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Gene inhibitor, salmon fibrin restore function lost in spinal cord injury
Date:7/23/2014

of salmon fibrin and a PTEN inhibitor called AAVshPTEN. A separate group of rodents got only AAVshPTEN.

The researchers saw that rats receiving the inhibitor alone did not exhibit improved motor function, whereas those given AAVshPTEN and salmon fibrin recovered forelimb use involving reaching and grasping.

"The data suggest that the combination of PTEN deletion and salmon fibrin injection into the lesion can significantly enhance motor skills by enabling regenerative growth of corticospinal tract axons," Steward said.

According to the Christopher & Dana Reeve Foundation, about 2 percent of Americans have some form of paralysis resulting from spinal cord injury, due primarily to the interruption of connections between the brain and spinal cord.

An injury the size of a grape can lead to complete loss of function below the site of occurrence. For example, an injury to the neck can cause paralysis of the arms and legs, an absence of sensation below the shoulders, bladder and bowel incontinence, sexual dysfunction, and secondary health risks such as susceptibility to urinary tract infections, pressure sores and blood clots due to an inability to move the legs.

Steward said the next objective is to learn how long after injury the combination treatment can be effectively administered. "It would be a huge step if it could be delivered in the chronic period weeks and months after an injury, but we need to determine this before we can engage in clinical trials," he said.


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Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

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