with dull finish....
Straight shafts with fine tips and dull finish. Insulated stop with tip gap set at 0.3 mm. Smooth handle....
Straight shafts with micro tips and sandblast finish. Insulated smooth handle....
Straight shafts with rounded tips. Smooth handle with dull finish....
Medicine Products: